apombo1.bsky.social
Ana Pombo
@apombo1.bsky.social
1.2K followers 1.1K following 3 posts
Research Professor Johns Hopkins University @jhuartssciences.bsky.social @mdc-berlin.bsky.social @mdc-bimsb.bsky.social @neurocure.bsky.social @spp2202.bsky.social
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apombo1.bsky.social
Ana Pombo @apombo1.bsky.social · Mar 9
Join us for the 2025 GRC Genome Architecture www.grc.org/genome-archi... @spp2202.bsky.social @jobdekker.bsky.social @metorrespadilla.bsky.social @jopkind.bsky.social @dimplenotani.bsky.social @stanleyqilab.bsky.social @andybelmont.bsky.social @fondufemittendorf.bsky.social @boyanbonev.bsky.social
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Reposted by Ana Pombo
janeskok.bsky.social
janeskok.bsky.social @janeskok.bsky.social · Sep 3
We’re back! Registration is NOW OPEN for the 6th Annual Meeting on Advances in Nuclear Topology & 3D Chromatin Architecture in Cancer. Don’t miss insights from leading experts in the field. Join us online on Nov 25, 2025—register for free: bit.ly/chromatin-2025 #chromatin2025
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Reposted by Ana Pombo
denisduboule.bsky.social
Denis Duboule @denisduboule.bsky.social · 6d
Vertebrate Genome Evolution. Annual Symposium of the @louisjeantetfdn.bsky.social Foundation in Geneva. Free access on site and on line. Great speakers for a super interesting topic. #SvantePaabo #HenrikKaessmann organisers 🙏 See you there! @biology-unige.bsky.social @genevunige.bsky.social
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mdc-bimsb.bsky.social
MDC-BIMSB @mdc-bimsb.bsky.social · 10d
Passionate about #SystemsBiology and ready to lead your own research group?
Join us at the forefront of discovery — apply now to be a #GroupLeader at the NOVA Institute for Medical Systems Biology, in beautiful Lisbon, PT!

Appl. by Oct 8:
www.nature.com/naturecareer...

#ScienceJobs #JobOffer
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Reposted by Ana Pombo
mdc-bimsb.bsky.social
MDC-BIMSB @mdc-bimsb.bsky.social · Aug 7
Great opportunity! Up to 4 Group Leader positions at the NOVA Institute for Medical Systems Biology (NIMSB) in Computational & Experimental Medical Systems Biology
📍 Lisbon
⏳ Apply by Oct 8
🔗 nimsb.unl.pt/wp-content/u...

#Job #SciencePositions #JobOffer #GroupLeaders #Innovation #systemsbiology
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jobrxiv.org
jobRxiv @jobrxiv.org · 23d
NIMSB announces Four Independent Group Leader positions #ScienceJobs #AcademicSky
NIMSB announces Four Independent Group Leader positions
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
jobrxiv.org
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carlbergstrom.com
Carl T. Bergstrom @carlbergstrom.com · 24d
3. The paper above looks at the role of "ex ante" peer review process, such as that of research grants, where results are not known at the time of review.

The paper below looks at inescapable incentive problems that arise when trying to incentivize both risk and effort.
Rationalizing risk aversion in science: Why incentives to work hard clash with incentives to take risks
Scientific research requires taking risks, so why does much funded scientific research play it safe? This study uses an economic contracting model to argue that this can be explained in part by the no...
journals.plos.org
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basvansteensellab.bsky.social
Bas van Steensel lab (NKI) @basvansteensellab.bsky.social · Sep 2
Very proud of our paper on "scrambling-by-hopping" LADs, which was just published: www.nature.com/articles/s41.... Congrats to Lise Dauban and the rest of the team – this was a real tour-de-force!
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cedricboeckx.bsky.social
Cedric Boeckx @cedricboeckx.bsky.social · Aug 14
New preprint from @apombo1.bsky.social’s lab on gene regulation; insights into super-enhancers and their role in establishing complex regulatory networks of cell-type specific interactions with other enhancers and genes with specialized cellular functions 🧪🧬
www.biorxiv.org/content/10.1...
Specialised super-enhancer networks in stem cells and neurons
Super-enhancers (SEs) are clusters of enhancers with high transcriptional activity that play essential roles in defining cell identity through regulation of nearby genes. SEs preferentially form multi...
www.biorxiv.org
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jmstein.bsky.social
Johannes Stein @jmstein.bsky.social · Aug 13
(1/n) DNA-PAINT imaging inside the nucleus at single antibody resolution using TIRF? Ultrathin sectioning makes it happen!

Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵
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jmstein.bsky.social
Johannes Stein @jmstein.bsky.social · Aug 13
(3/n) Inspired by work by Eric Betzig, @heilemannlab.bsky.social, @apombo1.bsky.social and others, we adopted Tokuyasu cryosectioning to enable TIRF-based DNA-PAINT imaging throughout fixed HeLa cells without range constraint. We started with the nucleus & Pol II to explore tkPAINT’s potential.
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gautamdey.bsky.social
Gautam Dey @gautamdey.bsky.social · Jul 23
1 month to abstract deadline for the first cell biology of the nucleus meeting at @embl.org in many years - organised by the stellar @luskinglab.bsky.social @sarawickstrom.bsky.social Tom Quail & Simone Koehler

