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Danica Milovanović

@1995dana.bsky.social

81 followers 190 following 11 posts

scientist | pacifist | transposable elements | evo-devo PhD @trono-lab.bsky.social

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Danica Milovanović @1995dana.bsky.social · May 19

New preprint of @trono-lab.bsky.social and my PhD work!
By modulating SWI/SNF remodeling at ancient transposable elements - LINE/L2s and SINE/MIRs, a "noncanonical" KZFP called ZNF436 protects cardiomyocytes from losing their identity.
🫀heartbeat on 🔁 repeat
www.biorxiv.org/content/10.1... #TEsky

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Danica Milovanović @1995dana.bsky.social · 22h

Beautiful 🦋

Current Biology @currentbiology.bsky.social · 1d

Which journal would publish such a fragmented mess?
www.cell.com/current-biol...

Reposted by Danica Milovanović

Guillaume Andrey @guandrey.bsky.social · Jul 9

Our work bridging enhancer-promoter proximity to phenotypic outcomes in vivo is out! Shout out to @olimpiabompadre.bsky.social, to Marie Kmita's lab, and to all the co-authors. www.nature.com/articles/s41...

Liebenberg syndrome severity arises from variations in Pitx1 locus topology and proportion of ectopically transcribing cells - Nature Communications

Here the authors show that reducing enhancer-promoter distance at the Pitx1 locus increases proportion of Pitx1 forelimb expressing cells, worsening skeletal defects in Liebenberg syndrome. They also ...

www.nature.com

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Reposted by Danica Milovanović

Olga Rosspopoff, PhD @orpsf.bsky.social · Jun 25

🚨 Check out the latest from @trono-lab.bsky.social showing how evolutionarily young transcription factors contribute to human cell cycle regulation!
Brilliant work led by Romain Forey and Cyril Pulver, now published in Cell Genomics. Check it out !
www.cell.com/cell-genomic...

Evolutionarily recent transcription factors partake in human cell cycle regulation

Pulver and Forey et al. generated a novel atlas reporting (1) gene expression over the cell cycle and (2) how systematic gene depletion affects cell cycle progression. They thereby identified evolutio...

www.cell.com

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Reposted by Danica Milovanović

FragileNucleosome @fnucleosome.bsky.social · May 30

🔔Upcoming Wednesday, June 4th! Join us for another #FragileNucleosome series! Two amazing talks by @1995dana.bsky.social & @chrishsiung.bsky.social! If you haven’t jooned for any of 2025 talks, register here:
us06web.zoom.us/webinar/regi...

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Danica Milovanović @1995dana.bsky.social · May 20

Thank you Maria! :D

Danica Milovanović @1995dana.bsky.social · May 19

Thank you Cedric!

Danica Milovanović @1995dana.bsky.social · May 19

Big thanks to all the authors, particularly @orpsf.bsky.social ⭐

Danica Milovanović @1995dana.bsky.social · May 19

Restricted enhancers are active in variety of other tissues 🧠🫁...

Danica Milovanović @1995dana.bsky.social · May 19

What happens on a molecular level? 🧬
ZNF436 associates preferentially with PBAF subunits of SWI/SNF and limits the accessibility at L2/MIR-derived enhancers

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Danica Milovanović @1995dana.bsky.social · May 19

🧬 Loss of ZNF436 leads to impaired cardiomyocyte contractility 🫀

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Danica Milovanović @1995dana.bsky.social · May 19

🧬 Loss of ZNF436 leads to:
⬇️ downregulation of cardiac genes
⬆️ upregulation of non-cardiac, alternative lineage programs

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Danica Milovanović @1995dana.bsky.social · May 19

One of the KZFPs that bind L2/MIRs, ZNF436, is
a conserved KZFP, highly expressed in the developing human heart. ⌛🫀

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Danica Milovanović @1995dana.bsky.social · May 19

We first mapped the chromatin state of KZFP-bound TEs in the human genome and found a new twist:
Even ancient TEs (like L2/MIR elements) are preferential KZFP targets — however, without much of the usual H3K9me3 silencing.

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Danica Milovanović @1995dana.bsky.social · May 19

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Reposted by Danica Milovanović

bioRxiv Genomics @biorxiv-genomic.bsky.social · May 16

Tissue-specific restriction of TE-derived regulatory elements safeguards cell-type identity https://www.biorxiv.org/content/10.1101/2025.05.13.653700v1

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Reposted by Danica Milovanović

Tilly S Scott @tillysscott.bsky.social · Nov 21

And with that the afternoon of @gensocuk.bsky.social short talks is done! We've had: 1) KRABs binding L2/MIR elements, which would effect cardiovascular development; 2) DGCR8 prevents the accumulation of TE-made double-stranded RNA; 1/3 🧵

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