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Johan Jakobsson @jakobssonlab.bsky.social · 4d

🇸🇪

Reposted by Johan Jakobsson

PLOS Biology @plosbiology.org · 7d

Join @embl.org for this conference exploring genetic and physiological impacts of transposable elements. Virtual registration is open until October 28. Learn more at plos.io/4nuqeZA.

Promotional graphic for an EMBO Workshop titled "The mobile genome: genetic and physiological impacts of transposable elements," scheduled for 4-7 November 2025, at EMBL Heidelberg and virtually. The background features abstract DNA strands and a stylized graphic of a fruit fly in orange and green tones.

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Johan Jakobsson @jakobssonlab.bsky.social · 6d

Todays labmeeting became a tribute to Jane Goodall. Such an outstanding role model. 🙊

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Reposted by Johan Jakobsson

Johan Jakobsson @jakobssonlab.bsky.social · Sep 7

New preprint from my lab! We describe how transposable elements are activated in Parkinson’s disease, which is linked to an interferon response. We believe this study significantly advances our understanding of transposons and their role in human brains.

www.biorxiv.org/content/10.1...

Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease

Parkinson's disease (PD) is a common age-related neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to i...

www.biorxiv.org

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Reposted by Johan Jakobsson

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Sep 7

Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease https://www.biorxiv.org/content/10.1101/2025.09.03.673956v1

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Johan Jakobsson @jakobssonlab.bsky.social · Sep 7

Fantastic collaboration with labs of @kirkebylab.bsky.social @mollygale.bsky.social and Roger Barker. Outstanding support from @asapresearch.parkinsonsroadmap.org

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Johan Jakobsson @jakobssonlab.bsky.social · Sep 7

New preprint from my lab! We describe how transposable elements are activated in Parkinson’s disease, which is linked to an interferon response. We believe this study significantly advances our understanding of transposons and their role in human brains.

www.biorxiv.org/content/10.1...

Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease

Parkinson's disease (PD) is a common age-related neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to i...

www.biorxiv.org

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Johan Jakobsson @jakobssonlab.bsky.social · Aug 29

New collaborative paper from our lab! We developed cell-type specific transcriptional ageing clocks using snRNA-seq data from human brain.

doi.org/10.1002/advs...

Human Brain Cell‐Type‐Specific Aging Clocks Based on Single‐Nuclei Transcriptomics

Muralidharan and colleagues develop cell-type-specific transcriptomic aging clocks using single-nucleus RNA sequencing of human post mortem prefrontal cortex samples. These clocks accurately predict ....

doi.org

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Reposted by Johan Jakobsson

ASAP Team Jakobsson @jakobssonasap.bsky.social · Aug 27

Team Jakobsson gathered in southern Sweden for a few inspiring days discussing PD, transposable elements and future plans. We even squeezed in a hike and enjoyed some beautiful views ☀️🌊 @jakobssonlab.bsky.social @kirkebylab.bsky.social @mollygale.bsky.social @asapresearch.parkinsonsroadmap.org

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Johan Jakobsson @jakobssonlab.bsky.social · Aug 26

www.stemcellcenter.lu.se/article/why-...

Why repetitive DNA matters for human brain evolution and disease

Lund University. DNA carries the complete set of instructions an organism needs to develop and survive, but only about 1.5% of it consists of protein-coding genes that determine traits such as eye col...

www.stemcellcenter.lu.se

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Johan Jakobsson @jakobssonlab.bsky.social · Aug 23

New paper from our lab! We found that LINE-1 transposons contribute to early human brain development.

Funded by @asapresearch.parkinsonsroadmap.org

www.cell.com/cell-genomic...

LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development

Adami et al. demonstrate that evolutionarily young L1s are expressed in human pluripotent stem cells and are dynamically regulated throughout neural differentiation. The study examines the role of L1s...

www.cell.com

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Reposted by Johan Jakobsson

Dinos Meletis @meletis.bsky.social · Dec 22

first thing to share here!

excited to share lab’s first study in Parkinson’s disease revealing the prodromal vulnerability and function of the dopamine neuron subtype defined by Anxa1 expression - a specialized system controlling procedural motor learning

www.biorxiv.org/content/10.1...

Anxa1+ dopamine neuron vulnerability defines prodromal Parkinson's disease bradykinesia and procedural motor learning impairment

Progressive degeneration of dopamine neurons (DANs) defines Parkinson's disease (PD). However, the identity and function of the most vulnerable DAN populations in prodromal PD remain undefined. Here, ...

www.biorxiv.org

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Reposted by Johan Jakobsson

Christopher Douse @chdouse.bsky.social · Jul 1

Very proud of this work where we define how the MORC2 ATPase directs CpG methylation of active human L1 transposons in early development.

Thanks to co-authors, funders & wonderful environment @lundstem.bsky.social

www.biorxiv.org/content/10.1...