Tons of open slots, invited and selected speakers all get 20 mins ❤️

#EESNucleus
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mireyaplass.bsky.social
Mireya Plass @mireyaplass.bsky.social · Jul 14
I’m really happy to present #SCALPEL, a new #Nextflow tool to quantify transcript isoforms at the single-cell level using conventional 3’ scRNA-seq data #scRNA-seq #single-cell #tools #isoforms
www.nature.com/articles/s41...
Quantification of transcript isoforms at the single-cell level using SCALPEL - Nature Communications
Single-cell RNA-seq facilitates the study of transcriptome diversity in individual cells. Here, authors introduce a tool for isoform quantification at the single-cell level using 3’ scRNA-seq data, co...
www.nature.com
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oceanfilly.bsky.social
Brooke Fitzwater, PhD (she/her) 🐟🪱🏳️‍🌈♾️ @oceanfilly.bsky.social · Jul 18
As requested - A Starter Pack of PIs in Biology (or related fields) who are recruiting PHD STUDENTS! If you would like to be added, feel free to ask! go.bsky.app/Bf4DRFm
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evgenykvon.bsky.social
Evgeny Kvon @evgenykvon.bsky.social · Jul 2
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
Range extender mediates long-distance enhancer activity - Nature
The REX element is associated with long-range enhancer–promoter interactions.
www.nature.com
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ruibenedito.bsky.social
Rui Benedito @ruibenedito.bsky.social · Jun 26
The new Department of Functional Genetics at the Max Planck Institute for Molecular Biomedicine is looking for scientists at any level. 👉 mpi-muenster.mpg.de/780013/profil
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heick.bsky.social
Torben Heick Jensen @heick.bsky.social · Jun 27
Postdoc positions available in the Heick Jensen lab in sunny Aarhus. Sorting of good and bad RNAs in mammalian nuclei. Please get in touch for further information and/or use the following link to apply:
mbg.au.dk/en/news-and-...
A postdoc position in the Torben Heick Jensen lab, Aarhus University, Denmark: Mammalian Nuclear RNA Production and Turnover Systems - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University
mbg.au.dk
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mpercharde.bsky.social
Michelle Percharde @mpercharde.bsky.social · Jun 26
The Chromatin And Development lab are hiring a postdoc!

Come join us; we are a happy and hard working team @mrc-lms.bsky.social in London UK. Projects span the intersection of chromatin and transposon biology in dev't and disease. Email/DM for more info. Pls RT!

lms.mrc.ac.uk/work/vacanci...
MRC Postdoctoral Research Scientist - MRC Laboratory of Medical Sciences
The MRC Laboratory of Medical Sciences (LMS) is a biomedical research institute where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. LMS...
lms.mrc.ac.uk
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carlbergstrom.com
Carl T. Bergstrom @carlbergstrom.com · Jun 25
A few months ago, Nature published how-to guide for using ChatGPT to write your peer reviews in 30 minutes.

This is, of course, a horrible idea. Here’s my response with @jbakcoleman.bsky.social .
AI, peer review and the human activity of science
When researchers cede their scientific judgement to machines, we lose something important.
www.nature.com
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gocastelobranco.bsky.social
Gonçalo Castelo-Branco @gocastelobranco.bsky.social · Jun 25
The call just opened!

ki.se/en/about-ki/...

You can apply to several departments simultaneously, check out which depts better fit your profile! Here is the call for our Department of Medical Biochemistry and Biophysics

ki.varbi.com/what:job/job...
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evgenykvon.bsky.social
Evgeny Kvon @evgenykvon.bsky.social · Jun 23
How do non-coding variants in enhancers lead to disease? Happy to share our recent work, led by @ewholling.bsky.social, in which we discovered that poised chromatin sensitizes enhancers to aberrant activation by non-coding mutations, contributing to disease. www.biorxiv.org/content/10.1... 1/
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sethblackshaw.bsky.social
Seth Blackshaw @sethblackshaw.bsky.social · Jun 14
Our paper on gene regulatory networks controlling hypothalamic and prethalamic development is now out in Cell Reports./1
www.cell.com/cell-reports...
Decoding gene networks controlling hypothalamic and prethalamic neuron development
Kim et al. map gene regulatory networks of the developing mouse hypothalamus and prethalamus using single-cell multiomics, identifying regulators of regionalization and neurogenesis. They further show...
www.cell.com
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danielibrahim.bsky.social
Daniel Ibrahim @danielibrahim.bsky.social · May 27
How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Conservation of regulatory elements with highly diverged sequences across large evolutionary distances
Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...
rdcu.be
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molsystbiol.org
Molecular Systems Biology @molsystbiol.org · May 15
Extensive differences observed in 3D genome structure between homologous heterozygous chromosomes revealed by Genome Architecture Mapping #GAM in the @apombo1.bsky.social lab ➡️ www.embopress.org/doi/full/10....
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biocomicslab.bsky.social
Computational Multi-Omics Lab @biocomicslab.bsky.social · Apr 30
Big congratulations to Silvia Carvalho for successfully defending her PhD! 🎓
Her thesis focusing on SRRM2 is an exciting contribution to our understanding of gene regulation and early development.
We'd like to thank @apombo1.bsky.social for her generous collaboration during this joint supervision.
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axeldelamarre.bsky.social
Axel Delamarre @axeldelamarre.bsky.social · Nov 13
Interested in chromatin architecture?

Checkout our new method - PCP - that can map genome organization as multi-way interactions as well as nucleosome footprint and nucleosome spacing at very high resolution.
www.biorxiv.org/content/10.1...
Chromatin architecture mapping by multiplex proximity tagging
Chromatin plays a pivotal role in genome expression, maintenance, and replication. To better understand chromatin organization, we developed a novel proximity-tagging method which assigns unique DNA b...
www.biorxiv.org
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