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Reposted by Yizhou Hu(Eugene)

bioRxiv Bioinfo @biorxiv-bioinfo.bsky.social · 18d

GUANACO: A Unified Web-Based Platform for Single-Cell Multi-Omics Data Visualization https://www.biorxiv.org/content/10.1101/2025.09.18.677070v1

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Yizhou Hu(Eugene) @yizhoueugene.bsky.social · 17d

Thrilled to collaborate on cosupervising this work! GUANACO puts single-cell MultiOmics visualization in reach for bench scientists: built-in stats, no code for publication-ready figures. pls explore more functions from the link 👇Congrats to the team!

Ping Chen @nunuping.bsky.social · 18d

🚀 Introducing GUANACO – our new bioinformatics tool for intuitive, interactive visualization of single-cell multiomics data.
🧬 No coding needed
📊 Built-in stats tools
🎨 High-quality figures in clicks
💻 Lightweight & deployable
Perfect for bench scientists!
👉 DEMO: guanaco-demo.chen-sysimeta-lab.com

bioRxiv Bioinfo @biorxiv-bioinfo.bsky.social · 18d

GUANACO: A Unified Web-Based Platform for Single-Cell Multi-Omics Data Visualization https://www.biorxiv.org/content/10.1101/2025.09.18.677070v1

Reposted by Yizhou Hu(Eugene)

Mattia Zaghi @matzag.bsky.social · 28d

A few weeks ago, I had to discuss about DynaTag, a smart tweak to CUT&Tag that enables single-cell transcription factor mapping with just a buffer change.
Opening a number of future avenues.
📰 Via
@GenomeWeb
: lnkd.in/djYm_sGg
#epigenetics #singlecell

This link will take you to a page that’s not on LinkedIn

lnkd.in

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Yizhou Hu(Eugene) @yizhoueugene.bsky.social · 29d

Our study on neuroblastoma developmental plasticity is the cover story in the latest issue of Dev. Cell @cp-devcell.bsky.social .The Chinese-ink Taiji (Yin–Yang) cover to echo cell-state transitions. Huge thanks to the editors, co-authors. #Neuroblastoma www.cell.com/developmenta...

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Reposted by Yizhou Hu(Eugene)

François Lallemend @flallemend.bsky.social · Jun 2

Postdoc in Computational Biology – Auditory Pathways & Sensory Disorders @LallemendLab to study how peripheral/central auditory pathways (circuit, cellular, molecular) are altered in tinnitus & age-related hearing loss. #scRNAseq, #barcode-lineage-tracing, #translational
ki.varbi.com/what:job/job...

Postdoctoral studies in single-cell and computational biology

Postdoctoral studies in single-cell and computational biology Do you want to contribute to top quality medical research? A postdoctoral position is available in the laboratory of Professor Francois

ki.varbi.com

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Reposted by Yizhou Hu(Eugene)

Jens Hjerling Leffler @hjerling-leffler.bsky.social · Jun 2

Postdoc positions available in my lab @ki.se Sweden - exciting science, fantastic environment and great quality of life. I take mentoring seriously - 7/7 postdocs that left my lab has faculty positions today. Existing datasets and funds to build new ones available. ki.varbi.com/en/what:job/...

Postdoc in Single Cell Genomics, Jens Hjerling-Leffler group, Karolinska Institutet

Do you want to contribute to top quality medical research? The position is located within The Division of Molecular Neurobiology in the lab of Professor Jens Hjerling-Leffler at the Department of Medi

ki.varbi.com

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Reposted by Yizhou Hu(Eugene)

UlrikaKMarklund @ulrikakmarklund.bsky.social · May 29

Check out our new study on the innermost nervous system of the body—the submucosal plexus. We define three neuronal classes, map their connectivity, and uncover their stepwise development via phenotypic switching. Congrats to all authors! #NatureNeuroscience #EntericNervousSystem rdcu.be/eoqXz

The transcriptomes, connections and development of submucosal neuron classes in the mouse small intestine

Nature Neuroscience - The neuronal composition of the intestinal submucosal plexus is incompletely understood. Here Li et al. define their neuron classes, connectome and stepwise acquisition of...

rdcu.be

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Reposted by Yizhou Hu(Eugene)

Igor Adameyko @adameykolab.bsky.social · May 20

If you want to run MERFISH spatial transcriptomics and you search for the optimized probe codebooks, here they are: www.science.org/doi/10.1126/...

Boosting multiplexing capabilities for error-robust spatial transcriptomic methods using a set exchange approach

Using an algorithm, highly optimized error-robust codebooks for spatial transcriptomic methods can systematically be produced.

www.science.org

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Reposted by Yizhou Hu(Eugene)

Silvia Remeseiro Lab @remeseiro-lab.bsky.social · May 12

🎫 Exclusive event: One-day symposium on #Brain #Tumor #Plasticity
🕣September 16, 2025. The Royal Swedish Academy of Sciences, Stockholm @scienceacademyswe.bsky.social

Few spots available. Register here: ui.ungpd.com/Events/ed387...

Brain Tumor Plasticity

A growing body of evidence emphasizes the presence of significant intra-tumoral phenotypic diversity and plasticity within brain tumors. Inherent plasticity introduces an additional layer of intricacy...

ui.ungpd.com

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Reposted by Yizhou Hu(Eugene)

Marek Bartosovic @mardzix.bsky.social · May 7

Epichrom 2025 !

