François Lallemend
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flallemend.bsky.social
François Lallemend
@flallemend.bsky.social
590 followers 160 following 46 posts
Professor of neurobiology of sensory systems @karolinska Institute, Stockholm, Sweden • single cell • development • cell state • system homeostasis • aging • auditory • vestibular • somatosensory • translational
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flallemend.bsky.social
New review out, together with Saida Hadjab and Prach Techameena @ki.se
We consolidate known proprioceptive neuron subtypes and propose a unified framework linking molecular identity to their potential roles in sensorimotor circuits.
elifesciences.org/articles/106...
Functional and molecular insights into muscle proprioceptors
The emerging taxonomy of proprioceptive neuron subtypes provides a framework for dissecting the cellular logic of sensorimotor control.
elifesciences.org
November 28, 2025 at 3:15 PM
Reposted by François Lallemend
carlstrom.bsky.social
We are hiring!!
Interested in applying various CRISPR editing approaches and cell profiling to address functional metabolic and epigenetic interplay in oligodendrocytes?!

Apply here 👇
www.linkedin.com/posts/karl-c...
We are looking for a Research Assistant with an interest in functional metabolic and epigenetic interplay in oligodendrocytes! To study this we apply a wide range of leading-edge technologies… | Kar...
We are looking for a Research Assistant with an interest in functional metabolic and epigenetic interplay in oligodendrocytes! To study this we apply a wide range of leading-edge technologies, inclu...
www.linkedin.com
November 27, 2025 at 4:27 PM
flallemend.bsky.social
Cool ... but not cool. Stress-induced hyperactivation of skin nerves kills your hair follicles, and primes your immune system for future attacks.

www.cell.com/cell/fulltex...
Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity
Acute stress causes immediate hair follicle necrosis and hair loss via sympathetic nerves, which in turn activates and expands autoreactive CD8⁺ T cells targeting hair follicles. Thus, a single stress...
www.cell.com
November 26, 2025 at 6:56 PM
Reposted by François Lallemend
labwaggoner.bsky.social
Enteric nervous system-derived VIP restrains differentiation of LGR5+ stem cells toward the secretory lineage controlling type 1 and 2 immune balance @natimmunol.nature.com @champalimaudf.bsky.social @neuroimmune-rok.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 25, 2025 at 8:36 PM
flallemend.bsky.social
"Sensory-neuron-derived CGRPα controls white adipocyte differentiation and tissue plasticity" great work by @ruaslab.bsky.social and Kyle Dumont et al.

www.sciencedirect.com/science/arti...
Sensory-neuron-derived CGRPα controls white adipocyte differentiation and tissue plasticity
Communication between the brain and adipose tissue is mediated in part by the peripheral nervous system. The sympathetic branch transmits lipolytic an…
www.sciencedirect.com
November 24, 2025 at 12:20 PM
Reposted by François Lallemend
mahabermann.bsky.social
Excited to share that the main work of my PhD has been published!

We found that having control over pain makes expectations more precise, and changes pain perception. This is accompanied by activation changes in the PAG, SMA and ACC.

You can read the full version of the paper here: rdcu.be/eQy6X
Controllability changes pain perception by increasing the precision of expectations
Nature Communications - Control over pain changes how intense it is perceived. Here, the authors show that this effect results from increased expectation precision with control, which changes...
rdcu.be
November 22, 2025 at 1:50 PM
Reposted by François Lallemend
tedpricethepainguy.bsky.social
Big new paper from us published yesterday: The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain
www.science.org/doi/10.1126/...
Led by @hajisciencebaji.bsky.social in my lab and a wonderful collaboration with Matthew Dalva's lab at Tulane
The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain
Phosphorylation of hundreds of protein extracellular domains is mediated by two kinase families but the functional role of these kinases is underexplored. We find that the presynaptic release of the t...
www.science.org
November 21, 2025 at 6:13 PM
Reposted by François Lallemend
fens.org
🧬 Gonçalo Castelo-Branco | Plenary Speaker

How do glial cells influence disease and brain repair? On 10 July at #FENS2026, join Prof. Gonçalo Castelo-Branco to explore the molecular mechanisms behind #oligodendrocyte lineage cells in development and #neuroinflammatory diseases.
November 21, 2025 at 8:00 AM
Reposted by François Lallemend
gocastelobranco.bsky.social
Our paper, driven by Chao Zheng and Bastien Hervé in the lab @ki.se, is now out in @natneuro.nature.com!
Check it out at:
www.nature.com/articles/s41...

