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Matthijs Dorst @mattneuro.bsky.social · 7h

I once handled a manuscript that came back from three very thorough reviewers, with only a minor revision.

Though I suspect that manuscript had been rejected post-review elsewhere, first. It was extremely polished.

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Matthijs Dorst @mattneuro.bsky.social · 14h

I mean, they're likely getting rid of some of the termites?

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Matthijs Dorst @mattneuro.bsky.social · 17h

I was thinking more in terms of the amount of f*cks given; nobody questions the patch clamp data!

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Matthijs Dorst @mattneuro.bsky.social · 18h

Calcium imaging / Patch Clamp / Neuropixels

Mark Copelovitch @mcopelov.bsky.social · 1d

Associate Professor / Full Professor / Assistant Professor

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Matthijs Dorst @mattneuro.bsky.social · 1d

One theory I've heard is that batteries use chemical reactions, which are temperature-dependent. As those batteries are getting near the threshold, it's the colder ambient air at night that pushes them over the edge.

That, or global conspiracy, of course.

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Matthijs Dorst @mattneuro.bsky.social · 1d

Just a few more, just for you.

A black-and-white rocky beach, trees visible through a thick mist on the opposite shore

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Matthijs Dorst @mattneuro.bsky.social · 1d

Today was grey and rainy; the perfect time to grab a camera and go outside.

Please enjoy a little Autumn timeline cleanse!

Green pine needles with water droplets at the tip

A branch with leaves coloured from red to green

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Matthijs Dorst @mattneuro.bsky.social · 1d

After surgeries and virus injections, I always have to wait 14 days before I can start recording.

And well, if the mice don't need me anyway...

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Reposted by Matthijs Dorst

Talia Lerner @talialerner.bsky.social · 1d

The program for the 2026 Basal Ganglia GRC is live! 🧠🧪
www.grc.org/basal-gangli...

We are already ~60% full, so apply now to join us! Submit an abstract by end of Oct to be considered for a short talk.

See you in Tuscany!

2026 Basal Ganglia Conference GRC

The 2026 Gordon Research Conference on Basal Ganglia will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.

www.grc.org

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Matthijs Dorst @mattneuro.bsky.social · 1d

Aah, if only I had a bit more time.. sounds like it'll be a fantastic conference!

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Matthijs Dorst @mattneuro.bsky.social · 2d

I have thrown away sweaters for the heinous crime of being not machine washable.

Life's too short for hand washing.

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Matthijs Dorst @mattneuro.bsky.social · 2d

Called it. My bet is an optogenetics Nobel in 2027.

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Matthijs Dorst @mattneuro.bsky.social · 4d

a monkey wearing a pirate hat is playing drums in a band

Alt: a monkey wearing a pirate hat is playing drums in a band

media.tenor.com

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Reposted by Matthijs Dorst

Arnd Roth @arndroth.bsky.social · 5d

Using a new genetically-encoded voltage indicator in an all-optical approach to measure synaptic plasticity in awake behaving mice. Great work by @jacquescarolan.bsky.social and colleagues. Check out www.nature.com/articles/s41...

All-optical voltage interrogation for probing synaptic plasticity in vivo - Nature Communications

Reliable measuring the voltage dynamics of individual neurons in the intact brain is significantly challenging. Here authors developed an all-optical method combining two-photon voltage imaging and optogenetics to measure and induce synaptic plasticity in vivo, revealing LTP of inhibition in cerebellar circuits and providing a blueprint to link synaptic changes to learning.

www.nature.com

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Reposted by Matthijs Dorst

Zoé @neptewns.bsky.social · 5d

#Neurons ! 🧫
#Neuroscience

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Matthijs Dorst @mattneuro.bsky.social · 5d

The ones I'm dealing with are pretty old LEDD1B's, and it may be dependent on the power supplies we used (in fact, I go into power-supply noise in ephys setups here: www.nature.com/articles/s41...).

Fantastic drivers otherwise, can recommend, just massively frustrating to ground.

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Matthijs Dorst @mattneuro.bsky.social · 5d

So true. My biggest recent problem are some LED drivers from @thorlabs.bsky.social. Thorlabs, of all people! They build microscopes for breakfast! How are their LED drivers noisy?! And no obvious way to ground them, either; had to ground them through the BNC cable.

Anyway, I do voltage imaging now

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Matthijs Dorst @mattneuro.bsky.social · 5d

Uuuugh, I used to stab my vacuum line with a needle (to ground it, not some horrid voodoo ritual), never managed to get it completely noise-free.

My favorite: the cable connecting my camera picked up noise. Didn't matter if it was plugged in or not. Ended up electrically isolating the camera.

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Reposted by Matthijs Dorst

Dr. Fiona @fionachembot.bsky.social · 5d

Early profs and profs alike:

What is your advice for people who are JUST starting their labs? First goals and tasks?

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Matthijs Dorst @mattneuro.bsky.social · 5d

Don't forget to swap your handlebar around for driving on the other side!

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Matthijs Dorst @mattneuro.bsky.social · 6d

Oooh, I bet those would go great on pizza; with some BBQ spices, of course.

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Reposted by Matthijs Dorst

Anders Borgkvist @borgkvistlab.bsky.social · 7d

Postdoc Opportunity at Karolinska Institutet: We're seeking an electrophysiologist to join an exciting collaborative project focusing on diabetes and Parkinson's disease.

Join us!

ki.varbi.com/what:job/job...

Postdoktor i Diabetes och Parkinsons sjukdom

Vill du bidra till medicinsk forskning av toppkvalitet? Det strategiska forskningsprogrammet för diabetes (SRP Diabetes) vid Karolinska Institutet finansierar ett prestigefyllt stipendieprogram för

ki.varbi.com

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Matthijs Dorst @mattneuro.bsky.social · 7d

Oooof.

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Matthijs Dorst @mattneuro.bsky.social · 7d

Ooh yes, good one! I have seen anywhere between zero and four; luckily, most search committees do not require letters of recommendation until you're shortlisted, otherwise things would get tiresome fast for your referees.

Matthijs Dorst @mattneuro.bsky.social · 7d

7/7 Anything I missed? If you are currently in the process, or if you recently got a faculty position, what did you learn?

a woman is asking how can i help while standing next to a man

ALT: a woman is asking how can i help while standing next to a man

media.tenor.com

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