Molecular Systems Biology
@molsystbiol.org
#OpenAccess @embopress.org journal publishing pioneering research in systems & synthetic biology, systems medicine
Pinned
11/2025 Issue ➡️ www.embopress.org/toc/17444292...
overflow metabolism, asymptomatic malaria, yeast variation, conserved PPI interfaces, persisters, base editing, immune signatures and cell patterning, viral protein structure prediction, GRN tool
Cover: vascular site-specific regulatory enhancers
overflow metabolism, asymptomatic malaria, yeast variation, conserved PPI interfaces, persisters, base editing, immune signatures and cell patterning, viral protein structure prediction, GRN tool
Cover: vascular site-specific regulatory enhancers
Early Registration deadline Nov 20th for @keystonesymposia.bsky.social #Microbiome Metabolism & #Metabolites, joint with Human #Microbiome, Jan 19-23 in Banff! See upcoming deadlines: keysym.us/KSMicroMetab26 keysym.us/KSMicrobiome26 #KSMicroMetab26 #KSMicrobiome26
Microbiome Metabolism and Metabolites: Discovery and Function in Health and Disease | Keystone Symposia
Join us at the Keystone Symposia on Microbiome Metabolism and Metabolites: Discovery and Function in Health and Disease, January 2026, in Banff, with field leaders!
keysym.us
November 17, 2025 at 6:05 PM
Early Registration deadline Nov 20th for @keystonesymposia.bsky.social #Microbiome Metabolism & #Metabolites, joint with Human #Microbiome, Jan 19-23 in Banff! See upcoming deadlines: keysym.us/KSMicroMetab26 keysym.us/KSMicrobiome26 #KSMicroMetab26 #KSMicrobiome26
11/2025 Issue ➡️ www.embopress.org/toc/17444292...
overflow metabolism, asymptomatic malaria, yeast variation, conserved PPI interfaces, persisters, base editing, immune signatures and cell patterning, viral protein structure prediction, GRN tool
Cover: vascular site-specific regulatory enhancers
overflow metabolism, asymptomatic malaria, yeast variation, conserved PPI interfaces, persisters, base editing, immune signatures and cell patterning, viral protein structure prediction, GRN tool
Cover: vascular site-specific regulatory enhancers
November 7, 2025 at 6:02 PM
11/2025 Issue ➡️ www.embopress.org/toc/17444292...
overflow metabolism, asymptomatic malaria, yeast variation, conserved PPI interfaces, persisters, base editing, immune signatures and cell patterning, viral protein structure prediction, GRN tool
Cover: vascular site-specific regulatory enhancers
overflow metabolism, asymptomatic malaria, yeast variation, conserved PPI interfaces, persisters, base editing, immune signatures and cell patterning, viral protein structure prediction, GRN tool
Cover: vascular site-specific regulatory enhancers
Reposted by Molecular Systems Biology
Explore emerging research with field leaders @keystonesymposia.bsky.social #Microbiome Metabolism & #Metabolites, this January in Banff! @molsystbiol.org scientific editor Poonam Bheda will attend.
Early registration deadline is Nov 20th => keysym.us/KSMicroMetab26 #KSMicroMetab26
Early registration deadline is Nov 20th => keysym.us/KSMicroMetab26 #KSMicroMetab26
Microbiome Metabolism and Metabolites: Discovery and Function in Health and Disease | Keystone Symposia
Join us at the Keystone Symposia on Microbiome Metabolism and Metabolites: Discovery and Function in Health and Disease, January 2026, in Banff, with field leaders!
keysym.us
October 23, 2025 at 12:12 PM
Explore emerging research with field leaders @keystonesymposia.bsky.social #Microbiome Metabolism & #Metabolites, this January in Banff! @molsystbiol.org scientific editor Poonam Bheda will attend.
