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Pedro Pimentel-Coelho @ppimentel-coelho.bsky.social · 8d

Targeting sodium channels — challenges for acute pain and the leap to chronic pain

Matthew Alsaloum, Dmytro Vasylyev & Stephen G. Waxman

www.nature.com/articles/s41...

Targeting sodium channels — challenges for acute pain and the leap to chronic pain - Nature Reviews Neurology

Earlier this year, the Nav1.8 channel inhibitor suzetrigine became the first new pain therapeutic to be approved in 20 years. Here, Waxman et al. discuss the challenges of improving Nav1.8-targeted relief for acute pain and the translation to chronic pain.

www.nature.com

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Pedro Pimentel-Coelho @ppimentel-coelho.bsky.social · 16d

Impact of prenatal delta-9-tetrahydrocannabinol exposure on mouse brain development: a fetal-to-adulthood magnetic resonance imaging study

Lani Cupo et al. 🧪

www.nature.com/articles/s41...

Impact of prenatal delta-9-tetrahydrocannabinol exposure on mouse brain development: a fetal-to-adulthood magnetic resonance imaging study - Molecular Psychiatry

Molecular Psychiatry - Impact of prenatal delta-9-tetrahydrocannabinol exposure on mouse brain development: a fetal-to-adulthood magnetic resonance imaging study

www.nature.com

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Pedro Pimentel-Coelho @ppimentel-coelho.bsky.social · 20d

Rethinking women’s brain health

Julia Sacher & Ingo Bechmann

@natrevneuro.nature.com

www.nature.com/articles/s41...

Rethinking women’s brain health - Nature Reviews Neuroscience

Far from being a niche concern, women’s brain health is a global issue, affecting more than half of the world’s population. Despite this, the unique aspects of how the female brain adapts, reorganizes...

www.nature.com

Pedro Pimentel-Coelho @ppimentel-coelho.bsky.social · 24d

Neonatal encephalopathy due to birth asphyxia and trauma: global trends and disparities

Fengling Du et al.

www.frontiersin.org/journals/pub...

Frontiers | Neonatal encephalopathy due to birth asphyxia and trauma: global trends and disparities

BackgroundNeonatal encephalopathy due to birth asphyxia and trauma (NE-BAT) is a leading cause of neonatal mortality and long-term neurodevelopmental disabil...

www.frontiersin.org

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Pedro Pimentel-Coelho @ppimentel-coelho.bsky.social · Sep 6

Microglia are prominent producers of inflammatory cytokines during the hyperacute phase of ischemic stroke

Joshua H. Bourne et al.

www.nature.com/articles/s42...

Microglia are prominent producers of inflammatory cytokines during the hyperacute phase of ischemic stroke - Communications Biology

In-depth characterization of the hyperacute phase (<3 h) following ischemic stroke reveals severe neuroinflammation before the arrival of brain-infiltrating peripheral immune cells, driven by micro...

www.nature.com

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Pedro Pimentel-Coelho @ppimentel-coelho.bsky.social · Sep 5

Interleukin-1 regulates myeloid cell trafficking and cerebral blood flow following intracerebral haemorrhage

Jack Barrington et al.

journals.biologists.com/dmm/article/...

Interleukin-1 regulates myeloid cell trafficking and cerebral blood flow following intracerebral haemorrhage

Intracerebral haemorrhage (ICH) is a devastating stroke subtype lacking effective therapies. Understanding key pathological processes related to acute brain damage will help deliver better outcomes fo...

journals.biologists.com

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Reposted by Pedro Pimentel-Coelho

Nature Portfolio @natureportfolio.nature.com · Sep 1

“There will never be a sound-bite answer to what causes autism,” says Helen Tager-Flusberg, a psychologist who studies neurodevelopmental conditions. Nature explores the decades of research on the causes of autism. #medsky 🧪

Autism is on the rise: what’s really behind the increase?

RFK Jr has vowed to find out what’s responsible, but scientists say he is ignoring answers from decades of research.

go.nature.com

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Pedro Pimentel-Coelho @ppimentel-coelho.bsky.social · Sep 1

Neuroimmune, metabolic and oxidative stress pathways in major depressive disorder

Michael Maes, Abbas F. Almulla, Zili You & Yingqian Zhang

rdcu.be/eDqBf

Neuroimmune, metabolic and oxidative stress pathways in major depressive disorder

Nature Reviews Neurology - In this Review, the authors describe perturbations in neuroimmune, metabolic and oxidative pathways in major depressive disorder and explore how imbalances in each of...

rdcu.be

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Reposted by Pedro Pimentel-Coelho

Marco A. Maximo Prado @maximoprado.bsky.social · Aug 31

Just out. Work by Marilene Lopes who did a sabbatical in the lab and her student Camila Fernandes We explored the mechanisms by which the co chaperone STIP1 affects embryogenesis and early development following the phenotypes of STIP1 KO mice 🐁 www.nature.com/articles/s42...

