Lightnews — Scholar-powered news

Reposted by Karl Carlström

Yizhou Hu(Eugene) @yizhoueugene.bsky.social · 28d

Our study on neuroblastoma developmental plasticity is the cover story in the latest issue of Dev. Cell @cp-devcell.bsky.social .The Chinese-ink Taiji (Yin–Yang) cover to echo cell-state transitions. Huge thanks to the editors, co-authors. #Neuroblastoma www.cell.com/developmenta...

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Reposted by Karl Carlström

Mattia Zaghi @matzag.bsky.social · 28d

A few weeks ago, I had to discuss about DynaTag, a smart tweak to CUT&Tag that enables single-cell transcription factor mapping with just a buffer change.
Opening a number of future avenues.
📰 Via
@GenomeWeb
: lnkd.in/djYm_sGg
#epigenetics #singlecell

This link will take you to a page that’s not on LinkedIn

lnkd.in

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Reposted by Karl Carlström

Jeppe D Larsen @jeppedlarsen.bsky.social · Sep 6

Min vän Jovan har startat cykelverkstad i Gubbängens centrum cykelnomad.com. Blev en räddad palm som inflyttningspresent. Vi jobbade tillsammans för 10 år sedan och han har jobbat heltid som cykelmekaniker sen dess. Sprid gärna ordet så han kommer igång ordentligt!

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Reposted by Karl Carlström

Fyodor Urnov @urnov.bsky.social · Sep 7

Of David's countless accomplishments is the important work that Matt Porteus did in his lab on early-stage genome editing with engineered nucleases (pubmed 12730593).
He and Matt both speak about this in the documentary "Human Nature."
A true titan.
www.nytimes.com/2025/09/07/s...

David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87

www.nytimes.com

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Reposted by Karl Carlström

John Doench @johndoench.bsky.social · Sep 7

Doomscrolling pause to chat CRISPR libraries! Preprint describes our new, data-driven approach to combine on-target and off-target predictions much more intelligently for *selecting* guides, which we use to develop our newest Cas9 knockout library, Jacquere. Thread: www.biorxiv.org/content/10.1...

Balancing off-target and on-target considerations for optimized Cas9 CRISPR knockout library design

The continued development of high-dimensional CRISPR screen readouts, such as single-cell RNA sequencing and high-content imaging, necessitates compact libraries to enable functional interrogation at ...

www.biorxiv.org

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Reposted by Karl Carlström

Anna Williams @annawilliamslab.bsky.social · Aug 31

Our new paper on metformin, myelin, mitochondria and metabolism is now out at rdcu.be/eDbFD
Thanks to Nina and all of the team!

Metformin alters mitochondria-related metabolism and enhances human oligodendrocyte function

Nature Communications - Metformin is under clinical trial for brain neuroprotection but how it may work is poorly understood. Here, the authors show that metformin helps myelin formation by human...

rdcu.be

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Reposted by Karl Carlström

Daniel Mucida @danmucida.bsky.social · Aug 29

A careful, comprehensive and creative characterization of T cell dynamics in response to pathogens, with all credits going to @rohamparsa.bsky.social who just opened his lab!

Roham Parsa @rohamparsa.bsky.social · Aug 29

Excited to share our new preprint! We studied how T cells are functionally & clonally shaped across organs over time. With the new TRACK mice, we genetically label recently activated T cells with tdTomato and track their migration across tissues. #immunology #science www.biorxiv.org/content/10.1...

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Reposted by Karl Carlström

Roham Parsa @rohamparsa.bsky.social · Aug 29

Excited to share our new preprint! We studied how T cells are functionally & clonally shaped across organs over time. With the new TRACK mice, we genetically label recently activated T cells with tdTomato and track their migration across tissues. #immunology #science www.biorxiv.org/content/10.1...

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Reposted by Karl Carlström

asabeckman.bsky.social @asabeckman.bsky.social · Aug 24

Träffade SR:s Mellanösternkorrespondent Cecilia Uddén och pratade om Gaza, opartisk journalistik och sorgen efter hennes kärlek Elisabet Ohlson.

