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Reposted by Stacey Kigar

ImmuNoah's Ark (Noe Rodriguez) @immunoah.bsky.social · 7d

📣📣We're seeking a postdoc to join us at the @mrclmb.bsky.social to investigate neuroimmune interactomes in tumour & viral immunity.
If you find fascinating & want to learn about #neuroscience & #immunology, tracing neurons, molecular biology & #flowcytometry, apply!
🧠🫁👀🩸🔬
mrc.tal.net/vx/mobile-0/...

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Stacey Kigar @staceykigar.bsky.social · 7d

Congrats to Varun, Xinhe, and the team on this very important work

Varun Warrier @vw1234.bsky.social · 7d

It is now clear that more people are being diagnosed as autistic in their teens and as adults than in childhood. A prevailing theory is that those diagnosed later have "milder" form of autism, and later diagnosis entirely due to social factors.

Stacey Kigar @staceykigar.bsky.social · 7d

Thank you! That is certainly the hope, though there’s much work ahead re: translating these results from rodent to human.

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Reposted by Stacey Kigar

NPR @npr.org · 7d

JUST IN: Jane Goodall, primatologist who transformed our understanding of the lives of apes, has died, according to an announcement from the Jane Goodall Institute.

Jane Goodall, legendary primatologist, has died at age 91

Jane Goodall, primatologist who transformed our understanding of the lives of apes, has died, according to an announcement from the Jane Goodall Institute.

n.pr

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Reposted by Stacey Kigar

Medicine at Cambridge @medcambridge.bsky.social · 9d

Upcoming seminar:

🎓Dr Stacey Kigar @staceykigar.bsky.social @medcambridge.bsky.social

📢"Chronic stress-mediated effects on the immune system: links to mental health"
📅 1-2PM, Thur 2 October
📍JCBC @cambridgebiocampus.bsky.social

buff.ly/ggnAwDO

#CITIID #MedSky #ImmunoSky 🧪

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Reposted by Stacey Kigar

Gergo Porkolab @gergoporkolab.bsky.social · 26d

Happy to share our new preprint on BBB mechanobiology on bioRxiv:
www.biorxiv.org/cgi/content/...

We describe an exciting new link between tight junctions and cell-matrix adhesions during BBB maturation and in epileptic BBB dysfunction.

Endothelial tight junctions and cell-matrix adhesions reciprocally control blood-brain barrier integrity

Brain endothelial cells (ECs) rely on mechanical cues to provide a physical barrier that protects the brain. Yet how ECs integrate forces to establish and maintain the blood-brain barrier (BBB) remain...

www.biorxiv.org

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Reposted by Stacey Kigar

Olivia Guest · Ολίβια Γκεστ @olivia.science · Sep 8

There are a lot more people than one might think who refuse this tech but are shamed by users. Once the space for their opinions and voices opens up, the scene will change. These stats, 18k views, are not a coincidence for example on this preprint. People want to not, yup.
zenodo.org/records/1706...

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Stacey Kigar @staceykigar.bsky.social · Sep 1

Check out this nice write-up of our work, out today in @natcomms.nature.com! 🧠🐁💉

Medicine at Cambridge @medcambridge.bsky.social · Sep 1

Can mood disorders be driven by inflammation?

Published today in @natcomms.nature.com, @staceykigar.bsky.social & colleagues found that chronic stress may release immune cells from bone marrow in the skull, potentially contributing to depression.

buff.ly/xAz0oiS

@cam.ac.uk

Depression linked to presence of immune cells in the brain’s protective layer

Immune cells released from bone marrow in the skull in response to chronic stress and adversity could play a key role in symptoms of depression and anxiety,

buff.ly

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Reposted by Stacey Kigar

Arghavan Salles, MD, PhD @arghavansallesmd.medsky.social · Sep 1

If you’ve ever compared unvaccinated kids to vaccinated kids, you’ve seen the former are more likely to die.

Figures showing deaths from smallpox and polio and cases of measles before and after vaccines were introduced for each respective disease. All three figures show declining rates after vaccine introduction

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Reposted by Stacey Kigar

Abby Polter @ampolter.bsky.social · Sep 1

One of my former students sent me an update letting me know she got into medical school and included a picture of her white coat ceremony. It made my day! Send your professors updates on what you're doing, it's a real highlight in this job.

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Stacey Kigar @staceykigar.bsky.social · Sep 1

I am so grateful to everyone involved in bringing this paper to fruition, and am especially grateful to the NIH and @cambridgebrc.bsky.social for supporting me throughout. To read a summary of the project, please check out this summary by Craig Brierley here: www.cam.ac.uk/research/new...

Depression linked to presence of immune cells in the brain’s protective layer

Immune cells released from bone marrow in the skull in response to chronic stress and adversity could play a key role in symptoms of depression and anxiety,

www.cam.ac.uk

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Stacey Kigar @staceykigar.bsky.social · Sep 1

It involved lots of hard work from my brilliant co-authors, including co-first author @maryellenlynall.bsky.social and others who as far as I know aren’t on blue sky. Data collection took place during Covid lockdown, and involved coordinating teams transatlantically, requiring lots of grit/tenacity!

