Lightnews — Scholar-powered news

Reposted by Francesca Mattiroli

MRC Laboratory of Molecular Biology @mrclmb.bsky.social · 9h

John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews

Black and white portrait of John Gurdon, 1971

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Reposted by Francesca Mattiroli

Hubrecht Institute @hubrechtinstitute.bsky.social · 1d

Save the date! The second Hubrecht Symposium will take place on March 26, 2026. This year’s theme is “Molecular Machines in Development”, with Petra Hajkova, Andrea Pauli and @danielgerlich.bsky.social as keynote speakers. Registration opens soon, stay tuned via hubrecht.eu/hubrecht-symposium/. ‬

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Reposted by Francesca Mattiroli

Edda Schulz @eddaschulz.bsky.social · 2d

⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial

Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology

Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.

www.nature.com

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Reposted by Francesca Mattiroli

Camille Moore @camille-moore.bsky.social · 5d

Today I am so pleased to present our work on how chromatin remodelers affect mesoscale chromatin organization.
www.science.org/doi/10.1126/...

ATP-dependent remodeling of chromatin condensates reveals distinct mesoscale outcomes

Adenosine triphosphate (ATP)–dependent chromatin remodeling enzymes mobilize nucleosomes, but how such mobilization affects chromatin condensation is unclear. We investigate effects of two major remod...

www.science.org

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Reposted by Francesca Mattiroli

GIIN @genomeiinetwork.bsky.social · 8d

Next week GIIN webinar will feature @fmattiroli.bsky.social and Marco Tigano. Join us on Tuesday, October 7th at 5 PM Rome / 11 AM NYC via zoom: uniroma1.zoom.us/j/95149984403
Register here to become part of our community: docs.google.com/forms/d/e/1F...

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Francesca Mattiroli @fmattiroli.bsky.social · 10d

Join us at the Hubrecht Institute in Utrecht to start your research group! Fantastic scientific environment, strong support, and nice colleagues :) Apply and please share broadly in your network.

Hubrecht Institute @hubrechtinstitute.bsky.social · 12d

Ready to establish your own research group at the Hubrecht Institute for Molecular and Developmental Biology? We’re seeking a tenure-track group leader to develop an innovative research line within our vibrant scientific community. Learn more & apply! https://f.mtr.cool/jncxfqkuds

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Francesca Mattiroli @fmattiroli.bsky.social · 15d

Thank you, Duncan!

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Francesca Mattiroli @fmattiroli.bsky.social · 15d

Thank you, Yisui!

Francesca Mattiroli @fmattiroli.bsky.social · 16d

Thank you, Jeroen!

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Francesca Mattiroli @fmattiroli.bsky.social · 17d

Teamwork at its best!! Thank you Vijay, for sharing your technologies and computational talent, for the fun discussions and work together, at random hours of the day or night 😃

Vijay Ramani @vram142.bsky.social · 18d

Will end w/ huge thank you to @fmattiroli.bsky.social & her team, esp Bruna, who spent time w/ us in SF thx to EMBO fellowship. This work exists bc of *international collaboration* & hard work across big time zone gap. We need MORE of this in the world, not LESS for the love of god.(7/7)

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Reposted by Francesca Mattiroli

Vijay Ramani @vram142.bsky.social · 18d

(2) we observe intrinsic asymmetry in single-molecule fiber structures assembled on lagging and leading strands. This is neither resolved by CAF-1/ASF1, nor addition of active ISWI remodeler (Isw1a). Will be exciting to identify the factors that restore symmetry in reconstituted setting!(6/n)

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Reposted by Francesca Mattiroli

Vijay Ramani @vram142.bsky.social · 18d

Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up!
www.biorxiv.org/content/10.1...
A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)

The eukaryotic replisome intrinsically generates asymmetric daughter chromatin fibers

DNA replication is molecularly asymmetric, due to distinct mechanisms for lagging and leading strand DNA synthesis. Whether chromatin assembly on newly replicated strands is also asymmetric remains un...

www.biorxiv.org

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Francesca Mattiroli @fmattiroli.bsky.social · 17d

The latest work from ours and @vram142.bsky.social lab is out! True teamwork to visualize nascent chromatin with strand resolution, using a fully reconstituted system. Very proud of superstar-PhD student Bruna, and @palindromephd.bsky.social. Learning so much from Vijay’s amazing technologies! RT

Vijay Ramani @vram142.bsky.social · 18d

Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up!
www.biorxiv.org/content/10.1...
A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)

The eukaryotic replisome intrinsically generates asymmetric daughter chromatin fibers

DNA replication is molecularly asymmetric, due to distinct mechanisms for lagging and leading strand DNA synthesis. Whether chromatin assembly on newly replicated strands is also asymmetric remains un...

www.biorxiv.org

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Francesca Mattiroli @fmattiroli.bsky.social · 18d

Do not miss this opportunity!! Incredible science and mentor!

puckknipscheer.bsky.social @puckknipscheer.bsky.social · 19d

Are you interested in working on related projects? 🌱
The Knipscheer lab at the Hubrecht Institute (Utrecht, the Netherlands) has openings for a postdoc and a PhD position.
Apply here: www.hubrecht.eu/jobs

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Francesca Mattiroli @fmattiroli.bsky.social · 19d

Check this out from our colleagues! Congratulations!

