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Reposted by Mia Levine

Charikleia Karageorgiou (Clio) @evobioclio.bsky.social · 8h

Epistasis among clustered lineage-specific adaptive amino acid substitutions in the Drosophila Trio protein

Intramolecular epistasis is increasingly recognized as a key factor shaping patterns of evolutionary rate variation among protein sites and constraining adaptive evolution. While genome-wide analyses ...

www.biorxiv.org

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Reposted by Mia Levine

bioRxivpreprint @biorxivpreprint.bsky.social · 20h

Long-read sequencing reveals telomere inheritance patterns from human trios https://www.biorxiv.org/content/10.1101/2025.10.07.680721v1

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Mia Levine @levine-lab.bsky.social · 4d

Check out this new Levine-Lampson collaboration, led by the talented Hyuk-Joon Jeon.

We explored the consequences of inheriting long telomeres from dad and short telomeres from mom. Or the reciprocal. Turns out, parent-of-origin matters (in mice, at least).

authors.elsevier.com/c/1loW-3QW8S...

authors.elsevier.com

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Reposted by Mia Levine

Arnau Sebé-Pedrós @arnausebe.bsky.social · 24d

Registration deadline for @embo.org workshop EvoChromo extended until September 30.

meetings.embo.org/event/24-evo...

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Reposted by Mia Levine

Arnau Sebé-Pedrós @arnausebe.bsky.social · 14d

Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...

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Reposted by Mia Levine

Jenn Coughlan @jenncoughlan.bsky.social · 14d

This was a HUGE effort, taking years of diligent work. Hongfei was a true leader, and I'm really proud of this cool piece. We'd love any feedback y'all might have. www.biorxiv.org/content/10.1...

Unique genetic bases of repeated life-history divergence associated with high altitude adaptation in Mimulus perennials

Understanding evolutionary repeatability is a central question in biology, as it informs how predictably organisms respond to similar selection pressures. However, the extent to which phenotypic repea...

www.biorxiv.org

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Reposted by Mia Levine

Jae Young Choi @jychoi.bsky.social · 16d

Excited to share a new method developed from my group thats published at Genome Biology. This was an amazing effort by my grad student Linh @linhngk.bsky.social. We developed Topsicle, a method that analyzes long read data for telomere analysis and length measuring.
doi.org/10.1186/s130...

Topsicle: a method for estimating telomere length from whole genome long-read sequencing data - Genome Biology

Telomeres protect chromosome ends and their length varies significantly between organisms. Because telomere length variation is associated with various biomedical and eco-evolutionary phenotypes, many...

doi.org

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Reposted by Mia Levine

Julius Brennecke @juliusbrennecke.bsky.social · 20d

Love RNA biology?

Join us to explore the piRNA pathway with structural and genetic approaches (see 👇👇).

PhD student/postdoc position co-supervised by Clemens Plaschka & myself.

DM or email us if you’d like to know more!

@vbcscitraining.bsky.social @imbavienna.bsky.social @impvienna.bsky.social

Julius Brennecke @juliusbrennecke.bsky.social · 21d

PIWI clade Argonautes are essential for transposon silencing. Without them, animals are sterile due to massive transposon activity.

But how does piRNA-guided target interaction translate into silencing?

PhD student Júlia Portell Montserrat has an intriguing answer

www.cell.com/molecular-ce...

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Reposted by Mia Levine

Alexandra Dallaire @alexdallaire.bsky.social · Sep 3

I’m super happy to present the first discoveries of the RIKEN-Cambridge Joint Crop Symbiosis Research Team, based in Japan 🇯🇵

doi.org/10.1101/2025...

A thread 👇

Reductive evolution of the DNA replication machinery in endosymbiotic fungi

The molecular machinery for replicating and repairing DNA accurately is critically important for life and highly conserved across the Tree of Life. Here we show that two major lineages of fungi, Glome...

doi.org

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Reposted by Mia Levine

Christian Landry @christianlandry.bsky.social · 28d

Really excited to share our latest paper led by @simonaube.bsky.social. Fascinating results examining whether regulatory mutations can lead to adaptation as fast as coding mutations do. #mevosky #evobio #evoSky

www.biorxiv.org/content/10.1...

Adaptation is less accessible through mutations in promoters than in coding sequences when large effect sizes are needed

Mutations within promoters and coding sequences are both involved in adaptation, but their relative contributions remain to be compared directly. Using the fungal enzyme cytosine deaminase, we examine...

www.biorxiv.org

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Reposted by Mia Levine

Tobias Warnecke @tobiaswarnecke.bsky.social · Sep 8

Please re-post:

Interested in chromatin and its evolution? Good news! There's still time to join us in beautiful Catalonia (9-12 Dec) to discuss eukaryotic, bacterial, archaeal, and viral chromatin and how it all hangs together meetings.embo.org/event/24-evo...

