Zamin Iqbal
@zaminiqbal.bsky.social
6K followers 4.7K following 870 posts
Professor of Algorithmic and Microbial Genomics at the University of Bath (UK). Pangenomes, drug resistance (esp TB), data structures for DNA search, plasmid evolution, global microbial surveillance. Open Data, reproducibility
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zaminiqbal.bsky.social
Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols.
Thread 1/n
Reposted by Zamin Iqbal
stcmicrobeblog.bsky.social
#MicroSky
surtlab.bsky.social
Here’s published version of our manuscript using GWAS to investigate tailocin sensitivity in Pseudomonas syringae. TL:DR pretty clear LPS is tailocin receptor but also that P.syringae often completely swaps out its entire O antigen biosynth pathway w/ recombination

academic.oup.com/g3journal/ad...
Genomic correlates of tailocin sensitivity in Pseudomonas syringae
Abstract. Phage-derived bacteriocins, also referred to as tailocins, are structures encoded by bacterial genomes and deployed into the extracellular enviro
academic.oup.com
Reposted by Zamin Iqbal
henrymance.ft.com
I know this is uncomfortable to admit, but there is a small area in England's second city where people are just not integrated with the rest of society. Many of them hold views that arguably go against British values.

Yes, we need to talk about the Tory conference in Manchester.
zaminiqbal.bsky.social
I did not expect to find a paper in a new graph genotyper (using colored de bruijn graphs) which quotes Maya Angelou on line 1!

academic.oup.com/gigascience/...
Reposted by Zamin Iqbal
benlangmead.bsky.social
I've added 7 videos to my Burrows-Wheeler indexing playlist (www.youtube.com/playlist?lis...), rounding out the r-index series and adding a 5-part series on the move structure. Now 27 videos in that playlist. I aim to add videos on prefix-free parsing, PBWT, Wheeler languages/automata in the future.
Burrows-Wheeler Indexing - YouTube
Videos on : (a) the Burrows-Wheeler Transform (BWT), (b) the FM Index, which uses the BWT to construct a full-text index, (c) Wheeler graphs, (d) r-index, an...
www.youtube.com
Reposted by Zamin Iqbal
nataliesedacca.bsky.social
Devastating critique of Labour’s plans to double wait to apply for ILR or claim benefits, and require volunteering to gain citizenship. RCN warns the NHS and social care would cease to function under these harsh rules, which would drive people and pander to Reform www.theguardian.com/uk-news/2025...
NHS could cease to function under Labour’s new visa rules, say nurses
Exclusive: Royal College of Nursing says plan to tighten rules for foreign workers is ‘pandering’ to Reform UK
www.theguardian.com
Reposted by Zamin Iqbal
barristersecret.bsky.social
This is a lie.

There are many criticisms you might sensibly and truthfully make of the Sentencing Council and the Sentencing Guidelines. I’ve been making them for years.

But this is an outright lie. Pure fabrication. A fraud on the public.
Reposted by Zamin Iqbal
lewisgoodall.com
Am wondering if all of those suddenly deciding they’re against communities living “parallel lives” might reconsider their support of religious schools? Or indeed private ones?
Reposted by Zamin Iqbal
boghuma.bsky.social
A new Nature Medicine study analyzing health records from >100 million people in the US offers compelling evidence that reactivation of varicella-zoster virus (VZV) ,the same virus that causes chickenpox and shingles may contribute to dementia risk.
www.nature.com/articles/s41...
Varicella-zoster virus reactivation and the risk of dementia - Nature Medicine
Large-scale longitudinal health records reveal consistent association of varicella-zoster virus reactivation with dementia.
www.nature.com
Reposted by Zamin Iqbal
elisewang.bsky.social
One of the more incredible stories out of LA this year has been how a taco review blog became the best on-the-ground coverage of ICE raids in the city.

They do a dispatch every day, follow-up on the kidnapped people (which almost no media outlet has done), and fact-check government claims.
motherjones.com
@lataco.bsky.social first began as a blog documenting local Mexican cuisine. Now, it’s an essential reporting powerhouse to the city as Trump’s mass deportation plot unfolds.

Check out the latest from our friends at Reveal: tinyurl.com/4cm2bsdr
Reposted by Zamin Iqbal
cazares-adr.bsky.social
Imagine we could travel back in time ⏪⌛️to explore the world of bacterial pathogens before humans discovered and industrialised antibiotics

We just did that to study the history of #AMR spread @science.org
doi.org/10.1126/scie...