Early registration deadline is Nov 20th => keysym.us/KSMicroMetab26 #KSMicroMetab26
Early registration deadline is Nov 20th => keysym.us/KSMicroMetab26 #KSMicroMetab26
Reposted by Molecular Systems Biology
Paper alert! doi.org/10.1038/s443... - "A scheduler for rhythmic gene expression". We show how 9 txn factors suffice for rhythmic gene expression of thousands of genes with any phase or amplitude in #Celegans larvae (and also look at the tissues where oscillations happen) 1/n
October 10, 2025 at 2:17 PM
Paper alert! doi.org/10.1038/s443... - "A scheduler for rhythmic gene expression". We show how 9 txn factors suffice for rhythmic gene expression of thousands of genes with any phase or amplitude in #Celegans larvae (and also look at the tissues where oscillations happen) 1/n
Reposted by Molecular Systems Biology
10/2025 Issue ➡️ www.embopress.org/toc/17444292...
reduced genomes, adaptive mutations under stress, xenobiotics and gut microbiome, DMS analysis, TF effector metabolites
Cover: proteins can agglomerate with limited impact on cell by @elevylab.bsky.social
reduced genomes, adaptive mutations under stress, xenobiotics and gut microbiome, DMS analysis, TF effector metabolites
Cover: proteins can agglomerate with limited impact on cell by @elevylab.bsky.social
October 7, 2025 at 6:16 PM
10/2025 Issue ➡️ www.embopress.org/toc/17444292...
reduced genomes, adaptive mutations under stress, xenobiotics and gut microbiome, DMS analysis, TF effector metabolites
Cover: proteins can agglomerate with limited impact on cell by @elevylab.bsky.social
reduced genomes, adaptive mutations under stress, xenobiotics and gut microbiome, DMS analysis, TF effector metabolites
Cover: proteins can agglomerate with limited impact on cell by @elevylab.bsky.social
Reposted by Molecular Systems Biology
🚨 New Web Resource Alert! 🚨 We're delighted to share Viro3D a database of >85000 viral protein structure predictions from >4400 human & animal viruses.
🔗 viro3d.cvr.gla.ac.uk
📄 www.embopress.org/doi/full/10....
@molsystbiol.org @cvrinfo.bsky.social @uofgmvls.bsky.social #Virology #AlphaFold 🧪 🦠
🔗 viro3d.cvr.gla.ac.uk
📄 www.embopress.org/doi/full/10....
@molsystbiol.org @cvrinfo.bsky.social @uofgmvls.bsky.social #Virology #AlphaFold 🧪 🦠
Viro3D
viro3d.cvr.gla.ac.uk
September 26, 2025 at 11:36 AM
🚨 New Web Resource Alert! 🚨 We're delighted to share Viro3D a database of >85000 viral protein structure predictions from >4400 human & animal viruses.
🔗 viro3d.cvr.gla.ac.uk
📄 www.embopress.org/doi/full/10....
@molsystbiol.org @cvrinfo.bsky.social @uofgmvls.bsky.social #Virology #AlphaFold 🧪 🦠
🔗 viro3d.cvr.gla.ac.uk
📄 www.embopress.org/doi/full/10....
@molsystbiol.org @cvrinfo.bsky.social @uofgmvls.bsky.social #Virology #AlphaFold 🧪 🦠
Reposted by Molecular Systems Biology
Our latest paper just came out in Molecular Systems Biology !
Transition between cell states of sensitivity reveals molecular vulnerability of drug-tolerant cells @molsystbiol.org
www.embopress.org/doi/full/10....
Transition between cell states of sensitivity reveals molecular vulnerability of drug-tolerant cells @molsystbiol.org
www.embopress.org/doi/full/10....
October 1, 2025 at 2:12 PM
Our latest paper just came out in Molecular Systems Biology !
Transition between cell states of sensitivity reveals molecular vulnerability of drug-tolerant cells @molsystbiol.org
www.embopress.org/doi/full/10....
Transition between cell states of sensitivity reveals molecular vulnerability of drug-tolerant cells @molsystbiol.org
www.embopress.org/doi/full/10....
