Ready to establish your own research group at the Hubrecht Institute for Molecular and Developmental Biology? We’re seeking a tenure-track group leader to develop an innovative research line within our vibrant scientific community. Learn more & apply! https://f.mtr.cool/jncxfqkuds

The latest work from ours and @vram142.bsky.social lab is out! True teamwork to visualize nascent chromatin with strand resolution, using a fully reconstituted system. Very proud of superstar-PhD student Bruna, and @palindromephd.bsky.social. Learning so much from Vijay’s amazing technologies! RT

Are you interested in working on related projects? 🌱
The Knipscheer lab at the Hubrecht Institute (Utrecht, the Netherlands) has openings for a postdoc and a PhD position.
Apply here: www.hubrecht.eu/jobs

Just one month left to apply for the Hubrecht International PhD Program! This fully funded 4-year PhD offers the opportunity to join a high-profile lab in molecular & developmental biology, exceptional training, and mentorship from leading scientists.

Apply before September 15 www.hubrecht.eu/hipp/

🧬 Looking for a PhD position in molecular or developmental biology? 🔬

✉️ The Hubrecht Institute now has its very own PhD program! Applications are open and will be accepted until September 15th. Read more here 👉 www.hubrecht.eu/hipp/

Thanks!

Thanks Sandra😍

Thanks Roman!

Thanks Gideon!

Thanks Floris!

Thanks Pablo!

Congrats to Koichi Sato and @puckknipscheer.bsky.social on this beautiful paper! The biochemistry is 🤯 Happy to help with scEdUseq to pinpoint the DNA replication defects! 🎉🧬

RNA transcripts regulate G-quadruplex landscapes through G-loop formation | Science www.science.org/doi/10.1126/...

New work from the Knipscheer group published in @science.org reveals a mechanism involving RNA and DNA repair proteins that helps cells remove G-quadruplex structures. G4 structures are knot-like formations in DNA that can cause damage if left unresolved. www.hubrecht.eu/cells-untie-dna-knots/

As the Science editor @dijiang319.bsky.social nicely worded: “This reveals a role for RNA transcripts in restoring genome architecture and maintaining its integrity and function”. Big thanks to all Knipscheer lab members, @hubrechtinstitute.bsky.social, and @oncodeinstitute.bsky.social (4/4)

Inhibition of this mechanism causes global G4 and R-loop accumulation, leading to transcription dysregulation, replication stress, and genome instability. Thanks to cells from @joost84.bsky.social from the Tijsterman lab and amazing scEdUseq by @jervdberg.bsky.social from the Oudenaarden lab (3/4)

We found G4s are recognized as DNA lesions leading to homology-directed invasion of RNA opposite the G4 to form a G-loop structure. This G-loop initiates G4 unwinding by DHX36 and FANCJ. Subsequent nucleolytic incision followed by renewal of the RNA-containing strand drive G-loop disassembly (2/4)

Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)

Hi Erik, i am a group leader at the Hubrecht Institute and I would like to be added to the feed. Here is the link to my lab website: www.hubrecht.eu/research-gro...

I totally agree Helen, trying to solve a problem actually makes it worse.

Another day another review request (10 days). With the usual ‘suggest alternatives from underrepresented communities’. This approach doesn’t just overburden the underrepresented groups, it under-burdens the overrepresented ones, freeing them up to do stuff that is ‘objectively’ judged as ‘better’.

@puckknipscheer.bsky.social, @luijsterburglab.bsky.social, @marcelvanvugt.bsky.social, @sylvie-noordermeer.bsky.social, @titiasixma.bsky.social, @marcelvanvugt.bsky.social, @marteijnlab.bsky.social

Mark your calendar: the next Egmond DNA repair meeting will take place in 2026 from April 19 - 24!

You can pre-register to receive announcement here: forms.lumc.nl/lumc2/Egmond

Registration will open by June 2025/