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Molly Gale (Gale-Hammell Lab)

@mollygale.bsky.social

670 followers 400 following 26 posts

Jumping Genomics! I run a lab in NYC that studies transposons 🧬in the brain 🧠 Opinions are all mine mghlab.org

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Molly Gale (Gale-Hammell Lab) @mollygale.bsky.social · Mar 10

Super happy to announce the latest work from my lab together with Hemali Phatnani @nygenome.org & NYGC ALS Consortium!

We've combined ALS patient profiling (100s!), ML classifiers and matched bulk/single-cell data to dive into ALS Molecular Subtypes

#NIHfundedResearch
www.cell.com/cell-reports...

ALS molecular subtypes are a combination of cellular and pathological features learned by deep multiomics classifiers

O’Neill et al. present a deep exploration of molecular subtypes in ALS postmortem tissues from the NYGC ALS Consortium. Matched bulk and single-cell profiles demonstrate that ALS subtypes are a combin...

www.cell.com

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Reposted by Molly Gale (Gale-Hammell Lab)

Emma Harding @emma-harding.bsky.social · 11d

Do you research endogenous retroviruses (ERVs) or want to learn more about them? 🧬🤔

Consider presenting at or attending AuusiERV - an inaugural online symposium for ERV research in Australia 🇦🇺 (and abroad) 🗺️

Abstracts due 1st October!

events.humanitix.com/aussierv-2025

#ERV #retrovirus

AussiERV 2025

AussiERV: Australia’s first symposium dedicated to endogenous retroviruses. Join us for this one-day virtual event on November 7th!

events.humanitix.com

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Reposted by Molly Gale (Gale-Hammell Lab)

Conrad Hackett @conradhackett.bsky.social · Sep 4

Disease prevalence in US states before & after vaccine introduction 🧪

From Edward Tufte & graphics.wsj.com/infectious-d...

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Reposted by Molly Gale (Gale-Hammell Lab)

Charles Jennings @chasjennings.bsky.social · Sep 3

Filmmaker Pamela Green is planning a movie about the late Ben Barres, transgender neuroscientist, world expert on glial cells, and an inspirational advocate for women and minorities in science. Pamela is seeking funds to finish her research and script – see fundraising trailer below.

AskTheQuestionMovie.com – An inspiring portrait of a rebel scientist with boundless curiosity, who, despit

askthequestionmovie.com

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Reposted by Molly Gale (Gale-Hammell Lab)

Shane Liddelow @liddelowsa.bsky.social · Aug 15

are you a PD in the glia (or neuroscience) space? Do you want to come to NYC and give a lecture and meet some amazing faculty here at @nyumedpostdocs.bsky.social?

LAST WEEK TO APPLY to be a SPiNES speaker for our next season.

Details and apply here: med.nyu.edu/departments-...

COME AND WOW US!

a black and white photo of a crowd of people standing and sitting in chairs .

ALT: a black and white photo of a crowd of people standing and sitting in chairs .

media.tenor.com

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Reposted by Molly Gale (Gale-Hammell Lab)

Mark Peifer (He, him) @peiferlabunc.bsky.social · Jul 2

For ESIs dealing with grants being rescinded: if an investigator’s 1st substantial independent research award is terminated within the first 3 years of the project period (not due to scientific misconduct ) they can request the reinstatement of ESI status

grants.nih.gov/news-events/...

My First Substantial Independent Research Award Was Terminated Early. Can My ESI Status Be Reinstated?
June 12, 2025
Investigators lose their Early Stage Investigator (ESI) eligibility when they successfully compete for and receive a substantial independent research award. In the event an investigator’s first substantial independent research award is terminated within the first three years of the project period, and this was not due to scientific misconduct or other disqualifying events, the investigator can request the reinstatement of ESI status, using the ESI Extensions request tool in eRA commons. See Requesting an Extension for instructions.

For more, see the Early Stage Investigators FAQ page.

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Reposted by Molly Gale (Gale-Hammell Lab)

MwahahahahahadScientist @mads100tist.bsky.social · Jun 27

TIL that one of the books removed from the Armed Forces Library because it "had DEI" in it is Ben Barres' autobiography. Remember that you can buy and should read this book because Ben was badass and an amazing scientist mitpress.mit.edu/978026253954...

