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Molly Przeworski

@mollyprz.bsky.social

6.5K followers 510 following 60 posts

Population & Human Genetics

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Molly Przeworski @mollyprz.bsky.social · Sep 2

In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social ‬ & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...

Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature

Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and thus are expected to differ across cell types with distinct exposures to mutagens, division ...

www.biorxiv.org

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Reposted by Molly Przeworski

Joshua G. Schraiber @jgschraiber.bsky.social · 2d

Just an absolutely horrific self own, depleting the US of amazing students from all over the world who contributed to what used to make America great: its diversity, its openness, and its leadership in education.

The New York Times @nytimes.com · 2d

The number of international students arriving in the U.S. in August fell by 19% this year compared with last year — the largest decline on record outside of the pandemic.

Nearly 20 Percent Fewer International Students Traveled to the U.S. in August

The data shows the steepest decline in August international student arrivals since the pandemic.

nyti.ms

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Society for Molecular Biology and Evolution @official-smbe.bsky.social · 7d

🔁 Please share - we remind the SMBE community that the Call for Symposia for SMBE2026 in Copenhagen is open.

We invite you to submit a symposium proposal to help shape the scientific content of our annual meeting.

🗓️ Deadline: October 15th

More information: smbe2026.org/symposia

#SMBE2026

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Noam Ross @noamross.net · 8d

The Damage Done: @marianneguenot.bsky.social tells the story of clinical trials derailed by the administration's reckless science policy, across kidney disease, HIV, Alzheimer's disease, and cancer. Years of work and money thrown away, at times just short of a cure.

www.nature.com/articles/s41...

The damage done - Nature Medicine

When clinical trials are suddenly halted by US funding cuts, there are repercussions for investigators and patients, and they do not stop at borders.

www.nature.com

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Brad Lander @bradlander.bsky.social · 8d

Another violent attack by an ICE officer on a civilian at 26 Federal Plaza—this time on a journalist, who had to be carried out on stretcher.

Another attack on the First Amendment, our neighbors, and our democracy.

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bioRxiv Genetics @biorxiv-genetic.bsky.social · 10d

Mutation bias in driver genes reveals the distribution of effects of oncogenic mutations https://www.biorxiv.org/content/10.1101/2025.09.25.678277v1

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Francesca Mattiroli @fmattiroli.bsky.social · 10d

Join us at the Hubrecht Institute in Utrecht to start your research group! Fantastic scientific environment, strong support, and nice colleagues :) Apply and please share broadly in your network.

Hubrecht Institute @hubrechtinstitute.bsky.social · 12d

Ready to establish your own research group at the Hubrecht Institute for Molecular and Developmental Biology? We’re seeking a tenure-track group leader to develop an innovative research line within our vibrant scientific community. Learn more & apply! https://f.mtr.cool/jncxfqkuds

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American Society of Human Genetics (ASHG) @geneticssociety.bsky.social · Aug 28

🎖️Congratulations to Carole Ober, PhD, winner of the ASHG 2025 Mentorship Award! Learn more about the award and Dr. Ober's work: https://www.ashg.org/membership/awards/2025-awardees/ #ASHG #HumanGenetic

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Brad Lander @bradlander.bsky.social · 13d

I was back at 26 Federal Plaza today, where an ICE agent violently threw this bereft woman to the ground in front of her kids. She had not touched him. She did not pose any threat. She had to be taken to the hospital. (🎥: Elias Eliahu)

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Human Evolution Research Program Uppsala University @humanevouu.bsky.social · 14d

Application deadline in less than a week! Apply to join the Uppsala Human Evolution team!

Human Evolution Research Program Uppsala University @humanevouu.bsky.social · Sep 5

We are recruiting an associate professor (senior lecturer) at our program in Human #Paleogenomics and #PopulationGenetics. Come and join the Uppsala team! Please see the ad for more information. Application deadline: Sept 30st.
www.uu.se/en/about-uu/...

Associate Professor in Human Paleo- and Population Genomics - Uppsala University

Associate Professor in Human Paleo- and Population Genomics, Disciplinary Domain of Science and Technology, Faculty of Biology, Department of Organismal Biology, Uppsala University

www.uu.se

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Eric Topol @erictopol.bsky.social · 15d

To be clear, there are no data that provide a link between short-term use of Tylenol during pregnancy and autism. In fact, one of the best prospective studies w/ sibling controls, if anything, pointed to a protective effect for use less than 7 days
acamh.onlinelibrary.wiley.com/doi/10.1002/...

