Dr David Joffe MB BS(Hons), PhD, FRACP
@davidjoffe64.bsky.social
Respiratory and Sleep Medicine
Neurobiology and Long CΓΆvid
WHN Long Covid Working Group Vice Chair
Neurobiology and Long CΓΆvid
WHN Long Covid Working Group Vice Chair
Pathetic π€¬π€¬π€¬
February 11, 2026 at 2:52 AM
Pathetic π€¬π€¬π€¬
π§ Daily Feed of Brain Damage π§
@atranscendedman.bsky.social ππ»
www.nature.com/articles/s41...
@atranscendedman.bsky.social ππ»
www.nature.com/articles/s41...
Impaired brain intrinsic connectivity in long COVID during cognitive exertion revealed by independent component analysis - Scientific Reports
Scientific Reports - Impaired brain intrinsic connectivity in long COVID during cognitive exertion revealed by independent component analysis
www.nature.com
February 9, 2026 at 3:48 PM
π§ Daily Feed of Brain Damage π§
@atranscendedman.bsky.social ππ»
www.nature.com/articles/s41...
@atranscendedman.bsky.social ππ»
www.nature.com/articles/s41...
Not really...
The virus enters the nose and goes straight up into the adjacent Prefrontal cortex. The PFC is crucial for initiating SWS
The virus enters the nose and goes straight up into the adjacent Prefrontal cortex. The PFC is crucial for initiating SWS
February 9, 2026 at 10:44 AM
Not really...
The virus enters the nose and goes straight up into the adjacent Prefrontal cortex. The PFC is crucial for initiating SWS
The virus enters the nose and goes straight up into the adjacent Prefrontal cortex. The PFC is crucial for initiating SWS
πππ
Slow Wave Sleep....
The essence of "Brainwashing"
Crucial for π§ function. Deep sleep is to our brains, what hunger and thirst are to eating and drinking. An irrepressible drive ππ»
Slow Wave Sleep....
The essence of "Brainwashing"
Crucial for π§ function. Deep sleep is to our brains, what hunger and thirst are to eating and drinking. An irrepressible drive ππ»
February 9, 2026 at 10:16 AM
πππ
Slow Wave Sleep....
The essence of "Brainwashing"
Crucial for π§ function. Deep sleep is to our brains, what hunger and thirst are to eating and drinking. An irrepressible drive ππ»
Slow Wave Sleep....
The essence of "Brainwashing"
Crucial for π§ function. Deep sleep is to our brains, what hunger and thirst are to eating and drinking. An irrepressible drive ππ»
This may be worth considering in CΓΆvid heart disease?? π§π§π€·π»ββοΈ
pubmed.ncbi.nlm.nih.gov/41648933/
pubmed.ncbi.nlm.nih.gov/41648933/
Ginkgetin Alleviates Doxorubicin-Induced Heart Failure by Regulating Mitochondrial Dysfunction Through the AMPK/Sirt1/NF-ΞΊB Signaling Pathway - PubMed
GK protects against DOX-induced HF by activating AMPK/Sirt1 and inhibiting NF-ΞΊB signaling, thereby mitigating OS, inflammation, apoptosis, and mitochondrial dysfunction.
pubmed.ncbi.nlm.nih.gov
February 8, 2026 at 6:35 AM
This may be worth considering in CΓΆvid heart disease?? π§π§π€·π»ββοΈ
pubmed.ncbi.nlm.nih.gov/41648933/
pubmed.ncbi.nlm.nih.gov/41648933/
Ummmm.... Thanx ππ»
But, I would suggest that we are merely canaries in the coal mine.
There aren't experts... Just the concernedππ»
But, I would suggest that we are merely canaries in the coal mine.
There aren't experts... Just the concernedππ»
February 8, 2026 at 12:53 AM
Ummmm.... Thanx ππ»
But, I would suggest that we are merely canaries in the coal mine.
There aren't experts... Just the concernedππ»
But, I would suggest that we are merely canaries in the coal mine.
There aren't experts... Just the concernedππ»
The kidney is the greatest source of ACE receptors... Ziyad Al-Aly's first paper was a serious warning.
He is a Renal Physician by trade
He is a Renal Physician by trade
February 8, 2026 at 12:51 AM
The kidney is the greatest source of ACE receptors... Ziyad Al-Aly's first paper was a serious warning.
He is a Renal Physician by trade
He is a Renal Physician by trade
The relationship between CΓΆvid and cancer is still being considered. Immune damage lowers cancer surveillance. Direct oncogenesis is theoretical.
Tbh?.... We don't know with any certainty
Tbh?.... We don't know with any certainty
February 8, 2026 at 12:49 AM
The relationship between CΓΆvid and cancer is still being considered. Immune damage lowers cancer surveillance. Direct oncogenesis is theoretical.
Tbh?.... We don't know with any certainty
Tbh?.... We don't know with any certainty
Heart and kidneys
Pump -> Filter
Pump -> Filter
February 7, 2026 at 10:48 PM
Heart and kidneys
Pump -> Filter
Pump -> Filter
CΓΆvid is Bad JuJu for kidneys... Even mild disease mattersβΌοΈ
Get your renal function reviewed following infection ππ»
doi.org/10.1172/jci....
