Lightnews — Scholar-powered news

Reposted by Ina Sonnen

Hubrecht Institute @hubrechtinstitute.bsky.social · 12d

Ready to establish your own research group at the Hubrecht Institute for Molecular and Developmental Biology? We’re seeking a tenure-track group leader to develop an innovative research line within our vibrant scientific community. Learn more & apply! https://f.mtr.cool/jncxfqkuds

14 15

Ina Sonnen @sonnenlab.bsky.social · 29d

I agree, it would be super interesting to zoom in further into specific regions. We were aiming for detection of low abundance proteins and decided against sectioning further. But definitely the next step, also with mass spec getting more and more sensitive.

1

Ina Sonnen @sonnenlab.bsky.social · 29d

This was an excellent collaboration with Michiel Vermeulen. Thanks to @ wilkemeijer.bsky.social, @virginiar-andra.bsky.social & Suzan Stelloo for the amazing work. And of course, to all other authors!

@hubrechtinstitute.bsky.social
@rimls.bsky.social

1

Ina Sonnen @sonnenlab.bsky.social · 29d

Key findings:
• Mapped novel oscillatory proteins and transcripts that could play a role in somitogenesis
• Discovered a dynamic, antagonistic ligand–receptor pattern in R-Spondin/LGR signalling
• Perturbing ligand dynamics impairs signalling strength and somite differentiation

1 1

Ina Sonnen @sonnenlab.bsky.social · 29d

Preprint alert!
We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength.

doi.org/10.1101/2025...

3 20 80

Reposted by Ina Sonnen

Hubrecht Institute @hubrechtinstitute.bsky.social · Aug 14

Just one month left to apply for the Hubrecht International PhD Program! This fully funded 4-year PhD offers the opportunity to join a high-profile lab in molecular & developmental biology, exceptional training, and mentorship from leading scientists.

Apply before September 15 www.hubrecht.eu/hipp/

3 6

Ina Sonnen @sonnenlab.bsky.social · Aug 2

Congratulations Simona!!

Ina Sonnen @sonnenlab.bsky.social · Jul 10

Please pread the word.

We have just launched the Hubrecht International PhD Program (HIPP).

Are you looking for a PhD position in molecular and developmental biology or related subject in an international, very supportive and collaborative environment?

Then apply to the HIPP!! 👇

Hubrecht Institute @hubrechtinstitute.bsky.social · Jul 10

🧬 Looking for a PhD position in molecular or developmental biology? 🔬

✉️ The Hubrecht Institute now has its very own PhD program! Applications are open and will be accepted until September 15th. Read more here 👉 www.hubrecht.eu/hipp/

18 24

Ina Sonnen @sonnenlab.bsky.social · Jul 2

Thank you for the kind words and highlighting this milestone. I’m thrilled and honoured to have reached tenure.
Big thanks to my lab, colleagues, mentors, friends and family who’ve supported me along the way.
Excited to keep doing what I love - now with slightly more security.

Hubrecht Institute @hubrechtinstitute.bsky.social · Jul 2

What if science is like solving puzzles?

We spoke with @sonnenlab.bsky.social, a group leader who recently received tenure. She tells us about her journey, her research on signaling dynamics, and the challenges of leading a lab.

Read her inspiring story here 👇 www.hubrecht.eu/ina-sonnen-t...

Ina Sonnen earned tenure: 'science is like a puzzle' - Hubrecht Institute

www.hubrecht.eu

20 1 59

Ina Sonnen @sonnenlab.bsky.social · Jun 25

It was fun reflecting on how my career path took me from a focus on cancer research to developmental biology, the urge to understand how development and tissue homeostasis work and how my time at the @biozentrum.unibas.ch contributed to this. Thank you, Katrin Bühler-Popowski, for the interview!

Biozentrum, University of Basel @biozentrum.unibas.ch · Jun 25

Since she was a child, Ina Sonnen dreamed of becoming a cancer researcher. Although her academic career took a slightly different path, the topic of cancer has never quite left the Biozentrum alumna. @sonnenlab.bsky.social ‪
@hubrechtinstitute.bsky.social www.biozentrum.unibas.ch/about/alumni...

Childhood dream: Becoming a scientist

Since she was a child, Ina Sonnen dreamed of becoming a cancer researcher. Although her academic career took a slightly different path, the topic of cancer has never quite left the Biozentrum alumna.

www.biozentrum.unibas.ch

2 21

Reposted by Ina Sonnen

Sandra Iden @sandraiden.bsky.social · Jun 9

W2 TT W3 professorship in the Dynamics of Biological
Systems at @uni-saarland.de - only a few days left to apply! (June 13) www.uni-saarland.de/fileadmin/up...

