Reliable measuring the voltage dynamics of individual neurons in the intact brain is significantly challenging. Here authors developed an all-optical method combining two-photon voltage imaging and optogenetics to measure and induce synaptic plasticity in vivo, revealing LTP of inhibition in cerebellar circuits and providing a blueprint to link synaptic changes to learning.

Zhang et al. develop a system that reads activity from individual neurons in real time and uses holographic light patterns to control specific neurons in mice, enabling automated, all-optical experime...

About the workshop This workshop will cover array tomography (AT) technology with a focus on “simple and affordable” workflows based on serial ultramicrotomy and imaging. The practicals include...

Studies in neuroscience have shown that biological synapses follow a log-normal distribution whose transitioning can be explained by noisy multiplicative dynamics. Biological networks can function sta...

Advanced modeling system sheds new light on the synaptic vesicle cycle, essential in human brain function.

Artificial neural networks are becoming more advanced and human-like in detail and behavior. The notion that machines mimicking human brain computations migh...