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Sidar Aydın

@sidaraydin.bsky.social

220 followers 310 following 25 posts

Postdoc at Daneman Lab at UCSD. PhD, Engelhardt Lab at Uni Bern. Brain barriers in health and disease. Neuroimmunologist. MS Society fellow. 🏳️‍🌈

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Sidar Aydın @sidaraydin.bsky.social · Jan 4

Hi Bluesky!
I'm Sidar Aydın, a postdoc in Richard Daneman’s lab at UCSD. I earned my PhD at the University of Bern in Britta Engelhardt’s lab, studying CD8 T cells/BBB. I continue to study brain barriers in disease, with a new focus on exploring the barriers at circumventricular organs!

Sidar Aydın @sidaraydin.bsky.social · Jun 29

New series start with a lecture by @brittae.bsky.social on July 8! Don’t miss out on this great talk!

Reposted by Sidar Aydın

Andrew MacAskill @macaskillaf.bsky.social · Jun 19

🚨🚨Job Alert🚨🚨!! Neuroscience, Physiology and Pharmacology are recruiting a new lecturer/associate professor! an amazing opportunity to join our fantastic dept! @ucl.ac.uk @ucllifesciences.bsky.social @uclnpp.bsky.social post here:
www.nature.com/naturecareer...

Lecturer / Associate Professor - London, England job with University College London (UCL) | 12840324

About usThe Division of Biosciences at UCL is one of the world's foremost centres for research and teaching in the biological sciences. We have an out

Reposted by Sidar Aydın

Shane Liddelow @liddelowsa.bsky.social · Jun 15

Calling all Neuroscience postdocs! 🧠 Share your research through SPiNES (Seminars from Postdocs in Neuroscience: Extramural Series) from the NYUGSoM Department of Neuroscience. Applications close 08/20/25. Apply today! 👉 nyumc.qualtrics.com/jfe/form/SV_...
#Neuroscience #Postdoc #ResearchOpportunity

Sidar Aydın @sidaraydin.bsky.social · May 29

Sidar Aydın @sidaraydin.bsky.social · May 28

and the technicians who contributed so much to this manuscript. Their hard work made this paper all the more meaningful.

Please reach out if you have any questions or comments!

Sidar Aydın @sidaraydin.bsky.social · May 28

I am incredibly thankful to everyone who helped move this project forward over the years. While Javi and I led the work under the supervision of @brittae.bsky.social, I want to give special appreciation to the early-career trainees, some of whom I had the joy of mentoring,

Sidar Aydın @sidaraydin.bsky.social · May 28

This discovery opens a new path for understanding how the glia limitans, a CNS barrier that is conserved across species through evolution, regulates immune cell migration into the CNS parenchyma.

Sidar Aydın @sidaraydin.bsky.social · May 28

Interestingly, although JAM-B is known to be expressed by the blood-brain barrier endothelial cells, it was not this barrier stopping the T cells. Instead, CD8 T-cells got trapped in the perivascular space, unable to cross the glia limitans and reach the CNS parenchyma.

Sidar Aydın @sidaraydin.bsky.social · May 28

In this study, we investigated how CD8 T cells enter the central nervous system (CNS) during neuroinflammation. We found that without JAM-B, mice developed much milder autoimmune disease and had far fewer CD8 T cells entering the brain tissue.

Sidar Aydın @sidaraydin.bsky.social · May 28

🔔New publication!🔔

Excited to share a study that started during my PhD and was beautifully brought to completion by Javier Pareja, PhD in the Engelhardt Lab.

actaneurocomms.biomedcentral.com/articles/10....

Lack of junctional adhesion molecule (JAM)-B traps CD8 T cells in CNS border zones and ameliorates autoimmune neuroinflammation - Acta Neuropathologica Communications

The endothelial blood-brain barrier (BBB) tightly controls T cell entry into the central nervous system (CNS). T cell extravasation across the BBB involves a multi-step cascade with a predominant role...

actaneurocomms.biomedcentral.com

Sidar Aydın @sidaraydin.bsky.social · May 4

Data from Munji et al. 2019, Pulido et al. 2020, and Profaci et al. 2024.

