Rahul K
@theresearch.bsky.social
I run, ski, and engineer cells and materials; asking how nutrient sensing & signaling work: bit.ly/RK-GoogleScholar
🇪🇪: TalTech| Ex: Tartu Ülikool; 🇸🇪: Karolinska Institutet, Chalmers; 🇯🇵: Kyutech; 🇮🇳: IITD
🇪🇪: TalTech| Ex: Tartu Ülikool; 🇸🇪: Karolinska Institutet, Chalmers; 🇯🇵: Kyutech; 🇮🇳: IITD
Pinned
Rahul K
@theresearch.bsky.social
· Nov 11
I’d like to invite everyone working on engineering living materials to share this starter pack. Please drop me a message or leave a comment if you like to join the #ELMs community. go.bsky.app/RinsDZh
Reposted by Rahul K
Single-Molecule DNA Footprinting and Transcription Imaging Reveal the Molecular Mechanisms of Promoter Dynamics https://www.biorxiv.org/content/10.1101/2025.11.26.690466v1
November 27, 2025 at 3:19 AM
Single-Molecule DNA Footprinting and Transcription Imaging Reveal the Molecular Mechanisms of Promoter Dynamics https://www.biorxiv.org/content/10.1101/2025.11.26.690466v1
Reposted by Rahul K
Tsa1-Mediated Regulation of PKA Tunes Trehalose Metabolism in Saccharomyces cerevisiae https://www.biorxiv.org/content/10.1101/2025.11.26.690464v1
November 27, 2025 at 3:18 AM
Tsa1-Mediated Regulation of PKA Tunes Trehalose Metabolism in Saccharomyces cerevisiae https://www.biorxiv.org/content/10.1101/2025.11.26.690464v1
Reposted by Rahul K
cAMP promotes acute lysosome biogenesis through TFEB nuclear import-export dynamics. https://www.biorxiv.org/content/10.1101/2025.11.24.690233v1
November 27, 2025 at 3:30 AM
cAMP promotes acute lysosome biogenesis through TFEB nuclear import-export dynamics. https://www.biorxiv.org/content/10.1101/2025.11.24.690233v1
Reposted by Rahul K
The publishing streak continues! Excited to share our new article in Nature Reviews Materials (@natrevmats.nature.com) entitled "Engineering Complexity into Protein-based Biomaterials for Biomedical Applications"!
Check it out here:
📜: doi.org/10.1038/s415...
🔓: rdcu.be/eRFDh
Check it out here:
📜: doi.org/10.1038/s415...
🔓: rdcu.be/eRFDh
Engineering complexity into protein-based biomaterials for biomedical applications - Nature Reviews Materials
Protein-based biomaterials are becoming increasingly prevalent in biomedical applications that treat and prevent disease. This Perspective examines the evolution of techniques used to build and design...
doi.org
November 26, 2025 at 10:58 PM
The publishing streak continues! Excited to share our new article in Nature Reviews Materials (@natrevmats.nature.com) entitled "Engineering Complexity into Protein-based Biomaterials for Biomedical Applications"!
Check it out here:
📜: doi.org/10.1038/s415...
🔓: rdcu.be/eRFDh
Check it out here:
📜: doi.org/10.1038/s415...
🔓: rdcu.be/eRFDh
Reposted by Rahul K
![Comic. Panels up to the 10-year point are grayed out. New panels since the Ten Years comic, which chronicles the first ten years of PERSON 1's journey with cancer: (1) [two people in bed] PERSON 1 (woman): One more chapter? PERSON 2 (man): Don’t we both have to get up early? PERSON 1: Nnnnnggggh PERSON 2: Sure, good point. (2) [many people wearing masks, walking while looking at graphs on their phones] (3) [birds landing on people] PERSON 2 in beanie and scarf: Hah! They like *my* seeds best. PERSON 1 in scarf holding phone with a bird sitting on it: Wait, how do I take a picture of this one? (4) [two people rowing boats with tree landscape] (5) [Person 1 carries overflowing stack of things to Person 2 in bed] PERSON 1: I brought you honey lemon tea, more pillows, a cinnamon roll, Tylenol, another blanket, a– PERSON 2: It was just Appendicitis, I’m really– PERSON 1: *It is my turn to take care of you and I am going to do it right!* (6) [Two people in car] (7) [still in car) PERSON 1: Oh my god. PERSON 2: Oh my god. (8) [car driving] PERSON 1: Pull over! PERSON 2: I am! (9) [both people get out of car] (10) [Large colored panel of aurora borealis over water with both people looking on] (11) [Person 1 sits against tree while Person 2 lies on the ground] PERSON 1: Fifteen years. No sign of the cancer. (12) I *am* having some weird symptoms. Joint pain. Fatigue. I think I’m losing my close-up vision. PERSON 2: Yeah. Me too. (13) PERSON 2: I think we’re getting old. (14) PERSON 1: I guess that’s okay. PERSON 2: It’s all I wanted.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreihwhjblp5lyiwp63ouar7ocfea7evmckytoeo7rkfuoo4gw5rnrra@jpeg)
November 26, 2025 at 10:32 PM
Reposted by Rahul K
Fun new preprint from the lab, headed up by two incredible undergraduate researchers: Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast. www.biorxiv.org/content/10.1...
Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast
The budding yeast, Saccharomyces cerevisiae, is the workhorse of the brewing industry. Brewers have domesticated a vast array of different strains with traits that complement the beers they wish to br...
www.biorxiv.org
November 26, 2025 at 8:18 PM
Fun new preprint from the lab, headed up by two incredible undergraduate researchers: Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast. www.biorxiv.org/content/10.1...
Reposted by Rahul K
Now online! Thermodynamic principles link in vitro transcription factor affinities to single-molecule chromatin states in cells
Thermodynamic principles link in vitro transcription factor affinities to single-molecule chromatin states in cells
In vitro-derived insights into features that drive transcription factor binding to DNA, including motif-adjacent sequence, enable prediction of chromatin states and transcription factor occupancy in cells.
dlvr.it
November 26, 2025 at 7:51 PM
Now online! Thermodynamic principles link in vitro transcription factor affinities to single-molecule chromatin states in cells
Reposted by Rahul K
Our new paper is out now in Nature Communications! We uncovered the function of XBP1 in beta cells of a preclinical model of T1D and identified unique and shared gene regulatory networks driven by IRE1 and XBP1.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Defining the role of β-cell IRE1α/XBP1 pathway and its gene regulatory network components in non-obese diabetic mice - Nature Communications
Modulating the unfolded protein response (UPR) can induce protective dedifferentiation of β-cells in non-obese diabetic mice. Here, the authors show that β-cell deletion of UPR transcription factor XB...
www.nature.com
November 26, 2025 at 2:28 PM
Our new paper is out now in Nature Communications! We uncovered the function of XBP1 in beta cells of a preclinical model of T1D and identified unique and shared gene regulatory networks driven by IRE1 and XBP1.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Rahul K
Excited to share our latest research in @natmicrobiol.nature.com . We uncover hundreds of inhibitory interactions between common chemical pollutants and human gut bacteria. A thread🧵 (1/10) #microbiomesky #microsky @kiranrpatil.bsky.social lab @mrc-tu.bsky.social www.nature.com/articles/s41...
Industrial and agricultural chemicals exhibit antimicrobial activity against human gut bacteria in vitro - Nature Microbiology
Screening of 1,076 compounds reveals 168 chemical pollutants with inhibitory effects on gut bacteria and genetic screens indicate commonality between pollutant and antibiotic resistance.
www.nature.com
November 26, 2025 at 10:30 AM
Excited to share our latest research in @natmicrobiol.nature.com . We uncover hundreds of inhibitory interactions between common chemical pollutants and human gut bacteria. A thread🧵 (1/10) #microbiomesky #microsky @kiranrpatil.bsky.social lab @mrc-tu.bsky.social www.nature.com/articles/s41...
Reposted by Rahul K
🎉Paper alert! How do #axolotls regrow their limbs to match their body size? A new publication by PoL @friedrich-group.bsky.social along with @tatianasg.bsky.social @crtd-tud.bsky.social shows that opposing morphogen gradients scaling with animal size are key.
Curious? Read our news: tud.link/z6tj5y
Curious? Read our news: tud.link/z6tj5y
Morphogen Math: A Model of Axolotl Limb Growth during Regeneration
In a new publication led by the Friedrich group at PoL and the Sandoval-Guzmán group at CRTD, scientists propose a model of morphogen scaling during limb regeneration in axolotls.
tud.link
November 26, 2025 at 10:18 AM
🎉Paper alert! How do #axolotls regrow their limbs to match their body size? A new publication by PoL @friedrich-group.bsky.social along with @tatianasg.bsky.social @crtd-tud.bsky.social shows that opposing morphogen gradients scaling with animal size are key.
Curious? Read our news: tud.link/z6tj5y
Curious? Read our news: tud.link/z6tj5y
Reposted by Rahul K
We celebrate Thanksgiving with a new issue of #AppEnvMicro in ASM Journals‼️
And, as appetizers, these fantastic articles I selected for the Spotlight section (see 🧵 in the comments below).
doi.org/10.1128/aem....
And, as appetizers, these fantastic articles I selected for the Spotlight section (see 🧵 in the comments below).
doi.org/10.1128/aem....
