David H Friedel Jr
@davidhfriedeljr.bsky.social
Always pushing as an author, entrepreneur, developer & visionary. Posts & comments are NOT advice, do your due diligence. Technical Analyst. nosce te ipsum 不怕慢, 就怕停。+35 years software development
Building a foundational global framework.
—> No DMs <—
Building a foundational global framework.
—> No DMs <—
Pinned
Remember, racism is based on fear, not fact. It stems from ignorance, not understanding; from insecurity, not strength.
The more we learn, connect, and empathize, the more we dissolve that fear.
The more we learn, connect, and empathize, the more we dissolve that fear.
Reposted by David H Friedel Jr
A guest columnist in this week's issue of The Edge says professors should remember three main principles: 1. Forgetting is part of learning, 2. learning is not linear, and 3. the brain learns in context. https://chroni.cl/4pCyGY2
Why Biology, Not Technology, Holds the Key to Learning
Improving education depends on understanding how the brain matures and processes information.
www.chronicle.com
November 26, 2025 at 7:12 PM
A guest columnist in this week's issue of The Edge says professors should remember three main principles: 1. Forgetting is part of learning, 2. learning is not linear, and 3. the brain learns in context. https://chroni.cl/4pCyGY2
Reposted by David H Friedel Jr
An investor explains the "buy, fix, and hold" model employed by Bending Spoons and similar companies that buy distressed startups.
Why 'hold forever' investors are snapping up venture capital 'zombies' | TechCrunch
An investor explains the "buy, fix, and hold" model employed by Bending Spoons and similar companies that buy distressed startups.
techcrunch.com
November 25, 2025 at 10:55 PM
An investor explains the "buy, fix, and hold" model employed by Bending Spoons and similar companies that buy distressed startups.
Reposted by David H Friedel Jr
Like what you're seeing? This feed runs on @graze.social, where the feeds you love come to life - pitch in below to support the team and keep the lights on!
Graze Social Tip Jar
Donate to the Graze Social team and keep the feeds flowing!
buy.stripe.com
November 15, 2025 at 12:11 AM
Like what you're seeing? This feed runs on @graze.social, where the feeds you love come to life - pitch in below to support the team and keep the lights on!
Ukraine loses territory. Russia keeps what it stole. And the world shrugs and calls it realistic.
That isn’t diplomacy. It’s appeasement dressed up as strategy, & it teaches every authoritarian on the planet the same lesson:
Invade your neighbor, threaten nukes, and you get to keep the land.
1/2
That isn’t diplomacy. It’s appeasement dressed up as strategy, & it teaches every authoritarian on the planet the same lesson:
Invade your neighbor, threaten nukes, and you get to keep the land.
1/2
November 24, 2025 at 10:14 PM
Ukraine loses territory. Russia keeps what it stole. And the world shrugs and calls it realistic.
That isn’t diplomacy. It’s appeasement dressed up as strategy, & it teaches every authoritarian on the planet the same lesson:
Invade your neighbor, threaten nukes, and you get to keep the land.
1/2
That isn’t diplomacy. It’s appeasement dressed up as strategy, & it teaches every authoritarian on the planet the same lesson:
Invade your neighbor, threaten nukes, and you get to keep the land.
1/2
The AI bubble is real. But it's not where anyone's looking. It's not GPUs. It's not data centers. It's not infrastructure.
It's the assumption that companies can train on the world's content for free forever, and that margins will never compress.
Two forces are about to collide.
It's the assumption that companies can train on the world's content for free forever, and that margins will never compress.
Two forces are about to collide.
The AI Bubble Isn’t Where Everyone Thinks
and the Break Won’t Come From GPUs
marketally.substack.com
November 24, 2025 at 8:16 PM
The AI bubble is real. But it's not where anyone's looking. It's not GPUs. It's not data centers. It's not infrastructure.
It's the assumption that companies can train on the world's content for free forever, and that margins will never compress.
Two forces are about to collide.
It's the assumption that companies can train on the world's content for free forever, and that margins will never compress.
Two forces are about to collide.
We rise by lifting the floor, by raising the baseline for everyone, not by removing the limits on the ceiling for a few.
Progress isn’t about creating unlimited advantage; it’s about ensuring that no one is left without the foundation to stand, grow, and contribute.
Progress isn’t about creating unlimited advantage; it’s about ensuring that no one is left without the foundation to stand, grow, and contribute.
November 23, 2025 at 1:27 PM
We rise by lifting the floor, by raising the baseline for everyone, not by removing the limits on the ceiling for a few.
Progress isn’t about creating unlimited advantage; it’s about ensuring that no one is left without the foundation to stand, grow, and contribute.
