Siegenthaler Lab
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siegenthalerlab.bsky.social
Siegenthaler Lab
@siegenthalerlab.bsky.social
Neuroscience, meninges, blood-brain barrier, cake (or cookies)
http://siegenthalerlabcu.weebly.com/
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Hi Bluesky! I am Julie Siegenthaler, I am research faculty in Pediatrics at the University of Colorado, Anschutz Medical Campus in Aurora, Colorado USA - the @siegenthalerlab.bsky.social studies the meninges & brain vasculature & we ❤️ all CNS barriers...but the ones in the meninges are the best.
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Missing local man call 843-833-1890 or 704-724-2105 if you see him
December 29, 2025 at 7:41 PM
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🎉 Join us at the UK Glia 2026 meeting, 8–9 June. Registration open now, abstracts due 16 Jan. 🔗 www.physoc.org/events/uk-gl... .In this post, meet Blanca Díaz Castro @bdiazcastro.bsky.social from UK DRI @ukdri.ac.uk and the University of Edinburgh @edinburgh-uni.bsky.social
December 29, 2025 at 12:15 PM
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You probably heard the US admin is threatening to break up the National Center for Atmospheric Research: but did you know they already froze funding for the 9 regional Climate Science Adaptation Centers? From tracking invasives to helping tribes with drought, here's why the CASCs matter ⬇️
From invasive species tracking to water security – what’s lost with federal funding cuts at US Climate Adaptation Science Centers
The people who manage America’s aquifers, wetlands, shorelines and recreation areas rely on federal science as they face new and rising risks in a changing climate.
theconversation.com
December 29, 2025 at 12:02 PM
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Last couple of days to vote for your favourite 'Featured image' from 2025 ❤️🔬!
focalplane.biologists.com/2025/12/19/v...
December 29, 2025 at 11:23 AM
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With Bardot's passing, the only named individuals in Billy Joel's We Didn't Start The Fire that are still alive are Bob Dylan, Chubby Checker, and Bernie Goetz. The last one standing will claim The Prize.
December 28, 2025 at 10:22 AM
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A paper published in Nature in September suggests a quarter of heatwave events from 2000-23 would have been near impossible without anthropogenic climate change. The paper also indicates that major carbon emitters are responsible for around 50% of the increase in intensity of these events. ⚒️ 🧪
Systematic attribution of heatwaves to the emissions of carbon majors - Nature
Climate change made 213 historical heatwaves reported over 2000–2023 more likely and more intense, to which each of the 180 carbon majors (fossil fuel and cement producers) substantially contributed.
go.nature.com
December 28, 2025 at 11:28 PM
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It's always a different type of excitement when you get an advanced book copy in the mail and it's a project you contributed to. Very excited that this gets released in early 2026. It was a joy and privilege to author a chapter in this text alongside a stellar cadre of co-authors and amazing editors
December 28, 2025 at 11:56 PM
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Statement from the American Academy of Neurology: “This decision was made without consulting key neurology stakeholders, and there was no formal announcement nor a clear succession plan for NINDS leadership. NINDS plays a vital role in funding and directing research into the brain”
Statement on Sudden Departure of NINDS Director
www.aan.com
December 28, 2025 at 9:22 PM
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🚨 Alarm!!! 🚨
AI/ML course for microscopy image analysis!!! 🧐
In 2026 at Janelia (@hhmijanelia.bsky.social), no tuition, housing and meals provided! Isn’t that borderline unbelievable?!?

20 students, ~14 TAs and lecturers
🗓️ June 4-18 2026

✍️ Jan 15 2026 ✍️

🔁 pls!!

www.janelia.org/you-janelia/...
Deep Learning for Microscopy Image Analysis
Topics The following will be covered extensively during lectures, exercises, and project work: Image denoising and restoration (fully supervised and self-supervised) Image translation (e.g.,
www.janelia.org
December 28, 2025 at 7:06 PM
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Two weeks ago I spent the whole day at the Museum of the Moving Image to listen to New Yorkers. This is what Liam shared with me.
December 28, 2025 at 6:03 PM
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More on the continuing purges at #NIH. Now 13 out of 27 institute directors have been gotten rid of. This is not normal. @jonathanwosen.bsky.social www.statnews.com/2025/12/27/n...
Director of NIH neurological disorders institute is ousted, adding to leadership churn
Walter Koroshetz, director of the National Institute of Neurological Disorders and Stroke, will soon be leaving his role, STAT has learned. His departure
www.statnews.com
December 27, 2025 at 7:05 PM
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“Recovering her story is important because it allows her scientific contributions to be appropriately recognised. Perhaps more importantly, her story reminds us that women have belonged in quantum physics from the beginning.” 🧪
In 1977, American physicist John H. Van Vleck won the Nobel prize for his work on magnetism. In his Nobel lecture, amid a discussion of rare earth elements, one sentence leaps out:

"Miss Frank and I made the relevant calculations."

Who was Amelia Frank?

theconversation.com/who-was-amel...
Who was Amelia Frank? The life of a forgotten physicist
In the 1930s, this quantum mechanical pioneer faced obstacles that still confront women in physics today.
theconversation.com
December 28, 2025 at 3:06 PM
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December 27, 2025 at 10:59 PM
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How does fever work?

Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence.

