arundurvasula.bsky.social
Arun Durvasula
@arundurvasula.bsky.social
390 followers 400 following 28 posts
Assistant Professor in the Center for Genetic Epidemiology at USC. My lab studies genetics and evolution. https://www.durvasula-lab.usc.edu
www.durvasula-lab.usc.edu
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Reposted by Arun Durvasula
genetics-gsa.bsky.social
Genetics Society of America @genetics-gsa.bsky.social · 3h
Science is intertwined with eugenics, and eugenic ideologies continue to negatively impact #Indigenous communities and science today.

Read a timely and important perspective piece in #GENETICS from @jazlynmooney.bsky.social and colleagues: buff.ly/T7rbV3k
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Reposted by Arun Durvasula
bennystrobes.bsky.social
Ben Strober @bennystrobes.bsky.social · 1d
Exciting updates!!
(1) I just opened my lab at Boston Children’s Hospital (Harvard-affiliated)
(2) I’m hiring a postdoc focused on integrating GWAS and functional genomic data. Reach out if you’re interested or connect at ASHG next week!
(3) Learn more at stroberlab.com
Strober Lab
The Strober lab is a computational group at Boston Children's Hospital (a Harvard Medical School affiliated hospital) focused on developing statistical and machine learning tools applied to human gene...
stroberlab.com
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Reposted by Arun Durvasula
stanfordpress.bsky.social
Stanford University Press @stanfordpress.bsky.social · 8d
Population Biology Modeling & Theory (PBMT) is a peer-reviewed journal reporting advances in modeling and theory within population biology. Its scope spans demography, ecology, epidemiology, evolutionary biology, population genetics, and phylogenetics. PBMT will be online soon.
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Reposted by Arun Durvasula
anaignatieva.bsky.social
Ana Ignatieva @anaignatieva.bsky.social · 5d
Delighted that our paper about the distribution of genomic spans of clades/edges in genealogies (ARGs), and using this for detecting inversions and other SVs (and other phenomena that cause local disruption of recombination) is out in MBE academic.oup.com/mbe/article/... (1/n)
The Length of Haplotype Blocks and Signals of Structural Variation in Reconstructed Genealogies
Abstract. Recent breakthroughs have enabled the accurate inference of large-scale genealogies. Through modelling the impact of recombination on the correla
academic.oup.com
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Reposted by Arun Durvasula
jmkreiner.bsky.social
Julia Kreiner @jmkreiner.bsky.social · 19d
Would be excited to chat with folks looking for a postdoc in AI to develop models for genomic prediction...

A great opportunity for funding coming up soon is the Schmidt AI in Science fellowship, due October 13th! apply.interfolio.com/173322
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
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Reposted by Arun Durvasula
klohmueller.bsky.social
Kirk Lohmueller @klohmueller.bsky.social · 22d
In the midst of the darkness, I am pleased to announce that UCLA will be hosting the upcoming Southern California Evolutionary Genetics (SCalE) conference on November 1! Registration & abstract submission is here: www.scalemeeting.org/home Deadline is October 13! Hope to see you at UCLA!
Home
The SCalE Meeting is a free, one day regional academic meeting focused on evolutionary genetics and genomics. This year's SCalE Meeting is hosted by UCLA, sponsored by the Institute for Quantitative ...
www.scalemeeting.org
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Reposted by Arun Durvasula
hggadvances.bsky.social
Human Genetics and Genomics Advances @hggadvances.bsky.social · 26d
📣Online now from @arundurvasula.bsky.social & co!
📄Pathway-specific polygenic scores substantially increase the discovery of gene-adiposity interactions impacting liver biomarkers
👉https://bit.ly/47HmkYW
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Reposted by Arun Durvasula
arundurvasula.bsky.social
Arun Durvasula @arundurvasula.bsky.social · 26d
Our work on leveraging pathway-specific polygenic scores to discover gene-environment interactions is now online at HGG Advances (@hggadvances.bsky.social). 10/10 great review process!

www.cell.com/hgg-advances...
cc @kewesterman.bsky.social
Pathway-specific polygenic scores substantially increase the discovery of gene-adiposity interactions impacting liver biomarkers
The authors describe a strategy for using pathway-specific polygenic scores to increase the detection and interpretability of gene-environment interactions, with an applied analysis uncovering genetic...
www.cell.com
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Reposted by Arun Durvasula
arundurvasula.bsky.social
Arun Durvasula @arundurvasula.bsky.social · Sep 2
Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1...

