Delighted to share our latest review in Nature Reviews Neuroscience!
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...

Congratulations Silvia, I look forward to reading it ☺️

Delighted to welcome a new Group Leader to our flagship vascular dementia research centre with @thebhf.bsky.social 🎉👏

Prof Catherine Hall @cathnaledi.bsky.social and her team will examine how changes in blood flow & oxygen supply drive the onset of vascular dementia & Alzheimer’s👉 buff.ly/gyouoEV

Come and join us in Manchester... We are looking for candidates interested in vascular health and neurodegeneration. This project is specifically exploring how menopause may increase Alzheimer's risk.
We also have a postdoc position available: www.jobs.manchester.ac.uk/Job/JobDetai...

Why does dementia hit women harder? It’s more than longer life spans.

🧠 Higher risk
⚡ Faster decline
🧑‍🤝‍🧑 Unpaid care burden
🧪 Underrepresented in trials & leadership

Job ad is live

Apply here 👇🏼

jobsite.sheffield.ac.uk/job/Research...

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We have a @thebhf.bsky.social funded postdoc position to work on a novel treatment option to improve cerebral blood flow in a model of vascular dementia. Application deadline 14th April. @gjbrainresearch.bsky.social www.jobs.manchester.ac.uk/internal/Job... Please RT

Hiring soon!
I am looking for a preclinical imaging physicist with MRI experience. We will be investigating gas exchange in the mammalian brain, with a particular focus on oxygen. Using a gas contrast agent to ask fundamental questions about gas exchange and cerebral perfusion #hiring #neuroscience

We term this early and remote decrease in the cerebral draining veins, “The B of the Bang” for neurovascular coupling.

Investigating whether this locomotion-induced haemodynamic response was altered in disease, we showed AD mice (APP/PS1) had a smaller HbT decrease in the draining vein than mixed disease mice (APP/PS1 combined with atherosclerosis, MIX).

When we looked at overlying meningeal vessels (MN), we also observed a decrease in HbT at the onset of locomotion, which unlike within the draining vein (which is contained within the cortex) did not go on to exceed baseline HbT levels for the remainder of the locomotion response.

We show locomotion evokes an initial decrease in total haemoglobin (HbT) in the draining vein, before the WBR HbT increase. Whilst the size of the locomotion event impacts the HbT response magnitude within WBR vessels, this is not true for the early HbT decrease within the draining veins (DV).

Within somatosensory cortex, responses were taken from pial vessels inside the whisker barrel region ([WBR]: "whisker artery" and "whisker vein"), a large vein from the sagittal sinus adjacent to the WBR (draining vein), and meningeal vessels from the dura mater (don't penetrate cortex).