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Craig MacLean @craigmaclean.bsky.social · 6d

Interesting job opportunity:
duunitori.fi/tyopaikat/ty...

Professor or Associate professor (Tenure Track/Full) in Microbial Genetics of Health - Turun yliopisto - Työpaikat - Duunitori

Avoin työpaikka: Professor or Associate professor (Tenure Track/Full) in Microbial Genetics of Health - Turun yliopisto, Turku. Duunitorilla lisäksi yli 30 000 muuta avointa työpaikkaa. Lue lisää nyt!

duunitori.fi

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Reposted by Craig MacLean

Will Matlock @wtmatlock.bsky.social · 8d

Now published in @natcomms.nature.com 🎉

www.nature.com/articles/s41...

With Gillian Rodger, @nstoesser.bsky.social, @samlipworth.bsky.social, @stat-sarah.bsky.social, and many others!

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Craig MacLean @craigmaclean.bsky.social · 8d

Builds on pre-print posted earlier this week and gratuitously reposted here

www.biorxiv.org/content/10.1...
#Phagesky

Evolutionary rescue accelerates competitive exclusion in a parasite community

Environmental stress drives biodiversity loss by altering competitive hierarchies and pushing taxa towards extinction. Parasites and their communities are particularly vulnerable to stress due to envi...

www.biorxiv.org

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Craig MacLean @craigmaclean.bsky.social · 8d

New pre-print
Competition between phage constrains adaptation to thermal fluctuating temperatures.
More work led by Sam Greenrod in collaboration with @kayla-king.bsky.social lab.
#Phagesky#Microsky

www.biorxiv.org/content/10.1...

www.biorxiv.org

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Reposted by Craig MacLean

Tami Lieberman @contaminatedsci.bsky.social · 8d

Precisely calling mutations across hundreds of bacterial isolates has been hard, requiring manual filtering and expertise.

Until now, using AccuSNV.

Herui Liao trained an ML model based on our previous meticulously called SNVs.
www.biorxiv.org/content/10.1...

High-accuracy SNV calling for bacterial isolates using deep learning with AccuSNV

Accurate detection of mutations within bacterial species is critical for fundamental studies of microbial evolution, reconstructing transmission events, and identifying antimicrobial resistance mutati...

www.biorxiv.org

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Craig MacLean @craigmaclean.bsky.social · 9d

#phagesky

Craig MacLean @craigmaclean.bsky.social · 9d

Most interesting result: thermosensitive phage (14-1) adapts to high temperature so quickly that it displaces dominant thermotolerant competitor (Luz-19).

Interestingly, DNA ligase mutations involved in adaptation both heat and competitors. Can any phage afficionados explain why?

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Craig MacLean @craigmaclean.bsky.social · 9d

New pre-print: Eco-evolutionary responses of phage to different thermal regimes.

Great work led by Sam Greenrod and fun collaboration with Kayla King's lab.
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www.biorxiv.org/content/10.1...

Evolutionary rescue accelerates competitive exclusion in a parasite community

Environmental stress drives biodiversity loss by altering competitive hierarchies and pushing taxa towards extinction. Parasites and their communities are particularly vulnerable to stress due to envi...

www.biorxiv.org

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Reposted by Craig MacLean

Zamin Iqbal @zaminiqbal.bsky.social · 12d

Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols.
Thread 1/n

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Reposted by Craig MacLean

Michael Brockhurst @brockhurstlab.bsky.social · 13d

Recent paper from the lab studying predictors of phage cocktail efficacy against complex clinical Pseudomonas populations

royalsocietypublishing.org/doi/epdf/10....

Led by Rosanna Wright with extraordinary MSc (PhD) student Maisie Czernuska

Bacteria–phage infection network structure and genomic defence system content predict efficacy of a phage therapy cocktail against Pseudomonas aeruginosa from chronic lung infections

royalsocietypublishing.org

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Craig MacLean @craigmaclean.bsky.social · 12d

Congrats Siobhán - well deserved promotion and I am glad to see that you are enjoying the moment

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Craig MacLean @craigmaclean.bsky.social · 12d

Thanks Rachel!

Craig MacLean @craigmaclean.bsky.social · 13d

Thanks Zam!

