Lightnews — Scholar-powered news

Reposted by Mike Inouye

Matthew Neville @mattneville.bsky.social · 6h

Now published! Our paper on:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
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www.nature.com/articles/s41...

Sperm sequencing reveals extensive positive selection in the male germline - Nature

A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.

www.nature.com

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Reposted by Mike Inouye

Nature @nature.com · 1d

Antimicrobial resistance is projected to cause 39 million deaths worldwide over the next 25 years

go.nature.com/42x5KHD

The rise of ‘nightmare bacteria’: antimicrobial resistance in six charts

Data reveal how the global challenge to reduce deaths and infections from drug-resistant bacteria is not going according to plan.

go.nature.com

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Reposted by Mike Inouye

University of Cambridge @cam.ac.uk · 1d

It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the @gurdoninstitute.bsky.social

Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r

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Reposted by Mike Inouye

Megan Ranney MD MPH @meganranney.bsky.social · 1d

I know the news is tough right now.

So take a moment and soak in the gorgeousness & promise of the science that led to this year’s Nobel Prize in Medicine & Physiology.

WOW.

www.nytimes.com/2025/10/06/h...

Nobel Prize in Physiology or Medicine Is Awarded for Work on Immune Systems

www.nytimes.com

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Reposted by Mike Inouye

Gen Wojcik @genandgenes.bsky.social · 2d

Are you going to #ASHG2025 next week in Boston? Interested in getting some mentorship from leading figures in the field (and me)?

Check out our speed mentoring event on Thursday! Sign-ups are online so reserve a spot ASAP.

site.pheedloop.com/event/ASHG25...

PheedLoop

PheedLoop: Hybrid, In-Person & Virtual Event Software

site.pheedloop.com

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Reposted by Mike Inouye

samuel mehr @mehr.nz · 2d

"the quickest way to get a collaborator to return edits on your manuscript is to write down their affiliation wrong" (ancient academic proverb)

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Mike Inouye @mikeinouye.bsky.social · 3d

Reading through the headlines these days can be a bit depressing. Having had dozens of students and staff from all over the world, there are indeed oceans of insight within Sofia Vergara's immortal words "Do you even know how smart I am in Spanish?"

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Reposted by Mike Inouye

Harmit Singh Malik @harmitmalik.bsky.social · 3d

I am leaving Rochester NY after attending the retirement fest of four giants in the field of evolutionary biology including my PhD advisor. This visit gave me a chance to revisit old haunts and reflect on my own somewhat unlikely origin story. 1/n

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Mike Inouye @mikeinouye.bsky.social · 3d

For me, figures 5 and 6 were really exciting.

CAD PRS could both improve early identification of future CVD cases *AND* improve fairness on top of QRISK3. www.medrxiv.org/content/10.1...

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Mike Inouye @mikeinouye.bsky.social · 3d

ICYMI 👉 Quantifying the fairness of polygenic risk scores: our modelling and analysis for CVD risk prediction www.medrxiv.org/content/10.1...

Overall PRS fairness levels similar to or better than traditional predictors (age, sex, BP, lipids)

h\t @iamslambert.bsky.social @clairecoffey.bsky.social

Current polygenic risk scores are unlikely to exacerbate unfairness in cardiovascular disease risk prediction

Background Current cardiovascular disease (CVD) risk prediction models place many individuals in an intermediate risk category where clinical decision-making remains uncertain, highlighting a critical...

www.medrxiv.org

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Mike Inouye @mikeinouye.bsky.social · 3d

Wow, didn't realise it was that bad in the US (nor that the UK was that good) www.bbc.co.uk/news/article...

Reposted by Mike Inouye

Mike Inouye @mikeinouye.bsky.social · 5d

Not unrelated... I've recently updated the Research page on our lab's website (first time in nearly 10 years!) www.inouyelab.org/home/research

and we are now recruiting PhD students for autumn 2026 @dphpc.bsky.social @cam.ac.uk - feel free to get in touch!

