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Reposted by François Lallemend

Olov Andersson @o-andersson-lab.bsky.social · 5d

Any danish located postdoc who wants to apply to work with us and zebrafish, pls contact me (postdocs from other places can also get in touch, as we have other alternatives)
novonordiskfonden.dk/en/grant/pos...

Postdoctoral Fellowships at Uppsala University - 2026 - Novo Nordisk Fonden

novonordiskfonden.dk

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Reposted by François Lallemend

Niccolò Zampieri @niccolozampieri.bsky.social · 5d

I really like this one 🤓. Work led by Elisa Toscano with invaluable help from many 🙏 @alesantuz.bsky.social, @lowensteined.bsky.social. A spinal circuit for skilled locomotion www.cell.com/current-biol...

A spinal circuit for skilled locomotion

Toscano et al. identify glutamatergic Pitx2+ V0 ascending neurons (V0g-aNs) that receive input from cerebrospinal fluid (CSF)-contacting neurons and target spinal premotor and motor neurons. Eliminati...

www.cell.com

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Reposted by François Lallemend

Onur Dagliyan @onurdagliyan.bsky.social · 6d

🤯

www.science.org/doi/10.1126/...

Intercellular communication in the brain through a dendritic nanotubular network

Intercellular nanotubular networks mediate material exchange, but their existence in neurons remains to be explored in detail. We identified long, thin dendritic filopodia forming direct dendrite–dend...

www.science.org

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Reposted by François Lallemend

Emma R Andersson @anderssonlab.bsky.social · 12d

👩‍🔬👨‍💻 Postdoc recruitment! 👨‍🔬👩‍💻

Join us to use next generation single cell lineage tracing (de Haan & He et al Science 2025) to resolve dermis developmental dynamics & mechanisms.

🚨 Deadline Oct 1st!! 🚨

Please re-post and help us spread the word far and wide! ✈

ki.varbi.com/en/what:job/...

Postdoctoral studies in next generation single cell lineage tracing of skin (scholarship)

Do you want to contribute to top quality medical research? A postdoctoral scholarship is available in the lab of Emma R Andersson at the Department of Cell and Molecular Biology, Karolinska Institutet

ki.varbi.com

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François Lallemend @flallemend.bsky.social · 12d

Immune-neuron circuits let pain jump between organs. Potential new treatment for bladder-gut disorders
doi.org/10.21203/rs....

An interorgan neuroimmune circuit promotes visceral hypersensitivity

Visceral pain disorders such as interstitial cystitis/bladder pain syndrome (IC/BPS) and irritable bowel syndrome (IBS) often manifest concurrently in the bladder and colon. Yet, the mechanistic basis...

doi.org

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Reposted by François Lallemend

Dr. Ali Barry @aliibarry.bsky.social · 29d

Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception #PainResearch

www.science.org/doi/10.1126/...

Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception

Regulatory T cells curb noxious sensory signaling to dampen cutaneous inflammation, a neuromodulatory mechanism for immunosuppression.

www.science.org

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Reposted by François Lallemend

Thiago Carvalho @cyrilpedia.bsky.social · Sep 3

'Here, we detail the biological, environmental and experimental factors that can affect circadian rhythms of mice and provide recommendations for designing and reporting experiments for in vivo metabolic studies.'
www.nature.com/articles/s42...

The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research - Nature Metabolism

This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental facto...

www.nature.com

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Reposted by François Lallemend

Pedro Pimentel-Coelho @ppimentel-coelho.bsky.social · Aug 29

Maternal stress triggers early-life eczema through fetal mast cell programming

Nadine Serhan et al. 🧪

www.nature.com/articles/s41...

