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gergoporkolab.bsky.social
Gergo Porkolab
@gergoporkolab.bsky.social
24 followers 30 following 3 posts
Research Fellow at the Campbell Lab @tcddublin.bsky.social studying signaling pathways that regulate blood vessels in the brain ---- Previously @BarriersGroup, Szeged, Hungary
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gergoporkolab.bsky.social
Gergo Porkolab @gergoporkolab.bsky.social · 26d
Super thankful for everyone involved – this was a huge collaborative effort between vascular biologist and biophysicist labs co-led by Maria Deli, Robert Horvath and @mattcampbelltcd.bsky.social
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gergoporkolab.bsky.social
Gergo Porkolab @gergoporkolab.bsky.social · 26d
Happy to share our new preprint on BBB mechanobiology on bioRxiv:
www.biorxiv.org/cgi/content/...

We describe an exciting new link between tight junctions and cell-matrix adhesions during BBB maturation and in epileptic BBB dysfunction.
Endothelial tight junctions and cell-matrix adhesions reciprocally control blood-brain barrier integrity
Brain endothelial cells (ECs) rely on mechanical cues to provide a physical barrier that protects the brain. Yet how ECs integrate forces to establish and maintain the blood-brain barrier (BBB) remain...
www.biorxiv.org
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gergoporkolab.bsky.social
Gergo Porkolab @gergoporkolab.bsky.social · Jun 8
fluidsbarrierscns.biomedcentral.com/articles/10....
Proteome profile differences among human, monkey, and mouse brain microvessels and cultured brain microvascular endothelial cells - Fluids and Barriers of the CNS
Background The blood-brain barrier (BBB) expresses transporters, receptors, and tight junction proteins that regulate the exchange of substances between the blood and brain. The differences in the exp...
fluidsbarrierscns.biomedcentral.com
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Reposted by Gergo Porkolab
chrisgreene.bsky.social
Chris Greene @chrisgreene.bsky.social · Mar 19
New paper led by Avril Reddy in @mattcampbelltcd.bsky.social lab showing IPS derived human RPE cells expressing aflibercept and/or soluble CD59 can attenuate lesions in mouse model of age-related macular degeneration. Cool project to help out with. www.cell.com/molecular-th...
Enhanced retinal pigment epithelial cells as a delivery vehicle for retinal disease
Age-related macular degeneration (AMD) is one of the leading causes of central retinal blindness. Here, Campbell and colleagues show that transplanted retinal pigment epithelial cells can be engineere...
www.cell.com
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