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Albert Vilella, PhD. @albertvilella.bsky.social · 2h

Original from @marcseitz, not on #Bluesky

Albert Vilella, PhD. @albertvilella.bsky.social · 2h

#biotech #VCs #VentureCapital

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Albert Vilella, PhD. @albertvilella.bsky.social · 5h

skywriter.blue/pages/did:pl...

Page by Albert Vilella, PhD. | @albertvilella.bsky.social

@ewanbirney.bsky.social on the new version of Alphafold at the @emblebi.bsky.social www.ebi.ac.uk AlphaFold has been a transformation not just in structural biology but also - due to its ability to b...

skywriter.blue

Albert Vilella, PhD. @albertvilella.bsky.social · 5h

providing intuitive displays and deep APIs for its use, and the ability to embed into other websites open to all. It truly has democratised this key technology.

This doesn't stand still as this post from Sameer Velankar and team show - more proteins - more data - more insight!

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Albert Vilella, PhD. @albertvilella.bsky.social · 5h

A huge part of this broad reach has been the collaboration between European Bioinformatics Institute | EMBL-EBI and Google DeepMind on AlphaFoldDB - AlphaFold database - running AlphaFold as baseline for all known proteins,

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Albert Vilella, PhD. @albertvilella.bsky.social · 5h

@ewanbirney.bsky.social on the new version of Alphafold at the @emblebi.bsky.social
www.ebi.ac.uk/about/news/t...
AlphaFold has been a transformation not just in structural biology but also - due to its ability to be applied to all proteins - to molecular biology as a whole.

EMBL-EBI and Google DeepMind renew partnership and release update to AlphaFold Database

Deeper collaboration between EMBL-EBI and Google DeepMind brings updates to the AlphaFold Database.

www.ebi.ac.uk

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Albert Vilella, PhD. @albertvilella.bsky.social · 7h

@shanumathew.bsky.social , not active on Bluesky, on the xAI deal with Nvidia

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Albert Vilella, PhD. @albertvilella.bsky.social · 8h

skywriter.blue/pages/did:pl...

Page by Albert Vilella, PhD. | @albertvilella.bsky.social

@nobelprize.bsky.social Our immune system is an evolutionary masterpiece. Every day it protects us from the thousands of different viruses, bacteria and other microbes that attempt to invade our bodi...

skywriter.blue

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Albert Vilella, PhD. @albertvilella.bsky.social · 8h

The BEACONS study will recruit, consent, and enroll up to 30,000 newborns in as many as 10 states over the next three years.
Presumably with Illumina sequencing as they are a member of the consortium.

Albert Vilella, PhD. @albertvilella.bsky.social · 8h

GeneDx Announces First U.S. National Genomic Newborn Screening Initiative Launched with $14.4 Million NIH Award
ir.genedx.com/news-release...

ir.genedx.com

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Albert Vilella, PhD. @albertvilella.bsky.social · 8h

‘BEACONS,’ a multi-state collaboration led by Mass General Brigham and Ariadne Labs, will enroll up to 30,000 newborns to explore adding genomic sequencing in U.S. newborn screening

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Albert Vilella, PhD. @albertvilella.bsky.social · 8h

GeneDx Announces First U.S. National Genomic Newborn Screening Initiative Launched with $14.4 Million NIH Award
ir.genedx.com/news-release...

ir.genedx.com

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Albert Vilella, PhD. @albertvilella.bsky.social · 1d

#Bioinformatics

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Reposted by Albert Vilella, PhD.

Sung Kim @sungkim.bsky.social · 1d

Meta open-sources OpenZL

A new data compression library and training tools to generator specialized compressors for structured data, achieving performance levels inaccessible to classic generic algorithms.

github.com/facebook/ope...

GitHub - facebook/openzl: A novel data compression framework

A novel data compression framework. Contribute to facebook/openzl development by creating an account on GitHub.

github.com

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Albert Vilella, PhD. @albertvilella.bsky.social · 1d

In the last 5 years, $AAPL, $AMZN, $META, $MSFT, and $GOOGL have generated a TOTAL of $1.4T of FCF in those 5 years.

Albert Vilella, PhD. @albertvilella.bsky.social · 1d

@rihardjarc, not on Bluesky:
Ok, all great, but where is the MONEY going to come from?

OAI, now with Stargate, $NVDA, and now $AMD, has said to spend and build 26GW of data centers in the next few years. 1GW = $60B. So the total "committed" spend is now at $1.56T.

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Reposted by Albert Vilella, PhD.

Eric Topol @erictopol.bsky.social · 2d

Exercising fathers, enhanced endurance and metabolic heath in offspring, through sperm microRNAs (as demonstrated in mice)
www.cell.com/cell-metabol...

Paternal exercise confers endurance capacity to offspring through sperm microRNAs

Yin et al. show that paternal exercise improves offspring endurance capacity and metabolic health via sperm microRNAs that reprogram gene expression in early embryos, revealing how exercise benefits c...

www.cell.com

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Albert Vilella, PhD. @albertvilella.bsky.social · 1d

@adrianoaguzzi, not on Bluesky:
"I had a colleague working 15m away from me who spent the past 20 years vehemently attacking the concept of Tregs, to an extent that bordered on obsession. I won't tell who, except that in the 1990s he got the award that was conferred to Shimon a few hours ago."

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Reposted by Albert Vilella, PhD.

bioRxivpreprint @biorxivpreprint.bsky.social · Aug 15

Predicting Experimental Success in De Novo Binder Design: A Meta-Analysis of 3,766 Experimentally Characterised Binders https://www.biorxiv.org/content/10.1101/2025.08.14.670059v1

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Albert Vilella, PhD. @albertvilella.bsky.social · 2d

Good question, I guess it depends on what the definition is...

Albert Vilella, PhD. @albertvilella.bsky.social · 2d

"To be honest, I am worried about all of this spending and the way these deals are structured. The fact that buyers and sellers are starting to mix equity and all this other stuff is just telling at the stage we are in.

We are past the transparent part of I buy & you sell.
"

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Albert Vilella, PhD. @albertvilella.bsky.social · 2d

Damn, in $NVDA's case, OAI buys $NVDA chips and $NVDA gets stake, but in $AMD's case, OAI buys $AMD, but $AMD must give stake.

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Albert Vilella, PhD. @albertvilella.bsky.social · 2d

@rihardjarc, not on #Bluesky, on the Big deal btw OpenAI and $AMD.

OAI could take a 10% stake in $AMD. OAI will deploy up to 6 GW of $AMD GPUs over multiple years beginning in 2026, with 1 GW.

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Albert Vilella, PhD. @albertvilella.bsky.social · 2d

However, our immune system turned out to be more complex than they believed. Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi have been awarded the 2025 Nobel Prize in Physiology or Medicine for their discoveries concerning peripheral immune tolerance.

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Albert Vilella, PhD. @albertvilella.bsky.social · 2d

Researchers long believed they knew the answer to these questions: that immune cells mature through a process called central immune tolerance (see image).

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Albert Vilella, PhD. @albertvilella.bsky.social · 2d

Many have also developed similarities to human cells, as a form of camouflage. So how does the immune system keep track of what to attack and what to protect? Why doesn’t the immune system attack our bodies more frequently?

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