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Reposted by Fran Martínez-Jiménez

Eric Topol @erictopol.bsky.social · 3h

Finding somatic mutations in healthy tissue that can lead to cancer, at scale. Yet another path to primary prevention
www.nature.com/articles/s41...
www.nature.com/articles/d41...

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Fran Martínez-Jiménez @franmj88.bsky.social · 12h

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As genomic profiling expands, such approaches are vital to balance patient benefit, cost, and sustainability. But will require systematic data generation and sharing to achieve real-world impact. End.

Fran Martínez-Jiménez @franmj88.bsky.social · 12h

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We also model the statistical power needed for clinical implementation of such biomarkers, offering a roadmap for translating non-response biomarkers into clinical practice. Our analysis revealed that we are still underpowered to implement it with existing data

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Fran Martínez-Jiménez @franmj88.bsky.social · 12h

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Under stringent analytical control, we found several known and novel biomarkers, many aligned with resistance mechanisms (e.g., KRASG12X in colorectal cancer treated with comb. chemotherapy agents, immune escape events in melanoma patients treated with ICIs). See full list in Supp. Tables

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Fran Martínez-Jiménez @franmj88.bsky.social · 12h

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We analyzed data from >2,500 patients with WGS/WTS and matched clinical outcomes — the largest dataset of its kind — to systematically identify non-response biomarkers.

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Fran Martínez-Jiménez @franmj88.bsky.social · 12h

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🚀 Excited to share our preprint tackling a key gap in precision oncology: the lack of robust non-response biomarkers to guide clinical decisions.
These markers can spare patients from ineffective treatments and ease pressure on healthcare systems.
www.biorxiv.org/content/10.1...

www.biorxiv.org

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Reposted by Fran Martínez-Jiménez

Marc A. Marti-Renom @mamartirenom.bsky.social · 1d

Working alongside with Fran, a no brainer 👇🏼

Fran Martínez-Jiménez @franmj88.bsky.social · 4d

🚨 International Postdoctoral Positions Open at VHIO! 🚨
The VHIO VIDA Postdoctoral Program is now open!
We’re a fully funded position for international postdocs to work on cutting-edge exciting projects, develop professionally, and pave the way toward independence.
👉 vhiovidaprogramme.eu

Home - VIDA

vhiovidaprogramme.eu

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Fran Martínez-Jiménez @franmj88.bsky.social · 4d

🚨 International Postdoctoral Positions Open at VHIO! 🚨
The VHIO VIDA Postdoctoral Program is now open!
We’re a fully funded position for international postdocs to work on cutting-edge exciting projects, develop professionally, and pave the way toward independence.
👉 vhiovidaprogramme.eu

Home - VIDA

vhiovidaprogramme.eu

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Reposted by Fran Martínez-Jiménez

Eric Topol @erictopol.bsky.social · 6d

How exercise promotes the immune system vs cancer, working through a gut bacteria metabolite
www.cell.com/cell/abstrac...

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Reposted by Fran Martínez-Jiménez

Magdalena Skipper @magdalenaskipper.bsky.social · 6d

The obsession with economic output as a measure of human development puts sustainability on the back burner

Time to end the GDP mania

Our editorial inspired by a @nature.com paper that looks at how the world should really measure prosperity
🧪 #SGDs #doughnuteconomics
www.nature.com/articles/d41...

End GDP mania: how the world should really measure prosperity

The obsession with economic output as a measure of human development puts sustainability on the back burner. Researchers can now help to devise better indicators.

www.nature.com

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Reposted by Fran Martínez-Jiménez

Magdalena Skipper @magdalenaskipper.bsky.social · 6d

The richest 20% of nations, with 15% of the global population, contribute more than 40% of annual ecological overshoot; the poorest 40% of countries, with 42% of the global population, experience more than 60% of social shortfall 🧪
A new analysis by Fanning & Raworth
www.nature.com/articles/s41...

Doughnut of social and planetary boundaries monitors a world out of balance - Nature

A revised ‘Doughnut’ providing a visual assessment of trends in social deprivation and planetary degradation over the past two decades shows more than doubling of global GDP accompanied by accelerating ecological overshoot but only a modest reduction in human deprivation.

www.nature.com

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Reposted by Fran Martínez-Jiménez

Molly Przeworski @mollyprz.bsky.social · Sep 2

In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social ‬ & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...

Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature

Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and thus are expected to differ across cell types with distinct exposures to mutagens, division ...

www.biorxiv.org

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Reposted by Fran Martínez-Jiménez

Ivano Amelio @ivanoamelio.bsky.social · Jul 19

www.science.org/doi/10.1126/...

Aberrant basal cell clonal dynamics shape early lung carcinogenesis

Preinvasive squamous lung lesions are precursors of lung squamous cell carcinoma (LUSC). The cellular events underlying lesion formation are unknown. Using a carcinogen-induced model of LUSC with no a...

www.science.org

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Reposted by Fran Martínez-Jiménez

IPBES @ipbes.net · Jul 14

Experts are concerned, as a number of scientists 🧪have recorded huge die-offs of insects in nature reserves around the world. The reported collapse of insect populations in supposedly protected regions is part of a newer phenomenon. 🌏🐜

Read more in @theguardian.com:

‘Half the tree of life’: ecologists’ horror as nature reserves are emptied of insects

A new point in history has been reached, entomologists say, as climate-led species’ collapse moves up the food chain even in supposedly protected regions free of pesticides

bit.ly

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Reposted by Fran Martínez-Jiménez

