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TRIDENT Preclinical Trials

@tridentpct.bsky.social

1.2K followers 9.8K following 230 posts

Multi-site, transformative preclinical evaluation of novel neurotherapeutics through a Government of Canada $24M New Frontiers In Research grant. Check out our website tridentpreclinicaltrials.org for more info or email [email protected]!

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TRIDENT Preclinical Trials @tridentpct.bsky.social · Nov 25

The TRIDENT proof-of-concept platform began in 2023 through the incredible support of a $24M grant from the Government of Canada's New Frontiers In Research Fund- Transformation stream.
Check out our website tridentpreclinicaltrials.org or the video below 👇 #NFRF
www.youtube.com/watch?v=RCr3...

Fight against neurodegenerative diseases - NFRF

YouTube video by Western University

www.youtube.com

TRIDENT Preclinical Trials @tridentpct.bsky.social · 1d

Check out the new podcast series below featuring Professor @liisagalea.bsky.social of CAMH and TRIDENT Sex-Based Analysis+ Core! 👇🎉🎤

Dementia Researcher @dementiaresearcher.bsky.social · 2d

Next week we launch a new podcast series with @laura-sofia-s.bsky.social XXplored: Women's Brain Health. Meet Professor Liisa Galea @liisagalea.bsky.social one of the great guests to feature in episode one.

www.dementiaresearcher.nihr.ac.uk/profile-prof...

Profile – Professor Liisa Galea, University of Toronto - DEMENTIA RESEARCHER

Professor Liisa Galea, Treliving Family Chair at CAMH Toronto, researches how sex and hormones shape brain health, neuroplasticity, and dementia risk.

www.dementiaresearcher.nihr.ac.uk

TRIDENT Preclinical Trials @tridentpct.bsky.social · 2d

The #TRIDENT Living Lab will be living it up in Toronto 1 month today at the 2025 Annual General Meeting! Amazing opportunity to bring together all members of TRIDENT for exciting research updates, interactive focus groups, and valuable networking sessions. #openscience #collaboration #NFRF

TRIDENT Preclinical Trials @tridentpct.bsky.social · 5d

Absolutely amazing work @mind-western.bsky.social... a true imaging treat to look at this #fluorescencefriday!

The MIND Platform @ Western @mind-western.bsky.social · 5d

#fluorescencefriday special. Half marmoset 🧠 cleared and stained using SHIELD and imaged by lightsheet microscopy. Courtesy of Jesleen Saini @shahrzadbahrampour.bsky.social and @stefan-everling.bsky.social

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TRIDENT Preclinical Trials @tridentpct.bsky.social · 5d

It's a rainbow of revolutionary insight from the Western Mouse research team for #fluorescencefriday. Take a peek, below! 👇👀🌈🔬

Marco A. Maximo Prado @maximoprado.bsky.social · 5d

#fluorescencefriday shows the intimate relationship between astrocytes, (cyan) microglia (green) and amyloid plaques (magenta). we find that in APOE4 mice there is much more glia associated with plaques.

TRIDENT Preclinical Trials @tridentpct.bsky.social · 5d

Check out this new video showcasing the #TRIDENT Sex-Based Analysis+ Core led by @liisagalea.bsky.social at @camhnews.bsky.social. 👇😍 Learn more via our website tridentpreclinicaltrials.org/sba! #neuroscience #sba #NFRF

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TRIDENT Preclinical Trials @tridentpct.bsky.social · 7d

Follow an exciting new brain imaging platform, @mind-western.bsky.social, partnering group of #TRIDENT. Article about it linked below! 👇🔬👀
www.schulich.uwo.ca/about/news-e...

Researchers launch brain imaging platform with $2.9M boost from Brain Canada - Schulich School of Medicine & Dentistry - Western University

A new high-resolution imaging platform is revealing the brain in extraordinary detail – and sharing the data with scientists worldwide.

www.schulich.uwo.ca

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TRIDENT Preclinical Trials @tridentpct.bsky.social · 7d

It's a Wonderful Wednesday to highlight Dr. Bonnie Lee of our SBA+ Core: "It’s essential to meaningfully and rigorously investigate both sex and within-sex factors to fully understand how diseases develop, progress, and respond to treatment." Read more: www.tridentpreclinicaltrials.org/hqpzone #NFRF

A graphic image of Dr. Bonnie Lee, Postdoctoral Fellow, TRIDENT SBA+ Core, and the words, "HQP Spotlight"

Reposted by TRIDENT Preclinical Trials

Western University @westernu.ca · 8d

Today, Sept. 30, we observe National Day for Truth and Reconciliation (NDTR). This day is dedicated to honouring the children who never made it home and the Survivors of residential schools. It also serves to raise awareness about the intergenerational impacts of these experiences.

