Lightnews — Scholar-powered news

Reposted by Chris Greene

Dr Yvonne Couch @dryvonnecouch.bsky.social · 6d

Ok so this is almost certainly not up your street but I LOVE this paper because it is simple, beautifully written and super clear. It's just a good paper and I fangirled the senior author about it in an email to him

www.jneurosci.org/content/40/2...

Acute Inflammation Alters Brain Energy Metabolism in Mice and Humans: Role in Suppressed Spontaneous Activity, Impaired Cognition, and Delirium

Systemic infection triggers a spectrum of metabolic and behavioral changes, collectively termed sickness behavior, which while adaptive, can affect mood and cognition. In vulnerable individuals, acute...

www.jneurosci.org

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Chris Greene @chrisgreene.bsky.social · 5d

I worked with John (first author on this paper) for years in Trinity, he taught me almost everything I know about mouse behaviour! Very cool to randomly see his paper here!

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Reposted by Chris Greene

FutureNeuro Centre @futureneuro.bsky.social · 22d

Researchers, including several from FutureNeuro, found people with temporal lobe epilepsy experience more widespread brain changes across adulthood, highlighting the importance of early diagnosis and treatment: futureneurocentre.ie/publications...

@researchireland.ie @epilepsyireland.bsky.social

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Chris Greene @chrisgreene.bsky.social · Aug 25

Come join my Department in @rcsi.bsky.social @futureneuro.bsky.social. We're especially interested in people with backgrounds in neuropsychiatry, neural engineering or digital health. Tenure track, start-up funding and protected time for research. Deadline this week.

FutureNeuro Centre @futureneuro.bsky.social · Aug 25

🚨 Applications close this week. If you work in neuropsychiatry, neural engineering, or digital health, consider the StAR Lecturer role at @rcsi.bsky.social. Hear how Dr @chrisgreene.bsky.social’s research and career have grown through this position 👇

FutureNeuro Centre @futureneuro.bsky.social · Aug 12

⭐ We’re hiring a StAR Lecturer at @rcsi.bsky.social with expertise in neuropsychiatry, neural engineering, or digital health. Dr @chrisgreene.bsky.social, last year’s StAR Lecturer, talks about how this role has accelerated his career growth. Apply by August 29: www.linkedin.com/jobs/view/42...

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Reposted by Chris Greene

JCI insight @insight.jci.org · Aug 9

ICYMI: Temporal lobe epilepsy affects ~50 million people globally

@brennan-lab-ucd.bsky.social @futureneuro.bsky.social & team link altered RNA methylation to changes in protein expression, neuronal structure, and seizure susceptibility across models: buff.ly/odAaTRs

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Reposted by Chris Greene

Silvia Anderle @silvia-anderle.bsky.social · Aug 5

Delighted to share our latest review in Nature Reviews Neuroscience!
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...

The vascular contribution to cognitive decline in ageing and dementia - Nature Reviews Neuroscience

Growing evidence suggests that reduced cerebral blood flow contributes to cognitive decline in ageing and dementia. Attwell and colleagues discuss the underlying mechanisms and functional consequences...

www.nature.com

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Reposted by Chris Greene

Axel Montagne @axelmontagne.bsky.social · Jul 22

🚨 Review Alert

*Walking on the tightrope: the shared roles of the bridging pericytes in the brain*

Congratulations Audrey Chagnot!! 🥳

Bias aside, this feels like a really meaningful piece for the cerebrovascular field! 😊

www.frontiersin.org/journals/cel...

Frontiers | Walking on the tightrope: the shared roles of the bridging pericytes in the brain

The vasculature of the central nervous system (CNS) is a highly specialized structure that delivers oxygen and nutrients to energy-demanding neural cells whi...

www.frontiersin.org

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Reposted by Chris Greene

FutureNeuro Centre @futureneuro.bsky.social · Jul 8

🚨 We’re hiring! FutureNeuro is looking for a StAR Lecturer to lead research in neuropsychiatry, neural engineering, or digital health. Join us at RCSI. Apply by August 29: www.linkedin.com/jobs/view/42...

