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Colin Conine

@colinconine.bsky.social

630 followers 450 following 26 posts

Small RNA biologist at UPenn & CHOP www.coninelab.com Interested in small RNAs, germlines, inheritance, sports, and Shiba Inu’s

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Colin Conine @colinconine.bsky.social · Apr 16

The first C. elegans paper from lab! We find that, similar to mammals, tRNA-fragments (or the new name in the field tDRs) accumulate in worm sperm and can transmit non-genetically inherited phenotypes to offspring. We also find an RNase that regulates their processing, showing that length matters

bioRxivpreprint @biorxivpreprint.bsky.social · Apr 16

tRNA-derived RNA processing in sperm transmits non-genetically inherited phenotypes to offspring in C. elegans https://www.biorxiv.org/content/10.1101/2025.04.14.648817v1

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Reposted by Colin Conine

Matthew Neville @mattneville.bsky.social · 7h

Now published! Our paper on:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...

Sperm sequencing reveals extensive positive selection in the male germline - Nature

A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.

www.nature.com

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Reposted by Colin Conine

Vladimir (Vova) Seplyarskiy @vseplyarskiy.bsky.social · 6h

Our paper on clonal expansions in Sperm is out in Nature www.nature.com/articles/s41...
If you are interested in working at an intersection of Mendelian genomics/Population genetics/Clonal expansions +Cancer genetics/ and of course mutagenesis, please rich out about postdoc in my lab

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Reposted by Colin Conine

Nature Biotechnology @natbiotech.nature.com · 1d

Generation of modified cows and sheep from spermatid-like haploid embryonic stem cells go.nature.com/42wdD05

Generation of modified cows and sheep from spermatid-like haploid embryonic stem cells - Nature Biotechnology

Haploid embryonic stem cells for cattle and sheep are produced, opening new reproductive possibilities.

go.nature.com

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Reposted by Colin Conine

bioRxivpreprint @biorxivpreprint.bsky.social · 2d

Protamine lacunae preserve the paternal chromatin landscape in sperm https://www.biorxiv.org/content/10.1101/2025.10.03.680364v1

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Reposted by Colin Conine

Mia Levine @levine-lab.bsky.social · 4d

Check out this new Levine-Lampson collaboration, led by the talented Hyuk-Joon Jeon.

We explored the consequences of inheriting long telomeres from dad and short telomeres from mom. Or the reciprocal. Turns out, parent-of-origin matters (in mice, at least).

authors.elsevier.com/c/1loW-3QW8S...

authors.elsevier.com

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Colin Conine @colinconine.bsky.social · 7d

Do you think it’s actually a miRNA? Any evidence of it loaded into Ago ?

Colin Conine @colinconine.bsky.social · 8d

Mouse miR-6236 comes up as very abundant in longer mRNA-seq (polyA and ribo-depletion). Also seems to have homology to rRNA

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Reposted by Colin Conine

Yogesh Goyal @goyallab.bsky.social · 19d

**POSTDOC POSITION** My lab (www.goyallab.org) at Northwestern and CZ Biohub Chicago looking for a postdoctoc in quantitative biology. We work on a range of topics, including single-cell cancer plasticity, modeling single-cell perturbations, theory, and stem-embryo models. contact via email. Pls RT

Goyal Lab

www.goyallab.org

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Reposted by Colin Conine

Dave Shechner @shechnerlab.bsky.social · 18d

AWESOME CONFERENCE ALERT!!

I had an absolute blast at the Fusion “Genome Regulation Through RNA” meeting back in 2024, and psyched to see its upcoming return! Let’s geek out about all things Chromatin and RNA together, in Cancun!

Talk abstract deadline: 10/17

Details👇

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Reposted by Colin Conine

Nicolas Robine @nicorobine.bsky.social · 20d

"Transposable elements are vectors of recurrent transgenerational epigenetic inheritance"
Congrats Vincent Colot and team!
www.science.org/doi/10.1126/...

Transposable elements are vectors of recurrent transgenerational epigenetic inheritance

DNA methylation loss at transposable elements (TEs) can affect neighboring genes and be epigenetically inherited in plants, yet the determinants and significance of this additional system of inheritan...

www.science.org

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Reposted by Colin Conine

Eric Joyce @ericjoyce.bsky.social · 22d

We’re excited to share that, after receiving many requests each year from the research community for Oligopaint DNA & RNA FISH probes, we’re piloting a service to design & prepare probes for labs.
Please share with colleagues who may benefit!
ericjoycelab.com/oligopaint-f...

Oligopaint Probe Requests

In an effort to make Oligopaint FISH probes more broadly available to the research community, we offer DNA and RNA FISH probe design, synthesis, and generation. By dedicating a full-time staff memb…

ericjoycelab.com

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Reposted by Colin Conine

Ai Ing Lim @aiinglim.bsky.social · 28d

LIMmunity is growing! 🤰🤱👶

We are looking for curious & driven postdocs to join us at @princetonmolbio.bsky.social & HHMI to explore the fascinating world of maternal-offspring immune partnerships!

