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Dave Shechner

@shechnerlab.bsky.social

1.7K followers 2.5K following 110 posts

The Shechner lab in UW Pharmacology. We study Noncoding RNAs and cellular architecture, and we build “democratized” RNA-focused chemical biology and genomics tools. He/His/Him. Almost cartainly not D.B. Cooper ShechnerLab.org

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Dave Shechner @shechnerlab.bsky.social · Nov 21

It's my great pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture.
If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)

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Dave Shechner @shechnerlab.bsky.social · 19d

AWESOME CONFERENCE ALERT!!

I had an absolute blast at the Fusion “Genome Regulation Through RNA” meeting back in 2024, and psyched to see its upcoming return! Let’s geek out about all things Chromatin and RNA together, in Cancun!

Talk abstract deadline: 10/17

Details👇

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Dave Shechner @shechnerlab.bsky.social · 19d

Yay! Welcome welcome!!

Dave Shechner @shechnerlab.bsky.social · Aug 7

Holy moly, that’s awesome!! Congrats, Rita!!

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Dave Shechner @shechnerlab.bsky.social · Aug 2

I’m a bit late to the game here, but wanted to highlight this very clever technique from @paraspeckle.bsky.social’s group! Congrats to all authors!!

Miha Modic @paraspeckle.bsky.social · Jun 2

New method drop:
HCR-Proxy, a modular proximity labelling approach to profile local proteome composition around RNA at nanoscale, subcompartmental resolution. Thereby we resolved nested nucleolar layers and uncovered the grammar of spatial protein partitioning.
www.biorxiv.org/content/10.1...

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Dave Shechner @shechnerlab.bsky.social · Aug 2

A day late but STILL IMPORTANT

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Dave Shechner @shechnerlab.bsky.social · Jul 23

Woohoo! So psyched to see this awesome work from the Jovanovic lab out in the world! Congrats to all the authors on this tour-de-force!

www.cell.com/cell/fulltex...

SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress

SPIDR, a massively multiplexed method that simultaneously maps dozens of RNA-binding proteins to their RNA targets at single-nucleotide resolution, uncovers new RNA-protein interactions and provides c...

www.cell.com

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Dave Shechner @shechnerlab.bsky.social · Jul 1

Aw man, the pleasure was all mine!! 🙏🙏🙏

Dave Shechner @shechnerlab.bsky.social · Jul 1

What is Phthalo Bluegrass?

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Dave Shechner @shechnerlab.bsky.social · Jul 1

Thanks, Dan!!

Dave Shechner @shechnerlab.bsky.social · Jul 1

a man in a bowling alley says " yeah well that 's just like your opinion man . "

ALT: a man in a bowling alley says " yeah well that 's just like your opinion man . "

media.tenor.com

Dave Shechner @shechnerlab.bsky.social · Jun 30

Thanks!! I hope you enjoy it!

Dave Shechner @shechnerlab.bsky.social · Jun 30

Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit!

tinyurl.com/ydn6e3ac

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Dave Shechner @shechnerlab.bsky.social · Apr 10

They will take over the middle parts of our feeds, surely.

Dave Shechner @shechnerlab.bsky.social · Apr 10

www.tiktok.com/@yayalexisga...

when you love the em-dash #punctuation #grammar #writing #comedy

TikTok video by Alexis Gay

www.tiktok.com

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Dave Shechner @shechnerlab.bsky.social · Apr 10

Invariably there’s a moment in all of my trainees’ careers where I have to explain the difference between hyphens, en-dashes, and em-dashes, and they look at me like, “what happened to you?!” And I just kinda’ stare off to space and wonder the same thing…

Dave Shechner @shechnerlab.bsky.social · Mar 15

Ridiculous. There’s no fourth month…

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Dave Shechner @shechnerlab.bsky.social · Mar 14

FUN FACT:
In Europe, they celebrate #PiDay on the 3rd day of the 14th month.

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Dave Shechner @shechnerlab.bsky.social · Feb 5

Who is the Grammar Hammer?

Dave Shechner @shechnerlab.bsky.social · Jan 22

But that pentavalent carbon though…

Dave Shechner @shechnerlab.bsky.social · Dec 31

TOP FIVE METABOLIC PATHWAYS
…Based on whether they sound like the name of an old-school anime:

5. The Pentose-Phosphate Shunt

4. Peptidoglycan Degradation

3. Fatty Acid Beta-Oxidation

2. The Dark Reactions of the Calvin Cycle

1. Gluconeogenesis

Dave Shechner @shechnerlab.bsky.social · Dec 20

Such awesome work from @nandangokhale.bsky.social, @ramlabuw.bsky.social, and colleagues! Fantastic seeing this paradigm-changing study out in the wild. Congrats, everyone!

Nandan Gokhale @nandangokhale.bsky.social · Dec 19

Our work on cellular RNA interactions with MAVS that promote antiviral signaling is finally live. So grateful to our indispensable collaborators as well as reviewers who helped to strengthen our work. #RNA #innateimmunity #virology

@ramlabuw.bsky.social

www.science.org/doi/10.1126/...

Cellular RNA interacts with MAVS to promote antiviral signaling

Antiviral signaling downstream of RIG-I–like receptors (RLRs) proceeds through a multi-protein complex organized around the adaptor protein mitochondrial antiviral signaling protein (MAVS). Protein co...

www.science.org

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Dave Shechner @shechnerlab.bsky.social · Dec 19

Good gravy, I have the keyboard shortcuts for all of these memorized, and I just don't know what to do with my life.

Dave Shechner @shechnerlab.bsky.social · Dec 19