This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧵

www.science.org/doi/10.1126/...
Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals
Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...
www.science.org
November 27, 2025 at 7:55 PM
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Lee et al. used B-lymphoblastoid cells from three great ape species and humans to show that human ZEB2 is distinct in regulating a larger repertoire of genes implicated in neuronal development.

🔗 doi.org/10.1093/molbev/msaf318

#evobio #molbio
Comparing great apes reveals human-specific ZEB2 roles in neural development
Abstract. Humans differ from other primates in various traits, despite nearly identical protein-coding sequences. Understanding the evolution of these diff
doi.org
December 26, 2025 at 1:06 PM
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I will be recruiting two postdocs early next year.
- One image analyst
- one biologist interested in working on lymphatics!

Reach out if you are interested 👍
The Center is a wonderful collaboration with scientists extraordinaire @taijamakinenlab.bsky.social Kari Vaahtomeri and Cecilia Sahlgren.

We are all recruiting, so keep an eye on our website If you are looking for a postdoc position 😀
I am delighted to introduce our new Centre of Excellence in Immune-Endothelial Interfaces (IMMENs) funded by the Research Council of Finland.

www.helsinki.fi/en/researchg...

I will be recruiting two postdocs early next year. One image analyst and one biologist interested in working on lymphatics!
December 21, 2025 at 8:58 AM
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#Atherosclerosis

Smooth Muscle Cell PCSK9 transgenic🐭
👉Ferroptosis (⏫Iron deposit ⏫4HNE ⏫PTGS2 ⏬GPX4)
👉Plaque instability

PCSK9 binds to YAP1 for lysosomal degradation▶️
⏬NUPR1 (ferroptosis suppressor)

Cadd4 - a PCSK9 PROTAC
⏫Lesion stability

Research 2025
spj.science.org/doi/full/10....
December 28, 2025 at 1:07 PM
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This is an outstanding essay describing some of the important roles and influences of NIH program officers (from an insider perspective).

Read!

elizabethginexi.substack.com/p/the-quiet-...
The Quiet Power of Program Officers
How invisible decisions shape what science gets done—and whether it matters
elizabethginexi.substack.com
December 28, 2025 at 11:56 AM
Reposted by Siegenthaler Lab
In 1977, American physicist John H. Van Vleck won the Nobel prize for his work on magnetism. In his Nobel lecture, amid a discussion of rare earth elements, one sentence leaps out:

"Miss Frank and I made the relevant calculations."

Who was Amelia Frank?

theconversation.com/who-was-amel...
Who was Amelia Frank? The life of a forgotten physicist
In the 1930s, this quantum mechanical pioneer faced obstacles that still confront women in physics today.
theconversation.com
December 27, 2025 at 5:46 PM
Reposted by Siegenthaler Lab
Applications are open for the 2026 Computational Cell Types Workshop! 🧠📈

🗓️ May 11-14 in Seattle
💻 Python experience required
💰 Support for travel
🔗 https://alleninstitute.org/events/2026-computational-cell-types-workshop/
2026 Computational Cell Types Workshop
Workshop in Seattle, WA to gain in-depth exposure to how Allen Institute defines "cell types" and walk away with direct applicable examples on using our free, open tools for their research
alleninstitute.org
December 27, 2025 at 3:51 PM
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I had the opportunity to do the most enjoyable and, hopefully, meaningful work of my scientific career thanks to the leadership of former NINDS Director Walter Koroshetz. He and his team at NINDS created visionary scientific programs for the pain field. He will be missed...
More news (not good) from NIH

The renewal request from National Institute of Neurological Diseases and Stroke Director Walter Koroshetz has been denied.

I guess the NIH_leadership™ needed another position to fill with their time-tested recruitment process.
December 27, 2025 at 4:39 PM
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Thanks for mentioning, Jeremy. We had a story about this go up a little while ago. 👇

www.statnews.com/2025/12/27/n...
Director of NIH neurological disorders institute is ousted, adding to leadership churn
Walter Koroshetz, director of the National Institute of Neurological Disorders and Stroke, will soon be leaving his role, STAT has learned. His departure
www.statnews.com
December 27, 2025 at 4:25 PM
Reposted by Siegenthaler Lab
More news (not good) from NIH

The renewal request from National Institute of Neurological Diseases and Stroke Director Walter Koroshetz has been denied.

I guess the NIH_leadership™ needed another position to fill with their time-tested recruitment process.
December 27, 2025 at 4:17 PM
Reposted by Siegenthaler Lab
Kristina Gjerde was a mentor to me in high seas policy. I, and many others, owe our careers to her.

May her memory be a blessing.

news.mongabay.com/2025/12/kris...
Kristina Gjerde, defender of the deep ocean, has died
Half the planet lies outside any country’s border. In those waters, rules have long been thinner than the myths: freedom to fish meant freedom to take; “out of sight” became “out of mind.” The deep oc...
news.mongabay.com
December 27, 2025 at 3:50 AM
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'Mechanistically, the distribution of GLP- 1R expression differs in the mouse versus the human heart, challenging the utility of preclinical studies for inferring underlying mechanisms in humans.'
www.science.org/doi/10.1126/...
The benefits of GLP-1 drugs beyond obesity
Glucagon-like peptide–1–based medicines have weight loss–independent actions
www.science.org
December 27, 2025 at 12:12 AM