Come be part of our collaborative team!

hhmi.wd1.myworkdayjobs.com/en-US/Extern...

Postdoctoral Scientist- Lim Lab

Primary Work Address: Dept of Molecular Biology, Princeton, NJ, 08544 Current HHMI Employees, click here to apply via your Workday account. The Lim Lab at Princeton University is seeking an energetic,...

hhmi.wd1.myworkdayjobs.com

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Reposted by Colin Conine

Victor Ambros @vambros.bsky.social · Sep 7

Sad to hear that David Baltimore died. I am one of hundreds of scientists that David generously mentored, supported, and inspired. His influence on each of us was deep and lasting, and his impact on the world immeasurable. Arguably David Baltimore is one of the greatest scientists of any generation.

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Reposted by Colin Conine

fly paper broadcast @fly-broadcast.bsky.social · Sep 6

Target RNA recognition drives PIWI^∗ complex assembly for transposon silencin#Drosophilala

Target RNA recognition drives PIWI<sup>∗</sup> complex assembly for transposon silencing #Drosophila

PubMed link

pubmed.ncbi.nlm.nih.gov

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Reposted by Colin Conine

Luisa Cochella @lcochella.bsky.social · Sep 3

Our work on the function of miR-51/miR-100 is out! miR-100 is widely conserved across eumetazoans but its function has been mysterious. Emilio Santillán found in worms it regulates signaling and extracellular matrix genes, some of which seem to be conserved targets! www.science.org/doi/10.1126/...

An ancient and essential miRNA family controls cellular interaction pathways in C. elegans

A microRNA that arose at the origin of eumetazoans regulates cell adhesion and signaling in C. elegans through conserved targets.

www.science.org

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Reposted by Colin Conine

Patrick Phillips @patrickphillips.bsky.social · Sep 2

Just out in press in eLife, a cool and brilliant piece of work by @amywebster.bsky.social: Gene expression variation across genetically identical individuals predicts reproductive traits. elifesciences.org/articles/106...

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Reposted by Colin Conine

M. Kabir @mkabir.bsky.social · Aug 30

“Blind obedience to authority is the greatest enemy of truth.”

— Albert Einstein (1879–1955)

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Reposted by Colin Conine

Maureen Barr @barrlab.bsky.social · Aug 29

🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯🤯

Transcription factors SP5 and SP8 drive primary cilia formation in mammalian embryos | Science www.science.org/doi/10.1126/...

Transcription factors SP5 and SP8 drive primary cilia formation in mammalian embryos

Although specific transcription factors (TFs) are known to regulate cell fate decisions, the degree to which they can stimulate formation of specific cell organelles is less clear. We used a multiomic...

www.science.org

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Colin Conine @colinconine.bsky.social · Aug 28

I had this as a kid! They make these heel cup things that help

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Julia Wittes @jwittes.bsky.social · Aug 27

My new paper is out in Current Biology!

Insulin signaling activity in the somatic gonad controls dauer entry via the germ line in C. elegans

C. elegans dauer diapause is a facultative state of cellular and developmental quiescence that enables survival in adverse conditions. Przybyl et al. show that a canonical insulin signaling pathway ac...

www.cell.com

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Reposted by Colin Conine

The Allard lab @allard-lab-ucla.bsky.social · Aug 25

🚨 New paper alert from our lab! Using model system and in vitro approaches, we demonstrate that PFAS, likely due to their physicochemical properties as surfactant, disrupt liquid-like condensates critical for reproduction. Link: academic.oup.com/toxsci/advan...

#PFAS #Toxicology #SystemsToxicology

A systems toxicology approach implicates post-transcriptional regulatory networks in reproductive defects from PFAS exposure

Abstract. Per- and polyfluoroalkyl substances (PFAS) are highly persistent in the environment and widespread in consumer products, environmental media, and

academic.oup.com

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Colin Conine @colinconine.bsky.social · Aug 23

All this was done in mice but the cherry on top is that we find that many of the sperm mRNAs we characterize are conserved and expressed in human sperm

Colin Conine @colinconine.bsky.social · Aug 23

Further >200 nt sperm RNA regulated postfertilization gene expression more than total RNA suggesting that sperm RNAs outside of small RNAs can influence early embryogenesis

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Colin Conine @colinconine.bsky.social · Aug 23

We did these injections with total and >200 nt “big” RNA isolated from sperm. Single parthenote/embryo RNA-seq revealed that big sperm RNA regulates preimplantation embryonic gene expression of parthenotes to more closely resemble normal developmental gene expression in sperm fertilized embryos

Colin Conine @colinconine.bsky.social · Aug 23

By additionally performing RNA-seq on eggs and zygotes we found that there are many mRNAs, including ones transferred to sperm by the epididymis, that accumulate in zygotes after fertilization. To determine if sperm mRNAs have postfertilization functions we performed parthenote RNA microinjections