The cover of the book, in greenish blueish color. The title is "The autobiography of a transgender scientist" by one of the most badass human beings that have ever existed, Ben Barres

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Reposted by Molly Gale (Gale-Hammell Lab)

Dana Foundation @danafoundation.bsky.social · Jun 23

Tomorrow, 6/24, NINDS is celebrating 75 years with a special congressional briefing spotlighting scientific advancements made possible from #NINDS over the past 75 years—from foundational discoveries in brain function to life-changing therapies for neurological diseases. #neurosociety #brainresearch

Celebrating 75 Years of Scientific Discovery and Innovation: NINDS 75th Anniversary Congressional Neuroscience Caucus Briefing & Reception

Event Timing: Tuesday, June 24, 2025 - 3:30-5:00pm ET Event Address: Longworth House Office Building Room 1539, Capitol Hill, Washington, DC Snacks and refreshments will be provided

docs.google.com

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Reposted by Molly Gale (Gale-Hammell Lab)

NSF–DOE Rubin Observatory @vrubinobs.bsky.social · Jun 23

The image offers a stunning variety of objects — from bright stars ranging from blue to red in color, to nearby blue spiral galaxies, to distant red galaxy groups — demonstrating the broad range of science made possible by Rubin data ✨🔭🧪

A sprawling, textured field of galaxies scattered across the deep black of space. It is filled with the delicate smudges and glowing cores of galaxies of many shapes, sizes and colors, as well as the bright multi-colored points of stars. To the lower left is a region filled with the hundreds of golden glittering gems of a distant galaxy cluster. In the foreground, below and right of center, two blue spiral galaxies look like eyes beneath the entangled mass of a triple galaxy merger in the upper right. A few bright blue points of foreground stars pierce the glittering tapestry.

Throughout the image, thousands of galaxies gather in clusters or are spread throughout, like glittering gems strewn on a table. Some are sharp-edged and spiral, like coiled ribbons; others round and diffuse, like polished pebbles. Still others are just smudges of various colors. The background is peppered with pinpoint stars in reds, yellows, and blues, crisp against the velvet black.

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Reposted by Molly Gale (Gale-Hammell Lab)

phoeberice.bsky.social @phoeberice.bsky.social · Jun 18

Dear Mobile DNA Researchers,

The 8th Woods Hole Mobile Genetic Elements meeting will be held Aug 28 to Aug 30, 2025, at the MBL in Woods Hole, Massachusetts.

Info, registration, and abstract submission: www.eventsquid.com/event/28372

#MobileDNA #MobileGeneticElements

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Molly Gale (Gale-Hammell Lab) @mollygale.bsky.social · Jun 16

Oh good catch - that was a copy-paste error! "DNA is the transforming principle" was 1944 while "DNA is the genetic material" (Hershey/Chase) was 1952

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Molly Gale (Gale-Hammell Lab) @mollygale.bsky.social · Jun 16

The field is still making new discoveries about transposons - how transposons function and how they contribute to (dys)function in ways both mind-boggling and also... already predicted by McClintock

Celebrate Transposon Day with your favorite TE-controlled trait!

pubmed.ncbi.nlm.nih.gov/22427337/

Retrotransposons control fruit-specific, cold-dependent accumulation of anthocyanins in blood oranges - PubMed

Traditionally, Sicilian blood oranges (Citrus sinensis) have been associated with cardiovascular health, and consumption has been shown to prevent obesity in mice fed a high-fat diet. Despite increasi...

pubmed.ncbi.nlm.nih.gov

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Molly Gale (Gale-Hammell Lab) @mollygale.bsky.social · Jun 16

The transposon work was not even McClintock's only major contribution to genetics. She also discovered chromosomal crossover in the 1930s and the breakage-fusion-bridge cycle that underlies aneuploidy in the 1940s

Timeline for "McClintock also discovered chromosomal crossover and breakage-fusion-bridge cycles"

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Molly Gale (Gale-Hammell Lab) @mollygale.bsky.social · Jun 16

Most people fail to appreciate just how groundbreaking McClintock's work truly was. Her transposon work was first presented in 1950 - before we knew, for example, "DNA is the genetic material." Long before most discoveries that we consider fundamental to the question of: "What is a gene?"

Timeline for major discoveries regarding "what is a gene"

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Molly Gale (Gale-Hammell Lab) @mollygale.bsky.social · Jun 16

🧬🌽 Happy Transposon Day! 🌽🧬

Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025

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Reposted by Molly Gale (Gale-Hammell Lab)

Lisa's Legacy for ALS @lisalegacy4als.bsky.social · Jun 10

We hate that this t-shirt has to exist but we love the creativity behind it. Our friend Ed created it as he works to bring about change for all battling ALS.