Reposted by Molecular Systems Biology
🏎️ We wrote a N&Vs on the great new work from Shalev Itzkovitz lab in @molsystbiol.org. Barkai et al. calculate a turnover score and map it into spatial transcriptomics maps of intestinal tissues, informing us about dynamic biological processes in static atlases: www.embopress.org/do... 🧪
October 3, 2025 at 7:27 AM
🏎️ We wrote a N&Vs on the great new work from Shalev Itzkovitz lab in @molsystbiol.org. Barkai et al. calculate a turnover score and map it into spatial transcriptomics maps of intestinal tissues, informing us about dynamic biological processes in static atlases: www.embopress.org/do... 🧪
Reposted by Molecular Systems Biology
@molsystbiol.org picked a neat cover for this month's issue 🙃 - Great work from Tal Levin, Hector Garcia-Seisdedos, many more colleagues (doi.org/10.1038/s443...) and great matching cover, too!
October 5, 2025 at 7:40 PM
@molsystbiol.org picked a neat cover for this month's issue 🙃 - Great work from Tal Levin, Hector Garcia-Seisdedos, many more colleagues (doi.org/10.1038/s443...) and great matching cover, too!
Reposted by Molecular Systems Biology
Years ago we discovered that missense mutations in homomeric proteins often induces their supramolecular assembly, as in the 📽️👇 - Are such aberrant assemblies of *folded* proteins toxic? Surprisingly, NO. Cells are amazingly robust systems! Paper now online @molsystbiol.org doi.org/10.1038/s443...
September 16, 2025 at 4:22 PM
Years ago we discovered that missense mutations in homomeric proteins often induces their supramolecular assembly, as in the 📽️👇 - Are such aberrant assemblies of *folded* proteins toxic? Surprisingly, NO. Cells are amazingly robust systems! Paper now online @molsystbiol.org doi.org/10.1038/s443...
Reposted by Molecular Systems Biology
👏 Congratulations @elevylab.bsky.social for your latest publication in @molsystbiol.org: Mutation-induced filaments of folded proteins are inert and non-toxic in a cellular system @mocel.bsky.social #UNIGE
Years ago we discovered that missense mutations in homomeric proteins often induces their supramolecular assembly, as in the 📽️👇 - Are such aberrant assemblies of *folded* proteins toxic? Surprisingly, NO. Cells are amazingly robust systems! Paper now online @molsystbiol.org doi.org/10.1038/s443...
September 17, 2025 at 7:28 AM
👏 Congratulations @elevylab.bsky.social for your latest publication in @molsystbiol.org: Mutation-induced filaments of folded proteins are inert and non-toxic in a cellular system @mocel.bsky.social #UNIGE
Reposted by Molecular Systems Biology
Our study on the role of LTR5HS and SVAs in regulation of human neural crest migration is now published as peer-reviewed paper on @molsystbiol.org!
Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social
www.embopress.org/doi/full/10....
Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social
www.embopress.org/doi/full/10....
September 22, 2025 at 11:24 AM
Our study on the role of LTR5HS and SVAs in regulation of human neural crest migration is now published as peer-reviewed paper on @molsystbiol.org!
Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social
www.embopress.org/doi/full/10....
Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social
www.embopress.org/doi/full/10....
9/2025 Issue ➡️ www.embopress.org/toc/17444292...
mutational bursts in subsets of yeast, directed evolution with optogenetics, mouse gut biosensor screening, gene program dysregulation analysis
Cover: AlphaDesign to generate various protein structures, e.g. protein site-specific binders and oligomers
mutational bursts in subsets of yeast, directed evolution with optogenetics, mouse gut biosensor screening, gene program dysregulation analysis
Cover: AlphaDesign to generate various protein structures, e.g. protein site-specific binders and oligomers
September 8, 2025 at 11:32 AM
9/2025 Issue ➡️ www.embopress.org/toc/17444292...