Brief thread below (do people still do that?) 1/X

MORC2 directs transcription-dependent CpG methylation of human LINE-1 transposons in early neurodevelopment

Methylation of CpG dinucleotides is essential for silencing genomic repeats such as LINE-1 retrotransposons (L1s) in the germline and soma. Evolutionarily-young L1s are transcribed in human pluripoten...

www.biorxiv.org

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Reposted by Johan Jakobsson

Johan Jakobsson @jakobssonlab.bsky.social · Jun 16

#TransposonDay2025 New manuscript from our center to which we contributed. Great work led by @chdouse.bsky.social ! Provides a mechanistic explanation for how L1s are silenced during early human development.

doi.org/10.1101/2025...

doi.org

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Reposted by Johan Jakobsson

Molly Gale (Gale-Hammell Lab) @mollygale.bsky.social · Jun 16

🧬🌽 Happy Transposon Day! 🌽🧬

Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025

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Johan Jakobsson @jakobssonlab.bsky.social · Jun 16

#TransposonDay2025 New manuscript from our center to which we contributed. Great work led by @chdouse.bsky.social ! Provides a mechanistic explanation for how L1s are silenced during early human development.

doi.org/10.1101/2025...

doi.org

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Reposted by Johan Jakobsson

Mike Fainzilber @mfainzilber.bsky.social · May 16

A 🧵 to walk those interested through this paper...

Mike Fainzilber @mfainzilber.bsky.social · May 16

Online now at @cp-cell.bsky.social , the culmination of a 12-year effort. 🧵 to follow later this evening

www.cell.com/cell/fulltex...

Repeat-element RNAs integrate a neuronal growth circuit

SINEs of recovery: A subset of small RNAs encoded by repetitive genomic elements are induced by nerve lesion to regulate protein synthesis and enhance axonal growth.

www.cell.com

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Reposted by Johan Jakobsson

Danica Milovanović @1995dana.bsky.social · May 19

New preprint of @trono-lab.bsky.social and my PhD work!
By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity.
🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1... #TEsky

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Reposted by Johan Jakobsson

Cedric Feschotte @cedricfeschotte.bsky.social · May 15

Good times in Lund 🇸🇪 with @jakobssonlab.bsky.social. Beautiful campus, great food, and awesome science! Thanks Johan!

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Johan Jakobsson @jakobssonlab.bsky.social · May 16

We had a fantastic guest speaker at our lab meeting this week who talked about the beautiful life of transposons and how they contributed to the evolution of the vertebrate brain. Thanks for the visit @cedricfeschotte.bsky.social !!

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Reposted by Johan Jakobsson

Raquel Fueyo @fueyoraquel.bsky.social · May 12

I am thrilled to share our preprint where we take advantage of the unique opportunities offered by human blastoids to uncover a human-specific mechanism potentially playing a role in preimplantation 🧵. www.biorxiv.org/content/10.1...

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Reposted by Johan Jakobsson

Cedric Feschotte @cedricfeschotte.bsky.social · Apr 30

💥🥳 At long last, our latest paper is out!

Gag proteins of endogenous retroviruses are required for zebrafish development

www.pnas.org/doi/10.1073/...

Led heroically by Sylvia Chang & @jonowells.bsky.social

A study which has changed the way I think of #transposons! No less! 🧵 1/n

Gag proteins encoded by endogenous retroviruses are required for zebrafish development | PNAS

Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound of TE-derived sequences repurposed for organismal function. ...

www.pnas.org

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Reposted by Johan Jakobsson

Nature Reviews Genetics @natrevgenet.nature.com · Apr 2

New online! Reactivation of retrotransposable elements is associated with environmental stress and ageing

Reactivation of retrotransposable elements is associated with environmental stress and ageing

Nature Reviews Genetics, Published online: 02 April 2025; doi:10.1038/s41576-025-00829-yIn this Review, Della Valle et al. discuss the role of retrotransposable elements (RTEs) in the onset and progression of ageing and ageing-related disease, including evidence that environmental stressors act through RTEs to shift the trajectory towards unhealthy ageing.

www.nature.com

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Reposted by Johan Jakobsson

Deborah Bourc’his @deborahbourchis.bsky.social · Apr 2

Do you have transposon-related research cooking, with some cool results you are exciting to share? Start thinking about registering to #EMBOMobileGenome workshop! Nov 4-7 2025 in Heidelberg. One of the historical TE meetings, with a diverse and welcoming community. www.embl.org/about/info/c...
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The mobile genome: genetic and physiological impacts of transposable elements

www.embl.org

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Reposted by Johan Jakobsson

Johan Jakobsson @jakobssonlab.bsky.social · Mar 29

New preprint from our lab! Why is not everyone working on Transposons?

Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons

www.biorxiv.org/content/10.1...

Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons

Heterochromatin is characterised by an inaccessibility to the transcriptional machinery and associated with the histone mark H3K9me3. Heterochromatin erosion is a hallmark of human ageing and H3K9me3 ...

www.biorxiv.org

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