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Reposted by Axel Montagne

UK Dementia Research Institute @ukdri.ac.uk · 2d

🌟 New job opportunity 🌟

Based within the UK DRI at Edinburgh, the Rajani Lab investigates the mechanisms of white matter damage in vascular and other dementias.

Find out more and apply via the link

🗓️ Apply by 22 October 2025

📌 Full details 👉 tinyurl.com/22y73642

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Reposted by Axel Montagne

UK Dementia Research Institute @ukdri.ac.uk · 13d

Congratulations to Dr Maura Malpetti (UK DRI at Cambridge), who has won the 2025 European Young Researcher Award from the Fondation Recherche Alzheimer in France. 🎉👏

Read the full story 👉 tinyurl.com/243s9tuf

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Reposted by Axel Montagne

Rikesh Rajani @rikeshrajani.bsky.social · 14d

The Rajani Lab is hiring again! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate vascular-oligodendrocyte interactions in dementia.

Apply here 👇
bit.ly/4nm8csZ

Research Fellow

We are looking for an enthusiastic postdoctoral Research Fellow to join the Rajani Lab as part of the new national BHF-UK DRI Centre for Vascular Dementia Research.

bit.ly

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Reposted by Axel Montagne

Anna Williams @annawilliamslab.bsky.social · 21d

The Edinburgh participants at dinner at VasCog!

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Axel Montagne @axelmontagne.bsky.social · Sep 1

💛

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Axel Montagne @axelmontagne.bsky.social · Aug 31

✨ Preorders are OPEN ✨

My amazing wife just finished her very first children’s book, and I couldn’t be prouder 💛

📚 Preorder until Sept 7
📦 Shipped w/ tracking
🔗 www.etsy.com/shop/ElodieWho

She’s poured her heart into this — every preorder, share, & boost means the world 🙌

www.etsy.com

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Reposted by Axel Montagne

Krystal K. Laing, MS @kklaing.bsky.social · Aug 13

Happy 32nd Birthday to ApoE in Dementia research🎈

On this day in 1993, Dr. Allen D. Roses (et al.) published that the presence of APOE4 genotype reliably predicts risk of early onset Alzheimer’s disease. Needless to say the AD research community was skeptical.

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Reposted by Axel Montagne

Britta Engelhardt @brittae.bsky.social · Aug 5

PhD position alert!

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Reposted by Axel Montagne

Hao Yin @haoyin.bsky.social · Aug 5

Serial block-face SEM of mouse Heart Capillaries #EndothelialCell #Pericyte #Telocyte

There are direct physical contacts b/w CD34+/CD44+ perivascular mesenchymal cells & abluminal protrusions of EC!

#Cells_MDPI 2025
www.mdpi.com/2073-4409/14...

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Axel Montagne @axelmontagne.bsky.social · Aug 5

Congrats Silvia!! 🤩🥳

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Reposted by Axel Montagne

Silvia Anderle @silvia-anderle.bsky.social · Aug 5

Delighted to share our latest review in Nature Reviews Neuroscience!
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...

The vascular contribution to cognitive decline in ageing and dementia - Nature Reviews Neuroscience

Growing evidence suggests that reduced cerebral blood flow contributes to cognitive decline in ageing and dementia. Attwell and colleagues discuss the underlying mechanisms and functional consequences...

www.nature.com

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Reposted by Axel Montagne

Rikesh Rajani @rikeshrajani.bsky.social · Aug 5

Just over a week left to apply for this position in our lab!

Rikesh Rajani @rikeshrajani.bsky.social · Jul 10

The Rajani Lab is hiring! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate neuronal activity and white matter changes in vascular dementia.

Apply here 👇
bit.ly/44AFJHx

Research Fellow

We are looking for a postdoctoral Research Fellow to join the Rajani Lab as part of the new national BHF-UK DRI Centre for Vascular Dementia Research.

bit.ly

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Axel Montagne @axelmontagne.bsky.social · Jul 22

🚨 Review Alert

*Walking on the tightrope: the shared roles of the bridging pericytes in the brain*

Congratulations Audrey Chagnot!! 🥳

Bias aside, this feels like a really meaningful piece for the cerebrovascular field! 😊

www.frontiersin.org/journals/cel...

Frontiers | Walking on the tightrope: the shared roles of the bridging pericytes in the brain

The vasculature of the central nervous system (CNS) is a highly specialized structure that delivers oxygen and nutrients to energy-demanding neural cells whi...

www.frontiersin.org

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Reposted by Axel Montagne

Rikesh Rajani @rikeshrajani.bsky.social · Jul 10

The Rajani Lab is hiring! We are looking for a postdoc to join us at @ukdri.ac.uk @edinburgh-uni.bsky.social to investigate neuronal activity and white matter changes in vascular dementia.

