Dr David Joffe MB BS(Hons), PhD, FRACP
@davidjoffe64.bsky.social
Respiratory and Sleep Medicine
Neurobiology and Long Cövid
WHN Long Covid Working Group Vice Chair
Neurobiology and Long Cövid
WHN Long Covid Working Group Vice Chair
Cøvid and a possible link to bowel cancer.
@atranscendedman.bsky.social 😔🙏🏻
www.sciencedirect.com/science/arti...
@atranscendedman.bsky.social 😔🙏🏻
www.sciencedirect.com/science/arti...
Viruses in gastrointestinal cancers: Molecular pathogenesis, oncogenic mechanisms, and translational perspectives
Viral pathogens are one of the most significant causes of human carcinogenesis, contributing to up to 15–20 % of worldwide cancers. The gastrointestin…
www.sciencedirect.com
November 25, 2025 at 7:40 PM
Cøvid and a possible link to bowel cancer.
@atranscendedman.bsky.social 😔🙏🏻
www.sciencedirect.com/science/arti...
@atranscendedman.bsky.social 😔🙏🏻
www.sciencedirect.com/science/arti...
Weight gain in Long C-19 is more than just inactivity. The greater the fat burden the bigger the cytokine storm
doi.org/10.1002/oby....
doi.org/10.1002/oby....
Adipose Tissue in SARS‐CoV‐2 Viral Tropism, Viral Replication, and the Concept of a Viral Reservoir: An Update
Adipose tissue as a potential reservoir for and modifier of SARS-CoV-2 infection and its complications. Schematic demonstrating the differences in subcutaneous and visceral adipose tissue and infecti....
doi.org
November 25, 2025 at 7:15 PM
Weight gain in Long C-19 is more than just inactivity. The greater the fat burden the bigger the cytokine storm
doi.org/10.1002/oby....
doi.org/10.1002/oby....
Long C-19 is not your friend.
"Conclusions: Long COVID affects over one-fifth of SARS-CoV-2 survivors, with fatigue and dyspnoea persisting in many. Female sex and severe acute infection increase risk. Standardized definitions and longer follow-up are needed."
www.mdpi.com/2227-9059/13...
"Conclusions: Long COVID affects over one-fifth of SARS-CoV-2 survivors, with fatigue and dyspnoea persisting in many. Female sex and severe acute infection increase risk. Standardized definitions and longer follow-up are needed."
www.mdpi.com/2227-9059/13...
www.mdpi.com
November 25, 2025 at 10:38 AM
Long C-19 is not your friend.
"Conclusions: Long COVID affects over one-fifth of SARS-CoV-2 survivors, with fatigue and dyspnoea persisting in many. Female sex and severe acute infection increase risk. Standardized definitions and longer follow-up are needed."
www.mdpi.com/2227-9059/13...
"Conclusions: Long COVID affects over one-fifth of SARS-CoV-2 survivors, with fatigue and dyspnoea persisting in many. Female sex and severe acute infection increase risk. Standardized definitions and longer follow-up are needed."
www.mdpi.com/2227-9059/13...
With huge thanks to @mikehoney.bsky.social
BA3.2... soon available in a human near you‼️
www.thelancet.com/journals/lan...
BA3.2... soon available in a human near you‼️
www.thelancet.com/journals/lan...
Epidemiological and virological update on the emerging SARS-CoV-2 variant BA.3.2
The constant emergence of novel SARS-CoV-2 variants has driven the COVID-19 pandemic
and sustains the current endemic. Saltation variants, such as BA.2.86,1 encode highly
mutated spike (S) proteins th...
www.thelancet.com
November 25, 2025 at 5:03 AM
With huge thanks to @mikehoney.bsky.social
BA3.2... soon available in a human near you‼️
www.thelancet.com/journals/lan...
BA3.2... soon available in a human near you‼️
www.thelancet.com/journals/lan...
Obstructive Sleep Apnea, Positive Airway Pressure, and Implications of Early Treatment in Parkinson Disease url: jamanetwork.com/journals/jam...
Obstructive Sleep Apnea, Positive Airway Pressure, and Implications of Early Treatment in Parkinson Disease
This cohort study examines the association between obstructive sleep apnea with incident Parkinson disease among US veterans and risk modification by continuous positive airway pressure.
jamanetwork.com
November 24, 2025 at 8:15 PM
Obstructive Sleep Apnea, Positive Airway Pressure, and Implications of Early Treatment in Parkinson Disease url: jamanetwork.com/journals/jam...
My longstanding observations with the Vagus Nerve damage in Long C-19 remains strong...
As per @harryspoelstra.bsky.social
#Nerve_of_Joffe 🤦🏻♂️
www.jacionline.org/article/S009...
As per @harryspoelstra.bsky.social
#Nerve_of_Joffe 🤦🏻♂️
www.jacionline.org/article/S009...
Autonomic dysfunction and vasoregulation in Long COVID-19 are linked to anti-GPCR autoantibodies
www.jacionline.org
November 23, 2025 at 12:04 PM
My longstanding observations with the Vagus Nerve damage in Long C-19 remains strong...
As per @harryspoelstra.bsky.social
#Nerve_of_Joffe 🤦🏻♂️
www.jacionline.org/article/S009...
As per @harryspoelstra.bsky.social
#Nerve_of_Joffe 🤦🏻♂️
www.jacionline.org/article/S009...
A link to the Symposium held yesterday in Italy...
Long C-19 with plenty of information.
Apologies, my Italian is non-existant🤦🏻♂️
youtu.be/FvsCBseYl0Q?...
Long C-19 with plenty of information.
Apologies, my Italian is non-existant🤦🏻♂️
youtu.be/FvsCBseYl0Q?...
