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Siegenthaler Lab

@siegenthalerlab.bsky.social

5.2K followers 4.5K following 590 posts

Neuroscience, meninges, blood-brain barrier, cake (or cookies) http://siegenthalerlabcu.weebly.com/

siegenthalerlabcu.weebly.com

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Siegenthaler Lab @siegenthalerlab.bsky.social · Nov 8

Hi Bluesky! I am Julie Siegenthaler, I am research faculty in Pediatrics at the University of Colorado, Anschutz Medical Campus in Aurora, Colorado USA - the @siegenthalerlab.bsky.social studies the meninges & brain vasculature & we ❤️ all CNS barriers...but the ones in the meninges are the best.

picture of a woman smiling next to a skeleton with a red wig, sunglasses and a black had

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University of California @uofcalifornia.bsky.social · 1m

Congratulations to @ucberkeleyofficial.bsky.social professor Omar M. Yaghi for winning the Nobel Prize in chemistry for his groundbreaking work, which has already shown promise in yielding drinkable water from desert air. 💙 💛 🏅 www.universityofcalifornia.edu/news/uc-berk...

UC Berkeley’s Omar Yaghi shares 2025 Nobel Prize in chemistry

Yaghi created a field called reticular chemistry, which involves stitching together molecular building blocks to form porous structures — metal-organic frameworks (MOFs) — with myriad applications.

www.universityofcalifornia.edu

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Waggoner Lab @labwaggoner.bsky.social · 1h

B cells promote atrial fibrillation via autoantibodies @natcardiovascres.nature.com @harvardmed.bsky.social @maartenhulsmans.bsky.social
www.nature.com/articles/s44...

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Michael Clemens @mclem.org · 4h

Former USAID official here.

The current Administration has done zero impact analysis to estimate the effects of its obliteration of USAID on deaths around the world.

It just keeps saying "no one has died" as a mesmeric incantation.

The facts, below. 🧵

Nathan Kalmoe (he/him) @nathankalmoe.bsky.social · 7h

apnews.com/article/myan...

Starving children screaming for food as US aid cuts unleash devastation and death across Myanmar

U.S. Secretary of State Marco Rubio has repeatedly said “no one has died" because of his government’s decision to gut its foreign aid program.

apnews.com

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Cathy Hernandez @cathyhernandez.bsky.social · 1h

Very happy to share that I will be starting as an Assistant Professor in the department of Biological Sciences at the University of South Carolina in January! My group will be working on environmental phage ecology and evolution, and I am recruiting for the upcoming year (more info below).

A graphic advertising phage ecology and evolution research at the University of South Carolina, showing a central image of a tide pool flanked by a photo of an agar plate containing diverse microbes and a TEM image of a virus particle.

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Cathy Hernandez @cathyhernandez.bsky.social · 1h

I am recruiting graduate students (MS and/or PhD) for the upcoming fall semester (more info here: tinyurl.com/35p6hfx7), and will soon be hiring a research associate/technician (details TBD).

Study - Department of Biological Sciences | University of South Carolina

tinyurl.com

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Dr Buki Fatona @bukifatona.bsky.social · 1h

This week seems apt to remember Dorothy Hodgkin (1910-1994).

The first British woman to receive a Nobel Prize in chemistry.

❤️ Maggi Hambling's painting of Hodgkin with multiple hands working at her desk. In the corner is a structurally accurate model of insulin which she solved.

#WomenInSTEM

"The first British woman to win the Nobel Prize in Chemistry in 1964, Hodgkin was able to define the structures of penicillin (1949), Vitamin B12 (1955) and insulin (1969) using x-ray crystallography, transforming their therapeutic potential. A Royal Society Fellowship scheme was established in her name, to help women who wish to be both career scientists and to raise children. Commissioned by the Gallery, and painted in Hodgkin’s study, Maggi Hambling depicts the chemist with a structural model of insulin in the foreground. Two pairs of hands convey energy and activity, which also refers to the subject’s acute arthritis, contracted when she was 28."

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Nuria Lopez-Bigas @nlbigas.bsky.social · 1h

🚨 New paper alert!