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Stacey Kigar @staceykigar.bsky.social · Sep 1

Systemic depletion of type I interferon signaling improved depressive behavior in chronically stressed mice, and may hold promise as a future target for depression treatment. This project was a labor of love, stemming from work done many years ago now while I was still a postdoc at the NIH campus…

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Stacey Kigar @staceykigar.bsky.social · Sep 1

A unique population of neutrophils that are regulated independently of neutrophils derived from other bone marrow stores, like tibia. Our single cell RNA sequencing analysis of meningeal tissue showed type I interferons as a plausible candidate triggering movement of neutrophils into the meninges…

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Stacey Kigar @staceykigar.bsky.social · Sep 1

However, we found neutrophils increased in the meninges—a protective tissue layer surrounding the brain. We were surprised to find that neutrophils did not seem to enter the meninges from the bloodstream, but instead entered from nearby skull bone marrow. The skull bone marrow appears to host..

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Stacey Kigar @staceykigar.bsky.social · Sep 1

It is not clear what if any relationship blood neutrophils have with mood disorders like depression. We hypothesized that neutrophils increased by stress could exert an effect on mood from within the brain or its surrounding/supporting tissues. We found no evidence that neutrophils enter the brain..

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Stacey Kigar @staceykigar.bsky.social · Sep 1

We used a combination of bioinformatics, immuno-, and behavioral assays to show “first responder” immune cells (neutrophils) accumulate around the brain following prolonged stress exposure. While it is well known that acute exposure to stress causes release of neutrophils into the bloodstream…

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Stacey Kigar @staceykigar.bsky.social · Sep 1

‼️ New manuscript alert ‼️ I’m thrilled to share this work examining chronic stress-related “depression” and immune cells at the blood brain barrier: www.nature.com/articles/s41...

Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling in male mice

Nature Communications - Chronic stress is a risk factor for depression, yet the mechanisms are unclear. Here, the authors show in mice that stress drives interferon-mediated neutrophil recruitment...

www.nature.com

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Stacey Kigar @staceykigar.bsky.social · Aug 18

It’s also factually incorrect that other countries lack mail-in voting: www.idea.int/news/how-us-...

How the US stacks up against global voting by mail trends

www.idea.int

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Reposted by Stacey Kigar

Fredrik Jutfelt 🐠 @jutfelt.bsky.social · Aug 18

Associate Professor position in animal physiology at the Norwegian University of Science and Technology
(to replace me basically). An amazing permanent position at a great university!

Please spread widely 🙏

www.jobbnorge.no/en/available...

Associate Professor in molecular/cellular animal physiology (281754) | NTNU - Norwegian University of Science and Technology

Job title: Associate Professor in molecular/cellular animal physiology (281754), Employer: NTNU - Norwegian University of Science and Technology, Deadline: Monday, September 1, 2025

www.jobbnorge.no

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Reposted by Stacey Kigar

Will Ratcliff @wcratcliff.bsky.social · Aug 12

Not sure how many scientists here have tried Claude Code or similar command line coding assistants. I had a complicated family property tax problem that was best solved by a brute force Monte Carlo simulation approach, so I spent a few days coding up and analyzing a model with Claude Code.

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Reposted by Stacey Kigar

PBS @pbs.org · Aug 7

An update from us here at PBS 💙

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Stacey Kigar @staceykigar.bsky.social · Aug 4

this is so beautifully done 👀🧬

Artologica aka Michele Banks @artologica.net · Aug 4

New little mitosis watercolor #sciart artologica.etsy.com/listing/4346...

watercolor of mitosis images in blue and white

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Reposted by Stacey Kigar

Harmit Singh Malik @harmitmalik.bsky.social · Aug 2

I spoke to Renaud Pourpe (of @lonelypipette.bsky.social fame with @epigenetique.bsky.social) about the unique challenges faced by postdocs and early-career PIs worldwide on the transition from postdoc to PI.

Lots of useful advice shared (by others):

www.alba.network/diversity-po...

Check it out.

ALBA-IBRO Diversity Podcast - Season 2

Episode 4 is out. In season 2, we focus on the transition from postdoc to PI, highlighting the unique challenges faced by postdocs and early-career PIs worldwide. Hosted by the Lonely Pipette.

www.alba.network

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Reposted by Stacey Kigar

Seth Boo!-ger Trueger @mdaware.org · Jul 31

one cool thing about Scandinavian countries with comprehensive public health insurance is places like Denmark can do a study on… everybody and conclude that yes COVID vaccines are safe

Ken Milne MD @thesgem.bsky.social · Jul 31

1.6 million people showed no statistical increase in 29 adverse events after mRNA covid vax
jamanetwork.com/journals/jam... #MedSky

Safety of JN.1-Updated mRNA COVID-19 Vaccines

This cohort study investigates the association between booster vaccinations containing the JN.1 lineage and 29 serious adverse events in Denmark.

jamanetwork.com

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