Three students stand outside the Wampum Learning Lodge wearing orange shirts that read, "Every Child Matters".

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TRIDENT Preclinical Trials @tridentpct.bsky.social · 9d

It's a Magnificent Monday to highlight a key article advancing SBA+ research, "Beyond Binary Policy: Precision Medicine Requires Sex-Inclusive Research" by Andrew J. McGovern, Kristen Montgomery, and @liisagalea.bsky.social #TRIDENT lead, take a look!

obgyn.onlinelibrary.wiley.com/doi/epdf/10....

Beyond Binary Policy: Precision Medicine Requires Sex‐Inclusive Research

You have to enable JavaScript in your browser's settings in order to use the eReader.

obgyn.onlinelibrary.wiley.com

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TRIDENT Preclinical Trials @tridentpct.bsky.social · 12d

All in for this! Nice spotlight on the @cfmm.bsky.social, TRIDENT MR Imaging Core partnering group! 👀🙌🌎👇👇

Western University @westernu.ca · 12d

It’s official, we are all in! Join us as we continue to drive impactful change for Canada and the world. There's so much to be proud of and so much more to do. #AllinWesternU

Learn more: allin.westernu.ca?utm_medium=s...

TRIDENT Preclinical Trials @tridentpct.bsky.social · 12d

Happy #Fluorescencefriday! Check out below from the incredible Western Mouse team, also part of TRIDENT! #neuroscience #braindisease #TRIDENT

Marco A. Maximo Prado @maximoprado.bsky.social · 12d

#fluorescencefriday courtesy of Alycia Crooks abeta plaques (magenta) surrounded by microglia labeled with IBA1 (cyan) and CD68 (green)

TRIDENT Preclinical Trials @tridentpct.bsky.social · 13d

It's #OpenScience Week and we love to talk about that at #TRIDENT, as our robust Open Science framework for research collaboration and results is key to ensuring accelerated growth in the field and reproducibility/integrity of results. Learn more via www.tridentpreclinicaltrials.org/openscience!

An image of the globe and a network of people with the text #openscience Week.

TRIDENT Preclinical Trials @tridentpct.bsky.social · 13d

Did you hear about the coolest, new, ultra-sensitive technique for detecting brain-wide changes? Check out this study below led by Drs. Gabriel Devenyi and Mallar Chakravarty of the @douglasresearch.bsky.social. 👇👇👌🌎

New Ultra-Sensitive Technique for Detecting Brain-Wide Changes – a study led by Drs. Devenyi and Chakravarty - The Douglas Research Centre

Dr. Jurgen Germann, Dr. Flavia Venetucci Gouveia, Dr. Mallar Chakravarty, Dr. Gabriel A. Devenyi A recent publication, led by Drs. Gabriel A. Devenyi and Mallar Chakravarty from the CoBrALab describes...

douglas.research.mcgill.ca

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TRIDENT Preclinical Trials @tridentpct.bsky.social · 17d

Thank you so much @maximoprado.bsky.social and @alzassociation.bsky.social for all your continued advocacy and hard work! 🙏

Marco A. Maximo Prado @maximoprado.bsky.social · 17d

On #worldalzheimersday our team
is thrilled with our efforts to understand how amyloid (magenta) interacts with blood vessels (green) and how better 🐁 models and translational approaches will help the fight to #endalz

And 🙏 @alzassociation.bsky.social for the support

TRIDENT Preclinical Trials @tridentpct.bsky.social · 17d

Today we stand in solidarity with #worldalzheimersday as #TRIDENT furthers innovative preclinical research that will accelerate discovery of new and better treatments for AD. #TRIDENT 🧠🔬🌎 Learn more at tridentpreclinicaltrials.org!