EMBL Events @events.embl.org · Jul 3

🚨 You have until 13 July to submit your abstract for #EMBLCanGen 👉 https://s.embl.org/can25-01-bl

🗓️ 11 – 14 November 2025
📍 EMBL Heidelberg & Virtual

Join top scientists and academic clinicians for an inspiring event to connect, collaborate, and accelerate breakthroughs in cancer genomics 🧬

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Reposted by Fran Martínez-Jiménez

Geoff Macintyre @gmaci.bsky.social · Jun 23

🚨Chemo treatment upgrade!🚨

Check out our approach to modernise chemotherapy treatment published today in @natgenet.nature.com. From @cniostopcancer.bsky.social #TailorBio @cruk-ci.bsky.social www.nature.com/articles/s41... More details 👇

www.nature.com

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Reposted by Fran Martínez-Jiménez

Luis González Reyes 🌱 @luisglezreyes.bsky.social · Jun 21

Tranquis, la tecnología nos salvará

www.elsaltodiario.com/cambio-clima...

Los espejitos de colores de la captura de CO2: la mayor planta del mundo no cubre sus propias emisiones

Una investigación periodística ha revelado que la empresa suiza Climeworks, que desde el 2021 apuesta por la captura de CO2 del aire como “solución tecnológica” a la crisis climática, emite más gases ...

www.elsaltodiario.com

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Reposted by Fran Martínez-Jiménez

Ewan Birney @ewanbirney.bsky.social · Jun 20

Powerful stuff from @juliosaezrod.bsky.social who found himself on the other end of the process - as a patient not a computational biology researcher - giving him insight into both research and patient perspectives. Huge credit to Julio for talking about his experiences here

Nature Reviews Nephrology @natrevneph.nature.com · Jun 19

Leveraging data as a patient–scientist: frustrations and opportunities

Nature Reviews Nephrology, Published online: 19 June 2025; doi:10.1038/s41581-025-00968-9The transition from data scientist to patient–scientist has given me new perspectives into clinical research and strengthened my commitment to open science. Although limitations on data availability have led to frustration, collaboration bodes well for a future in which patients will have access to more personalized information.

www.nature.com

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Fran Martínez-Jiménez @franmj88.bsky.social · Jun 9

🌟 Are you passionate about computational immuno-oncology research with real clinical impact? 🌟

Our group is looking for a motivated Bioinformatics Scientist for single-cell transcriptomics🧬💻

See offer here 👉 jobs.vhio.net/en/jobs/6016...

#Bioinformatics #SingleCellRNA #Immunogenomics

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Reposted by Fran Martínez-Jiménez

Lars Velten @larsplus.bsky.social · May 21

Out @nature.com: Clonal tracing with somatic epimutations

🧬 Single cell methylome encodes cell state & clonal identity

🔨 EPI-Clone reads out both (+mutations, +RNA) at scale

🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations

doi.org/10.1038/s415...
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Clonal tracing with somatic epimutations reveals dynamics of blood ageing - Nature

The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing th...

doi.org

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Reposted by Fran Martínez-Jiménez

Ana Dueso-Barroso @aduesoba.bsky.social · May 16

Wrapping up the week after three great days at the @helloeacr.bsky.social 'Defence is the Best Attack' conference. Thanks for the opportunity to (poster) present our work on immunoediting from @franmj88.bsky.social 's lab, and to learn from colleagues in immuno-oncology.

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Reposted by Fran Martínez-Jiménez

Elizabeth McKenna @elizsmckenna.bsky.social · Apr 9

Now online in Cancer Discovery: Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes - by Carlota Arenillas, Rodrigo Toledo, and colleagues doi.org/10.1158/2159... @vhio.bsky.social

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Reposted by Fran Martínez-Jiménez

Mariona Graupera @grauperalab.bsky.social · Mar 28

If you are interested in vascular malformations you may want to check our new work published today in Cancer Discovery, where we discover a somatic genetic event causing vascular malformations in PTEN hamartoma tumor syndrome (PHTS) aacrjournals.org/cancerdiscov...

Somatic uniparental disomy of PTEN in endothelial cells causes vascular malformations in patients with PTEN Hamartoma Tumor Syndrome

Abstract. PTEN Hamartoma Tumor Syndrome (PHTS) is a rare tumor risk disorder caused by germline loss-of-function mutations in PTEN. Half of these patients develop vascular malformations, a hamartoma c...

aacrjournals.org

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Reposted by Fran Martínez-Jiménez

Albert Vilella, PhD. @albertvilella.bsky.social · Feb 28

I wrote a deep dive post on Roche SBX announcement this week. Edwin Cuppen (not on #Bluesky) who heads the Hartwig Institute highlights what this new tech means for entities like him.

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Reposted by Fran Martínez-Jiménez

Mariona Graupera @grauperalab.bsky.social · Feb 26

We are excited to share our work on Context-dependent response of endothelial cells to PIK3CA mutation. A tour the force of many; thank you all for your invaluable contribution. @aangulou.bsky.social @ruibenedito.bsky.social @debocklab.bsky.social @sandradcastillo.bsky.social
bit.ly/4blKSqa

Context-dependent response of endothelial cells to PIK3CA mutation

Cancer mutations in the PIK3CA gene cause congenital disorders. The endothelium is among the most frequently affected tissues in these disorders, displaying aberrant vascular overgrowth in the form of...

bit.ly

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