Convegno internazionale a Cellamare sul Covid-19 , varianti e vaccini ( 22 novembre 2025)
YouTube video by ventiperquattro
youtu.be
November 22, 2025 at 9:48 PM
A link to the Symposium held yesterday in Italy...
Long C-19 with plenty of information.
Apologies, my Italian is non-existant🤦🏻♂️
youtu.be/FvsCBseYl0Q?...
Long C-19 with plenty of information.
Apologies, my Italian is non-existant🤦🏻♂️
youtu.be/FvsCBseYl0Q?...
Reposted by Dr David Joffe MB BS(Hons), PhD, FRACP
A phrase I’ve uttered since 2020…
..false economy 🤷♀️
..false economy 🤷♀️
With thanks to @atranscendedman.bsky.social
Remarkable how those reading the tea leaves can see the explosion of cases and costs, yet governments are mute.
☠️ Dead people don't shop
☠️ Sick people can't work
www.nature.com/articles/s41...
Remarkable how those reading the tea leaves can see the explosion of cases and costs, yet governments are mute.
☠️ Dead people don't shop
☠️ Sick people can't work
www.nature.com/articles/s41...
Economic burden of long COVID: macroeconomic, cost-of-illness and microeconomic impacts - npj Primary Care Respiratory Medicine
npj Primary Care Respiratory Medicine - Economic burden of long COVID: macroeconomic, cost-of-illness and microeconomic impacts
www.nature.com
November 21, 2025 at 11:00 PM
A phrase I’ve uttered since 2020…
..false economy 🤷♀️
..false economy 🤷♀️
Pregnancy and Cøvid aren't good companions.
@atranscendedman.bsky.social 🙏🏻
www.nature.com/articles/s41...
@atranscendedman.bsky.social 🙏🏻
www.nature.com/articles/s41...
Presence of SARS-CoV-2 in fetal organs via intraamniotic infection - Nature Communications
Infection with SARS-CoV-2 during pregnancy may result in maternal and fetal complications. Here, the authors analyze 18 fetuses following maternal SARS-CoV-2 infection and identify distribution in fet...
www.nature.com
November 21, 2025 at 9:14 PM
Pregnancy and Cøvid aren't good companions.
@atranscendedman.bsky.social 🙏🏻
www.nature.com/articles/s41...
@atranscendedman.bsky.social 🙏🏻
www.nature.com/articles/s41...
With thanks to @atranscendedman.bsky.social
Remarkable how those reading the tea leaves can see the explosion of cases and costs, yet governments are mute.
☠️ Dead people don't shop
☠️ Sick people can't work
www.nature.com/articles/s41...
Remarkable how those reading the tea leaves can see the explosion of cases and costs, yet governments are mute.
☠️ Dead people don't shop
☠️ Sick people can't work
www.nature.com/articles/s41...
Economic burden of long COVID: macroeconomic, cost-of-illness and microeconomic impacts - npj Primary Care Respiratory Medicine
npj Primary Care Respiratory Medicine - Economic burden of long COVID: macroeconomic, cost-of-illness and microeconomic impacts
www.nature.com
November 21, 2025 at 8:03 PM
With thanks to @atranscendedman.bsky.social
Remarkable how those reading the tea leaves can see the explosion of cases and costs, yet governments are mute.
☠️ Dead people don't shop
☠️ Sick people can't work
www.nature.com/articles/s41...
Remarkable how those reading the tea leaves can see the explosion of cases and costs, yet governments are mute.
☠️ Dead people don't shop
☠️ Sick people can't work
www.nature.com/articles/s41...
Cøvid isn't helpful for lung perfusion. Just one of several mechanisms contributing to breathlessness.
doi.org/10.1016/j.co...
doi.org/10.1016/j.co...
doi.org
November 19, 2025 at 11:45 PM
Cøvid isn't helpful for lung perfusion. Just one of several mechanisms contributing to breathlessness.
doi.org/10.1016/j.co...
doi.org/10.1016/j.co...
Yup ‼️
♨️♨️♨️
♨️♨️♨️
November 19, 2025 at 9:04 PM
Yup ‼️
♨️♨️♨️
♨️♨️♨️
🤦🏻♂️🤦🏻♂️
Oops
November 19, 2025 at 7:17 PM
🤦🏻♂️🤦🏻♂️
🚨🚨THIS 🚨🚨
Sleep architecture and rapid eye movement sleep without atonia in post-COVID-19 insomnia url: academic.oup.com/sleep/articl...
Sleep architecture and rapid eye movement sleep without atonia in post-COVID-19 insomnia url: academic.oup.com/sleep/articl...
Validate User
academic.oup.com
November 18, 2025 at 7:37 PM
🚨🚨THIS 🚨🚨
Sleep architecture and rapid eye movement sleep without atonia in post-COVID-19 insomnia url: academic.oup.com/sleep/articl...
Sleep architecture and rapid eye movement sleep without atonia in post-COVID-19 insomnia url: academic.oup.com/sleep/articl...
🧠 Daily Feed of Brain Damage 🧠
Part 3...
Depression is real and biological in Long Cövid
www.sciencedirect.com/science/arti...
Part 3...
Depression is real and biological in Long Cövid
www.sciencedirect.com/science/arti...
SARS-CoV-2 spike protein induces depressive-like behaviors by disrupting astrocytic Cx43-mediated gap junction intercellular communication
Long COVID has emerged as a global health concern, with depression being one of its most debilitating and poorly understood manifestations. Despite ev…
www.sciencedirect.com
November 17, 2025 at 11:23 AM
🧠 Daily Feed of Brain Damage 🧠
Part 3...
Depression is real and biological in Long Cövid
www.sciencedirect.com/science/arti...
Part 3...
Depression is real and biological in Long Cövid
www.sciencedirect.com/science/arti...