A picture of a purple ribbon and the text Wold Alzheimer's Day 21 Sep

TRIDENT Preclinical Trials @tridentpct.bsky.social · 19d

Don't MIND if we do! Check out our partner colleagues in the @mind-western.bsky.social channel, linked below! 👇🧠💡

Marco A. Maximo Prado @maximoprado.bsky.social · 19d

If you are interested in great #fluorescencefriday videos, images and anything microscopy or
MRI related follow our new account for the MIND platform @mind-western.bsky.social @neuroak.bsky.social @touchscreencog.bsky.social @tridentpct.bsky.social

TRIDENT Preclinical Trials @tridentpct.bsky.social · 22d

Awesome kick off for the MIND platform's lunch meeting series for users of Light Sheet Microscopy (LSM) 🔬 and MRI! 🧠💻🤩 #mri #data #lightsheet #microscopy #neuroscience

A picture of a presenter at the MIND Platform lunch and learn

A picture of attendees at the MIND Platform Lunch and Learn

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TRIDENT Preclinical Trials @tridentpct.bsky.social · 22d

Awesome opportunity to join one of our partnering research labs! 👇🔬🐁

Western BrainsCAN @westernubrainscan.bsky.social · 27d

Come join our team! We're looking for an experienced lab manager to oversee daily operations for the @tcnlab.bsky.social. Learn more: recruit.uwo.ca

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TRIDENT Preclinical Trials @tridentpct.bsky.social · 23d

"By combining molecular, imaging, motor, and cognitive assessments, we can capture a more complete picture of how potential therapies work. This holistic strategy not only strengthens scientific rigor but also increases the chances of successful translation from animal models to humantreatments."

TRIDENT Preclinical Trials @tridentpct.bsky.social · 23d

Thank you so much @bettymemoryprobs.bsky.social. We appreciate the heads up. Please see the text below :).

TRIDENT Preclinical Trials @tridentpct.bsky.social · 23d

It's a Marvelous Monday to celebrate one of our valued Highly Qualified Personnel, Medhinee Malavankar, PhD student at the @douglasresearch.bsky.social. Learn more about Medhinee's work, and about our other HQP via our website www.tridentpreclinicaltrials.org/hqpzone. #TRIDENT #NFRF #HQP

A graphic image of Medhinee Malavankar, PhD student with the TRIDENT Mouse Core, accompanied by a quote.

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TRIDENT Preclinical Trials @tridentpct.bsky.social · 26d

Thanks to the MIND Platform..SHIELD-ing my eyes from all the brilliance going on here. 👇😎🧠 #fluorescencefriday #TRIDENT @touchscreencog.bsky.social

Marco A. Maximo Prado @maximoprado.bsky.social · 26d

It is #fluorescencefriday and the MIND platform @touchscreencog.bsky.social @tridentpct.bsky.social invites you to see brain blood vessels stained with CD31 and imaged by lightsheet. 🐁 🧠 cleared with SHIELD . thanks as always to @shahrzadbahrampour.bsky.social @arashsalah.bsky.social and company.

TRIDENT Preclinical Trials @tridentpct.bsky.social · 27d

HAPPY BIRTHDAY !!!!!!

TRIDENT Preclinical Trials @tridentpct.bsky.social · 28d

#TRIDENT has a lot going on...check out the short reel below sharing the who, what and where of our project! #NFRF #neuroscience #braindisease #collaboration #neuroscience @schulichmeddent.bsky.social @utoronto.ca @mcgill.ca @camhnews.bsky.social @theneuro.bsky.social

TRIDENT Preclinical Trials @tridentpct.bsky.social · 29d

Look at the op-ed by #TRIDENT and @conscience-network.bsky.social researcher @richardgold.bsky.social, linked below. Open Science + IP...critical areas discussed! 👇🌎🗞️

Conscience @conscience-network.bsky.social · Jul 29

This new op-ed by @richardgold.bsky.social describes how sequencing #OpenScience before #IntellectualProperty companies can accelerate innovation while reducing cost and risk. It features our CACHE Challenges as an example of an open science initiative that can greatly benefit participating SMEs!

E. Richard Gold @richardgold.bsky.social · Jul 29

Simplistic models of #IntellectualProperty get in the way of building a biopharmaceutical company. Here I discuss how going #OpenScience can lead to proprietary rights later on: www.lifescienceleader.com/doc/open-sci... @conscience-network.bsky.social @tridentpct.bsky.social