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Julia Kreiner @jmkreiner.bsky.social · 1d

Thanks Joey!!!

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Julia Kreiner @jmkreiner.bsky.social · 2d

Would love your thoughts and comments, so please pass along if you have any to share 🙏😊

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Julia Kreiner @jmkreiner.bsky.social · 2d

We also find more drought tolerance and stronger selection on drought alleles in agricultural compared to natural environments, highlighting how agricultural intensification and climate change interact to shape adaptation!

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Julia Kreiner @jmkreiner.bsky.social · 2d

Herbarium specimens spanning over a century of changing climate, however, show evidence of fluctuating selection maintaining this adaptive variation. Drought alleles are selected for in hot, dry years but against in cooler, wetter periods

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Julia Kreiner @jmkreiner.bsky.social · 2d

Ancestry mapping identified a highly polygenic basis of drought tolerance—with loci across nearly all chromosomes experiencing extreme selection and rapid allele frequency change across the length of an extreme drought event

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Julia Kreiner @jmkreiner.bsky.social · 2d

We first combined a drought selection experiment with whole genome sequencing to uncover the genetic basis of drought adaptation in waterhemp across the landscape

Drought experiment setup in the greenhouse

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Julia Kreiner @jmkreiner.bsky.social · 2d

Human-mediated land-use and climate change occur simultaneously, but how do they interact to shape adaptive dynamics? Super excited to share the first paper from the Kreiner lab, led by postdoc extraordinaire @rpineau.bsky.social

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Reposted by Julia Kreiner

New Phytologist @newphyt.bsky.social · 9d

Join us tomorrow (30 Sept) at 14:00 BST to hear from 2024 #TansleyMedal winner Matthew Naish!

Matthew will be talking about unravelling plant centromeres in the telomere-to-telomere era.

Registration is free: www.newphytologist.org/events/2025-...

#PlantScience

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Reposted by Julia Kreiner

Andrew Hipp @andrewlhipp.bsky.social · 10d

Asters and goldenrods, Maple Grove Forest Preserve, yesterday morning. Fight for democracy, science, human decency, and the natural world, and continue celebrating what you are fighting for.

Aster shortii; Maple Grove Forest Preserve, 27 Sept 2025

Zig-zag goldenrod (Solidago flexicaulis); Maple Grove Forest Preserve, 27 Sept 2025

Drummond's aster (Symphyotrichum drummondii); Maple Grove Forest Preserve, 27 Sept 2025

Calico aster (Symphyotrichum lateriflorum); Maple Grove Forest Preserve, 27 Sept 2025

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Reposted by Julia Kreiner

👻Sewall Fright🎃 @stairwaytokevin.bsky.social · 10d

New — with @joannarifkin.bsky.social, @jotlovell.bsky.social, @spicybotrytis.bsky.social, and many more — we created seven new high-quality genomes and explored pangenomic variation in the emerging oilseed crop pennycress (Thlaspi arvense). 1/

Structure and sequence evolution in the pennycress (Thlaspi arvense) pangenome

Summary · Eukaryotic genomes harbor many forms of variation, including nucleotide diversity and structural polymorphisms, which experience natural selection and contribute to genome evolution and biod...

www.biorxiv.org

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Reposted by Julia Kreiner

Jenn Coughlan @jenncoughlan.bsky.social · 14d

This was a HUGE effort, taking years of diligent work. Hongfei was a true leader, and I'm really proud of this cool piece. We'd love any feedback y'all might have. www.biorxiv.org/content/10.1...

Unique genetic bases of repeated life-history divergence associated with high altitude adaptation in Mimulus perennials

Understanding evolutionary repeatability is a central question in biology, as it informs how predictably organisms respond to similar selection pressures. However, the extent to which phenotypic repea...

www.biorxiv.org

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Julia Kreiner @jmkreiner.bsky.social · 14d

Congrats, James!!

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Reposted by Julia Kreiner

James Harvey @keepof4worlds.bsky.social · 14d

Wonderful news. A salutary reminder of the absolute benefits of scientific progress, and the absolute evil of conspiracist bollocks.

Huntington's disease successfully treated for first time www.bbc.com/news/article...

Huntington's disease successfully treated for first time

One of the most devastating diseases finally has a treatment that could transform lives, tearful doctors tell BBC

www.bbc.com

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Julia Kreiner @jmkreiner.bsky.social · 16d

Fun to synthesize some exciting future directions for spatiotemporal genomics in this Tansley perspective.

Check er out!

New Phytologist @newphyt.bsky.social · 16d

✨ Paper spotlight ✨

The genetic architecture and spatiotemporal dynamics of adaptation across human-modified landscapes
doi.org/10.1111/nph....

(🧵 1/6) What determines how quickly species adapt to changing environments?...

Fig. 1 Temporal genomic approaches for measuring selection coefficients from allele frequency change vary in power and accuracy depending on sampling design, sample size, and dominance. SLiM design.