1 1

Reposted by Ina Sonnen

Leo Otsuki @leootsuki.bsky.social · May 21

Delighted that our work on positional memory is now published. We asked how axolotl cells 'know' which part of the limb to regenerate after injury.
www.nature.com/articles/s41...
A joy to work with super team Sarah Plattner, Yuka Sugiura, Francisco Falcon and Elly Tanaka.
🧵1/14

23 67 210

Ina Sonnen @sonnenlab.bsky.social · May 18

I am just on my way to Switzerland and looking forward to a fun and exciting day at the Institute of Cell Biology in Bern tomorrow.

Institute of Cell Biology @izb-unibern.bsky.social · May 15

📢Seminar Announcement 📢
We're looking forward to welcoming @sonnenlab.bsky.social this upcoming Monday, May 19th, as the next speaker in our Monday Seminar Series!
She will discuss "Signalling dynamics in embryonic development and tissue homeostasis”
More info on our website ➡️ izb.unibe.ch

6

Reposted by Ina Sonnen

Kristina Stapornwongkul @kstapornwongkul.bsky.social · May 2

Thoughtful preview article by María Rodríguez Colman & @sonnenlab.bsky.social on recent papers from our lab and @jesseveenvliet.bsky.social lab! Grateful for their in-depth analysis of the papers and their big-picture perspective on the role of metabolism in development.
doi.org/10.1016/j.st...

Signaling switches: Metabolism regulates gastruloid self-organization

Metabolic regulation of embryonic development is increasingly recognized. Villaronga-Luque et al. and Stopornwongkul et al. show that metabolic activity influences gastruloid formation from mouse embr...

www.cell.com

1 4 28

Reposted by Ina Sonnen

Development @dev-journal.bsky.social · Apr 23

In preprints: robust segmentation clock outputs via cell cycle and synthetic coupling

Here, @jorgelazaro.bsky.social and @ebisuyamiki.bsky.social discuss two #preprints looking into the mechanisms regulating somitogenesis through cell- and tissue-level couplings:
doi.org/10.1242/dev....

In preprints: a new preprint curation initiative from Development

7 7

Reposted by Ina Sonnen

Irene Li @irene-yuting-li.bsky.social · Apr 23

Thanks for featuring my work with @sonnenlab.bsky.social and @marekvanoostrom.bsky.social in this thoughtful article!

Development @dev-journal.bsky.social · Apr 23

In preprints: robust segmentation clock outputs via cell cycle and synthetic coupling

Here, @jorgelazaro.bsky.social and @ebisuyamiki.bsky.social discuss two #preprints looking into the mechanisms regulating somitogenesis through cell- and tissue-level couplings:
doi.org/10.1242/dev....

1 3

Reposted by Ina Sonnen

Hubrecht Institute @hubrechtinstitute.bsky.social · Mar 24

We challenged our researchers to describe their work in 10 words or less. See how they did in this video!

4 19 97

Ina Sonnen @sonnenlab.bsky.social · Apr 17

Thank you for highlighting our preprint on the coordination between cell proliferation and the segmentation clock www.biorxiv.org/content/10.1...

3

Ina Sonnen @sonnenlab.bsky.social · Mar 28

Well done @virginiar-andra.bsky.social from our lab for being awarded the Best Poster Prize at the International Dutch Embryo Model Meeting today for our work on “Spatiotemporally resolved omics reveals dynamic antagonistic gradients” in embryo segmentation. Congratulations!

Moritz Bauer @moritzbauer.bsky.social · Dec 3

📢 Save the date! We are excited to announce the International Dutch Embryo Model Meeting 2025 in Nijmegen (NL) on Thursday 27 March and Friday 28 March! Registration is open now. More information: ru.nl/en/about-us/...

Big thanks to Hendrik Marks for taking the lead this time!

1 9

Reposted by Ina Sonnen

Joaquina Delas @joadelas.bsky.social · Mar 14

And what a talk that was!

1 2

Ina Sonnen @sonnenlab.bsky.social · Mar 13

I’m very proud of Sonja from my lab who presented our work on frequency encoding of cell-type composition in the small intestine as an invited speaker at Sy-stem 2025.
www.biorxiv.org/content/10.1...

2 1 19

Ina Sonnen @sonnenlab.bsky.social · Mar 12

Thanks :-)

Ina Sonnen @sonnenlab.bsky.social · Mar 11

And a great collaboration with @irene-yuting-li.bsky.social and Ben Simons to understand how this coupling affects the somitogenesis.

1

Ina Sonnen @sonnenlab.bsky.social · Mar 11

Yes :-). What really made this project possible in the end was establishing single-cell tracking, which allowed us to quantify both cell cycle and signalling dynamics in single cells of the tissue. I’m very proud of Marek from the lab who set this up (and who started to look for postdoc positions!).

1 1 1

Ina Sonnen @sonnenlab.bsky.social · Mar 11

How do embryos ensure precise tissue patterning? It’s all about timing cell divisions! Our new preprint reveals how cell proliferation syncs with signaling oscillations to regulate precision of somite formation and growth. Check the full story: www.biorxiv.org/content/10.1...

2 16 68