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Marco A. Maximo Prado

@maximoprado.bsky.social

2.3K followers 630 following 790 posts

Canada Research Chair. Misfolding proteins, chaperones and cholinergic function in neurodegeneration. Interested in reproducibility, translational research and open science. ORCID: 0000-0002-3028-5778 I also post pics of sunsets and bikes.

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Marco A. Maximo Prado @maximoprado.bsky.social · Aug 31

Just out. Work by Marilene Lopes who did a sabbatical in the lab and her student Camila Fernandes We explored the mechanisms by which the co chaperone STIP1 affects embryogenesis and early development following the phenotypes of STIP1 KO mice 🐁 www.nature.com/articles/s42...

Stress-inducible phosphoprotein 1 (STIP1) is a critical stemness regulator in mouse embryonic stem cells and early mammalian development - Communications Biology

Combined in silico and in vitro approaches reveal that the co-chaperone STIP1 supports pluripotent stem cell identity, proliferation, and stress resilience, highlighting proteostasis as a key mechanis...

www.nature.com

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Reposted by Marco A. Maximo Prado

M. Natasha Rajah 🇨🇦 @mnrajah.bsky.social · 7h

@sfn.org please consider hosting your next meeting outside of the 🇺🇸

Society for Neuroscience @sfn.org · 7h

#SfN25 is packed with amazing science and networking opportunities!

The 2025 Neuroscience Meeting Planner makes it easy to find exactly what you're looking for.

Search, explore, and start planning your experience today.

🔗 vist.ly/49qex

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Reposted by Marco A. Maximo Prado

Ted Price @tedpricethepainguy.bsky.social · 2d

Just incredible findings, and a beautifully written paper: www.nature.com/articles/s41... Get your shingrix vaccine! You do not want peripheral neuropathy, and as a bonus you get substantial protection from later development of dementia.

Varicella-zoster virus reactivation and the risk of dementia - Nature Medicine

Large-scale longitudinal health records reveal consistent association of varicella-zoster virus reactivation with dementia.

www.nature.com

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Reposted by Marco A. Maximo Prado

tomwellborn3rd @patriotprogressive.bsky.social · 2d

RFK Jr. insanely moves MAHA to end animal testing, with NIH securing $87M for a center shifting to 3D tissue models. An 80% poll backs the phaseout. PETA applauds. A research group warns of risks. Grants can fund the rehoming of lab animals.

RFK Jr.’s MAHA movement focuses on animal welfare

Last week, the National Institutes of Health announced it had secured $87 million for a new research center.

www.newsnationnow.com

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Marco A. Maximo Prado @maximoprado.bsky.social · 2d

The one I wish I would have written. It is on point! This is my peer review of this article.

Earl K. Miller @earlkmiller.bsky.social · 2d

For all the knucklehead reviewers out there.
Principles for proper peer review - Earl K. Miller
jocnf.pubpub.org/pub/qag76ip8...
#neuroscience

Principles for proper peer review

jocnf.pubpub.org

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Reposted by Marco A. Maximo Prado

Caroline (Lindy) Rae @brainmetabolism.bsky.social · 3d

Just published ! Two chapters encapsulating the idea of constrained brain energy metabolism that lies at the heart of brain vulnerability in aging, development and stress. Result of a week's hard work at the Ernst Strüngmann forum.
rdcu.be/eJvXK
rdcu.be/eJv3I

Brain Energy Production Vulnerability and Pathophysiology

rdcu.be

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Reposted by Marco A. Maximo Prado

TRIDENT Preclinical Trials @tridentpct.bsky.social · 5d

Absolutely amazing work @mind-western.bsky.social... a true imaging treat to look at this #fluorescencefriday!

The MIND Platform @ Western @mind-western.bsky.social · 5d

#fluorescencefriday special. Half marmoset 🧠 cleared and stained using SHIELD and imaged by lightsheet microscopy. Courtesy of Jesleen Saini @shahrzadbahrampour.bsky.social and @stefan-everling.bsky.social

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Marco A. Maximo Prado @maximoprado.bsky.social · 5d

Great collaborative effort to get this done

The MIND Platform @ Western @mind-western.bsky.social · 5d

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Marco A. Maximo Prado @maximoprado.bsky.social · 5d

#fluorescencefriday shows the intimate relationship between astrocytes, (cyan) microglia (green) and amyloid plaques (magenta). we find that in APOE4 mice there is much more glia associated with plaques.

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Reposted by Marco A. Maximo Prado

Katja Röper @katjaroeper.bsky.social · 6d

Lovely summary of how the advent of confocal microscopy changed our research and ability to understand biology

Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 7d

New Online! The advent of confocal laser scanning microscopy in biological research

The advent of confocal laser scanning microscopy in biological research

Nature Reviews Molecular Cell Biology, Published online: 01 October 2025; doi:10.1038/s41580-025-00905-5The advent of laser-scanning confocal microscopy revolutionized cell biology, offering unprecedented resolution and depth and enabling scientists to visualize cellular structures in 3D.

bit.ly

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Reposted by Marco A. Maximo Prado

Stephen Curry @scurry.bsky.social · 7d

I am so dismayed a the statement today from the President of the @royalsociety.org that I want to publish here the letter I wrote to him yesterday urging him to address the clear concerns of the UK scientific community.

Screenshot of first part of letter (continues in next image). Text reads:

Dear Sir Adrian

I write to request that in its deliberations tomorrow the Council resolves to take a principled stand to defend the scientific values written into its code of conduct.

