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Nuria Lopez-Bigas @nlbigas.bsky.social · 2d

congratulations to all the team 👏

Nuria Lopez-Bigas @nlbigas.bsky.social · Aug 14

New paper from our lab - ‪@bbglab.bsky.social‬.

Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection

academic.oup.com/nar/article/...

Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel

Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection

Abstract. Identifying the genes capable of driving tumorigenesis in different tissues is one of the central goals of cancer genomics. Computational methods

academic.oup.com

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Reposted by Nuria Lopez-Bigas

Raquel Blanco @raquelbmi.bsky.social · Jun 20

Back after a few days in Lisbon for the annual #EACR2025 conference! Inspiring and great science. Glad for the opportunity to present our work, coming home with a bunch of new ideas! @bbglab.bsky.social @ferriol.bsky.social

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Reposted by Nuria Lopez-Bigas

Jeffrey Townsend @jeffreytownsend.bsky.social · Apr 25

@ewaszczurek.bsky.social explains how evolution is the generative process of cancer at #AACR25.

Ewa Sczurek presenting slides at a lectern on a podium.

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Reposted by Nuria Lopez-Bigas

Jeffrey Townsend @jeffreytownsend.bsky.social · Apr 25

Jeffrey Townsend (that's me!) presents on dismantling the coarse approximation of drivers and passengers in cancer at #AACR25.

Thank you @nlbigas.bsky.social for the photo!

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Reposted by Nuria Lopez-Bigas

Jeffrey Townsend @jeffreytownsend.bsky.social · Apr 25

@nlbigas.bsky.social explains how they assemble a compenduim of driver genes 🧬 in cancer at #AACR25.

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Nuria Lopez-Bigas @nlbigas.bsky.social · Apr 23

I hope you are getting better. I also listened a couple of years ago Project Hail Mary and loved it! Probably you have already read/listen The Martian, if not, also highly recommended.

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Reposted by Nuria Lopez-Bigas

CGI-Clinics @cgiclinics.bsky.social · Mar 21

We're at #CCG2025 in Amsterdam! Project Coordinator @nlbigas.bsky.social is delivering a keynote lecture on the CGI-Clinics project today, 'Data-driven cancer genome interpretation for clinical decision making': www.ccg2025.eu/speaker/nuri...

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Nuria Lopez-Bigas @nlbigas.bsky.social · Mar 10

European Association of Cancer Reasearch statement on threats to cancer reasearch

@helloeacr.bsky.social

eacr.org/statement-on...

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Nuria Lopez-Bigas @nlbigas.bsky.social · Mar 7

#standupforscience Boston

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Nuria Lopez-Bigas @nlbigas.bsky.social · Mar 5

Tackling Cancer through Global Team Science

aacrjournals.org/cancerdiscov...

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Nuria Lopez-Bigas @nlbigas.bsky.social · Mar 5

Seven New Cancer Grand Challenges Announced

www.cancergrandchallenges.org/new-challenges

With awards of up to £20m ($25m). Expressions of Interest are now open.

@cancergrand.bsky.social #CancerGrandChallenges

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Reposted by Nuria Lopez-Bigas

Sarah Aitken @s-j-aitken.bsky.social · Jan 15

🌟NEW PREPRINT ALERT!🌟

We are very pleased to introduce #StrainDifferences: “Genetic background sets the trajectory of cancer evolution”

www.biorxiv.org/content/10.1...

🧵[1/12]

Genetic background sets the trajectory of cancer evolution

Human cancers are heterogeneous. Their genomes evolve from genetically diverse germlines in complex and dynamic environments, including exposure to potential carcinogens. This heterogeneity of humans,...

www.biorxiv.org

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Reposted by Nuria Lopez-Bigas

Edwin Cuppen @ecuppen.bsky.social · Jan 10

Less than a week for registration. Check out the program: www.ccg2025.eu. With keynotes by @nlbigas.bsky.social and @charlesswanton.bsky.social and exciting sessions on clinical implementation and impact, research insights and future developments around cancer whole genome sequencing
#ccg2025

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Nuria Lopez-Bigas @nlbigas.bsky.social · Jan 1

Molt trista per aquesta notícia. Gran professor, comunicador i científic. Una persona propera que ha deixat empremta a tots els que hem tingut la sort d'interaccionar amb ell. Deixa un llegat immens a l'IRB i a la ciència al nostre país.

IRB Barcelona @irbbarcelona.org · Jan 1

With great sadness, we announce the passing of Dr. Joan Guinovart, founder, former scientist, director, and Emeritus Professor of IRB Barcelona.

Our deepest condolences to his loved ones and the IRB Barcelona community.

You will always be remembered, Captain.

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Reposted by Nuria Lopez-Bigas

David Martínez Millán @dmartmillan.bsky.social · Dec 12

🎉 I'm thrilled to announce that OpenVariant is finally published! A comprehensive toolkit to facilitate reading, parsing and refinement of diverse input file formats in a customizable structure, all within a single process. @bbglab.bsky.social at @irbbarcelona.bsky.social

doi.org/10.1093/bioi...

OpenVariant: a toolkit to parse and operate multiple input file formats

AbstractSummary. Advances in high-throughput DNA sequencing technologies and decreasing costs have fueled the identification of small genetic variants (suc

academic.oup.com

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Nuria Lopez-Bigas @nlbigas.bsky.social · Dec 10

Congratulations Direna 🎉
#IGNITE is a great project lead by an amazing scientist 💪🏻
And welcome to Bluesky

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Nuria Lopez-Bigas @nlbigas.bsky.social · Dec 9

**Clinical Cancer Genomics Conference**
First of an annual recurring series. It will be a very important meeting for the advance of clinical implementation of cancer genomics.

Proud to be part of it.

March 20th-21st 2025 in Amsterdam.

Registration open: www.ccg2025.eu
#CCG2025

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Nuria Lopez-Bigas @nlbigas.bsky.social · Dec 6

**Mutations in Time and Space**

Looking forward to it.

Abstract submission is now open

broadinstitute.swoogo.com/mits2025/

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Nuria Lopez-Bigas @nlbigas.bsky.social · Dec 4

👏🏻👏🏻👏🏻👏🏻

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Reposted by Nuria Lopez-Bigas

UCSF Helen Diller Family Comprehensive Cancer Center @ucsfcancer.bsky.social · Dec 3

This Friday 12/6 at 4pm, Núria López-Bigas, PhD @nlbigas.bsky.social @irbbarcelona.bsky.social presents "Somatic mutations in tumors and normal tissues" at our Friday Seminar Series in Basic and Translational Research cancer.ucsf.edu/seminars

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Nuria Lopez-Bigas @nlbigas.bsky.social · Dec 3

Read (actually listened) The Maniac, thanks to your and @landau.bsky.social suggestion, and I loved it!
Playground is now in my list for next.

Thanks for the suggestions.

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Reposted by Nuria Lopez-Bigas

Barcelona Biomedical Genomics Lab @bbglab.bsky.social · Nov 27

Today at IRB Barcelona (@irbbarcelona.bsky.social) #NodeSeminar Stefano Pellegrini presented:

"Detection of cancer driver genes with clusters of somatic mutations in protein three-dimensional structure"

Very good presentation and nice discussion within the IRB Barcelona community

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Nuria Lopez-Bigas @nlbigas.bsky.social · Nov 27

Only a subset of patients respond to immunotherapy

Why? Which ones?

We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response.

www.nature.com/articles/s41...

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Nuria Lopez-Bigas @nlbigas.bsky.social · Nov 25

Great idea! thanks for starting this. Can you please add @guixe-m.bsky.social and myself?

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