Stress-inducible phosphoprotein 1 (STIP1) is a critical stemness regulator in mouse embryonic stem cells and early mammalian development - Communications Biology

Combined in silico and in vitro approaches reveal that the co-chaperone STIP1 supports pluripotent stem cell identity, proliferation, and stress resilience, highlighting proteostasis as a key mechanis...

www.nature.com

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Pedro Pimentel-Coelho @ppimentel-coelho.bsky.social · Aug 29

Maternal stress triggers early-life eczema through fetal mast cell programming

Nadine Serhan et al. 🧪

www.nature.com/articles/s41...

Maternal stress triggers early-life eczema through fetal mast cell programming - Nature

Prenatal stress triggers molecular dysregulations in fetal neuroimmune circuits, leading to altered mast cell and sensory neuron function, which predisposes offspring to develop eczema in response to ...

www.nature.com

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Pedro Pimentel-Coelho @ppimentel-coelho.bsky.social · Aug 22

"Particularly with all the discouraging data out there already, pushing harder on the idea of stem cells for autism just doesn’t make sense now."

Why hype for autism stem cell therapies continues despite dead ends

Paul Knoepfler

The Transmitter @thetransmitter.bsky.social · Aug 22

Stem cell therapies for autism have been a dud. So why do they continue to be hyped?

By @stemcells.bsky.social

www.thetransmitter.org/spectrum/why...

Why hype for autism stem cell therapies continues despite dead ends

After numerous tests, there is still no evidence that these experimental treatments help, so now is not the time to expand access to them.

www.thetransmitter.org

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Reposted by Pedro Pimentel-Coelho

Allen Institute @alleninstitute.org · Aug 15

Holy Soma Batman!

You never know what you may find when you cruise our MICrONS Explorer, such as a blood vessel piercing the soma of a neuron!

👀 See this incredible find up close using this shortcut: ngl.microns-explorer.org#!%7B%22layer...

#NeuroSkyence #MICrONS #ElectronMicroscopy

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Pedro Pimentel-Coelho @ppimentel-coelho.bsky.social · Aug 13

A researcher's guide to studying sex differences in immune aging

Trends in Molecular Medicine @cp-trendsmolecmed.bsky.social 🧪

Clayton Baker, Minhoo Kim & Bérénice A. Benayoun

www.cell.com/trends/molec...

A researcher's guide to studying sex differences in immune aging

Sex differences in immune system aging significantly impact disease susceptibility and vaccine responses among older adults, but with notable disparities between men and women. This area has gained im...

www.cell.com

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Pedro Pimentel-Coelho @ppimentel-coelho.bsky.social · Jul 20

PASSIoN Trial (Perinatal Arterial Stroke Treated With Intranasal Stromal Cells): 2-Year Safety and Neurodevelopment

Nienke Wagenaar et al.

A post hoc analysis of the PASSIoN study.

www.ahajournals.org/doi/full/10....

PASSIoN Trial (Perinatal Arterial Stroke Treated With Intranasal Stromal Cells): 2-Year Safety and Neurodevelopment | Stroke

BACKGROUND: The PASSIoN study (Perinatal Arterial Stroke Treated With Stromal Cells Intranasally) demonstrated the feasibility and short-term safety of single-dose allogeneic mesenchymal stromal cells...

www.ahajournals.org

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Pedro Pimentel-Coelho @ppimentel-coelho.bsky.social · Jul 13

Early transcriptional responses reveal cell type-specific vulnerability and neuroprotective mechanisms in the neonatal ischemic hippocampus

Aleksandr Ianevski et al.

actaneurocomms.biomedcentral.com/articles/10....

Early transcriptional responses reveal cell type-specific vulnerability and neuroprotective mechanisms in the neonatal ischemic hippocampus - Acta Neuropathologica Communications

Neonatal hypoxic-ischemic (H-I) brain injury, a leading cause of neurodevelopmental disabilities, severely affects the metabolically active and neurogenic hippocampus. To investigate its acute effects...

actaneurocomms.biomedcentral.com

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Pedro Pimentel-Coelho @ppimentel-coelho.bsky.social · Jul 12

A physiological perspective on neuroimmune tissue innervation

Trends in Immunology

Daniel A. Waizman & Andrew Wang

www.cell.com/trends/immun...

A physiological perspective on neuroimmune tissue innervation

Organisms must adapt to unpredictable environmental perturbations. We propose that the immune system, which can be redistributed across tissues (‘immune innervation’), cooperates with the nervous syst...

www.cell.com

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Pedro Pimentel-Coelho @ppimentel-coelho.bsky.social · Jul 3

Identification of proliferating neural progenitors in the adult human hippocampus

Dumitru et al.

www.science.org/doi/10.1126/...