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Craig MacLean @craigmaclean.bsky.social · 13d

Thanks Sonja

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Craig MacLean @craigmaclean.bsky.social · 13d

New ERC funded computational postdoc position in my lab! We are looking for someone who will study the genomics of bacterial evolution using samples from experimental evolution and clinical trials. Lots of opportunities for interesting and fun collaboration!
my.corehr.com/pls/uoxrecru...

Job Details

my.corehr.com

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Craig MacLean @craigmaclean.bsky.social · 17d

Congratulations!

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Reposted by Craig MacLean

Jörg Vogel @jorg-vogel-lab.bsky.social · 28d

Looking for a new approach to studying or eliminating phages? Check out our study introducing anti-phage ASOs (antisense oligos) out in @Nature today. nature.com/articles/s4158…

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Reposted by Craig MacLean

José R Penadés @jrpenades.bsky.social · 29d

Our second paper with @tcostalab.bsky.social and GoogleDeepMind
reports our experience with Google’s co-scientist: remarkably, the AI independently recapitulated our experimental discovery on cf-PICIs, showcasing AI’s potential to accelerate biology.
www.cell.com/cell/fulltex...

AI mirrors experimental science to uncover a mechanism of gene transfer crucial to bacterial evolution

By solving a previously unsolved biological question, the AI co-scientist predicted a complex mechanism of gene transfer and generated hypotheses that opened new research directions, illustrating AI's...

www.cell.com

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Reposted by Craig MacLean

José R Penadés @jrpenades.bsky.social · 29d

Thrilled to share our two latest papers with the @tcostalab.bsky.social
lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species.
@imperialcollegeldn.bsky.social
www.cell.com/cell/fulltex...

Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization

Capsid-forming PICIs (cf-PICIs) produce their own capsids and exploit phage tails from unrelated species to transfer their DNA across bacterial hosts. This tail piracy enables broad dissemination and ...

www.cell.com

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Craig MacLean @craigmaclean.bsky.social · Aug 30

Nice video abstract!

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Craig MacLean @craigmaclean.bsky.social · Aug 13

This looks like a must read …

Alvaro San Millan @sanmillan.bsky.social · Aug 13

New paper in collaboration with the @asantoslopez.bsky.social lab!

www.biorxiv.org/content/10.1...

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Reposted by Craig MacLean

Michael Brockhurst @brockhurstlab.bsky.social · Aug 13

We are also hiring a 4-year postdoc to study the dynamics and evolution of mobile genetic elements in the C-fixing Icelandic host-spring microbiomes

Join our exciting multidisciplinary team funded by @ukri.org BBSRC sLoLa

www.jobs.manchester.ac.uk/Job/JobDetai...

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Craig MacLean @craigmaclean.bsky.social · Jul 29

This project is a team effort led by Weronika Slesak and the start of a new line of research in my group! Hopefully this will be a good summer read if you are looking for a short paper with a sense of foreboding.

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Craig MacLean @craigmaclean.bsky.social · Jul 29

New pre-print from my lab!
Plasmids link antibiotic resistance and phage defense.

E.coli plasmids are hotspots for both antibiotic resistance and phage defense. Phage therapy has the potential to accidentally select for antibiotic resistance!!!
#microsky#AMR#phage

www.biorxiv.org/content/10.1....

Plasmids link antibiotic resistance genes and phage defense systems in E. coli

Phage therapy has been proposed as an alternative to antibiotics to treat resistant infections. However, we have a limited understanding of how antibiotic resistance genes (ARGs) associate with bacter...

www.biorxiv.org

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Reposted by Craig MacLean

Jerónimo Rodríguez-Beltrán @jerorb.bsky.social · Jul 2

🚨🚨New paper out in @natcomms.nature.com!!

Come for the first large-scale analysis of plasmid copy number across species,
stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬

👉 www.nature.com/articles/s41...

Universal rules govern plasmid copy number - Nature Communications

Plasmids exhibit a broad range of sizes and copies per cell, and these two parameters appear to be negatively correlated. Here, Ramiro-Martínez et al. analyse the copy number of thousands of diverse b...

www.nature.com

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