with @pkukanja.bsky.social, @deckardw.bsky.social, among others
Distinct transcriptomic and epigenomic responses of mature oligodendrocytes during disease progression in a mouse model of multiple sclerosis - Nature Neuroscience
Single-cell ATAC/RNA multiomic profiling was used to investigate how oligodendrocyte lineage cells respond across multiple disease stages within a mouse MS model, revealing early activation of immune ...
www.nature.com
November 17, 2025 at 10:30 AM
flallemend.bsky.social
"Not Just Neurons: Pain Is Orchestrated in Partnership with Many Non-neuronal Cells"
psalmotoxin.bsky.social Ewan St. John Smith @psalmotoxin.bsky.social · 15d
With the annual @sfn.org meeting coming up, I'm looking forward to Saturday's symposium with @cherylstucky.bsky.social , @mdburton.bsky.social & Anne-Marie Heegaard on non-neuronal cells in #PainResearch

Here's our accompanying review!
www.jneurosci.org/content/45/4...
Figure 1. Non-neuronal–neuron communication in the skin. (1) Non-neuronal cells and extracellular matrix in the skin. (2) When in ammatory events such as IL-6, ATP, and protease production from injury or infection are introduced, it causes an activation of cells, a disruption in extracellular matrix, and damage to sensory neurons. (3) During in ammatory cascades, injured or sensitized neurons potentiate pain and the development of a chronic pain state. Figure 2. Cell–cell interactions in joint pain. Numerous pathogenic changes occur within the OA joint and other musculoskeletal conditions that can contribute to pain, including cartilage degradation, synovitis, and bone remodeling (1). Within the joint evidence has established the role of some key non-neuronal cell types that contribute to pain (2) and some of the signaling nociceptor activation and sensitization mechanisms involved (3). There is also growing evidence for cell–cell interactions within the DRG that contribute to pain (4). See text for more details. Figure 3. Keratinocytes contribute to normal touch and chemotherapy-induced mechanical sensitivity through PIEZO1. Keratinocytes in the most super cial layer of the skin respond to mechanical forces via their expression of PIEZO1 channels and activated keratinocytes release ATP which signals to P2X4 channels on cutaneous sensory nerve endings. After a patient is treated with the chemotherapeutic paclitaxel, keratinocyte PIEZO1 is sensitized; the keratinocytes release more ATP and additional mediators, resulting in greater action potential signaling in sensory neurons that is sent to the spinal cord and brain through touch and pain pathways.
November 13, 2025 at 8:38 PM
Reposted by François Lallemend
carlstrom.bsky.social
New preprint from
@gocastelobranco.bsky.social lab!! We use MPRA & scCRISPRi/a to interrogate possible functions of GWAS-identified Multiple sclerosis risk SNPs in iPSC-derived oligodendrocytes.
www.biorxiv.org/content/10.1...
www.biorxiv.org
November 13, 2025 at 8:35 AM
Reposted by François Lallemend
ki.se
The study is a collaboration between KI, @stockholm-uni.bsky.social and @au.dk. Link to publication: www.cell.com/cell-reports...
Maternal diabetes programs sexually dimorphic early-onset cardiovascular dysfunction in metabolically healthy offspring
Zhao et al. translationally demonstrate how maternal diabetes induces early-onset endothelial dysfunction in sons, but not daughters, even when offspring are metabolically healthy. This challenges pri...
www.cell.com
November 12, 2025 at 11:34 AM
Reposted by François Lallemend
ki.se
Maternal #diabetes may predispose sons, but not daughters, to early #cardiovascular dysfunction, even without metabolic disease. Study in @cp-cellrepmed.bsky.social by @qiaolindeng.bsky.social and @zhaoallan.bsky.social highlights oxidative stress as a key driver🧪 news.ki.se/sons-of-moth...
A boy looking out of a window. Photo: Getty Images
November 12, 2025 at 11:34 AM
Reposted by François Lallemend
sergiuppasca.bsky.social
This week, we published in @science.org an article outlining the current ethical and societal implications of research involving human neural #organoids and #assembloids, their transplantation, and highlighted potential next steps.
November 7, 2025 at 12:12 PM
Reposted by François Lallemend
🚨New paper from the NIH PRECISION Human Pain Network! We built a human DRG reference atlas: >500K cells from 126 donors to reveal 22 neuronal & 10 non-neuronal cell types. New insights into human sensory biology!
Paper: biorxiv.org/content/10.1...
Data: humandrg.painseq.com
biorxiv.org
November 7, 2025 at 4:43 AM
Reposted by François Lallemend
gocastelobranco.bsky.social
Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com