Abstract deadline: 30 September

EvoChromo: Evolutionary approaches to research in chromatin

Chromatin is the complex of DNA, RNA and protein that is found making up the chromosomes in eukaryotic cells. Chromatin is essential for proper genome function and is involved in chromosome segregati…

meetings.embo.org

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Reposted by Mia Levine

Colin Conine @colinconine.bsky.social · Aug 23

New from the lab led by @natrigg.bsky.social. We started by characterizing mRNA in sperm, EVs, and the epithelium across epididymal transit. This revealed evidence that sperm acquire specific mRNAs through fusion with epididymal EVs, which we further established with in vitro co-incubation assays

bioRxivpreprint @biorxivpreprint.bsky.social · Aug 22

Epididymal extracellular vesicles harbor and convey mRNA to sperm for transfer to zygotes https://www.biorxiv.org/content/10.1101/2025.08.18.670952v1

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Reposted by Mia Levine

Tomas Janovic @janovictom.bsky.social · Aug 25

🚨 Excited to share my main postdoc work from the @jenscs83.bsky.social lab, now out in Cell Reports! 👉 www.sciencedirect.com/science/arti... We dissect how shelterin proteins organize at telomeres in human cancer cells—revealing distinct subcomplexes that maintain chromosome ends. 🧵

TRF1 and TRF2 form distinct shelterin subcomplexes at telomeres

The shelterin complex protects chromosome ends from aberrant DNA repair and regulates telomerase access to telomeres. Shelterin is composed of six pro…

www.sciencedirect.com

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Mia Levine @levine-lab.bsky.social · Aug 24

Hey Drosophilists: Might you maintain Fuyama's original gynogenetic "gyn-F9" (BDSC #5353) stock in your library?

The current stock from Bloomington is not producing progeny with ms(k81) males.

Thank you!!!

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Reposted by Mia Levine

FlyBase @flybase.bsky.social · Aug 15

FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...

FlyBase:Contribute to FlyBase - FlyBase Wiki

wiki.flybase.org

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Eric Joyce @ericjoyce.bsky.social · Aug 14

🚨New preprint from the lab🚨
🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK.
www.biorxiv.org/content/10.1...

Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide Imaging Screen

The nuclear periphery is a key site for heterochromatin organization in eukaryotic cells, where lamina-associated domains (LADs) promote transcriptional repression and genome stability. Despite their ...

www.biorxiv.org

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Reposted by Mia Levine

Peter Sudmant @psudmant.bsky.social · Aug 13

The Sudmant lab at UC Berkeley is seeking a postdoc to work on a fully funded NIH project to understand differences in DNA repair and somatic mutation across the primate tree of life. Please spread widely to those who may be interested aprecruit.berkeley.edu/JPF05052

Postdoctoral Scholar – Genomics, Aging, Somatic Mutation, Structural Variation, Evolution , Cancer – Integrative Biology

University of California, Berkeley is hiring. Apply now!

aprecruit.berkeley.edu

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PlantEvolution 🌱🌾 @plantevolution.bsky.social · Aug 10

Wonderful (and humble) essay on mentorship by Brandon Gaut, on occasion of Brandon receiving the inaugural Mentorship Award of @genetics-gsa.bsky.social. I hope this will be widely read!

academic.oup.com/genetics/art...

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Julius Brennecke @juliusbrennecke.bsky.social · Aug 3

piRNAs are essential for transposon silencing in the animal germline.
But how do hosts trap transposon sequences in genomic loci that help establish a piRNA response?

Looking at a natural transposon invasion, Baptiste Rafanel and Kirsten Senti made some remarkable observations.

bioRxiv Genetics @biorxiv-genetic.bsky.social · Aug 1

Antisense transposon insertions into host genes trigger piRNA mediated immunity https://www.biorxiv.org/content/10.1101/2025.07.28.667215v1

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Julius Brennecke @juliusbrennecke.bsky.social · Jul 29

last call!
submit your abstract by tonight to be selected for one of the many oral presentations at the leading European Transposon Meeting. We are very much looking forward to your contribution and attendance!

EMBL Events @events.embl.org · Jun 18

⏰ Abstract deadline for 'The mobile genome' is 29 July!

👉 https://s.embl.org/mge25-01-bl

Join us 4–7 Nov 2025 at EMBL Heidelberg (or online) to explore the impact of TEs across biology. 🧬🔍

⭐🧑🏼‍🔬 24 talks + 15 flash talks from posters – don't miss out!

#EMBOMobileGenome

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Reposted by Mia Levine

EvolDir @evoldir.bsky.social · Jul 24

The Mathieson Lab at the University of Pennsylvania is hiring a computational postdoc in machine learning and evolutionary biology. Apply with a CV and references: [email protected]. More info: https://saramathieson.github.io/lab #postdoc

We are a computational lab focusing on developing machine learning algorithms for biological data. Currently we are working on inference tasks related to natural selection and demographic inference, as well as generative models for genomic data from humans, mosquitos, and other species.

saramathieson.github.io

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Reposted by Mia Levine

Nandita Garud @nanditagarud.bsky.social · Jul 22

I am seeking a postdoc for my group at UCLA. We work at the intersection of population genetics x microbiome (garud.eeb.ucla.edu). If interested, please message me!

Garud Lab

garud.eeb.ucla.edu

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Abby Buchwalter @abbybuch.bsky.social · Jul 22

Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...

The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate - Nature Cell Biology

Marin et al. report the role of lamin proteins and the lamin B receptor (LBR) in chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse embryonic stem cells leads to h...

www.nature.com

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Reposted by Mia Levine

Guillaume Bourque @guilbourque.bsky.social · Jul 21

Is the annotation of viruses in the human genome accurate? We think not. Take a look at our new paper and let us know if you agree! www.science.org/doi/10.1126/...

A phylogenetic approach uncovers cryptic endogenous retrovirus subfamilies in the primate lineage

A phylogenetic approach reveals cryptic LTR subfamilies and functional insights at nucleotide resolution in primates.

www.science.org

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Reposted by Mia Levine

Julian Stingele @jstingele.bsky.social · Jul 21

Now peer reviewed and in its final form @natcomms.nature.com

www.nature.com/articles/s41...

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