If you like time travel & biology, this 🧵is for you👇
Pre- and postantibiotic epoch: The historical spread of antimicrobial resistance
Plasmids are now the primary vectors of antimicrobial resistance, but our understanding of how human industrialisation of antibiotics influenced their evolution is limited by a paucity of data predati...
doi.org
Reposted by Zamin Iqbal
3rdreviewer.bsky.social
The most important paper in evolutionary biology I'd never heard of:

1/

www.sciencedirect.com/science/arti...
Reposted by Zamin Iqbal
rjme.bsky.social
Physics Nobel announcement tomorrow.

If you know and dislike a famous physicist, this is the day of the year to call them up in the middle of the night, wait 10 seconds, and then do you best Swedish Chef impression...
a chef in a kitchen with the words borg written on the bottom
ALT: a chef in a kitchen with the words borg written on the bottom
media.tenor.com
Reposted by Zamin Iqbal
cameronpat.bsky.social
knowing how to speak Latin famously did not, in fact, save the Romans
axdouglas.bsky.social
I’m a strong advocate of ancient languages, but it seems dangerous to overpromise…
Reposted by Zamin Iqbal
brockhurstlab.bsky.social
New preprint!

Ever wondered why only a fraction of genomes encode CRISPR immunity? 🧬 🦠

Turns out CRISPR is rarely beneficial against virulent phages, being most beneficial against those for which resistance mutations are rare!

An epic effort by Rosanna Wright

www.biorxiv.org/content/10.1...
Resistance mutation supply modulates the benefit of CRISPR immunity against virulent phages
Only a fraction of bacterial genomes encode CRISPR-Cas systems but the selective causes of this variation are unexplained. How naturally virulent bacteriophages (phages) select for CRISPR immunity has...
www.biorxiv.org
zaminiqbal.bsky.social
Woah, immense. Many congrats!
Reposted by Zamin Iqbal
blaftrakesh.bsky.social
When I was researching my book Ghosts, Monsters, and Demons of India, I learned of a 1000-year-old myth about Roman tech being used to build killer robots to guard the Buddha's remains in Pataliputra, and a Hungarian folklorist read my book & got excited about it, & she managed to dig up a🧵(1/3)
Romanised Pali manuscript of the Lokapannati Ghosts, Monsters, and Demons of India
p. 60
Bhoota Vahana Yanta
Bhoota Vahana Yanta means “spirit movement machine.” The term is used
for several varieties of robot drone assassins and sword-wielding machine-
men mentioned in the Lokapannati, a Pali-language text written between
1000 and 1200 CE by Saddhammaghosa of Thaton, but concerning
events that took place much earlier, around 500 to 200 BCE.
According to the story, robots were first invented by engineers of the
early Roman Republic. These robots were used for commerce, in agriculture,
as a police force, and as executioners. The secret of how to build these
spirit-engines was fiercely protected. If any engineer dared to take the designs
out of the city, one of his own executioner robots would come after
him and kill him.
At that time, in Pataliputra (then in the kingdom of Magadha, now
Patna in the state of Bihar), there lived a young man who had heard of the
Romans’ magical androids. He became so determined to learn the secrets
of their manufacture and share them with the people of Magadha that he
arranged his own death. Then, on his deathbed, he vowed to be reincarnated
as a Roman.
This indeed took place. In his new life, the man grew up to join the
Roman guild of engineers. He even married the daughter of the Master
Robot-Maker, and had a son by her.
Once he learned the secrets of the Bhoota Vahana Yanta, the man resolved
to transfer the information back to Pataliputra. But he was well
aware that now, since he was a member of the guild, he would be killed as
soon as he left. So he cut a gash in his thigh, inserted the plans in his flesh,
and sewed the wound back up.
Reposted by Zamin Iqbal
levine-lab.bsky.social
Check out this new Levine-Lampson collaboration, led by the talented Hyuk-Joon Jeon.

We explored the consequences of inheriting long telomeres from dad and short telomeres from mom. Or the reciprocal. Turns out, parent-of-origin matters (in mice, at least).

authors.elsevier.com/c/1loW-3QW8S...
authors.elsevier.com