Inouye Lab - Research

Background Technological advances have continued to drive the study of biology towards the statistical and computational sciences. We are now able to differentiate and quantify biomolecules at levels ...

www.inouyelab.org

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Mike Inouye @mikeinouye.bsky.social · 4d

Now published @nataging.nature.com: A rare sole author paper on "Refining the generation, interpretation and application of multi-organ, multi-omics biological aging clocks" www.nature.com/articles/s43...

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Mike Inouye @mikeinouye.bsky.social · 4d

Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities www.nature.com/articles/s41...

Cool findings: Two obesity GRSs for stratification, one with cardiometabolic comorbidities (GRS_BFP) and one without (GRS_uncoupling)

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Mike Inouye @mikeinouye.bsky.social · 5d

Not unrelated... I've recently updated the Research page on our lab's website (first time in nearly 10 years!) www.inouyelab.org/home/research

and we are now recruiting PhD students for autumn 2026 @dphpc.bsky.social @cam.ac.uk - feel free to get in touch!

Inouye Lab - Research

Background Technological advances have continued to drive the study of biology towards the statistical and computational sciences. We are now able to differentiate and quantify biomolecules at levels ...

www.inouyelab.org

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Reposted by Mike Inouye

Varun Warrier @vw1234.bsky.social · 7d

It is now clear that more people are being diagnosed as autistic in their teens and as adults than in childhood. A prevailing theory is that those diagnosed later have "milder" form of autism, and later diagnosis entirely due to social factors.

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Reposted by Mike Inouye

Hilary Martin @hilarycmartin.bsky.social · 6d

Pleased to have contributed to this paper out at @nature.com today from @vw1234.bsky.social and Yira (Xinhe) Zhang showing that the common variant contribution to autism varies substantially by age of diagnosis www.nature.com/articles/s41.... Critical for understanding heterogeneity in autism.

Polygenic and developmental profiles of autism differ by age at diagnosis - Nature

A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

www.nature.com

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Reposted by Mike Inouye

University of Cambridge @cam.ac.uk · 7d

We are deeply saddened to hear of the passing of Jane Goodall.

Jane was a much-loved member of the conservation community in Cambridge and worldwide. She completed her PhD at @darwincollegecam.bsky.social and was an Honorary Fellow at @newnhamcollege.bsky.social.

www.youtube.com/watch?v=ZIzR...

Jane Goodall - Finding our way to a better future

YouTube video by Cambridge University

www.youtube.com

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Mike Inouye @mikeinouye.bsky.social · 10d

Well done Kara!

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Reposted by Mike Inouye

Ben Vezina @bananabenana.bsky.social · 11d

Staggering analysis here linking ciprofloxacin resistance to specific mutations in #Klebsiella.

In short, using ONLY genotype, one can reasonably predict phenotypic CIP MICs! See Fig 3 (below).

Loving the splitting of MIC and disk diffusion data as well.

#AMR #MicroSky #IDSky

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Reposted by Mike Inouye

derek guy @dieworkwear.bsky.social · 11d

Let me tell you a beautiful story about this couch. 🧵

IG msviciousdesign

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Mike Inouye @mikeinouye.bsky.social · 12d

New Health Data Insights Podcast up! This one with Sam Lambert @iamslambert.bsky.social of PGS Catalog fame 👉 podcasts.apple.com/gb/podcast/i...

Covering...
-ethics of genetic prediction
-risk models for diverse populations
-polygenic scores in healthcare

...and being Dean of Churchill College

Insights from Dr Sam Lambert

Podcast Episode · Health Data Science Insights - Cambridge · 23/09/2025 · 29m

podcasts.apple.com

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Reposted by Mike Inouye

Zamin Iqbal @zaminiqbal.bsky.social · 13d

Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols.
Thread 1/n

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Mike Inouye @mikeinouye.bsky.social · 14d

From the UK Academy of Medical Sciences & US National Academy of Medicine 👉 The ‘For people, for planet’ policy report: environmentally sustainable health research in the UK and US acmedsci.ac.uk/file-downloa...

Wonderful to see www.green-algorithms.org highlighted!!

ping @loiclnlg.bsky.social

Green Algorithms

Towards environmentally sustainable computational science

www.green-algorithms.org

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