@rcsi.bsky.social @rcsi-research.bsky.social

Royal College of Surgeons in Ireland (RCSI) hiring FutureNeuro StAR Lecturer in Dublin, County Dublin, Ireland | LinkedIn

Posted 10:10:05 AM. Job Title: FutureNeuro StAR LecturerReporting To: Head of Department or nomineeLocation:…See this and similar jobs on LinkedIn.

www.linkedin.com

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Reposted by Chris Greene

Jennifer Dowling @dowlingjk.bsky.social · Jul 2

We are very excited to be hiring a Postdoc to our expanding team! Are you interested in neuroinflammation, immunometabolism and/or epilepsy research?? 🧠 Apply now my.corehr.com/pls/coreportal……
@Futureneuro_ie @RCSIPharmBioMol
***Closing date 16th July***

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Chris Greene @chrisgreene.bsky.social · Mar 19

New paper led by Avril Reddy in @mattcampbelltcd.bsky.social lab showing IPS derived human RPE cells expressing aflibercept and/or soluble CD59 can attenuate lesions in mouse model of age-related macular degeneration. Cool project to help out with. www.cell.com/molecular-th...

Enhanced retinal pigment epithelial cells as a delivery vehicle for retinal disease

www.cell.com

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Reposted by Chris Greene

Nature Neuroscience @natneuro.nature.com · Mar 10

IL-1- and IL-6-related systemic inflammation in #COVID19 is associated with #microglia dysfunction, neurovascular inflammation, and focal neuropathologies 🧪🧠

www.nature.com/articles/s41...

Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19 - Nature Neuroscience

The authors show that brain inflammation in COVID-19 correlates with viral load, systemic inflammation and virus-sensing pattern recognition receptors. Microglial dysfunction occurs at sites of vascul...

www.nature.com

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Reposted by Chris Greene

Twisteddoodles @twisteddoodles.bsky.social · Mar 6

Made some science books for kids #worldbookday

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Reposted by Chris Greene

Kevin Mitchell @wiringthebrain.bsky.social · Mar 4

The gut microbiota: an amazing technicolour dream coat or the emperor's new clothes? physoc.onlinelibrary.wiley.com/doi/full/10.... - an excellent corrective to the relentless hype

The gut microbiota: an amazing technicolour dream coat or the emperor's new clothes?

Click on the article title to read more.

physoc.onlinelibrary.wiley.com

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Chris Greene @chrisgreene.bsky.social · Feb 27

Beautiful work Katarzyna, Caroline and team!

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Reposted by Chris Greene

Caroline Menard @caromenard666.bsky.social · Feb 27

So excited to share the work of the fantastic Katarzyna, 1st 🧪PhD student of my lab 🧠, out in @natureneuro.bsky.social 🥂🥳
Cheers to the team, thanks to our precious collaborators and support from @braincanada.bsky.social #CIHR @fondsrechercheqc.bsky.social #newPI

www.nature.com/articles/s41...

Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood–brain barrier alterations - Nature Neuroscience

The mechanisms of neurovascular adaptations underlying stress resilience remain unclear. Here the authors show that the astrocytic endocannabinoid system modulates the blood–brain barrier changes duri...

www.nature.com

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Reposted by Chris Greene

RCSI University of Medicine and Health Sciences @rcsi.bsky.social · Feb 21

New RCSI research has uncovered how T cells may contribute to blood clot risk in inflammatory bowel disease.

The findings, published in @NatureComms also suggest a potential treatment approach to manage this risk.

Read more 🔗 www.rcsi.com/dublin/news-...

#RCSIdiscover @rcsi-research.bsky.social

New RCSI research identifies key role of T cells in blood clot risk for inflammatory bowel disease patients

Researchers from RCSI University of Medicine and Health Sciences have uncovered a novel mechanism linking inflammatory bowel disease (IBD) with an increased risk of a serious blood clotting disorder, ...

www.rcsi.com

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Reposted by Chris Greene

Proceedings of the National Academy of Sciences @pnas.org · Feb 18

A gene linked to age-related cognitive decline, APOE ε4, is also associated with cognitive advantage below the age of 50 in women, according to data from the @ukbiobank.bsky.social, a finding that could explain APOE ε4’s persistence in the human genome. In PNAS: www.pnas.org/doi/10.1073/...

