Lightnews — Scholar-powered news

Nandan Gokhale @nandangokhale.bsky.social · 4d

Wonderful opportunity. Go join Emmanuelle’s lab!

Emmanuelle Genoyer @immunuelle.bsky.social · 5d

Excitingly, we are now hiring at all levels!! Please reach out if you are interested in RNA viruses, viral replication, innate immunity, RNA imaging, or are just excited about having fun doing cool science! Information about specific positions here www.genoyerlab.com/join

Join — Genoyer Lab

www.genoyerlab.com

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Reposted by Nandan Gokhale

Emmanuelle Genoyer @immunuelle.bsky.social · 5d

I'm thrilled to announce I'll be joining the Department of Molecular Genetics & Microbiology at the University of Florida in January 2026! My lab will study RNA virus-host interactions with a particular focus on the spatial regulation of viral replication and innate immune activation. genoyerlab.com

Genoyer Lab

genoyerlab.com

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Reposted by Nandan Gokhale

Jordan Meier @doc-jlmeier.bsky.social · Apr 5

Last Saturday morning ☕ saved for this gem:

www.science.org/doi/10.1126/...

CRISPR screening reveals TRIM25 as a pH-sensitive sensor that specifically targets foreign RNAs entering through endosomes. N1-methylpseudouridine helps repel TRIM25 binding & enhances protein production.

Exogenous RNA surveillance by proton-sensing TRIM25

Exogenous messenger RNAs (mRNAs) require cellular machinery for delivery and translation but also encounter inhibitory factors. To investigate their regulation, we performed genome-wide CRISPR screens...

www.science.org

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Nandan Gokhale @nandangokhale.bsky.social · Apr 1

Congrats to Julian and others from @ramlabuw.bsky.social on this cool work that finds that the loss of the RNA-binding protein CELF2 leads to accumulation of endogenous RIG-I ligands! #RNA #innateimmunity #IFNs

Ram Savan @ramlabuw.bsky.social · Apr 1

CELF2 suppresses immunostimulatory endogenous RNAs that activate the RIG-I-MAVS pathway in macrophages, preventing type I IFN-signature. Congrats to Julian Smith, Olivia Kern, and all the co-authors for their hard work! #innateimmunity #dsRNA #IFN

www.biorxiv.org/content/10.1...

www.biorxiv.org

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Nandan Gokhale @nandangokhale.bsky.social · Jan 28

Chicken Soup for the Scientist's Soul

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Nandan Gokhale @nandangokhale.bsky.social · Jan 11

Really cool work from @thehornerlab.bsky.social and colleagues highlighting a role for the UFMylation post-translational modification system in flavivirus viral particle production!

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · Jan 10

UFMylation promotes orthoflavivirus infectious particle production https://www.biorxiv.org/content/10.1101/2025.01.09.632082v1

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Reposted by Nandan Gokhale

Arjun Raj @arjunraj.bsky.social · Jan 2

Reposting my offer for 1-1 mentoring for anyone… email me and we'll find a time! Especially happy to talk with those from diverse backgrounds and non-traditional career trajectories.

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Reposted by Nandan Gokhale

Chris Brooke @christopherbrooke.bsky.social · Sep 9

We have an open faculty search for TWO positions in microbiology and virology at the University of Illinois! We have world class core facilities and a fantastic collaborative group of young faculty...you could be next!
Please re-post/skeet!

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Nandan Gokhale @nandangokhale.bsky.social · Dec 21

Thanks Alex!

Nandan Gokhale @nandangokhale.bsky.social · Dec 21

Yes! I'm wondering the same thing :D

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Nandan Gokhale @nandangokhale.bsky.social · Dec 21

Thanks Dave!!!

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Nandan Gokhale @nandangokhale.bsky.social · Dec 20

Thanks Sunny!

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Nandan Gokhale @nandangokhale.bsky.social · Dec 20

Thank you Marco!

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Nandan Gokhale @nandangokhale.bsky.social · Dec 20

I am so excited to join the faculty in the Division of Immunobiology at Cincinnati Children's Hospital Medical Center in March 2025. My lab will study how RNA biology regulates and is regulated by infection and immunity.

We'll be hiring at all levels in 2025 - stay tuned!

www.gokhalelab.com

Cincinnati Children’s Research @cincyresearch.bsky.social · Dec 19

Excited that @nandangokhale.bsky.social plans to join the faculty at Cincinnati Children's in March! Check out the UW story about the study: www.eurekalert.org/news-release...

