Kasra Nikouei
@kasran.bsky.social
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Reposted by Kasra Nikouei
interneuron.bsky.social
Our study on the impact of altered serotonin (5-HT) signalling on the developing sensory cortex is now live at Nature Comms.

We use longitudinal in vivo imaging of 5-HT and neural activity to show that this neuromodulator is buffered in early life to promote bottom-up instruction of sensory areas.
Image of a coronal section through postnatal mouse somatosensory cortex (S1BF with transient expression of the serotonin transporter in thalamic afferents shown in red.
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10x Genomics v3.1
10x Genomics Flex.
Evercode v2 Parse Bio.
PIPseq v5.0 Fluent Bio.
Smart-Seq3xpress
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Planning to perform single nuclei RNA-sequencing (snRNA-seq) experiments in complex tissues?

We performed a head-to-head comparison with five different methods on human post-mortem brain tissue.
Check out the benchmarking in our new preprint.

papers.ssrn.com/sol3/papers....
Benchmarking of Single Nuclei Rna-Seq Methods on Human Post-Mortem Brain Tissue
Molecular analysis of human post-mortem brain tissue by single nuclei RNA-sequencing (snRNA-seq) holds the promise to identify disease associated mechanisms. In
papers.ssrn.com