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Reposted by Julia Kreiner

Sam Yeaman @samyeaman.bsky.social · 19d

I'll start reviewing applications in a little over 3 weeks for this PhD position. You could be doing fieldwork here! (or focus only on dry lab work if that floats your boat)

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Julia Kreiner @jmkreiner.bsky.social · 19d

Would be excited to chat with folks looking for a postdoc in AI to develop models for genomic prediction...

A great opportunity for funding coming up soon is the Schmidt AI in Science fellowship, due October 13th! apply.interfolio.com/173322

Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio

apply.interfolio.com

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Reposted by Julia Kreiner

Chise @sailorrooscout.bsky.social · 22d

GOOD NEWS! A new cancer vaccine has shown progress in triggering POWERFUL and LASTING immune responses in patients with pancreatic AND colorectal cancer. The vaccine, known as ELI-002 2P, targets mutant KRAS proteins AND had a huge impact on PREVENTING or DELAYING cancer recurrence in patients.

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Reposted by Julia Kreiner

Dmitri Petrov @petrovadmitri.bsky.social · 23d

Very excited to see this work in press! I think there is a reason to believe that this is a common means of stabilizing large-effect polymorphisms in general and might be an important reason for why diploidy is so common. news.stanford.edu/stories/2025...

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Reposted by Julia Kreiner

Marianna Karageorgi @mkarag.bsky.social · 23d

How do populations maintain an evolutionary memory? I am happy to share that our work with Dmitri Petrov @petrovadmitri.bsky.social, Paul Schmidt, and colleagues on dominance reversal and stabilization of insecticide resistance in changing environments over time is now published at Nature EE.

Beneficial reversal of dominance maintains a large-effect resistance polymorphism under fluctuating insecticide selection - Nature Ecology & Evolution

Measuring selection and dominance in fitness of the insecticide-resistant Ace alleles in Drosophila melanogaster, the authors show evidence for beneficial reversal of dominance, a mechanism that can s...

www.nature.com

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Reposted by Julia Kreiner

Daniel Ortiz-Barrientos @dortizba.bsky.social · Sep 3

We’ve just published a paper on Senecio showing that ecological speciation and mutation-order speciation can act together rather than as an either/or. Congratulations, Maddie James and MC Melo!

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Reposted by Julia Kreiner

Ronan @omalley-regulome.bsky.social · Aug 28

Our new Nature Plants paper is out (and we’re on the cover 😁)!👉 bit.ly/4lS8sOB
By combining scRNA-seq with conserved TF binding (multiDAP) we define gene regulatory networks for 65 cell types across 4 tissues in a wide range of flowering plants!

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Reposted by Julia Kreiner

Ethan Bass @ethanbass.bsky.social · Aug 22

Check out my primer in PLOS biology and the associated article by Wan and colleagues showing interesting new patterns in inducibility across multiple defense traits.

PLOS Biology @plosbiology.org · Aug 18

Plants have limited resources for #defense. @ethanbass.bsky.social explores a @plosbiology.org study revealing how #plants limit costs by deploying cheap traits immediately, delaying spending on costly ones until a critical damage threshold is reached 🧪 Paper: plos.io/45iSFUd Primer: plos.io/45kLk6C

Predicted reaction norms of costly and cheap traits. Schematic of reaction norms for two hypothetical traits: a metabolically cheap trait (e.g., a chemical toxin) with a continuous reaction norm (solid line) and a more expensive trait (e.g., trichome density) with a segmented reaction norm (dotted line). A hypothetical experiment with only two treatments (Control and Condition 1) might erroneously conclude that the segmented trait is fixed. Conversely, an experiment with stronger induction (Condition 2) would find no difference in inducibility between the two traits. By measuring trait values over a gradient of damage, the shapes of the reaction norms can be clearly distinguished. The organization of traits into continuous and threshold defenses may form a tiered defense system that balances cost savings with flexibility against variable threats.

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Julia Kreiner @jmkreiner.bsky.social · Aug 20

Caillebotte exhibit on at the Chicago Art Institute is absolutely stunning! This one is featured of course along w a lot of his studies of Paris, but his paintings of folks lounging by bodies of water also had that transportive effect on me!!

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Reposted by Julia Kreiner

Javier Santoyo @jsantoyo.bsky.social · Aug 17

Pangenome analysis of transposable element insertion polymorphisms reveals features underlying cold tolerance in rice. #TransposableElements #TE #Pangenomes #RiceGenomes @natcomms.nature.com
www.nature.com/articles/s41...

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Reposted by Julia Kreiner

Claus Wilke @clauswilke.com · Aug 15

A simple design framework that will massively improve your slides and your public speaking
clauswilke.substack.com/p/slides-tha...

Slide designs that present themselves: The assertion–evidence template

Your slides are not your talk.

clauswilke.substack.com

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