In its attempts to deal with the actions of Elon Musk FRS, the Royal Society has repeatedly failed to explain how his repudiation of those values is consistent with the code of conduct that all Fellows must adhere to as a condition of their fellowship. As is now well established, these actions include attacking Antony Fauci FRS without good cause; spreading scientific misinformation on X [through his own utterances and by relaxing controls on the platform]; recklessly and unlawfully degrading the research ecosystem of the US as part of DOGE; and bragging publicly about "feeding USAID into the wood chipper", which the Lancet estimates will cause the deaths of 14 million people, many of them children under the age of five, by 2030.

The Society’s inaction extends to the recent brief exchange of correspondence between Prof Sir Paul Nurse and Mr Musk. Although there was some initial contact, when Sir Paul laid out the Society’s specific concerns there was no reply or explanation from Musk. For reasons that I’m afraid I cannot fathom, you chose once again not to enforce your code of conduct.

Screenshot of letter. Text continues:

"You will be aware that the sense of bewildered dismay over this affair is shared by Royal Society Fellows, medallists and journals editors, and many thousands within the scientific community here and abroad. The Royal Society still claims to speak for scientists in the UK, but on this vital issue, its inaction represents an inexplicable rupture with values that our community holds very dear.

In all this my primary concern is has been for the good standing of the Royal Society as the UK’s national academy. As I am sure you understand all too well (given your recent remarks in the wake of Mr Musk’s ill-judged speech at the Tommy Robinson rally), the country, the world at large, and the very practice of science itself face severe challenges from technologies and populist politics that foment division and ignorance. In such troubled times, people look to our established institutions to have the courage to stand by long-held values of truth and decency.

It is my sincere hope the Royal Society will demonstrate tomorrow that it is just such an institution.

Yours faithfully,

Stephen"

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Reposted by Marco A. Maximo Prado

TRIDENT Preclinical Trials @tridentpct.bsky.social · 7d

Follow an exciting new brain imaging platform, @mind-western.bsky.social, partnering group of #TRIDENT. Article about it linked below! 👇🔬👀
www.schulich.uwo.ca/about/news-e...

Researchers launch brain imaging platform with $2.9M boost from Brain Canada - Schulich School of Medicine & Dentistry - Western University

A new high-resolution imaging platform is revealing the brain in extraordinary detail – and sharing the data with scientists worldwide.

www.schulich.uwo.ca

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Reposted by Marco A. Maximo Prado

Dr. Genevieve Eastabrook, MD FRCSC (she/her) @placentadoc.bsky.social · 8d

We must honour the memory of children lost and mourn with the families shattered by residential schools today and every day 🧡
Truth and Reconciliation is the responsibility of all settlers on this stolen land.

Every Child Matters, art by Emily Kewageshig

Painting by Indigenous artist Emily Kewageshig “Every Child Matters”

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Reposted by Marco A. Maximo Prado

Paola A. Marignani @pmarignani.bsky.social · 8d

Today I honour the Survivors of residential schools and remember the children who never came home. Reconciliation means listening, learning, and doing better. To Survivours: your stories matter, your resilience inspires. #Truth #Reconciliation #NDTR

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Timothy Caulfield @caulfieldtim.bsky.social · 9d

Great resource for all!

How to gauge the quality of a research study: 13 questions journalists should ask journalistsresource.org/media/good-r...

Eg:
- peer reviewed?
- top-tier academic journal?
- other scholars trust this work?
- funding?
- credentials?
- COI?
- sample size?
- methods?

13 questions journalists should ask to gauge research quality

Asking these 13 questions can help journalists spot red flags in research, including studies that policymakers cite to defend their stances.

journalistsresource.org

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Marco A. Maximo Prado @maximoprado.bsky.social · 8d

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Marco A. Maximo Prado @maximoprado.bsky.social · 9d

Marco A. Maximo Prado @maximoprado.bsky.social · 10d

Reposted by Marco A. Maximo Prado

Jonathan Jarry @jonathanjarry.bsky.social · 12d

I read close to 50 papers in order to give an evidence-based, accurate response to Monday's press conference.

There's a lot to unpack here. I hope you find this informative.

Cc: @mcgilloss.bsky.social

www.mcgill.ca/oss/article/...

All About the Tylenol-Autism Brouhaha

At an unhinged press conference last Monday, Donald Trump and his medical acolytes revealed an actionable cause of autism at long last: Tylenol. In what felt like a social media post come to life, Tru...

www.mcgill.ca

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Reposted by Marco A. Maximo Prado

Angie Rasmussen @angierasmussen.bsky.social · 12d

These are unprecedentedly challenging times for virology & vaccine research. I am so grateful to face them at @vido.org.

It's an amazing place to study & make vaccines to improve human & animal health in Canada & around the world.

#VIDOis50
www.cbc.ca/news/canada/...

As VIDO turns 50, Sask. virus research hub has opportunity to fill global gaps | CBC News

One of Canada's premier vaccine centres celebrates its 50th birthday this week, but researchers say it comes amid unease over U.S. policy changes and funding cuts that threaten to upend the global fig...

www.cbc.ca

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Marco A. Maximo Prado @maximoprado.bsky.social · 12d

#fluorescencefriday courtesy of Alycia Crooks abeta plaques (magenta) surrounded by microglia labeled with IBA1 (cyan) and CD68 (green)

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Marco A. Maximo Prado @maximoprado.bsky.social · 12d

Reposted by Marco A. Maximo Prado

Keri Martinowich @martinowk.bsky.social · 13d

We have several positions open at various levels (Research Assistant, Research Associate, Postdoctoral Fellow) across our highly interactive teams in the Division of Translational Neuroscience 🧠🔬🧪 @lieberinstitute.bsky.social

www.libd.org/careers/

Links to individual positions in the thread below.