Identification of proliferating neural progenitors in the adult human hippocampus

Continuous adult hippocampal neurogenesis is involved in memory formation and mood regulation but is challenging to study in humans. Difficulties finding proliferating progenitor cells called into que...

www.science.org

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Pedro Pimentel-Coelho @ppimentel-coelho.bsky.social · Jul 3

Glia is inviting applications for the role of Editor-in-Chief

onlinelibrary.wiley.com/page/journal...

Glia is inviting applications for the role of Editor-in-Chief

Glia is the top neurobiology journal for research into glial cells (also called gliocytes or neuroglia). Articles cover all aspects of glial cell biology in health and disease.

onlinelibrary.wiley.com

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Reposted by Pedro Pimentel-Coelho

Staci Bilbo @sbilbo.bsky.social · Jul 2

Excited to share this new paper from the lab, now out in @cp-immunity.bsky.social! Led by the talented @bendevlin.bsky.social and in collab with @anneschaefer.bsky.social. a brief 🧵

Excitatory-neuron-derived interleukin-34 supports cortical developmental microglia function

Neuron-microglia interactions dictate the development of neuronal circuits in the brain. However, the factors that regulate these processes across dev…

www.sciencedirect.com

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Pedro Pimentel-Coelho @ppimentel-coelho.bsky.social · Jul 2

History of pre-eclampsia negatively impacts stroke severity postpartum in rats

Ari Kropf et al. 🧪

@neuropjournal.bsky.social

onlinelibrary.wiley.com/doi/10.1002/...

History of pre‐eclampsia negatively impacts stroke severity postpartum in rats

Diagrammatic representation of the effect of pre-eclampsia on postpartum stroke severity. e7, gestational day 7; ePE, experimental pre-eclampsia; NormP, normal pregnancy; PP, postpartum; tMCAO, trans...

onlinelibrary.wiley.com

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Pedro Pimentel-Coelho @ppimentel-coelho.bsky.social · Jun 26

Plasma periaxin is a biomarker of peripheral nerve demyelination

Roberto Bellanti et al.

academic.oup.com/brain/advanc...

Plasma periaxin is a biomarker of peripheral nerve demyelination

Bellanti et al. have developed an ultrasensitive assay for periaxin, a biomarker of peripheral nerve demyelination. When used alongside existing tests, the

academic.oup.com

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Pedro Pimentel-Coelho @ppimentel-coelho.bsky.social · Jun 24

www.nature.com/articles/s41...

TGFα controls checkpoints in CNS resident and infiltrating immune cells to promote resolution of inflammation

Lena Lößlein et al.

#multiplesclerosis

TGFα controls checkpoints in CNS resident and infiltrating immune cells to promote resolution of inflammation - Nature Communications

Some brain lesions recover in multiple sclerosis, while others do not; however, the underlying mechanisms are unclear. Here, the authors show that microglia-derived TGFα orchestrates immune control an...

www.nature.com

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Pedro Pimentel-Coelho @ppimentel-coelho.bsky.social · Jun 23

Healthy human induced pluripotent stem cell-derived cardiomyocytes exhibit sex dimorphism even without the addition of hormones

Sophie E. Givens and colleagues 🧪

academic.oup.com/stmcls/advan...

Healthy human induced pluripotent stem cell-derived cardiomyocytes exhibit sex dimorphism even without the addition of hormones

Abstract. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are a valuable cell type for studying human cardiac health and disease in v

academic.oup.com

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Pedro Pimentel-Coelho @ppimentel-coelho.bsky.social · Jun 20

academic.oup.com/stmcls/artic...

SARS-CoV2 infection triggers inflammatory conditions and astrogliosis-related gene expression in long-term human cortical organoids

Mathilde Colinet et al.

Stem Cells 🧪

SARS-CoV2 infection triggers inflammatory conditions and astrogliosis-related gene expression in long-term human cortical organoids

Abstract. SARS-CoV2, severe acute respiratory syndrome coronavirus 2, is frequently associated with neurological manifestations. Despite the presence of mi

academic.oup.com

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Pedro Pimentel-Coelho @ppimentel-coelho.bsky.social · Jun 14

www.nature.com/articles/s41...

Early life high fructose impairs microglial phagocytosis and neurodevelopment

Zhaoquan Wang et al.

@nature.com 🧪

Early life high fructose impairs microglial phagocytosis and neurodevelopment - Nature

Exposure of mice to high fructose during gestation or early postnatal life causes decreased microglial phagocytosis during brain development and leads to anxiety-like behaviour in adolescence.

www.nature.com

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