Scientists have used low-error genome-sequencing methods in normal tissues from large cohorts of individuals to scan for mutations that set the stage for cancer

go.nature.com/42vakWS

New research from team PROMINENT (@nlbigas.bsky.social), published in @nature.com, uncovers clues why men face a higher risk of bladder cancer and reveals that tobacco smoke acts as a promoter, not an initiator, in bladder cancer development.

Read more: www.cancergrandchallenges.org/news/early-c...

🧪 Out in @nature.com: Smoking and biological sex shape healthy bladder tissue evolution, offering clues to #cancer risk.

✍️ #IRBBarcelona & University of Washington

➡️ bit.ly/42wcIN5

📌 DOI: 10.1038/s41586-025-09521-x

#IRBScience #CancerResearch #BladderCancer @bbglab.bsky.social

🧵👇

Very happy to share that our paper on the influence of biological sex and smoking in the clonal landscape of the normal human bladder is out today in Nature. Kudos to all the authors and especially to @ferriol.bsky.social for coming along with me during this project's journey!

🧵Summary following ⬇️

New paper from our lab - ‪@bbglab.bsky.social‬.

Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection

academic.oup.com/nar/article/...

Kudos to Stefano, Olivia, @fmuinos.bsky.social and Abel

To better treat cancer, we need to understand its underlying biology. Despite decades of research, some fundamental questions remain unanswered. One is why certain key tumor suppressor or oncogenes lead to cancer predominantly in single tissue: e.g. Rb in the retina, or APC in the colon 1/n 🧪

Back after a few days in Lisbon for the annual #EACR2025 conference! Inspiring and great science. Glad for the opportunity to present our work, coming home with a bunch of new ideas! @bbglab.bsky.social @ferriol.bsky.social

Our colleagues Olivia Dove, Raquel Blanco and Ferriol Calvet are attending the #EACR2025. They are sharing their research results with their respective posters and are for sure learning a lot in an excellent Congress with an outstanding list of speakers. @ferriol.bsky.social @raquelbmi.bsky.social

Today is the start of #EACR2025! We’re excited to welcome a record number of participants from 66 countries to our Annual Congress here in Lisbon. Find the programme at 2025.eacr.org and don’t forget to use the hashtag!

An analysis in Nature Medicine confirms that the microbiome can be a clinical target for colorectal cancer screening and characterizes it as a biomarker for colorectal cancer progression. go.nature.com/3Hrux8m #medsky 🧪 🧬

🌟 Are you passionate about computational immuno-oncology research with real clinical impact? 🌟

Our group is looking for a motivated Bioinformatics Scientist for single-cell transcriptomics🧬💻

See offer here 👉 jobs.vhio.net/en/jobs/6016...

#Bioinformatics #SingleCellRNA #Immunogenomics

Kudos to @raquelbmi.bsky.social and @ferriol.bsky.social, first authors of the study, for the insane amount of good work put into this.

Hello world! Kicking off my first post with some exciting news 📣 Our study on tobacco smoke-induced mutagenesis in head & neck cancer (HNC) is out today in
@naturegenet.bsky.social! rdcu.be/efNiH 🧬🔥
We uncover the multiple ways tobacco and alcohol drive HNC development. A short thread 🧵⬇️

Congratulations Victor and team!!

Join us in beautiful Barcelona!!

🎉 I'm thrilled to announce that OpenVariant is finally published! A comprehensive toolkit to facilitate reading, parsing and refinement of diverse input file formats in a customizable structure, all within a single process. @bbglab.bsky.social at @irbbarcelona.bsky.social

doi.org/10.1093/bioi...

Hi Bluesky! Nice to see the scientific community growing here 🤗