The endothelial blood-brain barrier (BBB) tightly controls T cell entry into the central nervous system (CNS). T cell extravasation across the BBB involves a multi-step cascade with a predominant role...

A popular hypothesis for how the brain clears molecular waste, which may help explain why sleep feels refreshing, is a subject of debate.

Hasel et al. show that molecularly and morphologically specialized astrocytes make up the brain and spinal cord surface, thereby creating the glia limitans superficialis. These astrocytes selectively ...

Ein besonderer Höhepunkt des diesjährigen «MS State of the Art Symposium» war die Verleihung des zweiten Forschungspreises der Schweiz. MS-Gesellschaft. Die mit 100’000 Franken dotierte Auszeichnung e...

Zi et al. elucidate the developmental dynamics of brain pericytes and reveal that blood flow promotes pericyte proliferation. The effect of blood flow is dependent on the mechanosensitive ion channel Piezo1 in ECs, subsequently mediated by the EC-intrinsic Notch signaling, and it involves the activation of Notch signaling in pericytes.

Nature Neuroscience - The authors review current knowledge of the molecular identity and functions of the dura, arachnoid and pial layers of meninges and controversial aspects of meningeal biology...