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Reposted by Nandan Gokhale

Waggoner Lab @labwaggoner.bsky.social · Dec 19

Cellular RNAs directly regulate the activity of an antiviral immune signaling complex
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
@science.org @nandangokhale.bsky.social @ramlabuw.bsky.social

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Reposted by Nandan Gokhale

Sarah Ross @sarahhross.bsky.social · Dec 19

This Perspective by Sonja Best and Adam Hage puts tuning the MAVS signalosome by cellular mRNAs into context.

buff.ly/4fxVMcx

#Immunology @science.org

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Reposted by Nandan Gokhale

Sarah Ross @sarahhross.bsky.social · Dec 19

#Immunology out now @science.org

An unstructured region within MAVS interacts with cellular, rather than viral, RNA. This alters how MAVS interacts with other proteins and influences antiviral responses.

https://buff.ly/4grnf18

By @nandangokhale.bsky.social with @ramlabuw.bsky.social et al.

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Nandan Gokhale @nandangokhale.bsky.social · Dec 19

We are grateful for this perspective on our work authored by Sonja Best and Adam Hage

www.science.org/doi/10.1126/...

Platform influencers—host RNA control of antiviral immunity

Cellular RNAs directly regulate the activity of an antiviral immune signaling complex

www.science.org

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Nandan Gokhale @nandangokhale.bsky.social · Dec 19

Here’s a tweetorial/BSorial? of the preprint that highlights our key findings

bsky.app/profile/nand...

Nandan Gokhale @nandangokhale.bsky.social · Sep 26

m7GpppNm - VERY EXCITED to share my postdoctoral work in @ramlabuw.bsky.social’s lab, now @bioRxiv. We find that cellular RNA interacts with MAVS, the adaptor protein of the RIG-I-like receptor pathway, to promote antiviral signaling. A 🧵:

bioRxiv Immunology @biorxiv-immuno.bsky.social · Sep 26

Cellular RNA interacts with MAVS to promote antiviral signaling https://www.biorxiv.org/content/10.1101/2023.09.25.559083v1

Nandan Gokhale @nandangokhale.bsky.social · Dec 19

Our work on cellular RNA interactions with MAVS that promote antiviral signaling is finally live. So grateful to our indispensable collaborators as well as reviewers who helped to strengthen our work. #RNA #innateimmunity #virology

@ramlabuw.bsky.social

www.science.org/doi/10.1126/...

Cellular RNA interacts with MAVS to promote antiviral signaling

Antiviral signaling downstream of RIG-I–like receptors (RLRs) proceeds through a multi-protein complex organized around the adaptor protein mitochondrial antiviral signaling protein (MAVS). Protein co...

www.science.org

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Nandan Gokhale @nandangokhale.bsky.social · Nov 30

Will email you to set up a locus!

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Nandan Gokhale @nandangokhale.bsky.social · Nov 30

Do you have any spare ploidy this month? Would love to take you to lunch/coffee/drinks as a thank you!

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Reposted by Nandan Gokhale

Simon Bekker-Jensen lab @bekkerjensenlab.bsky.social · Nov 26

Time for our first post here 🥳 Our latest paper is online 🙌
We show that UV activates the ribotoxic stress response, which causes inflammation, cell death and thickening in skin. Read about a role for the RSR separate from DNA damage signaling in response to sunburn: ✨☀️ www.cell.com/molecular-ce...

The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo

The acute skin reaction to sunburn, encompassing keratinocyte cell death, inflammation, and epidermal thickening, has traditionally been ascribed to DNA damage responses. Using a mouse model deficient...

www.cell.com

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Nandan Gokhale @nandangokhale.bsky.social · Nov 22

Really interesting work by Rachel van Gelder and the @ramlabuw.bsky.social lab! #RNA #immunity

Ram Savan @ramlabuw.bsky.social · Nov 22

Rachel Van Gelder, a recently minted PhD from the lab, shows IL-2 splices IFNG mRNA introns, increasing protein levels via NF-κB signaling. She uncovers a novel role for cytokine-induced splicing in immunity! 🧬 #RNA #Immunology #Research

www.embopress.org/doi/full/10....

Interleukin-2-mediated NF-κB-dependent mRNA splicing modulates interferon gamma protein production | EMBO reports

imageimageIL-2 stimulation post-transcriptionally enhances splicing of IFNG mRNA in NK cells. Further, NF-κB signaling downstream of the IL-2 receptor is required for IFNG mRNA processing. IL-12 and ...

www.embopress.org

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Reposted by Nandan Gokhale

Lee Grimes Lab @leegrimeslab.bsky.social · Nov 20

CHMC Division of Immunobiology is hiring Assistant Professors. You can have a lab next to mine if you like.

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