After 3 years, Epichrom is revived and will take place in Stockholm on the 12th of June. Great opportunity to share your research and hear about latest epigenetics/chromatin research in Sweden.

Registration is free of charge
www.bartosovic-lab.com/epichrom

This link will take you to a page that’s not on LinkedIn

lnkd.in

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Yizhou Hu(Eugene) @yizhoueugene.bsky.social · May 12

Thank you @ki.se for sharing our @cp-devcell.bsky.social study on neuroblastoma developmental plasticity! 🙏🚀

Karolinska Institutet @ki.se · May 12

A study published in @cp-devcell.bsky.social points to new treatment strategies for the #childhoodcancer #neuroblastoma. Researchers have identified key transcription factor ‘switches’ that can be targeted to lock the cancer into a less aggressive state. #CancerResearch 🧪 doi.org/10.1016/j.de...

Redirecting

doi.org

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Yizhou Hu(Eugene) @yizhoueugene.bsky.social · May 10

Thank you, Susanne! Your help made this possible.

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Yizhou Hu(Eugene) @yizhoueugene.bsky.social · May 9

9/9🙏 Thanks to our collaborators:
@schlisio-lab.bsky.social
, Prof. Arthur Tischler (@tuftsmedicalcenter.bsky.social), Prof. Ronald de Krijger (
@themaximacenter.bsky.social
), and all the other amazing team members!

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Yizhou Hu(Eugene) @yizhoueugene.bsky.social · May 9

8/9 Our enhanced neural-network tool, scCAMEL, now aligns cross-species, multimodal data in a single workflow—empowering comprehensive mapping of tumor plasticity. sccamel.readthedocs.io/en/latest/

scCAMEL — scCAMEL 0.26b documentation

sccamel.readthedocs.io

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Yizhou Hu(Eugene) @yizhoueugene.bsky.social · May 9

7/9 Spatial maps reveal clonal pockets of bridge & neural‑crest‑like cells encircled by TAMs & CAFs that sustain aggressiveness—micro‑environment is a Dev. state‑specific partner‑in‑crime.

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Yizhou Hu(Eugene) @yizhoueugene.bsky.social · May 9

6/9 Functional hits 👉 E2F7-networks fuel de‑differentiation, while HMX1 can force differentiation—unless MYCN amplification blocks it.---> Dev. state‑specific vulnerabilities = therapeutic targets.

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Yizhou Hu(Eugene) @yizhoueugene.bsky.social · May 9

5/9 🔑 Enhancer–gene regulatory networks uncover 121 core TF gene patterns organized into five principal patterns: Cell Cycle, ADRN-meta, ADRN-neu, Mes-Prog, and Mes-immune.

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Yizhou Hu(Eugene) @yizhoueugene.bsky.social · May 9

4/9 The enhancer‑primed epigenetic landscape gives neuroblastoma cells the "latent" capacity to shift between developmental programs.

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Yizhou Hu(Eugene) @yizhoueugene.bsky.social · May 9

3/9 We traced 7 NBL cell states back to the trunk neural crest lineage. A previously less-appreciated “bridge” state acts as the hub for state switching and, together with neural‑crest‑like cells, dominates high‑risk NBL.

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Yizhou Hu(Eugene) @yizhoueugene.bsky.social · May 9

2/9 In collaboration with
@patrikernfors.bsky.social
and Jian Wang’s team, we integrated single-cell and spatial transcriptomics from patient tumors and scRNA+ATAC data from mouse spontaneous models to construct a high-resolution disease atlas.

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Yizhou Hu(Eugene) @yizhoueugene.bsky.social · May 9

1/9 🚀 Our latest findings in
@cp-devcell.bsky.social : #Neuroblastoma cells aren’t locked into one single fate—they flip between developmental programs, driving tumor heterogeneity and malignancy. www.sciencedirect.com/science/arti...

Single-cell MultiOmics and spatial transcriptomics demonstrate neuroblastoma developmental plasticity

Neuroblastoma, the most prevalent extracranial pediatric solid tumor, arises from neural crest progeny cells. It exhibits substantial developmental pl…

www.sciencedirect.com

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Reposted by Yizhou Hu(Eugene)

Gonçalo Castelo-Branco @gocastelobranco.bsky.social · May 5

Join us at the Nobel Symposium

Multiple Sclerosis: Past, Present and Future Treatment

June 5th, 2025 | Jacob Berzelius lecture hall @ki.se | Stockholm, Sweden

free registration at:

jirango.com/cview/web/f0...

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Reposted by Yizhou Hu(Eugene)

Patrik Ernfors @patrikernfors.bsky.social · Mar 24

How is the input of the different kinds of primary sensory neurons responding to heat and mechanical stimuli summarized in the spinal cord? Check out our recent study.

www.nature.com/articles/s41...

Neural ensembles that encode nocifensive mechanical and heat pain in mouse spinal cord - Nature Neuroscience

Zhang et al. identify unimodal neural representations in the spinal cord of cutaneous mechanical and heat stimuli gated by a shared feed-forward local inhibitory neuron type and a neural transition du...

www.nature.com

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Yizhou Hu(Eugene) @yizhoueugene.bsky.social · Mar 13

New mug, #science_doesn’t_care_what_U_believe