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graycamplab.bsky.social
Camp Lab
@graycamplab.bsky.social
1.3K followers 210 following 33 posts
Curiosity. Human Model Systems. Single-Cell Genomics. EvoDevo…and more!
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cp-cellhostmicrobe.bsky.social
Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 1d
Molecular mechanisms of host-microbiome interactions:

We teamed up w/ @cp-cellchembiol.bsky.social for a Collection of articles uncovering mechanisms by which microbes communicate w/their hosts, shedding light on various conditions & offering therapeutic avenues.Enjoy!
www.cell.com/cp/collectio...
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Reposted by Camp Lab
biozentrum.unibas.ch
Biozentrum, University of Basel @biozentrum.unibas.ch · 22d
We’re proud of our global research community at the Biozentrum @unibas.ch!
Our scientists from 40+ countries bring their passion & diverse cultures to every discovery.
🔬Join us: www.youtube.com/watch?v=p_Cg...
Working at the Biozentrum Basel | World-Class Science & Life in Switzerland
YouTube video by BiozentrumBasel
www.youtube.com
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Reposted by Camp Lab
fmiscience.bsky.social
FMI science @fmiscience.bsky.social · Sep 8
🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
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Reposted by Camp Lab
maxplanck.de
Max-Planck-Gesellschaft @maxplanck.de · 29d
Springboard for an international scientific career! 🧬🧪🔭⚛️🧠🌱 Call for #MaxPlanckResearchGroups launched; applications are possible until October 14, 2025 www.mpg.de/max-planck-r... #ScienceCareer
Call for Applications / Ausschreibung
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Reposted by Camp Lab
vanderhaeghenp2.bsky.social
Pierre Vanderhaeghen @vanderhaeghenp2.bsky.social · Sep 3
New from the lab: Fatty Acid Metabolism Sets the Species-specific Tempo of Cortical Development through Protein Acetylation Dynamics. Led by amazing trio: @ryo2iwata.bsky.social , Isabel Gallego, @emirerkol.bsky.social, together with @steinaerts.bsky.social , @fendtlab.bsky.social
Species-specific Rates of Fatty Acid Metabolism Set the Scale of Temporal Patterning of Corticogenesis through Protein Acetylation Dynamics
Developmental processes display temporal differences across species, leading to divergence in organ size and composition. In the cerebral cortex, neurons of diverse identities are generated sequential...
www.biorxiv.org
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Reposted by Camp Lab
mathewkiang.com
Mathew Kiang @mathewkiang.com · Jun 25
Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages.

ki.se/en/about-ki/...
Call for 20 Assistant Professor positions
Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...
ki.se
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graycamplab.bsky.social
Camp Lab @graycamplab.bsky.social · Aug 22
Final version @science.org "Recent evolution of the developing human intestine affects metabolic and barrier functions". Evolutionary preparation for microbiota, diet, and pathogen exposure is fascinating! Thank you @erc.europa.eu for supporting our vision!
www.science.org/doi/10.1126/...
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Reposted by Camp Lab
bsse.ethz.ch
D-BSSE, ETH Zurich @bsse.ethz.ch · Aug 11
At their annual retreat, fellows of the
@ethz.ch & #pRED #teamIHB #Roche | #NextGenBioeng programme showcased how organoids, CRISPR screens & spatial omics are reshaping translational #bioengineering. A hub of ideas, data & new collaborations🚀 > u.ethz.ch/1gMXI
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Reposted by Camp Lab
embl.org
EMBL @embl.org · Aug 7
We’re looking for curious, innovative science leaders at EMBL Heidelberg! 🔬🧬🦠

Join a vibrant, interdisciplinary community where collaboration and innovation are nurtured at all levels.