The influence of APOE, sex, and age on cognitive performance for female and male participants.

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Reposted by Chris Greene

Caroline Menard @caromenard666.bsky.social · Feb 6

Thanks @blacoste.bsky.social! I want to highlight that it's a new peer-reviewed, interdisciplinary open access journal: #Glia #Health #Research 🧪

All articles submitted before April 30, 2026 are 🚨 free, no publication fees! 🤑

Baptiste Lacoste @blacoste.bsky.social · Feb 6

Super cool new review by @caromenard666.bsky.social’s team on neuro-glio-vascular alterations #cerebrovascular

Neurogliovascular alterations in brain pathologies across lifespan

Neurological and psychiatric illnesses present significant challenges across different stages of life. Adolescence is associated with a high incidence…

www.sciencedirect.com

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Reposted by Chris Greene

Nature @nature.com · Jan 27

Nature research paper: CD45-PET is a robust, non-invasive tool for imaging inflammation

https://go.nature.com/4jmStIF

CD45-PET is a robust, non-invasive tool for imaging inflammation - Nature

A non-invasive in vivo positron emission tomography imaging approach detects inflammatory disease using various preclinical models.

go.nature.com

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Reposted by Chris Greene

RCSI University of Medicine and Health Sciences @rcsi.bsky.social · Jan 27

A new collaborative study led by FutureNeuro researchers at RCSI offers hope for predicting and preventing the development of epilepsy following traumatic brain injury.

The research identifies an important role for a brain receptor called P2X7.

More ➡️ www.rcsi.com/dublin/news-...

#RCSIdiscover

New research offers hope for preventing epilepsy after traumatic brain injury

A new international study has unveiled critical insights in understanding post-traumatic epilepsy, a condition that can develop following traumatic brain injury.

www.rcsi.com

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Reposted by Chris Greene

Shane Liddelow @liddelowsa.bsky.social · Jan 15

Check out this paper and tool that we worked on with @sloanlab.bsky.social and Ye Zhang.
Think of it as 'the Barres datasets 2.0'

Lots of input and feedback from the amazing #Glia community.

Steven Sloan @sloanlab.bsky.social · Jan 15

Hi #neuroscience community! This is one of my favorite posts ever. In close collaboration with @liddelowsa.bsky.social and Ye Zhang, we've built a new tool that we are eager to share! www.webseq.net

WEBseq

share freely

www.webseq.net

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Reposted by Chris Greene

Science Magazine @science.org · Jan 15

The blood-brain barrier can prevent therapeutic drugs from reaching the brain.

Researchers in #ScienceAdvances have identified a peptide that increases the barrier’s permeability, showing potential for more effective drug delivery to treat brain diseases. scim.ag/4jhnWf6

A claudin5-binding peptide enhances the permeability of the blood-brain barrier in vitro

A claudin5 binding peptide enhances transport across the blood-brain barrier by transiently permeabilizing tight junctions.

scim.ag

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Chris Greene @chrisgreene.bsky.social · Jan 11

Sudden urge to stick on Joy Division though...

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Reposted by Chris Greene

Nature Neuroscience @natneuro.nature.com · Jan 6

In vivo hyperphosphorylation of #tau is associated with synaptic loss and behavioral abnormalities even in the absence of tau seeds 🧪🧠

www.nature.com/articles/s41...

In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds - Nature Neuroscience

Mice expressing humanized mutant tau exhibit synaptic loss and behavioral abnormalities in the absence of abnormal tau conformers, suggesting that hyperphosphorylated tau can be pathological, at least...

www.nature.com

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Reposted by Chris Greene

Nature Neuroscience @natneuro.nature.com · Jan 2

A single-cell mass cytometry-based atlas of the developing mouse brain 🧪🧠

www.nature.com/articles/s41...

A single-cell mass cytometry-based atlas of the developing mouse brain - Nature Neuroscience

In recent years, valuable mRNA-based developmental atlases of the mouse brain have been made available. Here, the authors use single-cell mass cytometry to build a protein-based single-cell profiling ...

www.nature.com

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