As biomedical research prioritizes human models and translational promise, classic model organisms are increasingly dismissed. Here we argue that they have a lasting value, both in enabling discovery and in cultivating scientific thinking, by training researchers in systems reasoning, integrative thinking and independent inquiry.

Methylated amino acids accumulate upon the degradation of methylated proteins and are implicated in diverse metabolic and signaling pathways. Disturbe…

Koo et al. apply genome-scale double-CRISPRi to map cell envelope gene interactions in Bacillus subtilis, revealing >1,000 genetic interactions and uncovering gene networks in envelope biogenesis and ...

The U.S. Department of Education recently sent MIT and eight other institutions a proposed “Compact for Academic Excellence in Higher Education," along with a letter asking that MIT review the document.

The Nobel Peace Prize 2025 was awarded to Maria Corina Machado “for her tireless work promoting democratic rights for the people of Venezuela and for her struggle to achieve a just and peaceful transi...

Deep learning-based generative tools are used to design protein building blocks with well-defined directional protein bonding interactions, allowing for the generation of a variety of scalable protein assemblies from a small set of reusable subunits.

Engineered aminoacyl-tRNA synthetase (aaRS) mutants have been developed that facilitate ultrafast bioorthogonal noncanonical amino acid tagging (BONCAT) of newly synthesized proteins in diverse bacteria, including ESKAPE pathogens. The substrate polyspecificity of the aaRS mutants enables pulse-chase BONCAT and differential tagging of temporally distinct nascent proteomes in cells.

Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...

Malignant tumors are characterized by diverse metabolic stresses, including nutrient shortages, hypoxia, and buildup of metabolic by-products. To understand how cancer cells adapt to such challenges, ...

InThisTogether

Job Title: Associate or Senior Editor (Nature Metabolism and Nature Communications) Location(s): New York, Jersey City, Philadelphia, Beijing or Shanghai Application Deadline: October 26th, 2025 About...

About EMBL-EBI EMBL’s European Bioinformatics Institute is a data powerhouse, utilised on a global scale to advance scientific discovery through bioinformatics and solutions to some of the world’s mos...

Nobel Prize–winning technology engineered to treat autoimmune diseases and cancer

Kalchschmidt et al. combine 47 reporter cell lines and CRISPR screens to map gene regulation in human B cell lymphoma. They establish the interactive B-LEARN portal and discover that mTORC1 and GSK3 oppositely regulate cell cycle and immune response genes, offering insights and treatment targets for lymphoma and autoimmune diseases.

The future of science will be written by humans and machines together. Awards should reflect that reality.

Nature Protocols, Published online: 09 October 2025; doi:10.1038/s41596-025-01256-3Filter-aided expansion proteomics facilitates spatial proteomics at subcellular resolution by integrating tissue expansion, imaging-guided microdissection and filter-aided in-gel digestion. This combination enhances the resolution, throughput and reproducibility for data-independent acquisition-based mass spectrometry analysis.