Articles of Significant Interest in This Issue | Applied and Environmental Microbiology
Compost is a valuable amendment for suppression of soil pathogens. Logo et al. (e01100-25) describe biomarkers of disease-suppressive composts, laying the groundwork for targeted
isolation and functio...
doi.org
November 26, 2025 at 10:08 AM
We celebrate Thanksgiving with a new issue of #AppEnvMicro in ASM Journals‼️
And, as appetizers, these fantastic articles I selected for the Spotlight section (see 🧵 in the comments below).
doi.org/10.1128/aem....
And, as appetizers, these fantastic articles I selected for the Spotlight section (see 🧵 in the comments below).
doi.org/10.1128/aem....
Reposted by Rahul K
Outstanding PhD fellowship call OPEN for excellent students.
lacaixafoundation.org/en/doctoral-...
This is for students incoming from outside Spain. And it is VERY well supported (ie at European levels).
If you’re interested in doing a PhD in our lab @irbbarcelona.org, reach out!!!!
lacaixafoundation.org/en/doctoral-...
This is for students incoming from outside Spain. And it is VERY well supported (ie at European levels).
If you’re interested in doing a PhD in our lab @irbbarcelona.org, reach out!!!!
Doctoral INPhINIT fellowships - Incoming Call 2026
We grant 30 fellowships for researchers of any nationality who wish to pursue a doctorate in a STEM discipline at research centres of excellence in Spain or Portugal.
www.google.com
November 26, 2025 at 7:43 AM
Outstanding PhD fellowship call OPEN for excellent students.
lacaixafoundation.org/en/doctoral-...
This is for students incoming from outside Spain. And it is VERY well supported (ie at European levels).
If you’re interested in doing a PhD in our lab @irbbarcelona.org, reach out!!!!
lacaixafoundation.org/en/doctoral-...
This is for students incoming from outside Spain. And it is VERY well supported (ie at European levels).
If you’re interested in doing a PhD in our lab @irbbarcelona.org, reach out!!!!
Reposted by Rahul K
Synthetic niches enable co-culture bioprocessing but are prone to mutational escape https://www.biorxiv.org/content/10.1101/2025.11.24.690348v1
November 26, 2025 at 2:02 AM
Synthetic niches enable co-culture bioprocessing but are prone to mutational escape https://www.biorxiv.org/content/10.1101/2025.11.24.690348v1
Reposted by Rahul K
I am looking for a PostDoc to join my group at Genentech to drive the development of proteomics technologies to fuel target and therapeutic discovery and development. Check out the link below!
careers.gene.com/us/en/job/20...
careers.gene.com/us/en/job/20...
November 25, 2025 at 12:39 AM
I am looking for a PostDoc to join my group at Genentech to drive the development of proteomics technologies to fuel target and therapeutic discovery and development. Check out the link below!
careers.gene.com/us/en/job/20...
careers.gene.com/us/en/job/20...
Reposted by Rahul K
The effects of rapid mitochondrial gene loss on organellar proteomes https://www.biorxiv.org/content/10.1101/2025.11.24.690252v1
November 26, 2025 at 5:16 AM
The effects of rapid mitochondrial gene loss on organellar proteomes https://www.biorxiv.org/content/10.1101/2025.11.24.690252v1
Reposted by Rahul K
A great intro to academic conferencing.
Not sure how I missed this one.
scienceforeveryone.science/getting-the-...
Not sure how I missed this one.
scienceforeveryone.science/getting-the-...
Getting the most of out a scientific conference
A slightly unconventional guide to your first time
scienceforeveryone.science
November 26, 2025 at 4:47 AM
A great intro to academic conferencing.
Not sure how I missed this one.
scienceforeveryone.science/getting-the-...
Not sure how I missed this one.
scienceforeveryone.science/getting-the-...
Reposted by Rahul K
Interested in research on soft and biological materials in Germany?
Our lab alumnus Lotta is starting her own group at RWTH Aachen 🎉Huge congrats, Lotta!
Her lab will focus on soft and biological materials towards biomedical and sustainable applications, and she’s looking for motivated PhD students!
Our lab alumnus Lotta is starting her own group at RWTH Aachen 🎉Huge congrats, Lotta!
Her lab will focus on soft and biological materials towards biomedical and sustainable applications, and she’s looking for motivated PhD students!
Doktorand*in (w/m/d) im Fachbereich Biophysik, Biochemie und/oder Biomaterialien: Struktur komplexer phasenseparierender Flüssigkeiten | Jobs bei DWI Leibniz-Institut für Interaktive Materialien e.V. ...
🎉Very happy to share that I will start my own research group as an independent group leader at the DWI – Leibniz Institute for Interactive Materials at RWTH Aachen University in February 2026!
🚀We w...
www.linkedin.com
November 26, 2025 at 12:23 AM
Interested in research on soft and biological materials in Germany?
Our lab alumnus Lotta is starting her own group at RWTH Aachen 🎉Huge congrats, Lotta!
Her lab will focus on soft and biological materials towards biomedical and sustainable applications, and she’s looking for motivated PhD students!