Progress isn’t about creating unlimited advantage; it’s about ensuring that no one is left without the foundation to stand, grow, and contribute.
You can see certain groups are doing everything they can to keep oil from dropping below $50 a barrel.
We likely break it between January to March.
We likely break it between January to March.
November 22, 2025 at 8:19 AM
You can see certain groups are doing everything they can to keep oil from dropping below $50 a barrel.
We likely break it between January to March.
We likely break it between January to March.
Reposted by David H Friedel Jr
RESEARCH | F Kaluba, EC Lien et al.
@vai.org
Cancer cells can reroute ketones to produce cytosolic acetyl-CoA and support tumour growth. 🧪
@vai.org
Cancer cells can reroute ketones to produce cytosolic acetyl-CoA and support tumour growth. 🧪
An alternative route for β-hydroxybutyrate metabolism supports cytosolic acetyl-CoA synthesis in cancer cells - Nature Metabolism
Kaluba, Rogers et al. show that in cancer cells that can metabolize ketones, they may reroute them to produce cytosolic acetyl-CoA and support tumour growth.
bit.ly
November 20, 2025 at 8:01 PM
RESEARCH | F Kaluba, EC Lien et al.
@vai.org
Cancer cells can reroute ketones to produce cytosolic acetyl-CoA and support tumour growth. 🧪
@vai.org
Cancer cells can reroute ketones to produce cytosolic acetyl-CoA and support tumour growth. 🧪
The union formed by Indigenous nations (notably the Iroquois) provided an example of a durable federated system which some colonial thinkers noticed and referenced, reminding us that elements of what we often call "original" in American governance...
1/2
1/2
The American Revolution | All Episodes Now Streaming | Ken Burns | PBS
Thirteen colonies unite in rebellion, win their independence, and found the United States. Stream the full documentary from Ken Burns, Sarah Botstein and David Schmidt.
www.pbs.org
November 20, 2025 at 3:00 PM
The union formed by Indigenous nations (notably the Iroquois) provided an example of a durable federated system which some colonial thinkers noticed and referenced, reminding us that elements of what we often call "original" in American governance...
1/2
1/2
Reposted by David H Friedel Jr
Hi, scientist here:
This statement from the Trumpers at CDC is not how scientific truth works.
This is a Merchants of Doubt rhetorical trick. No study can prove a negative. Scientific evidence shows vaccines do not cause autism. 🧪
This statement from the Trumpers at CDC is not how scientific truth works.
This is a Merchants of Doubt rhetorical trick. No study can prove a negative. Scientific evidence shows vaccines do not cause autism. 🧪
This is completely disgusting. Today, the CDC updated their vaccine safety page. It now says:
“The claim "vaccines do not cause autism" is not an evidence-based claim because studies have not ruled out the possibility that infant vaccines cause autism”.
“The claim "vaccines do not cause autism" is not an evidence-based claim because studies have not ruled out the possibility that infant vaccines cause autism”.
November 20, 2025 at 4:55 AM
Hi, scientist here:
This statement from the Trumpers at CDC is not how scientific truth works.
This is a Merchants of Doubt rhetorical trick. No study can prove a negative. Scientific evidence shows vaccines do not cause autism. 🧪
This statement from the Trumpers at CDC is not how scientific truth works.
This is a Merchants of Doubt rhetorical trick. No study can prove a negative. Scientific evidence shows vaccines do not cause autism. 🧪
In the late 90s, boiler-room brokers made a living cold-calling executives to push penny stocks. I know, because they called me too.
Today, we’re seeing a new version of that same playbook. Only now, it’s disguised as family office funding offers promising millions in cold outreach.
Today, we’re seeing a new version of that same playbook. Only now, it’s disguised as family office funding offers promising millions in cold outreach.
The New Wave of "Fake Family Office" Funding Offers, And How to Protect Yourself
Why Founders Must Learn to Pre-Qualify Capital Outreach in 30 Seconds
marketally.substack.com
November 19, 2025 at 6:54 PM
In the late 90s, boiler-room brokers made a living cold-calling executives to push penny stocks. I know, because they called me too.
Today, we’re seeing a new version of that same playbook. Only now, it’s disguised as family office funding offers promising millions in cold outreach.
Today, we’re seeing a new version of that same playbook. Only now, it’s disguised as family office funding offers promising millions in cold outreach.
When attacks on our institutions look coordinated, don’t assume masterminds. Sometimes fear writes the playbook, and the damage spreads on its own.