Sex and smoking bias in the selection of somatic mutations in human bladder

www.nature.com/articles/s41...

by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)

Sex and smoking bias in the selection of somatic mutations in human bladder - Nature

Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.

www.nature.com

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Frankie D Heyward @frankiedheyward.bsky.social · 1h

I’m excited to share our new preprint! We built a single-nucleus multiomic (snRNA-seq+snATAC-seq) atlas of leptin receptor-expressing hypothalamic neurons (LepRᴴʸᵖᵒ) and identified conserved cis-regulatory elements overlapping human obesity-linked variants and eQTLs🧠🧬
www.biorxiv.org/content/10.1...

Single-nucleus transcriptional and chromatin accessibility profiling of mouse hypothalamic LepRb neurons reveals cell type-specific cis-regulatory elements linked to human obesity

Leptin receptor-expressing hypothalamic neurons (LepRHypo) are key regulators of energy balance, yet a comprehensive, cell type-resolved, chromatin accessibility map of these neurons is lacking. We pr...

www.biorxiv.org

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Kurianlab @kurianlab.bsky.social · 1h

We lost another Gem of a scientist:

www.cam.ac.uk/research/new...
His work inspired so many of us, such a brilliant mind and a kind human

Apart from rewriting our fundamental understanding of cell identity, his love for science is equally legendary

"I was the worst out of 250." John Gurdon, Nobel Prize in Physiology or Medicine 2012

YouTube video by Nobel Prize

www.youtube.com

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Kurianlab @kurianlab.bsky.social · 1h

from doing bench work and publishing first-author papers, until recently

www.pnas.org/doi/10.1073/...

His story about his high school teacher discouraging him, and taking it as an inspiration, is a great lesson to all of us:
www.youtube.com/shorts/UKc5N...

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

www.pnas.org

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jamelle @jamellebouie.net · 3h

i desperately want everyone involved in the destruction of USAID to have to, st the very least, answer to the american people for the suffering and misery they have caused apnews.com/article/myan...

Starving children screaming for food as US aid cuts unleash devastation and death across Myanmar

U.S. Secretary of State Marco Rubio has repeatedly said “no one has died" because of his government’s decision to gut its foreign aid program.

apnews.com

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Benjy Sarlin @benjysarlin.bsky.social · 4h

In related news, let me know if you or someone you know has any interesting work opportunities!

Dave Jorgenson @davejorgenson.bsky.social · 5h

The Post laid off seemingly the remaining of their liberal-leaning staff members on Opinion last Thursday, when some of them were observing Yom Kippur.

from @oliverdarcy.bsky.social for Status
status.news/p/washington-post-opinion-cuts-adam-oneal

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Zoe McElligott @nanopharmnc.bsky.social · 4h

October 9th is the deadline for poster submissions for #WCBR2026 please share! www.winterbrain.org

one more day left for poster submissions to Winter Brain 2026

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Sheila Teves @sheilateves.bsky.social · 22h

How does a “universal” transcription factor evolve to do species-specific jobs?
Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes.

Read it here 👉

www.biorxiv.org/content/10.1...

#MolecularEvolution #Transcription

Molecular determinants underlying functional divergence of TBP homologs

The TATA-box binding protein (TBP) is a highly conserved basal transcription factor and a core component of the pre-initiation complex (PIC) for all three eukaryotic RNA polymerases (RNA Pols). Despit...

www.biorxiv.org

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Max Planck Institute for the Science of Light (MPL) @mpi-scienceoflight.bsky.social · 5h

With deep sadness, we share that Prof. Jochen Guck, Director at the Max Planck Institute for the Science of Light passed away on October 3. His visionary work bridged physics and medicine. We have lost a brilliant scientist and dear friend.

mpl.mpg.de/news/article...
@fau.de

📸 Stephan Spangenberg

Professor Jochen Guck, Director at the Max Planck Institute for the Science of Light (MPL), He headed the division “Cell Physics” at MPL and the Max-Planck-Zentrum für Physik und Medizin (MPZPM).