Maternal stress triggers early-life eczema through fetal mast cell programming - Nature

Prenatal stress triggers molecular dysregulations in fetal neuroimmune circuits, leading to altered mast cell and sensory neuron function, which predisposes offspring to develop eczema in response to ...

www.nature.com

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Reposted by François Lallemend

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Aug 24

Social Touch Suppresses Aggression via Thalamic Mechanisms https://www.biorxiv.org/content/10.1101/2025.08.23.670446v1

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Reposted by François Lallemend

Alles Lab @alleslab.bsky.social · Aug 21

Transporters in pain! Exciting work from @middletonsj.bsky.social & Bennett lab @ox.ac.uk www.nature.com/articles/s41... #PainResearch

SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature

The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.

www.nature.com

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Reposted by François Lallemend

Hunter Schone @hunterschone.bsky.social · Aug 21

Now out in @natneuro.nature.com

What happens to the brain’s body map when a body-part is removed?

Scanning patients before and up to 5 yrs after arm amputation, we discovered the brain’s body map is strikingly preserved despite amputation

www.nature.com/articles/s41593-025-02037-7

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François Lallemend @flallemend.bsky.social · Aug 13

Gut bacteria produce proteins that could seve as new drugs for metabolism disorders, including diabetes or obesity
www.nature.com/articles/s41...

Polypeptides synthesized by common bacteria in the human gut improve rodent metabolism - Nature Microbiology

Two polypeptides synthesized by common bacterial strains in human gut microbiota lower body fat and blood glucose and increase bone density, improving the metabolism of rodents.

www.nature.com

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François Lallemend @flallemend.bsky.social · Aug 11

Deep neural network analysis is a powerful tool, biological experimentation remains however essential: it reveals principles that AI can't infer on its own, yet.

Antonino Greco @agreco.bsky.social · Aug 9

🔵 Proud to share our new preprint 🔵

We compared humans and deep neural networks on sound localization 👂📍

Humans robustly localized OOD sounds even without primary interaural cues (ITD & ILD)

Models localized well only in-training distribution sounds, failing on OOD regime

Link & full story 🧵👇

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Reposted by François Lallemend

Nature Methods @natmethods.nature.com · Aug 4

An analysis shows that current deep learning models do not beat linear baselines in predicting gene perturbation effects, thus emphasizing the importance of further method development and evaluation. @const-ae.bsky.social @wkhuber.bsky.social @s-anders.bsky.social

www.nature.com/articles/s41...

Deep-learning-based gene perturbation effect prediction does not yet outperform simple linear baselines - Nature Methods

The analysis presented in this Brief Communication shows that, despite their complexity, current deep learning models do not outperform linear baselines in predicting gene perturbation effects, thus e...

www.nature.com

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Reposted by François Lallemend

Dr. Rajesh Khanna of the KhannaLabUF @khannalabuf.bsky.social · Jul 14

WOW!!!!!😱😮

High-speed mapping of whole-mouse peripheral nerves at subcellular resolution: Cell www.cell.com/cell/fulltex...

High-speed mapping of whole-mouse peripheral nerves at subcellular resolution

A high-speed pipeline enables whole-mouse imaging and mesoscopic analysis of peripheral nerves using transgenic, immunostaining, and viral labeling, providing an effective means to map body-wide struc...

www.cell.com

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Reposted by François Lallemend

Gonçalo Castelo-Branco @gocastelobranco.bsky.social · Jul 12

12th Dev Brains:

@junyuecao.bsky.social @alainchedotal.bsky.social
@cecilecharrier.bsky.social
@trayon.bsky.social
Isabel Espinosa-Medina
Beatriz Rico
Michael Ziller
Dwight Bergles

news.ki.se/calendar/dev...

@hjerling-leffler.bsky.social
@ulrikakmarklund.bsky.social
@flallemend.bsky.social

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Reposted by François Lallemend

Anna Krook @annakrook.bsky.social · Jul 9

A human specific lncRNA important for ribosomal biogenesis in skeletal muscle- reduced in people with type 2 diabetes.Latest from the team! @ilkesen.bsky.social @juleenrzierath.bsky.social Science Advances www.science.org/doi/10.1126/...