I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)
Exposure accumulation drives age-dependent disease architectures and polygenic risk scores
Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to quantify age-dependent genetic and environm...
www.medrxiv.org
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Reposted by Arun Durvasula
americanbystander.bsky.social
The American Bystander @americanbystander.bsky.social · 26d
We regret to inform you we have returned to social media. Sorry.
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arundurvasula.bsky.social
Arun Durvasula @arundurvasula.bsky.social · 26d
Our work on leveraging pathway-specific polygenic scores to discover gene-environment interactions is now online at HGG Advances (@hggadvances.bsky.social). 10/10 great review process!

www.cell.com/hgg-advances...
cc @kewesterman.bsky.social
Pathway-specific polygenic scores substantially increase the discovery of gene-adiposity interactions impacting liver biomarkers
The authors describe a strategy for using pathway-specific polygenic scores to increase the detection and interpretability of gene-environment interactions, with an applied analysis uncovering genetic...
www.cell.com
1 3 16
arundurvasula.bsky.social
Arun Durvasula @arundurvasula.bsky.social · 28d
First author @xilinjiang.bsky.social is now on Bluesky!
arundurvasula.bsky.social
Arun Durvasula @arundurvasula.bsky.social · Sep 2
Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1...

I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)
Exposure accumulation drives age-dependent disease architectures and polygenic risk scores
Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to quantify age-dependent genetic and environm...
www.medrxiv.org
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Reposted by Arun Durvasula
jrossibarra.bsky.social
Jeffrey Ross-Ibarra @jrossibarra.bsky.social · Sep 3
Save the date! #PEQG26 June 9-12 2026 in Asilomar, CA. Happens only every 2yrs, but is my favorite conference. Full website coming soon, and registration and abstract submission opens November 14, but I'm allowed to tease that keynotes will be @jnovembre.bsky.social @jennytung.bsky.social and me!
Homepage - Population, Evolutionary, and Quantitative Genetics Conference
Visit our website to learn more.
genetics-gsa.org
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Reposted by Arun Durvasula
mikeinouye.bsky.social
Mike Inouye @mikeinouye.bsky.social · Sep 3
📣Just out: Exposure accumulation drives age-dependent disease architectures and polygenic risk scores www.medrxiv.org/content/10.1...

Very cool results: Accumulating E with age reduces heritability & PGS effects

Led by Xilin Jiang (Wellcome ECR joint w/Alkes Price) + @arundurvasula.bsky.social
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arundurvasula.bsky.social
Arun Durvasula @arundurvasula.bsky.social · Sep 2
There's a lot more that would take quite a bit more space to explain, so please check out the manuscript: www.medrxiv.org/content/10.1...

The Supplementary Note also has some good stuff! Thanks to our coauthors as well: Alkes Price, John Danesh, Gil McVean, @mikeinouye.bsky.social, and Sarah Urbut!
Exposure accumulation drives age-dependent disease architectures and polygenic risk scores
Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to quantify age-dependent genetic and environm...
www.medrxiv.org
4
arundurvasula.bsky.social
Arun Durvasula @arundurvasula.bsky.social · Sep 2
This model is able to explain 85% of the variation in PRS across age (of which there is a lot! See Figure 5).
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arundurvasula.bsky.social
Arun Durvasula @arundurvasula.bsky.social · Sep 2
In our new manuscript, we show that age-dependent architectures for complex traits and predicted disease liability are driven by the accumulation of variance from environmental exposures and an age-dependent liability threshold model (liability-threshold+EA model).
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arundurvasula.bsky.social
Arun Durvasula @arundurvasula.bsky.social · Sep 2
Xilin observed decreasing PRS accuracy with age across many diseases (see figure) and we wondered if GxE played a role.
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arundurvasula.bsky.social
Arun Durvasula @arundurvasula.bsky.social · Sep 2
This project started as a follow-up to my paper earlier this year on GxE[1] and on a previous paper led by Xilin that looked at age-dependency of genetic variants on complex disease risk [2]