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Laura Helmuth @laurahelmuth.bsky.social · 5h

Six of the nine Nobel Prize winners this year work in the U.S.
Three of the six were born outside the U.S., which is the pattern most years. No country has benefited more from welcoming immigrants from around the world.
www.nobelprize.org

The official website of the Nobel Prize - NobelPrize.org

The Nobel Prize rewards science, humanism and peace efforts. This is one of the central concepts in the will of Alfred Nobel, and it also permeates the outreach activities that have been developed for...

www.nobelprize.org

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Hao Yin @haoyin.bsky.social · 7h

p21/Rb-activated SMAD/STAT/NFκB-dependent secretome activates a reversible immunoclearance program

Fibroblast in vitro
Hepatocyte in vivo

Senescence-independent😎

CXCL14
IGFBP3
ADAM15
SSC5D
APP
FN1
Prosaposin

@science.org 2021
www.science.org/doi/10.1126/...

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Current Biology @currentbiology.bsky.social · 6h

Which journal would publish such a fragmented mess?
www.cell.com/current-biol...

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Dr. Kat Napaaqtuk❄️ @napaaqtuk.bsky.social · 6h

I made a list of Native songs by Native artists on tidal. It has punk, throat singer, R&B, pop, a little bit of everything.

Related, I noticed that a bunch of the artists don't have their albums on Tidal anymore, anyone know what's up with that? Did I miss something?

tidal.com/playlist/e2a...

Natives

Playlist - Natives - 58 items

tidal.com

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Black Microbiologists Assoc (Black In Micro) @blackinmicro.bsky.social · 6h

🌟 Don't miss CAREERS & RESEARCH Day on Oct 15! Hear highlights from Dr. Lauryn Alexander, Dr. Shanna Ashley, and Dr. Corey Reynolds. Secure your spot now by pre-registering: linktr.ee/BlackInMicro. Show your support by donating here: tinyurl.com/GiveBiM (links in bio) #BlackInMicro #BiM2025

Black in Microbiology Week 2025 Panel: Navigating Careers in Microbiology – Careers & Research. Event time: 2–3 PM EST, Oct. 15, 2025. Speakers: Lauryn Alexander, PhD (Law Student, West Virginia University), Shanna Ashley, PhD (Medical Science Liaison, AbbVie), and Corey Reynolds, PhD (Regional Medical Scientific Director, Merck).

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University of Cambridge @cam.ac.uk · 1d

It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the @gurdoninstitute.bsky.social

Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r

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Nicole Rust @nicolecrust.bsky.social · 21h

Please spread the word! I am recruiting a PhD student this cycle (Fall 2026 start) to join my team in a new venture: the neuroscience of mood.

If you are curious to learn more, this short talk provides a good overview of why, what and how.

www.youtube.com/watch?v=gjIK...

Nicole Rust - The representation of mood in the primate insula (May 6, 2025)

YouTube video by Simons Foundation

www.youtube.com

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Allen Institute @alleninstitute.org · 18h

🍳🍕 Free breakfast and lunch? Yes, please!

Undergraduate educators going to #CellBio2025 are invited to apply for our “Open Science & Authentic Research in Undergraduate Education” workshop happening on Dec. 5 in Philadelphia.

Apply by Oct 20: alleninstitute.org/events/open-...

Open Science & Authentic Research in Undergraduate Education: Pre-CellBio Workshop

Join the Open Science & Authentic Research in Undergraduate Education Workshop in Philadelphia, PA on December 5, 2025.

alleninstitute.org

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Rita Strack @ritastrack.bsky.social · 21h

I hope this Nobel Prize gets people talking meaningfully about our amazing immune systems and the importance of basic research to human health (and funding basic research).

I am also glad young women get to see that women can not only work at this level, but that those who do can get recognized.

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Phil Lewis @phillewis.bsky.social · 19h

Dolly Parton's sister is asking fans to "pray with me" amid the country music icon's health issues

Dolly Parton’s Sister Says ‘I Was Up All Night Praying’ Amid Country Icon’s Health Issues and Asks Fans to ‘Pray With Me’

Dolly Parton's sister Frieda is asking fans of the Queen of Country to "pray with me" amid Dolly's continued health struggles.

variety.com

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