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Reposted by Michael Brockhurst

Filip Husnik @filiphusnik.bsky.social · 1d

OIST is seeking up to four tenure-track or tenured faculty in Ecology, Environmental Science, Earth Science, and Oceanography. Application deadline: Oct 15. Please share. Thx!
www.oist.jp/careers/facu...

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Reposted by Michael Brockhurst

Ákos T Kovács @evolvedbiofilm.bsky.social · 18h

Metabolic interplay drives population cycles in a cross-feeding microbial community

@natcomms.nature.com from @oventurelli2.bsky.social

www.nature.com/articles/s41...

Metabolic interplay drives population cycles in a cross-feeding microbial community - Nature Communications

Here the authors leverage a crossfeeding, engineered microbial community to demonstrate that strain abundance cycles are robust across environmental conditions. They pair this with a nonlinear dynamic model to elucidate population cycles.

www.nature.com

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Michael Brockhurst @brockhurstlab.bsky.social · 1d

Thanks!

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Michael Brockhurst @brockhurstlab.bsky.social · 1d

Thanks!

For phages where resistance mutation supply is high, resistance mutation dominates and CRISPR plays no role in survival. Whereas, for phages where resistance mutation supply is sufficiently low, CRISPR (rarely) permits population survival. It’s a numbers game!

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Michael Brockhurst @brockhurstlab.bsky.social · 2d

PS Simon’s tail fibre protein structure models showing the variants causing altered surface receptor binding specificity are Lovell-y

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Reposted by Michael Brockhurst

Adrian Cazares @cazares-adr.bsky.social · 2d

Fusions 🧬🔄 are particularly fascinating because they tend to be massive in size, but most are single instances, suggesting they are only brief snapshots 📸 in time.
Plus, if you try to track what has fused with what... well, it's utter chaos!
So the process is highly dynamic.

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Reposted by Michael Brockhurst

Adrian Cazares @cazares-adr.bsky.social · 2d

Imagine we could travel back in time ⏪⌛️to explore the world of bacterial pathogens before humans discovered and industrialised antibiotics

We just did that to study the history of #AMR spread @science.org
doi.org/10.1126/scie...

If you like time travel & biology, this 🧵is for you👇

Pre- and postantibiotic epoch: The historical spread of antimicrobial resistance

Plasmids are now the primary vectors of antimicrobial resistance, but our understanding of how human industrialisation of antibiotics influenced their evolution is limited by a paucity of data predati...

doi.org

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Reposted by Michael Brockhurst

Tung Le @tunglejic.bsky.social · 4d

Independent research fellowships leading to tenured positions at the John Innes Centre.

Repost = nice. Thank you very much!!!

John Innes Centre @johninnescentre.bsky.social · 4d

Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026.

Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.

Find out more: www.jic.ac.uk/training-car...

Independent Research Fellowships Leading to Tenured Faculty Positions | John Innes Centre

The John Innes Centre (JIC), is a world leading centre of excellence in plant and microbial sciences based on the Norwich Research Park, UK. We are inviting applications from outstanding researchers…

www.jic.ac.uk

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Michael Brockhurst @brockhurstlab.bsky.social · 2d

Thanks Zam! All credit to Rosanna 💪

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Michael Brockhurst @brockhurstlab.bsky.social · 2d

5-years in the making this paper has been a real journey!

Also, a fun collaboration with @frimanscience.bsky.social @jofoth.bsky.social Edze Westra, Simon Lovell, Aras Kadioglu

#mevosky #phagesky

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Michael Brockhurst @brockhurstlab.bsky.social · 2d

For LPS phages we identified the genetic basis of the variation: a handful of amino acid changes affecting H-bonding residues at the tip of tail fibre protein which altered the binding site from O-antigen (high rate of resistance mutation) to LPS core (low rate)

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Michael Brockhurst @brockhurstlab.bsky.social · 2d

Rosanna designed a high-throughput evolutionary screen with ~20k populations comparing CRISPR+ vs CRISPR- Pseudomonas against 351 phage treatments

Benefit of CRISPR varied among phages and increased 📈 as surface receptor resistance mutations supply decreased 📉

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Michael Brockhurst @brockhurstlab.bsky.social · 2d

New preprint!

Ever wondered why only a fraction of genomes encode CRISPR immunity? 🧬 🦠

Turns out CRISPR is rarely beneficial against virulent phages, being most beneficial against those for which resistance mutations are rare!

An epic effort by Rosanna Wright

www.biorxiv.org/content/10.1...