Sidar Aydın @sidaraydin.bsky.social · May 4

🧬The interactive RNA sequencing resource from the Daneman Lab is now live!🧬

Built by Ben Gastfriend, this user-friendly tool lets you explore gene expression changes across multiple conditions!

Check it out here: danemanlab.shinyapps.io/bbbtranscrip...

Sidar Aydın @sidaraydin.bsky.social · Apr 29

This is a trainee seminar series and your participation is very important and much appreciated. Join us next week. Here is the free registration link:

streamyard.com/watch/wHnr7P...

Sidar Aydın @sidaraydin.bsky.social · Apr 22

The scientific exchange with top-notch researchers from around the world who share the same passion was phenomenal. And us, the (ex-)Daneman lab crew delivered some amazing talks! Catching up with friends was the cherry on top. Can’t wait for the next BB meeting!

Sidar Aydın @sidaraydin.bsky.social · Apr 22

It was a true pleasure to attend and give a talk at the Cold Spring Harbor Laboratories Brain Barriers conference in NY. By now, the brain barriers community feels like my extended science family, each meeting is like a family reunion.

Sidar Aydın @sidaraydin.bsky.social · Apr 12

🚨 A new Daneman Lab preprint!! 🚨

Reid Larsen, one of the brightest scientists I know, studied the BBB glycocalyx, identified its structure, composition, and function and uncovered what makes the CNS glycocalyx unique. It was a true pleasure to be a part of this seminal study!
shorturl.at/Wkhxr

Multi-omic analysis reveals the unique glycan landscape of the blood-brain barrier glycocalyx

The blood-brain barrier (BBB) glycocalyx is the dense layer of glycans and glycoconjugates that coats the luminal surface of the central nervous system (CNS) vasculature. Despite being the first point...

www.biorxiv.org

Reposted by Sidar Aydın

Siegenthaler Lab @siegenthalerlab.bsky.social · Apr 12

@cshlmeetings.bsky.social Brain Barriers 2025 is a wrap! It was an honor to co-organize this meeting in 2023 & 2025, a highlight of my scientific career.
I am amazed by all the great science presented by these awesome scientists over the last five days...the future of CNS barrier biology is 🤩 💫!

Sidar Aydın @sidaraydin.bsky.social · Feb 27

IBBS Horizons Global Research Rounds starts next week, with Prof. Norman Saunders kicking off the series! We’ll then host monthly sessions with senior grad students, postdocs, and junior faculty. I’m excited to connect with the community and share our science! The event is open to all. Come join us!

Sidar Aydın @sidaraydin.bsky.social · Feb 18

Writing my ideas down, going over my hypotheses, thinking through how I want to study the questions I’m asking etc. It was so helpful and, to be honest, quite relieving. Let’s see what comes out of this. Wish me luck! 🍀

Sidar Aydın @sidaraydin.bsky.social · Feb 18

I have no idea how this will turn out, whether I’ll get funded or not (hoping for the best! 🤞), but one thing I do know is that this process helped me crystallize my vision for what I want to do in the next few years as a faculty member.

Sidar Aydın @sidaraydin.bsky.social · Feb 18

I appreciate all the people who supported me, including those who wrote reference letters, provided collaborator support, and helped in ways big and small. A huge huge thank you to my mentor Rich Daneman, who guided me through it all.

Sidar Aydın @sidaraydin.bsky.social · Feb 18

As someone who wasn’t familiar with the NIH system, I didn’t realize just how much extra work would come with it. So many unexpected steps and so many documents.

But if there’s one thing this process proved to me once more, it’s that science is never a solo journey and we truly lift each other up!

Sidar Aydın @sidaraydin.bsky.social · Feb 18

🚀 First NIH Grant Submitted! 🚀

Despite all the turbulence in the science world in the US lately, last week, I submitted my K99/R00 Pathway to Independence Award, which is also my very first NIH grant!

Sidar Aydın @sidaraydin.bsky.social · Jan 4

Thank you!

Sidar Aydın @sidaraydin.bsky.social · Jan 4

Thank you!!