Lightnews — Scholar-powered news

Jens Hjerling Leffler @hjerling-leffler.bsky.social · 17h

Final speaker in the first session of (news.ki.se/calendar/dev...) with Michael Ziller (Muenster) talking about functional genomics of scizophrenia

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Jens Hjerling Leffler @hjerling-leffler.bsky.social · 18h

Next up in our great line up at Developing Brains (news.ki.se/calendar/dev...) is Beatriz Rico (King’s College)

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Jens Hjerling Leffler @hjerling-leffler.bsky.social · 18h

Kicking off the 12th edition of the Developing Brain Conference (news.ki.se/calendar/dev...) with Cecile Charrier (ENS).

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Reposted by Jens Hjerling Leffler

Butt Lab - Oxford @interneuron.bsky.social · 20d

A rather 'unique' paper from our lab is online in @cp-cellreports.bsky.social now. Unique in the sense that I don't think anyone else will be rushing to optotag cortical interneurons in the early postnatal brain... because it is nigh on impossible!

www.sciencedirect.com/science/arti...

GABAergic circuits reflect different requirements for sensory integration in postnatal mouse neocortex

Information transfer in mammalian cerebral cortex is dependent on GABAergic interneuron circuits that are widely assumed to be uniform across the neoc…

www.sciencedirect.com

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Jens Hjerling Leffler @hjerling-leffler.bsky.social · 21d

Well done, and well deserved my friend!

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Jens Hjerling Leffler @hjerling-leffler.bsky.social · 27d

Having a great time at the HiiLIFE Science Days at @Helsinki.fi Gracious hosts, beautiful venue, fantastic science and plenty of real coffee.

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Reposted by Jens Hjerling Leffler

Claire Foldi @foldi.bsky.social · Sep 7

Incredibly proud of @kxhuang.bsky.social for persisting with such a challenging dataset from her PhD! We found some intriguing genetic targets in a corticostriatal circuit that may be involved in the development of #anorexia nervosa 🤔 onlinelibrary.wiley.com/doi/10.1002/...

Toward a Genetic Signature of Resistance to Activity‐Based Anorexia in Striatal Projecting Cortical Neurons

Objective Converging evidence from neuroimaging studies and genome-wide association study (GWAS) suggests the involvement of prefrontal cortex (PFC) and striatum dysfunction in the pathophysiology o...

onlinelibrary.wiley.com

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Reposted by Jens Hjerling Leffler

Mary-Ellen Lynall @maryellenlynall.bsky.social · Sep 1

How do neutrophils contribute to mental health? Delighted to share research led by @staceykigar.bsky.social: meningeal neutrophils shape how the brain responds to stress. Out today @natcomms.nature.com. More in the thread⬇️ @psychiatry-ucam.bsky.social @medcambridge.bsky.social @camneuro.bsky.social

Stacey Kigar @staceykigar.bsky.social · Sep 1

‼️ New manuscript alert ‼️ I’m thrilled to share this work examining chronic stress-related “depression” and immune cells at the blood brain barrier: www.nature.com/articles/s41...

Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling in male mice

Nature Communications - Chronic stress is a risk factor for depression, yet the mechanisms are unclear. Here, the authors show in mice that stress drives interferon-mediated neutrophil recruitment...

www.nature.com

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Reposted by Jens Hjerling Leffler

Cambridge Psychiatry @psychiatry-ucam.bsky.social · Sep 4

Understanding why antidepressants don't always work 🧠🛡️
New research by @maryellenlynall.bsky.social reveals the key role played by the immune system in symptoms of depression.

📖https://bit.ly/469cXyI

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Reposted by Jens Hjerling Leffler

Gord Fishell @gordfishell.bsky.social · Aug 25

New updated on how pyramidal neurons impact interneuron subtypes. Turns out spontaneous activity, Wnt signaling in PV Interneurons and integrin-signaling in SST neurons are the culprits! Also see how optimal transport tracks identity.https://www.biorxiv.org/content/10.1101/2024.07.20.604399v2

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Reposted by Jens Hjerling Leffler

Sten Linnarsson @sten.linnarsson.org · Jun 25

A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)

Karolinska Institutet @ki.se · Jun 25

Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential.
🔗 All positions: ki.se/en/about-ki/...

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Reposted by Jens Hjerling Leffler

Madhu Pai, MD, PhD @madhupai.bsky.social · Jul 25

Wow

Karolinska Institutet is recruiting 20 outstanding early-career researchers for assistant professor positions

ki.se/en/about-ki/...

Call for 20 Assistant Professor positions

Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...

ki.se

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Reposted by Jens Hjerling Leffler

Olov Andersson @o-andersson-lab.bsky.social · Jun 24

Join us as a professor by taking this great opportunity in pharmacology (in any system/area) www.uu.se/en/about-uu/...

Professor of Pharmacology - Uppsala University

Professor of Pharmacology, Department of Medical Cell Biology, Uppsala University

www.uu.se

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Jens Hjerling Leffler @hjerling-leffler.bsky.social · Jun 19

I definitely never regretted the decision to leave New York for Stockholm and Karolinska - now you can join us: big call for assistant professors across medical disciplines coming up. news.ki.se/ki-to-recrui...