1. www.cell.com/ajhg/abstrac...
2. journals.plos.org/plosgenetics...
Distinct explanations underlie gene-environment interactions in the UK Biobank
The role of gene-environment (GxE) interaction in disease and complex trait architectures is widely hypothesized but currently unknown. Here, we apply three statistical approaches to quantify and dist...
www.cell.com
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arundurvasula.bsky.social
Arun Durvasula @arundurvasula.bsky.social · Sep 2
Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1...

I am attempting an explainer thread for the first time here:
(I am usually too exhausted to post one)
Exposure accumulation drives age-dependent disease architectures and polygenic risk scores
Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to quantify age-dependent genetic and environm...
www.medrxiv.org
2 25 54
Reposted by Arun Durvasula
alondra.bsky.social
Alondra Nelson @alondra.bsky.social · Aug 20
Call for Papers! 🧵

The Public's Science–A New Social Contract for American Research Policy a Special Issue of The ANNALS of the American Academy of Political and Social Science

Editors: Alondra Nelson (IAS) and Jenny Reardon (UC, Santa Cruz)

Abstract Deadline: Sept 19

www.ias.edu/stsv-lab/pub...
Public Science
Call for Papers Special Issue of The ANNALS of the American Academy of Political and Social ScienceThe Public's Science–A New Social Contract for American Research Policy
www.ias.edu
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Reposted by Arun Durvasula
relenski.bsky.social
Richard Lenski @relenski.bsky.social · Aug 12
Excited to share new #program, STEPS, which can simulate #dynamics of the E. coli Long-Term Evolution Experiment (#LTEE) or other microbes in serial transfer regime.

telliamedrevisited.wordpress.com/2025/08/12/s...

STEPS developed by @devinmlake.bsky.social, Zachary Matson, Minako Izutsu, and me.
STEPS To It
Announcing a new program, called STEPS, to simulate the dynamics of evolving microbial populations.
telliamedrevisited.wordpress.com
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Reposted by Arun Durvasula
jrossibarra.bsky.social
Jeffrey Ross-Ibarra @jrossibarra.bsky.social · Aug 11
Our paper showing that variation in transcription factor binding sites underlies the majority of additive genetic variance for phenotypic variation in maize is finally out!

Sadly they didn't use our suggested cover image below (made by the inimitable Andi Kur).

www.nature.com/articles/s41...
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Reposted by Arun Durvasula
roshnipatel.bsky.social
Roshni Patel @roshnipatel.bsky.social · Aug 6
Bittersweet to be leaving @docedge.bsky.social after a wonderful postdoc, but excited to share that I'm joining @uoregon.bsky.social next month as an Assistant Professor in the Department of Data Science.
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Reposted by Arun Durvasula
keck.usc.edu
Keck School of Medicine of USC @keck.usc.edu · Jun 10
Arun Durvasula, PhD, of @uscpphs.bsky.social writes, "Lifestyle factors play a large role in determining who gets a disease and who doesn’t. But they are far from the entire story."

A fascinating read about the relationship between genetics and our environment. ⬇️ 🔗

#Science #MedSky #ResearchSky
How your genes interact with your environment changes your disease risk − new research counts the ways
Environmental factors such as lifestyle and the medications you take influence the effects your genes have on your body − and can clarify how diseases develop.
theconversation.com
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