Gonçalo Castelo-Branco
@gocastelobranco.bsky.social
1.7K followers 700 following 43 posts
Professor of Glial Cell Biology @ Karolinska Institutet, Stockholm, Sweden • epigenomics • single-cell • spatial • oligodendrocytes • myelin • multiple sclerosis • 🎧 Stella Explorer • https://ki.se/en/people/goncalo-castelo-branco
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gocastelobranco.bsky.social
Two of our latest this year...

Our collaboration with Mats Nilsson, using ISS for spatial insights on dynamics of multiple sclerosis disease evolution in mouse EAE and in human, e.g. centrifugal propagation of lesions, disease-associated glia independent from lesions...
www.cell.com/cell/fulltex...
Reposted by Gonçalo Castelo-Branco
ki.se
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body 🧪 www.nobelprize.org/prizes/medic...
Photo: Cecilia Odlind
gocastelobranco.bsky.social
Deadline (September 2) approaching! Join us and start your lab at @ki.se!
gocastelobranco.bsky.social
The call just opened!

ki.se/en/about-ki/...

You can apply to several departments simultaneously, check out which depts better fit your profile! Here is the call for our Department of Medical Biochemistry and Biophysics

ki.varbi.com/what:job/job...
Reposted by Gonçalo Castelo-Branco
kitazawa-taro.bsky.social
Please RP.
We are thrilled to announce that our lab’s first preprint is out!
”Whole-genome single-cell multimodal history tracing to reveal cell identity transition”

We report HisTrac-seq, a multiomic single-cell molecular recording platform.
www.biorxiv.org/content/10.1...
Reposted by Gonçalo Castelo-Branco
gocastelobranco.bsky.social
Join us at the FENS Single-Cell & Spatial Omics Winter School with:

@sarabiz86.bsky.social
@rongfan8.bsky.social
@gokcegroup.bsky.social
@gioelelamanno.bsky.social
@sj-marzi.bsky.social
@jplopez-atalaya.bsky.social
Ana Falcão
Florian Rosenberger
Gabriel Baró
Bosiljka Tasic
Barbara Treutlein
fens.org
🌟 Registration is now OPEN! 🌟

Join the 2025-2026 #FENS-Hertie #WinterSchool and explore this year's topic – Single-cell and Spatial Omics to Understand Brain Heterogeneity! 🔬

📍 Alicante, Spain
🗓️ 11-17 Jan 2026

🔗 https://loom.ly/RM55lFQ
Reposted by Gonçalo Castelo-Branco
epistrucstab.bsky.social
🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
Image credit: @gloglita.bsky.social‬ @lifescienceeditors.bsky.social‬ captured DynaTag in action: a pA-Tn5 probe (multicoloured) binds an antibody (white), which binds p53 DNA-binding domain (green) on DNA (blue) within 2 nucleosomes
Reposted by Gonçalo Castelo-Branco
fusionconf.bsky.social
🚨 Don’t forget to register for #Neuroepi25!
⏳ The deadline is fast approaching - Thursday 7th August 2025.
This is your last chance to join; don't miss out on a fantastic meeting!
Click here to register➡️ bit.ly/4f5Zpbq
#FusionNeuro #FusionAgingResearch #FusionEpigenetics
Reposted by Gonçalo Castelo-Branco
graycamplab.bsky.social
Neuron programming! Pro-neural TFs + 480 morphogen conditions + scRNA-seq --> Diverse iN subtypes of forebrain, midbrain, hindbrain, spinal cord, and PNS. @hsiuchuanlin.bsky.social@jasperjanssens.bsky.social‬ and Treutlein Lab! @science.org www.science.org/doi/10.1126/... #NGN2 #ASCL1
gocastelobranco.bsky.social
@carlstrom.bsky.social Clemens Ries, and Ting Sun rocking at #GLIA2025! And the launch of the Carlström lab!
gocastelobranco.bsky.social
Great to catch up with @rongfan8.bsky.social in Marseille, where we both end up for two completely unrelated conferences!
gocastelobranco.bsky.social
The call just opened!

ki.se/en/about-ki/...

You can apply to several departments simultaneously, check out which depts better fit your profile! Here is the call for our Department of Medical Biochemistry and Biophysics

ki.varbi.com/what:job/job...
Reposted by Gonçalo Castelo-Branco
sten.linnarsson.org
Heads-up for major new faculty search at KI — with great startup packages and a wide range of subject areas.
Reposted by Gonçalo Castelo-Branco
fusionconf.bsky.social
📢 Big news! #Neuroepi25 has just released the final programme!
👉 Check it out now on the conference website
✅ And don't forget to register - this is a conference you won’t want to miss!
Click here for more information: bit.ly/3SWoIlO
gocastelobranco.bsky.social
Thanks all speakers, chairs, panelists, MS patients and other participants that joined us at Karolinska Institutet @ki.se and that made this Symposium an unique thinktank (on the true sense of the word) on MS.
gocastelobranco.bsky.social
...and it is a wrap! 4 days of fantastic talks and brainstormings on the molecular and cellular mechanisms of multiple sclerosis and how this knowledge has been leading to disease-modifying treatments. And what we still don't know and where we are/should be moving towards.
Reposted by Gonçalo Castelo-Branco
hjerling-leffler.bsky.social
Postdoc positions available in my lab @ki.se Sweden - exciting science, fantastic environment and great quality of life. I take mentoring seriously - 7/7 postdocs that left my lab has faculty positions today. Existing datasets and funds to build new ones available. ki.varbi.com/en/what:job/...
Postdoc in Single Cell Genomics, Jens Hjerling-Leffler group, Karolinska Institutet
Do you want to contribute to top quality medical research? The position is located within The Division of Molecular Neurobiology in the lab of Professor Jens Hjerling-Leffler at the Department of Medi
ki.varbi.com
Reposted by Gonçalo Castelo-Branco
carlstrom.bsky.social
Happy to share that I will kickstart my research group at @ki.se this autumn!🎉🎉 Are you interested in glial biology, using high-end tools for gene and cell programming to study metabolic and epigenetic interactions? Stay tuned! Will be 🔭 for RA, PhD-students & postdocs!
Let the journey begin! 🧬🧫🔬