Cecilia Uddén: ”Som journalist ska du vara opartisk – men objektiv kan ingen vara”

Cecilia Uddén har hamnat i fokus för debatten om journalistik och opartiskhet.

www.dn.se

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Reposted by Karl Carlström

Gonçalo Castelo-Branco @gocastelobranco.bsky.social · Aug 23

Deadline (September 2) approaching! Join us and start your lab at @ki.se!

Gonçalo Castelo-Branco @gocastelobranco.bsky.social · Jun 25

The call just opened!

ki.se/en/about-ki/...

You can apply to several departments simultaneously, check out which depts better fit your profile! Here is the call for our Department of Medical Biochemistry and Biophysics

ki.varbi.com/what:job/job...

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Reposted by Karl Carlström

Johan Jakobsson @jakobssonlab.bsky.social · Aug 23

New paper from our lab! We found that LINE-1 transposons contribute to early human brain development.

Funded by @asapresearch.parkinsonsroadmap.org

www.cell.com/cell-genomic...

LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development

Adami et al. demonstrate that evolutionarily young L1s are expressed in human pluripotent stem cells and are dynamically regulated throughout neural differentiation. The study examines the role of L1s...

www.cell.com

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Karl Carlström @carlstrom.bsky.social · Aug 18

www.dn.se/debatt/darfo...

DN Debatt. ”Därför slutar jag som statsepidemiolog”

Statsepidemiologen Magnus Gisslén berättar i debattartikel att han tappat sitt förtroende för Folkhälsomyndigheten

www.dn.se

Reposted by Karl Carlström

oZgun Gokce @gokcegroup.bsky.social · Aug 18

I am hiring an halftime administrative assistant for my lab! we are fun dynamic group located in Bonn DZNE. Pls Spread the word.
Learn more & apply
karriereamukb.de/jobs/teamass...

Teamassistenz (m/w/d) Klinik für Alterspsychiatrie und Kognitive Störungen - Karriereamukb | Jobs & Karriere an der Uniklinik Bonn

In der Klinik für Alterspsychiatrie und Kognitive Störungen des Universitätsklinikums Bonn ist zum nächstmöglichen Zeitpunkt folgende Stelle in Teilzeit (19,25 Std. / Woche) zu besetzen. Die Stelle is...

karriereamukb.de

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Reposted by Karl Carlström

Amina Manzoor @aminamnzr.bsky.social · Aug 14

Tillbaka i tjänst och första texten handlar naturligtvis om RFK jr. Det är svårt att ignorera allt som han gör och förstör. (Premium, men kan läsas om man har en prenumeration på någon Bonnier-titel via Plus allt)

Kennedys stopp för mRNA-forskning är en present till antivaxxare

Kennedys pengastopp till mRNA-forskning i USA riskerar att hindra medicinska framsteg. Dessutom ger han antivaxxare ännu fler skäl att misstro myndigheter.

www.expressen.se

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Reposted by Karl Carlström

Gonçalo Castelo-Branco @gocastelobranco.bsky.social · Aug 12

Join us at the FENS Single-Cell & Spatial Omics Winter School with:

@sarabiz86.bsky.social
@rongfan8.bsky.social
@gokcegroup.bsky.social
@gioelelamanno.bsky.social
@sj-marzi.bsky.social
@jplopez-atalaya.bsky.social
Ana Falcão
Florian Rosenberger
Gabriel Baró
Bosiljka Tasic
Barbara Treutlein

Federation of European Neuroscience Societies - FENS @fens.org · Aug 5

🌟 Registration is now OPEN! 🌟

Join the 2025-2026 #FENS-Hertie #WinterSchool and explore this year's topic – Single-cell and Spatial Omics to Understand Brain Heterogeneity! 🔬

📍 Alicante, Spain
🗓️ 11-17 Jan 2026

🔗 https://loom.ly/RM55lFQ

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Reposted by Karl Carlström

Itai Yanai @itaiyanai.bsky.social · Aug 11

The creative process in science has a set of thinking tools that we could do a better job teaching. Here are the 12 articles that Martin and I wrote about them, including "It takes two to think", "A hypothesis is a liability" and "The two languages of science". night-science.org/home/learn/r...