Apply here 👇
bit.ly/44AFJHx

Research Fellow

We are looking for a postdoctoral Research Fellow to join the Rajani Lab as part of the new national BHF-UK DRI Centre for Vascular Dementia Research.

bit.ly

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Reposted by Axel Montagne

Kira Shaw @kirasha.bsky.social · Jul 16

Come and join us in Manchester... We are looking for candidates interested in vascular health and neurodegeneration. This project is specifically exploring how menopause may increase Alzheimer's risk.
We also have a postdoc position available: www.jobs.manchester.ac.uk/Job/JobDetai...

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Reposted by Axel Montagne

Carmen Ruiz de Almodóvar @ruizdealmodovar.bsky.social · Jul 14

Amazing opportunity! specially looking for neurovascular research junior PIs!!

Hellmut Augustin @hellmutaugustin.bsky.social · Jul 14

Spread the word: The European Center for Angioscience @uniheidelberg.bsky.social continues to grow: We have openings for 2 additional Junior Group Leader positions. Get in touch with us if you are ready to start your own lab. See also corresponding ad in @nature.com: www.nature.com/naturecareer...

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Axel Montagne @axelmontagne.bsky.social · Jun 29

Enjoy the conference!! Cheers 😊

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Reposted by Axel Montagne

UK Dementia Research Institute @ukdri.ac.uk · Jun 24

We're excited to welcome a new Group Leader to our vascular dementia research centre with the BHF🎉👏

Prof Susanne van Veluw's research focuses on cerebral amyloid angiopathy, where amyloid beta accumulates in the walls of the brain's blood vessels👉https://buff.ly/rNxxNRz

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Axel Montagne @axelmontagne.bsky.social · Jun 7

Congrats Manon, very well deserved 🤩

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Axel Montagne @axelmontagne.bsky.social · May 18

www.sciencedirect.com/science/arti...

Blood-brain barrier permeability varies by brain region and APOE4 status and correlates with brain microstructure among high-AD risk groups

Although strong evidence exists for blood–brain barrier (BBB) disruption in Alzheimer’s disease (AD), substantial uncertainty remains regarding its ro…

www.sciencedirect.com

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Reposted by Axel Montagne

Sebastien Foulquier, Pharm.D., Ph.D. @sfoulquier.bsky.social · May 10

🧠 New paper out in Biogerontology!
We reviewed evidence linking circulating immune cells to cSVD features. Thanks to all co-authors, and the journal team!
🔗 link.springer.com/article/10.1...
More coming soon!
#Neuroimmunology #cSVD #Biomarkers #AgingBrain #Biogerontology

Circulating immune cells in cerebral small vessel disease: a systematic review - Biogerontology

Cerebral small vessel disease (cSVD) refers to all pathologies of the brain’s arterioles, capillaries, and venules. cSVD is highly prevalent with ageing and is diagnosed by its characteristic neuro-im...

link.springer.com

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Axel Montagne @axelmontagne.bsky.social · May 9

www.sciencedirect.com/science/arti...

Alzheimer's disease and vascular biology – A focus on the procoagulant state

Alzheimer's disease (AD) is characterized by a multifactorial pathophysiology. Beyond its classical hallmarks, growing evidence highlights vascular co…

www.sciencedirect.com

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Axel Montagne @axelmontagne.bsky.social · May 6

onlinelibrary.wiley.com/doi/10.1002/...

The Soluble Platelet‐Derived Growth Factor β Receptor Induces Postoperative Delirium by Downregulating the Clearance of β‐Amyloid in the Brain

Brain pericyte injury may contribute to the onset and progression of POD by influencing the blood–brain barrier's capacity to clear Aβ protein. The combination of CSF sPDGFRβ with CSF AD biomarkers e...

onlinelibrary.wiley.com

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Reposted by Axel Montagne

Edinburgh Neuroscience @edinunineuro.bsky.social · May 5

Colleagues at Row Fogo Centre for Research into Ageing and the Brain (@svdresearch.bsky.social) have revealed how specific blood biomarkers may help predict the progression of cerebral small vessel disease — a major contributor to #stroke and #dementia.

Read the full paper: edin.ac/4cZfM8q

Blood biomarkers of vascular dysfunction in small vessel disease progression: Insights from a longitudinal neuroimaging study

INTRODUCTION This study explored the relationship between blood biomarkers of cerebrovascular function and small vessel disease (SVD) neuroimaging markers and cognitive outcomes in highly-phenotyped...

edin.ac

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Axel Montagne @axelmontagne.bsky.social · May 5

www.thelancet.com/journals/ebi...

Dissection of blood–brain barrier dysfunction through CSF PDGFRβ and amyloid, tau, neuroinflammation, and synaptic CSF biomarkers in neurodegenerative disorders

CSF PDGFRβ, a candidate biomarker of BBB dysfunction, is increased in the early stages of neurodegenerative disorders, in association with neuroinflammation and axonal and synaptic damage.

www.thelancet.com

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