mutational bursts in subsets of yeast, directed evolution with optogenetics, mouse gut biosensor screening, gene program dysregulation analysis
Cover: AlphaDesign to generate various protein structures, e.g. protein site-specific binders and oligomers
mutational bursts in subsets of yeast, directed evolution with optogenetics, mouse gut biosensor screening, gene program dysregulation analysis
Cover: AlphaDesign to generate various protein structures, e.g. protein site-specific binders and oligomers
Reposted by Molecular Systems Biology
Identifying genes essential to survival of bacteria Mycoplasma pneumoniae – the relevant new treatment targets
📷 Maria Lluch-Senar, research Samuel Miravet-Verde & Raul Burgos et al Serrano lab @crg.eu in @molsystbiol.org
➡️ bpod.org.uk/archive/2025... with
@rooph.bsky.social
📷 Maria Lluch-Senar, research Samuel Miravet-Verde & Raul Burgos et al Serrano lab @crg.eu in @molsystbiol.org
➡️ bpod.org.uk/archive/2025... with
@rooph.bsky.social
August 29, 2025 at 8:17 AM
Identifying genes essential to survival of bacteria Mycoplasma pneumoniae – the relevant new treatment targets
📷 Maria Lluch-Senar, research Samuel Miravet-Verde & Raul Burgos et al Serrano lab @crg.eu in @molsystbiol.org
➡️ bpod.org.uk/archive/2025... with
@rooph.bsky.social
📷 Maria Lluch-Senar, research Samuel Miravet-Verde & Raul Burgos et al Serrano lab @crg.eu in @molsystbiol.org
➡️ bpod.org.uk/archive/2025... with
@rooph.bsky.social
Reposted by Molecular Systems Biology
#ResultatScientifique 🔎 | Saviez-vous que l’IA peut aider à prévoir comment un organisme réagit à son environnement ? Des scientifiques utilisent la levure comme modèle et réussissent à prédire plus de 200 traits grâce au machine learning
✍️ @litinice.bsky.social
📕 @molsystbiol.org | buff.ly/MliXXKz
✍️ @litinice.bsky.social
📕 @molsystbiol.org | buff.ly/MliXXKz
September 1, 2025 at 4:01 PM
#ResultatScientifique 🔎 | Saviez-vous que l’IA peut aider à prévoir comment un organisme réagit à son environnement ? Des scientifiques utilisent la levure comme modèle et réussissent à prédire plus de 200 traits grâce au machine learning
✍️ @litinice.bsky.social
📕 @molsystbiol.org | buff.ly/MliXXKz
✍️ @litinice.bsky.social
📕 @molsystbiol.org | buff.ly/MliXXKz
A. Mardinoglu et al. explore how AI + systems biology are transforming multi-omics integration for precision health and medicine ➡️ www.embopress.org/doi/full/10....
August 8, 2025 at 11:31 AM
A. Mardinoglu et al. explore how AI + systems biology are transforming multi-omics integration for precision health and medicine ➡️ www.embopress.org/doi/full/10....
AlphaDesign uses hallucination + sequence generation to create diverse proteins—from monomers to oligomers to site-specific binders ➡️ www.embopress.org/doi/full/10....
August 8, 2025 at 11:30 AM
AlphaDesign uses hallucination + sequence generation to create diverse proteins—from monomers to oligomers to site-specific binders ➡️ www.embopress.org/doi/full/10....
generative AI model PerturbNet predicts changes in gene expression and cell state in response to unseen chemical and genetic perturbations ➡️ www.embopress.org/doi/full/10....
August 4, 2025 at 1:55 PM
generative AI model PerturbNet predicts changes in gene expression and cell state in response to unseen chemical and genetic perturbations ➡️ www.embopress.org/doi/full/10....