When the Playbook Writes Itself
Why attacks on American institutions don’t require masterminds and why the available defenses are far narrower than we pretend
open.substack.com
November 19, 2025 at 2:42 PM
When attacks on our institutions look coordinated, don’t assume masterminds. Sometimes fear writes the playbook, and the damage spreads on its own.
If exotic systems like positron-stabilized Be₂ exist, then bonding itself is not a fixed concept.
It is contingent on which agents are allowed to participate and all can be altered drastically by adding or removing a single agent with the right coupling properties.
Let’s scale it out.
1/2
It is contingent on which agents are allowed to participate and all can be altered drastically by adding or removing a single agent with the right coupling properties.
Let’s scale it out.
1/2
This week's Chemical Science Pick of the Week is "Watch out electrons!: Positron Binding Redefines Chemical Bonding in Be2" by Andrés Reyes (Universidad Nacional de Colombia, Colombia) and co-workers.
Read it here for free: doi.org/10.1039/D5SC...
#ChemSky
Read it here for free: doi.org/10.1039/D5SC...
#ChemSky
November 19, 2025 at 11:15 AM
If exotic systems like positron-stabilized Be₂ exist, then bonding itself is not a fixed concept.
It is contingent on which agents are allowed to participate and all can be altered drastically by adding or removing a single agent with the right coupling properties.
Let’s scale it out.
1/2
It is contingent on which agents are allowed to participate and all can be altered drastically by adding or removing a single agent with the right coupling properties.
Let’s scale it out.
1/2
When you hear people tout how we are in an AI bubble and the investment is not driving actual results, look no further than these 15 actual impacts.
Top 15 New Discoveries MADE By AI (Part 3)
YouTube video by AI Uncovered
youtu.be
November 18, 2025 at 9:08 PM
When you hear people tout how we are in an AI bubble and the investment is not driving actual results, look no further than these 15 actual impacts.
Hear me out, what if Trump were a queen?
If a parasitic queen can hack a colony by altering threat perception…
What does it mean when a political figure alters the emotional signals of a large population to the point where they will attack their own institutions?
1/2
If a parasitic queen can hack a colony by altering threat perception…
What does it mean when a political figure alters the emotional signals of a large population to the point where they will attack their own institutions?
1/2
This parasitic ant tricks workers into killing their own queen | Science | AAAS www.science.org/content/arti... 🧪
This parasitic ant tricks workers into killing their own queen
Scientists capture a unique—and gruesome—example of matricide in the animal kingdom
www.science.org
November 18, 2025 at 7:41 PM
Hear me out, what if Trump were a queen?
If a parasitic queen can hack a colony by altering threat perception…
What does it mean when a political figure alters the emotional signals of a large population to the point where they will attack their own institutions?
1/2
If a parasitic queen can hack a colony by altering threat perception…
What does it mean when a political figure alters the emotional signals of a large population to the point where they will attack their own institutions?
1/2
The launch of Emulate’s new Brain-Chip R1 matters because it finally gives neuroscience a human-relevant, reproducible model of the blood-brain barrier and neuroinflammation, two of the biggest reasons more than 99% of CNS drugs fail.
Animal models & static cultures simply don’t mimic
1/2
Animal models & static cultures simply don’t mimic
1/2
🧠 Learn more in our press release: emulatebio.com/press/emulat...
#BrainChip #NeurovascularUnit #Neuroscience #BBB #CNSResearch
#BrainChip #NeurovascularUnit #Neuroscience #BBB #CNSResearch
Emulate Launches Brain-Chip R1 to Advance Neurological Drug Development, in Partnership with FUJIFILM Cellular Dynamics
BOSTON, MA – [Nov 18, 2025] – Emulate, Inc., the leading provider of next-generation Organ-on-a-Chip technology, in partnership with FUJIFILM Cellular Dynamics, Inc., a pioneering global developer and...
emulatebio.com
November 18, 2025 at 7:29 PM
The launch of Emulate’s new Brain-Chip R1 matters because it finally gives neuroscience a human-relevant, reproducible model of the blood-brain barrier and neuroinflammation, two of the biggest reasons more than 99% of CNS drugs fail.
Animal models & static cultures simply don’t mimic
1/2
Animal models & static cultures simply don’t mimic
1/2
Miran, Bowman, & Waller are trying to bake in inequality at an alarming rate. Their understanding & use of economic policy will serve to weaken America on the global stage.
It is very disheartening to see all the work Powell has done show the underpinnings of stability and broad-based growth,
1/3
It is very disheartening to see all the work Powell has done show the underpinnings of stability and broad-based growth,
1/3
November 18, 2025 at 10:41 AM
Miran, Bowman, & Waller are trying to bake in inequality at an alarming rate. Their understanding & use of economic policy will serve to weaken America on the global stage.