Now please follow the alien's request and complete an ALS Clinic Survey today. bit.ly/448GkkF

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Reposted by Molly Gale (Gale-Hammell Lab)

Liz Haswell @ehaswell.bsky.social · Jun 9

*URGENT* please support NIH research and the NIH employees who are standing up for science at the risk of losing their jobs! Sign *TODAY* in support of the Bethesda Declaration. The senate appropriations committee is reviewing the NIH budget Tuesday at 10 am. SHARE widely! 🧪

ADD YOUR NAME: Sign the Open Letter in Support of NIH Staff

Join the courageous and committed National Institutes of Health (NIH) public servants by adding your name now.

actionnetwork.org

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Reposted by Molly Gale (Gale-Hammell Lab)

Katie Mack @astrokatie.com · Jun 3

If you burn down a forest, you don't miss out on lumber for just that season. You have to replant all the trees, nurture them, and wait for them to grow.

The science and research budget cuts happening now are wanton, senseless arson. Recovery, if it ever happens, will take generations.

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Reposted by Molly Gale (Gale-Hammell Lab)

SalehLab @salehlabparis.bsky.social · May 20

Stop for a second and try to imagine this: a heat shock protein relocalizes to the cell surface and mediates dsRNA binding and internalization!
Intrigued? Read our newly minted paper in Science Advances www.science.org/doi/10.1126/...
Congrats to all the authors and thanks to reviewers and editor!

Hsc70-4: An unanticipated mediator of dsRNA internalization in Drosophila

Hsc70-4 localizes to the cell surface of Drosophila cells, binds to exogenous dsRNA, and mediates its internalization.

www.science.org

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Reposted by Molly Gale (Gale-Hammell Lab)

Ammar Al-Chalabi @ammaralchalabi.bsky.social · May 9

Our paper describing the results of the MIROCALS trial of low-dose interleukin-2 in #ALS #MND is out in the Lancet @thelancet.bsky.social

Open access

Read it here:
www.thelancet.com/journals/lan...

Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, double-blind, randomised, placebo-controlled trial

With this treatment schedule, IL-2LD resulted in a non-significant reduction in mortality in the primary unadjusted analysis. However, the difference between the results of unadjusted and adjusted ana...

www.thelancet.com

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Reposted by Molly Gale (Gale-Hammell Lab)

Tom Ellis @proftomellis.bsky.social · May 2

My dept in London at Imperial (Bioengineering) is recruiting a group leader at Professor level 🧑‍🎓 Please RT. It's a great place with world-class expertise in all sorts of biomedical & biological engineering topics like synthetic biology. It's also not in the USA. www.imperial.ac.uk/jobs/search-...

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Reposted by Molly Gale (Gale-Hammell Lab)

Whitney Gibbs @whitgibbs.bsky.social · Apr 30

My lab at NYU is hiring a postdoc interested in RNA biology and local translation in neurons following axonal injury/neurodegenerative diseases!! Apply here: apply.interfolio.com/165681

Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio

apply.interfolio.com

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Reposted by Molly Gale (Gale-Hammell Lab)

Andreas Prokop @poppi62.bsky.social · Apr 10

If using Bloomigton #Drosophila Stock Center stocks, pls. acknowledge them & their NIH funding (P40 OD018537). Papers listing this no. are being harvested as evidence. We massively depend on the @bdsc.bsky.social & they need our support in these dire times! @flybase.bsky.social @fly-eds.bsky.social

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Reposted by Molly Gale (Gale-Hammell Lab)

Jordan Meier @doc-jlmeier.bsky.social · Apr 10

Great news: NIH postbac program is recruiting again! If your grad school plans were affected by program cutbacks or admissions freezes this year I highly encourage you to apply, this could be a perfect opportunity. Please repost.

www.training.nih.gov/research-tra...

www.training.nih.gov

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Reposted by Molly Gale (Gale-Hammell Lab)

Deborah Bourc’his @deborahbourchis.bsky.social · Apr 2

Do you have transposon-related research cooking, with some cool results you are exciting to share? Start thinking about registering to #EMBOMobileGenome workshop! Nov 4-7 2025 in Heidelberg. One of the historical TE meetings, with a diverse and welcoming community. www.embl.org/about/info/c...
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The mobile genome: genetic and physiological impacts of transposable elements

www.embl.org

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