Resistance mutation supply modulates the benefit of CRISPR immunity against virulent phages

Only a fraction of bacterial genomes encode CRISPR-Cas systems but the selective causes of this variation are unexplained. How naturally virulent bacteriophages (phages) select for CRISPR immunity has...

www.biorxiv.org

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Reposted by Michael Brockhurst

Nature @nature.com · 3d

Nature research paper: Monoclonal antibodies protect against pandrug-resistant Klebsiella pneumoniae

go.nature.com/4gXwTtu

Monoclonal antibodies protect against pandrug-resistant Klebsiella pneumoniae - Nature

Capsule-specific human monoclonal antibodies are protective against bloodstream infection by Klebsiella pneumoniae sequence type 147 in a mouse model of septicaemia, and could provide a useful strategy against pathogens with antimicrobial resistance.

go.nature.com

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Reposted by Michael Brockhurst

Jan-Willem Veening @veeninglab.com · 4d

Finally out, such an awesome piece of work, very proud of this one: www.cell.com/cell-systems... #MicroSky

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Reposted by Michael Brockhurst

Ákos T Kovács @evolvedbiofilm.bsky.social · 5d

Filamentous cheater phages drive bacterial and phage populations to lower fitness

Pseudomonas aeruginosa VS Pf phage

@currentbiology.bsky.social by @nanamikubota.bsky.social, @shellyscrib.bsky.social and @vscooper.micropopbio.org

www.cell.com/current-biol...

#PhageSky

Filamentous cheater phages drive bacterial and phage populations to lower fitness

Kubota et al. show that bacteria can use their filamentous phage to outcompete other bacteria, but increased phage production enables the evolution of cheater miniphages with truncated genomes. Miniph...

www.cell.com

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Reposted by Michael Brockhurst

Ben Adler @benadler.bsky.social · 6d

Today in @nature.com , we highlight how a cousin of CRISPR-Cas10, mCpol, establishes an evolutionary trap in anti-phage immune systems.

Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here:
www.nature.com/articles/s41...

A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling - Nature

Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.

www.nature.com

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Michael Brockhurst @brockhurstlab.bsky.social · 6d

Have they heard of Pseudomonas? Gonna be 🤯

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Michael Brockhurst @brockhurstlab.bsky.social · 6d

Bradyrhizobium shrugs

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Reposted by Michael Brockhurst

Tobias Warnecke @tobiaswarnecke.bsky.social · 9d

Become my colleague @oxfordbiochemistry.bsky.social !
2 Associate Professorships in the areas of
- prokaryotic/eukaryotic microbiology
- metabolism

my.corehr.com/pls/uoxrecru...

Job Details

my.corehr.com

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Reposted by Michael Brockhurst

Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 8d

Come and work with me and @ariannebabina.bsky.social on #Streptomyces evolution and antibiotic production

Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces

www.gla.ac.uk/postgraduate...

please repost

University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Underpinning Bioscience - Paul A Hoskisson

www.gla.ac.uk

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Reposted by Michael Brockhurst

Teppo Hiltunen @teppo-h.bsky.social · 8d

Professor (full) or Associate Professor (tenure track) in Microbial Genetics of Health (U. Turku Finland). Competitive starting package included! Please share.

duunitori.fi/tyopaikat/ty...

Professor or Associate professor (Tenure Track/Full) in Microbial Genetics of Health - Turun yliopisto - Työpaikat - Duunitori

Avoin työpaikka: Professor or Associate professor (Tenure Track/Full) in Microbial Genetics of Health - Turun yliopisto, Turku. Duunitorilla lisäksi yli 30 000 muuta avointa työpaikkaa. Lue lisää nyt!

duunitori.fi

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Reposted by Michael Brockhurst

Andy Edwards @bugsinblood.bsky.social · 8d

Now published! www.nature.com/articles/s41...

Very nice collaboration with Hoogenboom ( @ucl.ac.uk ) and Bonev ( @uniofnottingham.bsky.social ) labs.

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Reposted by Michael Brockhurst

Craig MacLean @craigmaclean.bsky.social · 8d

New pre-print: Eco-evolutionary responses of phage to different thermal regimes.

Great work led by Sam Greenrod and fun collaboration with Kayla King's lab.
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www.biorxiv.org/content/10.1...

Evolutionary rescue accelerates competitive exclusion in a parasite community

Environmental stress drives biodiversity loss by altering competitive hierarchies and pushing taxa towards extinction. Parasites and their communities are particularly vulnerable to stress due to envi...

www.biorxiv.org

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Michael Brockhurst @brockhurstlab.bsky.social · 10d

The Chorley Putt-aaaaaaah

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