Take a look at these four open positions 👇
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graycamplab.bsky.social
Camp Lab @graycamplab.bsky.social · Jul 24
Altogether, we identify the developing human intestinal epithelium as a rapidly evolving system, and show that great ape #organoids provide insight into human biology. 🙏Thanks 🙏 to all authors! Especially co-first authors: @CY_Qianhui_YU @KlkUmut @stefanosecchia 11/11
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graycamplab.bsky.social
Camp Lab @graycamplab.bsky.social · Jul 24
We identify and functionally evaluate 2 human accelerated regions (HARs) at the IGFBP2 locus. Provocatively, these data indicate that the IGF pathway contributed to evolutionary change in the developing human intestine, potentially augmenting small intestine length. 10/11
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graycamplab.bsky.social
Camp Lab @graycamplab.bsky.social · Jul 24
Organoid KO/Reporter assays confirm a bona fide Lactase expression enhancer within an MCM6 intron. Deep learning predicts that a selected SNP associated with lactase persistence removes a transcriptional repressor binding site, a potential mechanism for hypolactasia. 9/11
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graycamplab.bsky.social
Camp Lab @graycamplab.bsky.social · Jul 24
We used a composite annotation to identify intestinal gene regulatory regions that have strong signatures of function and evolutionary change in humans. Willow plots aesthetically showcase the diverse gene ontologies affected by regulatory changes. 8/10
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graycamplab.bsky.social
Camp Lab @graycamplab.bsky.social · Jul 24
We identified conservation and divergence between human and chimpanzee intestinal epithelial gene regulation associated with metabolic and barrier functions. 7/10
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graycamplab.bsky.social
Camp Lab @graycamplab.bsky.social · Jul 24
Truly incredible chimpanzee intestinal tissues can be generated from chimpanzee pluripotent stem cells, providing a very exciting inroad into comparative species analysis! Builds on extraordinary work from @JimWellsLab @TheSpenceLab #organoids #evodevo 6/10
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graycamplab.bsky.social
Camp Lab @graycamplab.bsky.social · Jul 24
Pluripotent stem cells can generate intestinal organoid tissues that have remarkable similarity to primary tissue counterparts. We performed a multiplexed reporter assay to assess putative enhancers for activity in intestinal organoids. 5/10
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graycamplab.bsky.social
Camp Lab @graycamplab.bsky.social · Jul 24
We explored the evolution of cell types and gene regulation by comparing tissue and #organoids from humans, chimps, and mice. Many genes and reg. regions active in enterocytes and associated with barrier function and metabolism have signatures of recent change. 4/10
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graycamplab.bsky.social
Camp Lab @graycamplab.bsky.social · Jul 24
At birth, the human GI tract becomes exposed to the outside world. Prior to birth, gene regulatory networks must orchestrate intestinal development to prepare for dynamic diet and microbiota exposures, which change over lifespan. 3/10
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graycamplab.bsky.social
Camp Lab @graycamplab.bsky.social · Jul 24
Recent genetic change affects gut function, including variants involved in Crohn’s disease (CD), inflammatory bowel disease (IBD), and hypolactasia. An evolutionary perspective on the developing intestine has human health relevance and can shed light on modern GI disorders. 2/10
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graycamplab.bsky.social
Camp Lab @graycamplab.bsky.social · Jul 24
Diet/microbes place the gut epithelium as a nexus for evolutionary change. With Jason Spence and Craig Lowe labs we use #organoids to explore how evolution prepared the developing human intestine for exposure to the environment. @science.org #evodevo www.science.org/doi/10.1126/... 1/11
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Reposted by Camp Lab
kaessmannlab.bsky.social
Kaessmann Lab @kaessmannlab.bsky.social · Jul 16
Our study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...
A male-essential miRNA is key for avian sex chromosome dosage compensation - Nature
Birds have evolved a unique sex chromosome dosage compensation mechanism involving the male-biased microRNA (miR-2954), which is essential for male survival by regulating the expression of dosage-sens...
www.nature.com
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Reposted by Camp Lab
hsiuchuanlin.bsky.social
Hsiu-Chuan Lin @hsiuchuanlin.bsky.social · Jul 12
My postdoc work at Treutlein lab and @graycamplab.bsky.social with @jasperjanssens.bsky.social is out in @science.org ! We screen for neuron subtypes using pro-neural TFs + morphogen combinations + scRNA-seq and profiled over 700,000 cells in 480 conditions. www.science.org/doi/10.1126/...
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graycamplab.bsky.social
Camp Lab @graycamplab.bsky.social · Jul 11
Neuron programming! Pro-neural TFs + 480 morphogen conditions + scRNA-seq --> Diverse iN subtypes of forebrain, midbrain, hindbrain, spinal cord, and PNS. @hsiuchuanlin.bsky.social‬ @jasperjanssens.bsky.social‬ and Treutlein Lab! @science.org www.science.org/doi/10.1126/... #NGN2 #ASCL1
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sten.linnarsson.org
Sten Linnarsson @sten.linnarsson.org · Jun 25
A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)
ki.se
Karolinska Institutet @ki.se · Jun 25
Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential.
🔗 All positions: ki.se/en/about-ki/...
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slefkopoulos.bsky.social
Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · Jun 21
OK, who will be attending the @bacell3d.bsky.social 2025 meeting on Monday? Let's connect there - looking forward!
#organoidconference #bacell3d #organoids
www.bacell3d.com
BaCell 3D | Organoid conference
BaCell 3D is the essential meeting point for researchers and industry professionals dedicated to transforming developmental and biomedical science through cutting-edge in-vitro multicellular systems.
www.bacell3d.com
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