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bioRxiv Genetics @biorxiv-genetic.bsky.social · 18d

Sex differences in transcription-associated mutagenesis in the human germline https://www.biorxiv.org/content/10.1101/2025.09.18.677082v1

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Yun S. Song @yun-s-song.bsky.social · 16d

We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics.
www.biorxiv.org/content/10.1...
(1/n)

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Andres Bendesky @bendeskylab.com · 18d

Tenure-track Assistant Professor in Computational Ecology and/or Evolution @columbiauniversity.bsky.social.
Deadline to apply September 30.
Reach out if you have questions.

apply.interfolio.com/172496

Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio

apply.interfolio.com

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Sasha Gusev @sashagusevposts.bsky.social · 18d

Massive sibling regression study finds that human traits are largely environmentally driven (average heritability = 0.3)

Within-family heritability estimates for behavioural and disease phenotypes from 500,000 sibling pairs of diverse ancestries

Quantification of the direct effect of genetic variation on human behavioural traits is important for understanding between-individual variation in socio-economic and health outcomes but estimates of ...

www.medrxiv.org

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Michael Baym @baym.lol · 18d

Immigrants, particularly on H1Bs, are the lifeblood of American innovation. If you wanted to hurt US competitiveness in the next century, I can think of few more effective ways than a move like this

Even when found illegal, the mere intent will have irreparably harmed our future

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Georgii "Yegor" Bazykin @gbazykin.bsky.social · 20d

Now hiring a computational postdoc (evolutionary genomics, molecular evolution) in my lab at Emory University.
If you’re interested in population genetics, fitness landscapes, and viral evolution — get in touch.
faculty-emory.icims.com/jobs/151181/...

Careers | Emory University | Atlanta GA

faculty-emory.icims.com

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Gwynne Hogan @gwynnefitz.bsky.social · 20d

Just now, 11 state and city lawmakers were arrested by DHS police on the 10th floor of 26 Federal Plaza after a hour of demanding access to the ICE lock up on the same floor. @thecity.nyc

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Rebecca Mosher @rm0sher.bsky.social · 23d

Three Associate Professor (or Professor) positions available at Oxford Biology. Come be my colleague! www.biology.ox.ac.uk/article/we-a...

We are hiring! Oxford biology has three associate professorships available as we move to new state-of-the-art facilities

www.biology.ox.ac.uk

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Carl Zimmer @carlzimmer.com · 24d

A deep dive into the destruction of US cancer research by @jonathanmahler.bsky.social “It’s an absolutely unmitigated disaster,” a former top official at NIH told him. “It will take decades to recover from this, if we ever do.” Gift link: nyti.ms/48iH3Cr

nyti.ms

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Yun S. Song @yun-s-song.bsky.social · 28d

SINGER, our ARG inference method, is finally published and freely available online:

doi.org/10.1038/s415...

It was a long journey – 16 months from initial submission to acceptance. Is it just me, or has peer review gotten more arduous lately? 4+ rounds of review isn't so unusual these days...

Robust and accurate Bayesian inference of genome-wide genealogies for hundreds of genomes - Nature Genetics

SINGER is a method for creating ancestral recombination graphs to understand the genealogical history of genomes. The method has increased speed, and thus scalability, without sacrificing accuracy.

doi.org

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Lino Ferreira @linoafferreira.bsky.social · 28d

Delighted to see this paper with @anaignatieva.bsky.social now published in Genetics!
academic.oup.com/genetics/adv...

We tackle a thorny issue arising in statistical tests for genetic interactions (epistasis) using ancestral recombination graphs (ARGs)... 🧵

Phantom epistasis through the lens of genealogies

Abstract. Phantom epistasis arises when, in the course of testing for gene-by-gene interactions, the omission of a causal variant with a purely additive ef

academic.oup.com

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Maria Antonietta Tosches @matosches.bsky.social · Aug 25

Excited to share our latest work on brain evolution, where we dive into the evolution of Cajal-Retzius cells! If you are interested in cell type evolution and cerebral cortex evo-devo, please read on… www.biorxiv.org/content/10.1... 🧵 1/7

Evolution of Cajal-Retzius Cells in Vertebrates from an Ancient Class of Tp73+ Neurons

In the developing cerebral cortex, Cajal Retzius (CR) cells are early-born neurons that orchestrate the development of mammalian-specific cortical features. However, this cell type has not been conclu...

www.biorxiv.org

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Denis Duboule @denisduboule.bsky.social · Sep 3

‘Our Ancestors the Fish’, a course by Prof. @neilshubin.bsky.social, Univ of Chicago, invited Prof @college-de-france.fr. in Paris @psl-univ.bsky.social. Four conferences, free access, open to everyone, with Tiktaalik as a guest star. Friends, colleagues and fossils in Paris and around, please RT🥁

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Arun Durvasula @arundurvasula.bsky.social · Sep 2

Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1...

I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)

Exposure accumulation drives age-dependent disease architectures and polygenic risk scores

Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to quantify age-dependent genetic and environm...

www.medrxiv.org

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