Our lab alumnus Lotta is starting her own group at RWTH Aachen 🎉Huge congrats, Lotta!
Her lab will focus on soft and biological materials towards biomedical and sustainable applications, and she’s looking for motivated PhD students!
Reposted by Rahul K
I’ve been running around asking tech execs and academics if language was the same as intelligence for over a year now - and, well, it isn’t. @benjaminjriley.bsky.social explains how the bubble is built on ignoring cutting-edge research into the science of thought www.theverge.com/ai-artificia...
November 25, 2025 at 1:54 PM
I’ve been running around asking tech execs and academics if language was the same as intelligence for over a year now - and, well, it isn’t. @benjaminjriley.bsky.social explains how the bubble is built on ignoring cutting-edge research into the science of thought www.theverge.com/ai-artificia...
Reposted by Rahul K
Check out our most recent published paper in @natcomms.nature.com about the effects of cell surface crowding in cell-cell fusion: rdcu.be/ezCOF
Cell surface crowding is a tunable energetic barrier to cell-cell fusion
Nature Communications - Cell-cell fusion is fundamental to physiological processes such as muscle formation and viral infection. Here, the authors show that the proteins embedded on the plasma...
rdcu.be
August 7, 2025 at 12:58 AM
Check out our most recent published paper in @natcomms.nature.com about the effects of cell surface crowding in cell-cell fusion: rdcu.be/ezCOF
Reposted by Rahul K
Check out our latest published manuscript: SurFlex microscopy, a new technique to measure molecular flexibility. Congrats to Aymeric, @sid592.bsky.social, @blenackmon.bsky.social, and Andres! www.pnas.org/doi/10.1073/...
SurFlex microscopy: Measuring flexibility of surface-tethered biomolecules | PNAS
The flexibility of tethered molecules, such as those bound to biological membranes,
is an important property that can influence molecular height, m...
www.pnas.org
November 25, 2025 at 7:40 PM
Check out our latest published manuscript: SurFlex microscopy, a new technique to measure molecular flexibility. Congrats to Aymeric, @sid592.bsky.social, @blenackmon.bsky.social, and Andres! www.pnas.org/doi/10.1073/...
Reposted by Rahul K
#OPENACCESS: Chromatin unfolding via loops can drive clustered transposon insertion. Roshan Prizak, Aaron Gadzekpo, and Lennart Hilbert.
Chromatin unfolding via loops can drive clustered transposon insertion
Transposons, DNA sequences capable of relocating within the genome, make up a significant portion of eukaryotic genomes and are often found in clusters. Within the cell nucleus, the genome is…
www.cell.com
November 25, 2025 at 7:02 PM
#OPENACCESS: Chromatin unfolding via loops can drive clustered transposon insertion. Roshan Prizak, Aaron Gadzekpo, and Lennart Hilbert.
Reposted by Rahul K
Today is the International day for the elimination of violence against women. In 2024, an estimated 50,000 women and girls were killed by intimate partners or family members worldwide. That is 137 women and girls every day. One every ten minutes. www.un.org/en/observanc...
International Day for the Elimination of Violence against Women | United Nations
The International Day for the Elimination of Violence against Women aims to create awareness of the fact that violence against women is a human rights violation that impedes progress in many areas, in...
www.un.org
November 25, 2025 at 4:28 PM
Today is the International day for the elimination of violence against women. In 2024, an estimated 50,000 women and girls were killed by intimate partners or family members worldwide. That is 137 women and girls every day. One every ten minutes. www.un.org/en/observanc...
Reposted by Rahul K
Students applying for grad school, or reaching out to professors. I have an important piece of advice for you: STOP DOING THIS 👇 (a thread) #STEM #PhD #gradschool #academictips
November 21, 2025 at 9:53 PM
Students applying for grad school, or reaching out to professors. I have an important piece of advice for you: STOP DOING THIS 👇 (a thread) #STEM #PhD #gradschool #academictips
Reposted by Rahul K
New preprint with @pyjiang.bsky.social and @kelleyharris.bsky.social! The discovery and patterns of the underlying long-standing mild-effect mutator alleles in S. cerevisiae populations www.biorxiv.org/content/10.1...
The discovery and patterns of the underlying long-standing mild-effect mutator alleles in S. cerevisiae populations
Most mutations are neutral or deleterious, and mutator alleles that increase the mutation rate of an organism are considered rare and short-lived. Here, we report a genomic signature consistent with t...
www.biorxiv.org
November 25, 2025 at 3:12 PM
New preprint with @pyjiang.bsky.social and @kelleyharris.bsky.social! The discovery and patterns of the underlying long-standing mild-effect mutator alleles in S. cerevisiae populations www.biorxiv.org/content/10.1...
Reposted by Rahul K
A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 25, 2025 at 12:16 PM
A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...