KI to recruit junior researchers with a focus on excellence

On 25 June, Karolinska Institutet will be starting a major recruitment drive for 20 junior researchers with a focus on excellence and mobility. As one of Europe’s leading medical universities, KI offe...

news.ki.se

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Reposted by Jens Hjerling Leffler

Matthijs Dorst @mattneuro.bsky.social · Jun 13

#neuroskyence folks: as my postdoc grant is running out soon, I am looking for new opportunities in systems neuroscience!

Keywords: patch clamp ephys, opto, mouse behavior, (in vivo) voltage imaging. Would love to return to the Basal Ganglia.

Sharing appreciated, and happy #FluorescenceFriday !

Brightly labelled pyramidal cells in the mouse retrosplenial cortex. Blood vessels are visible of various thicknesses in darker colours.

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Reposted by Jens Hjerling Leffler

Butt Lab - Oxford @interneuron.bsky.social · Jun 6

Our study on the impact of altered serotonin (5-HT) signalling on the developing sensory cortex is now live at Nature Comms.

We use longitudinal in vivo imaging of 5-HT and neural activity to show that this neuromodulator is buffered in early life to promote bottom-up instruction of sensory areas.

Image of a coronal section through postnatal mouse somatosensory cortex (S1BF with transient expression of the serotonin transporter in thalamic afferents shown in red.

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Reposted by Jens Hjerling Leffler

Keri Martinowich @martinowk.bsky.social · Jun 5

While commercialization and decreasing costs has democratized access to genomics and transcriptomics techniques for many, including in the neurosciences (good thing), there's been, IMO, some issues in adoption without corresponding best case analysis practices from the genomics field (bad thing)

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Jens Hjerling Leffler @hjerling-leffler.bsky.social · Jun 2

Postdoc positions available in my lab @ki.se Sweden - exciting science, fantastic environment and great quality of life. I take mentoring seriously - 7/7 postdocs that left my lab has faculty positions today. Existing datasets and funds to build new ones available. ki.varbi.com/en/what:job/...

Postdoc in Single Cell Genomics, Jens Hjerling-Leffler group, Karolinska Institutet

Do you want to contribute to top quality medical research? The position is located within The Division of Molecular Neurobiology in the lab of Professor Jens Hjerling-Leffler at the Department of Medi

ki.varbi.com

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Jens Hjerling Leffler @hjerling-leffler.bsky.social · May 28

Godspeed Karl! Looking forward to interacting. A win for @ki.se

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Reposted by Jens Hjerling Leffler

Karl Carlström @carlstrom.bsky.social · May 28

Happy to share that I will kickstart my research group at @ki.se this autumn!🎉🎉 Are you interested in glial biology, using high-end tools for gene and cell programming to study metabolic and epigenetic interactions? Stay tuned! Will be 🔭 for RA, PhD-students & postdocs!
Let the journey begin! 🧬🧫🔬

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Reposted by Jens Hjerling Leffler

Berna Devezer @devezer.bsky.social · May 28

Lastly to round up the 🧵: Science works doesn't mean every scientific study produces a fact ready for public consumption. Scientific work is incremental, iterative, nonlinear, slow, imperfect, relentless. Continuous improvement upon what was. Science works not despite but because of many failures.

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Reposted by Jens Hjerling Leffler

parafilm is cool dot com @parafilmm.bsky.social · May 26

At times like these it's important to remember the 3 branches of science

The side of a box of Parafilm that features the flask, dish, and beaker. Text has been added under them. The flask is labelled chemistry, the dish biology, and the beaker jam making. Jam making is written in a different handwritten font

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Jens Hjerling Leffler @hjerling-leffler.bsky.social · May 24

A recent preprint from the lab. Turns out biology trumps technical measures for benchmarking of transcriptomics.

Kasra Nikouei @kasran.bsky.social · May 22

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Planning to perform single nuclei RNA-sequencing (snRNA-seq) experiments in complex tissues?

We performed a head-to-head comparison with five different methods on human post-mortem brain tissue.
Check out the benchmarking in our new preprint.

papers.ssrn.com/sol3/papers....

Benchmarking of Single Nuclei Rna-Seq Methods on Human Post-Mortem Brain Tissue

Molecular analysis of human post-mortem brain tissue by single nuclei RNA-sequencing (snRNA-seq) holds the promise to identify disease associated mechanisms. In

papers.ssrn.com

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Reposted by Jens Hjerling Leffler

Debby Silver @debbysilver.bsky.social · May 14

Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...

A human-specific enhancer fine-tunes radial glia potency and corticogenesis - Nature

HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...

www.nature.com

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Reposted by Jens Hjerling Leffler

Paul T. Levin @paultlevin.bsky.social · May 12

Detta är ett allvarligt underbetyg för 🇸🇪. Det är många aspekter som spelar in här: den stramare migrationspolitiken, informella värderingar som gör det svårt att komma in i det svenska universitetsväsendet utifrån & en slutenhet som tex illustreras av att Etikprövning bara kan göras på svenska.+

International PhD students advise against doctoral studies in Sweden - Universitetsläraren

Sweden is no longer an attractive country for international early-career researchers, says the SULF Doctoral Candidate Association in a new report.

universitetslararen.se

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