Down-regulation of human-specific lncRNA TMEM9B-AS1 in skeletal muscle of people with type 2 diabetes affects ribosomal biogenesis

TMEM9B-AS1, down-regulated in type 2 diabetes, regulates ribosomal biogenesis in muscle by promoting IGF2BP1-MYC mRNA interaction.

www.science.org

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Reposted by François Lallemend

Jeff Mold @jeffmold.bsky.social · Jul 3

Woohoo! From superstars ionut and Marta in the Frisén lab! www.science.org/doi/10.1126/... can’t wait to see what the anti-neurogenesis folks say about it 😃

Identification of proliferating neural progenitors in the adult human hippocampus

Continuous adult hippocampal neurogenesis is involved in memory formation and mood regulation but is challenging to study in humans. Difficulties finding proliferating progenitor cells called into que...

www.science.org

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François Lallemend @flallemend.bsky.social · Jul 2

Gene therapy to treat deafness now a success in young adults!
www.nature.com/articles/s41...

AAV gene therapy for autosomal recessive deafness 9: a single-arm trial - Nature Medicine

Preliminary results from an investigator-initiated clinical trial showed that an AAV-OTOF gene therapy was safe and led to hearing improvements in ten patients with congenital deafness with 6–12 month...

www.nature.com

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Reposted by François Lallemend

Olov Andersson @o-andersson-lab.bsky.social · Jun 24

Join us as a professor by taking this great opportunity in pharmacology (in any system/area) www.uu.se/en/about-uu/...

Professor of Pharmacology - Uppsala University

Professor of Pharmacology, Department of Medical Cell Biology, Uppsala University

www.uu.se

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Reposted by François Lallemend

Takaki Komiyama @takakikomiyama.bsky.social · Jun 20

Our new paper is out in Science.

We identified a subgroup of cholinergic neurons that mediate sensory modality-specific attention. They change their funcitonal properties within secs of behavioral context change.

Congrats to Bin for the great thesis, and the team!

www.science.org/doi/10.1126/...

Cholinergic feedback for modality- and context-specific modulation of sensory representations

The brain’s ability to prioritize sensory information is crucial for adaptive behavior, yet its mechanisms remain unclear. We investigated basal forebrain cholinergic neurons modulating olfactory bulb...

www.science.org

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Reposted by François Lallemend

Ted Price @tedpricethepainguy.bsky.social · Jun 18

BOOM! I think this paper fills a big gap in understanding how motor cortex stim works for pain... like so many things, it all seems to boil down to the ventral-lateral periaqueductal grey (vlPAG) www.cell.com/neuron/fullt...

A sensory-motor-sensory circuit underlies antinociception ignited by primary motor cortex in mice

Wang et al. unravel the fundamental reason why activation of the primary motor cortex produces analgesia in mice from the angle of sensory-motor interaction and elucidate it from a descending M1-LH in...

www.cell.com

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Reposted by François Lallemend

Patrik Ernfors @patrikernfors.bsky.social · Jun 13

A read only for the DRG nerd: "Spatial organization, chromatin accessibility and gene-regulatory programs defining mouse sensory neurons". www.nature.com/articles/s42...

Spatial organization, chromatin accessibility and gene-regulatory programs defining mouse sensory neurons - Communications Biology

Single cell RNA-sequencing, spatial transcriptomics and chromatin analyses of sensory neurons provide insights into cell type organization of the dorsal root ganglion and the enhancer-driven co-regula...

www.nature.com

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Reposted by François Lallemend

Donald Iain MacDonald @dimacd.bsky.social · Jun 6

Some very nice 50 year old immunostaining that showed for the first time that Substance P was in sensory neurons and their central terminals. Only three pictures, published in Science! www.science.org/doi/abs/10.1...

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François Lallemend @flallemend.bsky.social · Jun 2

Postdoc in Computational Biology – Auditory Pathways & Sensory Disorders @LallemendLab to study how peripheral/central auditory pathways (circuit, cellular, molecular) are altered in tinnitus & age-related hearing loss. #scRNAseq, #barcode-lineage-tracing, #translational
ki.varbi.com/what:job/job...

Postdoctoral studies in single-cell and computational biology

Postdoctoral studies in single-cell and computational biology Do you want to contribute to top quality medical research? A postdoctoral position is available in the laboratory of Professor Francois

ki.varbi.com

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