Jop Kind @jopkind.bsky.social · 21d

1/ 🧵 I am excited to share a new preprint from our group:
Single-cell Dam&T-seq during mouse corticogenesis reveals how genome–lamina interactions regulate long neuronal genes.
doi.org/10.1101/2025...
#Neurodevelopment #Epigenetics @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social

MeCP2 binding and genome–lamina reorganization precede long gene activation during mouse corticogenesis

During corticogenesis, neural gene expression is tightly coordinated by chromatin and epigenetic changes, whose misregulation can lead to neurodevelopmental disorders[1][1]–[4][2]. The role of spatial...

doi.org

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Reposted by Francesca Mattiroli

GIIN @genomeiinetwork.bsky.social · 28d

We thank Diego Dibitetto and @polosophie.bsky.social for sharing their research with the GIIN community today!
Our next seminar will take place on Tuesday, October 7th featuring @fmattiroli.bsky.social and Marco Tigano.
Subscribe here to join our mailing list: docs.google.com/forms/d/e/1F...

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Francesca Mattiroli @fmattiroli.bsky.social · 25d

Check this out!!

Tassos Perrakis @tassosperrakis.bsky.social · 25d

Featuring #AlphaBridge features from @alvarezsalmoral.bsky.social, with @jonasteuwen.bsky.social and team, our new work from @nkinl.bsky.social nl.bsky.social @oncodeinstitute.bsky.social . Have a look at ahmpc.eu for more!

bioRxivpreprint @biorxivpreprint.bsky.social · 25d

Integrating computational protein structure predictions and genetic dependencies yields an atlas of human multi-protein complexes (AHMPC) https://www.biorxiv.org/content/10.1101/2025.09.09.675133v1

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Reposted by Francesca Mattiroli

Ina Sonnen @sonnenlab.bsky.social · 29d

Preprint alert!
We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength.

doi.org/10.1101/2025...

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Reposted by Francesca Mattiroli

Arjen Jakobi @cryotud.bsky.social · Sep 8

Together with colleagues at the Dept. of Microsystems Engineering, we are looking for a PhD student to develop methods for femtoliter-scale sample dispensing in cryoEM sample preparation.

edu.nl/h436k

If you like interdisciplinary research & fascinating physics at ultrasmall scales, please apply!

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Francesca Mattiroli @fmattiroli.bsky.social · Sep 4

Yes! Congratulations Vale!! Well deserved 👏👏

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Francesca Mattiroli @fmattiroli.bsky.social · Sep 4

Congratulations, Hanneke!! Well deserved 👏👏

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Reposted by Francesca Mattiroli

Gregg Gonsalves @gregggonsalves.bsky.social · Aug 24

The @NYTimes has done a fantastic job on explaining what the Trump administration’s savage
cuts to biomedical research mean: cures that won’t happen. Please share this widely. This is a catastrophe. www.nytimes.com/2025/08/24/o...

Opinion | America First? Not When It Comes to Your Health.

www.nytimes.com

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Reposted by Francesca Mattiroli

Duxin lab @duxinlab.bsky.social · Aug 22

It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it".

During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication.

Read our review and find out why and how: doi.org/10.1016/j.ti...

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Reposted by Francesca Mattiroli

Karolin Luger @nucleosomepolice.bsky.social · Jul 26

if i were a better person i would do a tweetorial on our recent paper - but, hey, read the paper. its right there, waiting for you. #Giantvirus #histones are cool! their #nucleosomes are cool. check it out.! thats the tweetorial.
rdcu.be/exXBX

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Reposted by Francesca Mattiroli

AmélieFT@AFTLab @amelieft.bsky.social · Aug 13

I am very excited to share the newest paper of the lab, a huge amount of work led by our talented PhD student Maxime Galloy, in close collaboration with Andréanne Blondeau, our dedicated research assistant for 10 years! 🙌

www.cell.com/molecular-ce...

Ubiquitination of the histone variant mH2A1.2 prevents toxic RAD18 accumulation at a subset of genomic loci upon replication stress

Using biochemical assays and a mutant disrupting RNF168-dependent ubiquitination of the histone variant macroH2A1.2, Galloy et al. identified an unexpected role for histone mH2A1.2 ubiquitination in p...

www.cell.com

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