www.nature.com/articles/s41...
Spatial dynamics of brain development and neuroinflammation - Nature
A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.
www.nature.com
November 5, 2025 at 4:03 PM
Reposted by François Lallemend
jonathanamichaels.bsky.social
Thrilled that our paper is out today in Nature!
www.nature.com/articles/s4...
Sensory expectations shape neural population dynamics in motor circuits
Nature - Experiments with human volunteers and macaques show that expectations produced by probabilistic cueing of future sensory inputs shape motor circuit dynamics in order to increase the...
www.nature.com
October 29, 2025 at 4:11 PM
Reposted by François Lallemend
thetransmitter.bsky.social
How is it that some nociceptors—the sensory neurons that detect heat, chemical irritants and toxins—can withstand a lifespan’s worth of exposure to noxious stimuli, whereas others die? New findings reveal how they do it.

By @vcallier.bsky.social

#neuroskyence
www.thetransmitter.org/sensory-syst...
Neurons modulate sensitivity via electron transport chain
Some nociceptors can survive a lifetime’s worth of exposure to noxious stimuli by reducing their mitochondria’s production of reactive oxygen species.
www.thetransmitter.org
October 22, 2025 at 4:57 PM
Reposted by François Lallemend
junnagai.bsky.social
Just out in Nature! “The astrocytic ensemble acts as a multiday trace to stabilize memory.” We identified astrocytic ensembles that link experiences across days to stabilize memory nature.com/articles/s41.... New astrocyte tools are openly available at Addgene: addgene.org/Jun_Nagai/. 1/8
October 15, 2025 at 4:11 PM
Reposted by François Lallemend
gioelelamanno.bsky.social
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
October 16, 2025 at 6:23 AM
Reposted by François Lallemend
o-andersson-lab.bsky.social
Any danish located postdoc who wants to apply to work with us and zebrafish, pls contact me (postdocs from other places can also get in touch, as we have other alternatives)
novonordiskfonden.dk/en/grant/pos...
Postdoctoral Fellowships at Uppsala University - 2026 - Novo Nordisk Fonden
novonordiskfonden.dk
October 4, 2025 at 10:19 AM
Reposted by François Lallemend
niccolozampieri.bsky.social
I really like this one 🤓. Work led by Elisa Toscano with invaluable help from many 🙏 @alesantuz.bsky.social, @lowensteined.bsky.social. A spinal circuit for skilled locomotion www.cell.com/current-biol...
A spinal circuit for skilled locomotion
Toscano et al. identify glutamatergic Pitx2+ V0 ascending neurons (V0g-aNs) that receive input from cerebrospinal fluid (CSF)-contacting neurons and target spinal premotor and motor neurons. Eliminati...
www.cell.com
October 3, 2025 at 3:21 PM
Reposted by François Lallemend
anderssonlab.bsky.social
👩‍🔬👨‍💻 Postdoc recruitment! 👨‍🔬👩‍💻

Join us to use next generation single cell lineage tracing (de Haan & He et al Science 2025) to resolve dermis developmental dynamics & mechanisms.

🚨 Deadline Oct 1st!! 🚨

Please re-post and help us spread the word far and wide! ✈

ki.varbi.com/en/what:job/...
Postdoctoral studies in next generation single cell lineage tracing of skin (scholarship)
Do you want to contribute to top quality medical research? A postdoctoral scholarship is available in the lab of Emma R Andersson at the Department of Cell and Molecular Biology, Karolinska Institutet
ki.varbi.com
September 27, 2025 at 7:41 AM
flallemend.bsky.social
Immune-neuron circuits let pain jump between organs. Potential new treatment for bladder-gut disorders
doi.org/10.21203/rs....
An interorgan neuroimmune circuit promotes visceral hypersensitivity
Visceral pain disorders such as interstitial cystitis/bladder pain syndrome (IC/BPS) and irritable bowel syndrome (IBS) often manifest concurrently in the bladder and colon. Yet, the mechanistic basis...
doi.org
September 27, 2025 at 8:53 AM