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Karl Carlström @carlstrom.bsky.social · Aug 5

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Reposted by Karl Carlström

Robert Hänsel-Hertsch @epistrucstab.bsky.social · Jul 28

🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)

Image credit: @gloglita.bsky.social‬ @lifescienceeditors.bsky.social‬ captured DynaTag in action: a pA-Tn5 probe (multicoloured) binds an antibody (white), which binds p53 DNA-binding domain (green) on DNA (blue) within 2 nucleosomes

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Reposted by Karl Carlström

Sternberg Lab @sternberglab.bsky.social · Jul 24

1/16 New pre-print from the Sternberg Lab!
We uncover how temperate phages can use RNA-guided transcription factors to remodel the flagellar composition of their bacterial host and enhance their fitness.
Find the preprint and full story here: tinyurl.com/mshwjd77

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Reposted by Karl Carlström

Skalman @owallstromer.bsky.social · Jul 26

Herregud vad uselt chefredaktören på DN svarar. Det är så pinsamt, så skamligt. Återigen: ingen av alla dessa medlöpare och självpåtagna censorer som bidragit till att folkmordet har fått fortgå ohejdat ska någonsin få glömma det.

Jawad Zanganeh @jawadzanganeh.bsky.social · Jul 26

Röstlund: I april dödades flera hjälparbetare av drönare som troligen kom från Elbit. Läsare hörde av sig igen: Varför skriver inte DN att det finns ett miljardavtal med Elbit? Jag ifrågasatte varför vi inte skrev. Jag fick svar av en nyhetschef: Israel har enligt folkrätten rätt att försvara sig.

Därför lämnade grävreportern DN: ”Det har varit svårt att göra journalistik om Gaza” - Medierna

Reportrar och chefer är oense om Gazajournalistik. På Dagens Nyheter har det gått så långt att journalister lämnat sina tjänster.

sverigesradio.se

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Reposted by Karl Carlström

Gonçalo Castelo-Branco @gocastelobranco.bsky.social · Jul 12

12th Dev Brains:

@junyuecao.bsky.social @alainchedotal.bsky.social
@cecilecharrier.bsky.social
@trayon.bsky.social
Isabel Espinosa-Medina
Beatriz Rico
Michael Ziller
Dwight Bergles

news.ki.se/calendar/dev...

@hjerling-leffler.bsky.social
@ulrikakmarklund.bsky.social
@flallemend.bsky.social

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Reposted by Karl Carlström

Gonçalo Castelo-Branco @gocastelobranco.bsky.social · Jul 11

@carlstrom.bsky.social Clemens Ries, and Ting Sun rocking at #GLIA2025! And the launch of the Carlström lab!

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Reposted by Karl Carlström

Camp Lab @graycamplab.bsky.social · Jul 11

Neuron programming! Pro-neural TFs + 480 morphogen conditions + scRNA-seq --> Diverse iN subtypes of forebrain, midbrain, hindbrain, spinal cord, and PNS. @hsiuchuanlin.bsky.social‬ @jasperjanssens.bsky.social‬ and Treutlein Lab! @science.org www.science.org/doi/10.1126/... #NGN2 #ASCL1

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Reposted by Karl Carlström

Shane Liddelow @liddelowsa.bsky.social · Jul 11

On now, last session of #Glia2025, and last presenter from the lab.

S26 | Exploring glial diversity using single cell and spatial genomics
@mrodea.bsky.social
10:00 S26-01 Multi-omic definition of astrocyte diversity in the healthy and inflamed brain

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Reposted by Karl Carlström

Ardem Patapoutian @ardemp.bskyverified.social · Jul 10

This is insane! "'Positive review only': Researchers hide AI prompts in papers"
asia.nikkei.com/Business/Tec...
h/t Ryan Pack

'Positive review only': Researchers hide AI prompts in papers

Instructions in preprints from 14 universities highlight controversy on AI in peer review

asia.nikkei.com

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