8/2025 Issue ➡️ www.embopress.org/toc/17444292... spatial metabolomics, protein compensation upon gene loss, ancient yeast gene family evolution, prion-like protein fibrils in the gut
Cover: PerturbNet deep generative model predicts states of cells perturbed by chemicals or genetics
Cover: PerturbNet deep generative model predicts states of cells perturbed by chemicals or genetics
August 4, 2025 at 1:52 PM
8/2025 Issue ➡️ www.embopress.org/toc/17444292... spatial metabolomics, protein compensation upon gene loss, ancient yeast gene family evolution, prion-like protein fibrils in the gut
Cover: PerturbNet deep generative model predicts states of cells perturbed by chemicals or genetics
Cover: PerturbNet deep generative model predicts states of cells perturbed by chemicals or genetics
Reposted by Molecular Systems Biology
Excited to share the latest paper from the Riglar lab @imperialinfect.bsky.social & @crick.ac.uk.
We use #synbio for biosensor discovery in our quest to build 'smart probiotics' to sense and treat disease.
Well done @clare-r.bsky.social et al!
Thanks to @wellcometrust.bsky.social for funding!
We use #synbio for biosensor discovery in our quest to build 'smart probiotics' to sense and treat disease.
Well done @clare-r.bsky.social et al!
Thanks to @wellcometrust.bsky.social for funding!
July 20, 2025 at 7:25 PM
Excited to share the latest paper from the Riglar lab @imperialinfect.bsky.social & @crick.ac.uk.
We use #synbio for biosensor discovery in our quest to build 'smart probiotics' to sense and treat disease.
Well done @clare-r.bsky.social et al!
Thanks to @wellcometrust.bsky.social for funding!
We use #synbio for biosensor discovery in our quest to build 'smart probiotics' to sense and treat disease.
Well done @clare-r.bsky.social et al!
Thanks to @wellcometrust.bsky.social for funding!
@skamrad.bsky.social @kiranrpatil.bsky.social show xenobiotics impact growth of gut bacteria and their metabolic homeostasis by affecting amine metabolism ➡️ www.embopress.org/doi/full/10....
July 3, 2025 at 12:44 PM
@skamrad.bsky.social @kiranrpatil.bsky.social show xenobiotics impact growth of gut bacteria and their metabolic homeostasis by affecting amine metabolism ➡️ www.embopress.org/doi/full/10....
@mariananatalin6.bsky.social @marcofumasoni.bsky.social show evolutionary repair in response to DNA replication stress in yeast is predictable and consistent across different environments #CompensatoryEvolution #NutrientAvailability #ReplicationStress #GxE ➡️ www.embopress.org/doi/full/10....
July 3, 2025 at 12:39 PM
@mariananatalin6.bsky.social @marcofumasoni.bsky.social show evolutionary repair in response to DNA replication stress in yeast is predictable and consistent across different environments #CompensatoryEvolution #NutrientAvailability #ReplicationStress #GxE ➡️ www.embopress.org/doi/full/10....
A bacterial synthetic memory system is used to enhance screening for new biosensors in the mouse gut by @driglar.bsky.social @clare-r.bsky.social ➡️ www.embopress.org/doi/full/10....
July 3, 2025 at 12:36 PM
A bacterial synthetic memory system is used to enhance screening for new biosensors in the mouse gut by @driglar.bsky.social @clare-r.bsky.social ➡️ www.embopress.org/doi/full/10....
integrated temporally resolved transcriptomic, proteomic, and secretomic profiling of human kidney mesenchymal cells from @savitski-lab.bsky.social @saezlab.bsky.social @miraburtscher.bsky.social identify dynamic changes upon TGF-beta stimulation ➡️ www.embopress.org/doi/full/10....
July 3, 2025 at 12:30 PM
integrated temporally resolved transcriptomic, proteomic, and secretomic profiling of human kidney mesenchymal cells from @savitski-lab.bsky.social @saezlab.bsky.social @miraburtscher.bsky.social identify dynamic changes upon TGF-beta stimulation ➡️ www.embopress.org/doi/full/10....