It is very disheartening to see all the work Powell has done show the underpinnings of stability and broad-based growth,
1/3
It is very disheartening to see all the work Powell has done show the underpinnings of stability and broad-based growth,
1/3
I do hope they go public cause it will burn a ton of people who try to short this stock too soon.
The emotional algos on this stock will be legendary.
The emotional algos on this stock will be legendary.
November 17, 2025 at 10:13 AM
I do hope they go public cause it will burn a ton of people who try to short this stock too soon.
The emotional algos on this stock will be legendary.
The emotional algos on this stock will be legendary.
We collectively suffer from empathy as a reflex rather than understanding.
November 16, 2025 at 4:38 PM
We collectively suffer from empathy as a reflex rather than understanding.
There’s a strange solace in the melancholy of those cryptic writings from the poets of the Dark Ages.
Their language bends like candlelight in stone corridors,
Their language bends like candlelight in stone corridors,
November 16, 2025 at 2:06 PM
There’s a strange solace in the melancholy of those cryptic writings from the poets of the Dark Ages.
Their language bends like candlelight in stone corridors,
Their language bends like candlelight in stone corridors,
AlphaProof is different because its answers are always 100% correct.
That's because it uses a specialized software environment called Lean (originally developed by Microsoft Research) that acts like a strict teacher verifying every logical step.
That's because it uses a specialized software environment called Lean (originally developed by Microsoft Research) that acts like a strict teacher verifying every logical step.
AI math genius delivers 100% accurate results
At the 2024 International Mathematical Olympiad (IMO), one competitor did so well that it would have been awarded the Silver Prize, except for one thing: it was an AI system. This was the first time A...
phys.org
November 16, 2025 at 12:07 PM
AlphaProof is different because its answers are always 100% correct.
That's because it uses a specialized software environment called Lean (originally developed by Microsoft Research) that acts like a strict teacher verifying every logical step.
That's because it uses a specialized software environment called Lean (originally developed by Microsoft Research) that acts like a strict teacher verifying every logical step.
Reposted by David H Friedel Jr
When an insurance company is deciding whether to pay for your medical treatment, it generates a file, which should contain all records associated with your case, including documents explaining why the claim was denied.
You have a right to see this file.
(Published May 2023)
You have a right to see this file.
(Published May 2023)
Health Insurance Claim Denied? See What Insurers Said Behind the Scenes
Learn how to request your health insurance claim file, which can include details about what your insurer is saying about you and your case.
www.propublica.org
November 15, 2025 at 2:35 AM
When an insurance company is deciding whether to pay for your medical treatment, it generates a file, which should contain all records associated with your case, including documents explaining why the claim was denied.
You have a right to see this file.
(Published May 2023)
You have a right to see this file.
(Published May 2023)
When the public realizes they were talking to Billionaires the whole time. 💀
November 14, 2025 at 12:13 PM
When the public realizes they were talking to Billionaires the whole time. 💀
Reposted by David H Friedel Jr
🚀.NET 10 is here!
✅ LTS release
⚡ Faster: JIT, NativeAOT, AVX10.2
🔐 Post-quantum crypto + AES KeyWrap
🛠 File-based apps (run main.cs directly!)
🤖 #AI Agent Framework + #MCP
🌐 #Blazor upgrades, OpenAPI
💻 C# 14: field-backed properties
via.anuraj.dev/announcing-d...
#dotnet
✅ LTS release
⚡ Faster: JIT, NativeAOT, AVX10.2
🔐 Post-quantum crypto + AES KeyWrap
🛠 File-based apps (run main.cs directly!)
🤖 #AI Agent Framework + #MCP
🌐 #Blazor upgrades, OpenAPI
💻 C# 14: field-backed properties
via.anuraj.dev/announcing-d...
#dotnet
November 12, 2025 at 12:29 AM
🚀.NET 10 is here!
✅ LTS release
⚡ Faster: JIT, NativeAOT, AVX10.2
🔐 Post-quantum crypto + AES KeyWrap
🛠 File-based apps (run main.cs directly!)
🤖 #AI Agent Framework + #MCP
🌐 #Blazor upgrades, OpenAPI
💻 C# 14: field-backed properties
via.anuraj.dev/announcing-d...
#dotnet
✅ LTS release
⚡ Faster: JIT, NativeAOT, AVX10.2
🔐 Post-quantum crypto + AES KeyWrap
🛠 File-based apps (run main.cs directly!)
🤖 #AI Agent Framework + #MCP
🌐 #Blazor upgrades, OpenAPI
💻 C# 14: field-backed properties
via.anuraj.dev/announcing-d...
#dotnet