Get your renal function reviewed following infection ππ»
doi.org/10.1172/jci....
JCI Insight -
Levels of circulating kidney injury markers and IL-10 identify non-critically ill patients with COVID-19 at risk of death
doi.org
February 7, 2026 at 9:42 PM
CΓΆvid is Bad JuJu for kidneys... Even mild disease mattersβΌοΈ
Get your renal function reviewed following infection ππ»
doi.org/10.1172/jci....
Get your renal function reviewed following infection ππ»
doi.org/10.1172/jci....
The cost of this study are massiveβΌοΈ
This isn't new science. This finding dates back to the early 1990's. But fMRI wasn't available until the early 2000's.
This merely confirms the neurocognitive issues derived from testing ππ»
This isn't new science. This finding dates back to the early 1990's. But fMRI wasn't available until the early 2000's.
This merely confirms the neurocognitive issues derived from testing ππ»
February 6, 2026 at 8:13 PM
The cost of this study are massiveβΌοΈ
This isn't new science. This finding dates back to the early 1990's. But fMRI wasn't available until the early 2000's.
This merely confirms the neurocognitive issues derived from testing ππ»
This isn't new science. This finding dates back to the early 1990's. But fMRI wasn't available until the early 2000's.
This merely confirms the neurocognitive issues derived from testing ππ»
More from the Sleep Science. Acute sleep deprivation and chronic reduced sleep time have different brain consequences
Divergent disruption of brain networks following total and chronic sleep loss: a longitudinal fMRI study
academic.oup.com/sleep/advanc...
Divergent disruption of brain networks following total and chronic sleep loss: a longitudinal fMRI study
academic.oup.com/sleep/advanc...
Divergent disruption of brain networks following total and chronic sleep loss: a longitudinal fMRI study
Statement of significance Sleep deprivation is a growing public health concern, yet it remains unclear whether total and chronic sleep loss affect the brai
academic.oup.com
February 6, 2026 at 8:08 PM
More from the Sleep Science. Acute sleep deprivation and chronic reduced sleep time have different brain consequences
Divergent disruption of brain networks following total and chronic sleep loss: a longitudinal fMRI study
academic.oup.com/sleep/advanc...
Divergent disruption of brain networks following total and chronic sleep loss: a longitudinal fMRI study
academic.oup.com/sleep/advanc...
Yep....
Like all good predators... The weak and infirm first... Then the young and the fit
The Komodo Dragon part of the Pandemic is now ππ»
Like all good predators... The weak and infirm first... Then the young and the fit
The Komodo Dragon part of the Pandemic is now ππ»
February 6, 2026 at 12:52 AM
Yep....
Like all good predators... The weak and infirm first... Then the young and the fit
The Komodo Dragon part of the Pandemic is now ππ»
Like all good predators... The weak and infirm first... Then the young and the fit
The Komodo Dragon part of the Pandemic is now ππ»
And back to school we go π₯
Victorian Weekly Respiratory Surveillance Report: 6 Feb 2026
From 25 Jan to 31 Jan 2026:
πΈCOVID positivity rate: 2.8% (+0.8%)
πΉCOVID: 202 (+13%)
πΉInfluenza A: 250 (-34%)
πΉInfluenza B: 33 (+106%)
πΉRSV: 132 (+10%)
Source: www.health.vic.gov.au/infectious-d...
From 25 Jan to 31 Jan 2026:
πΈCOVID positivity rate: 2.8% (+0.8%)
πΉCOVID: 202 (+13%)
πΉInfluenza A: 250 (-34%)
πΉInfluenza B: 33 (+106%)
πΉRSV: 132 (+10%)
Source: www.health.vic.gov.au/infectious-d...
February 6, 2026 at 12:00 AM
And back to school we go π₯
@jukka235.bsky.social
A big call out and thanx to the Swedish
"Infectionists" ππ
At some point they ought to be called to account, perhaps?
Sadly, they are but the canary in everyone's coalmine. No country will be left behind in the race to chronic diseases and disabling Long C-19
A big call out and thanx to the Swedish
"Infectionists" ππ
At some point they ought to be called to account, perhaps?
Sadly, they are but the canary in everyone's coalmine. No country will be left behind in the race to chronic diseases and disabling Long C-19
Mortality in Sweden:
The good news: deaths are declining in most age groups >=15. At the same time, causes of death that started rising after 2019 are becoming increasingly dominant across all age groups <15. Most affected are 5-9 and 10-14 year olds.
1/x
The good news: deaths are declining in most age groups >=15. At the same time, causes of death that started rising after 2019 are becoming increasingly dominant across all age groups <15. Most affected are 5-9 and 10-14 year olds.
1/x
February 5, 2026 at 11:37 PM
@jukka235.bsky.social
A big call out and thanx to the Swedish
"Infectionists" ππ
At some point they ought to be called to account, perhaps?
Sadly, they are but the canary in everyone's coalmine. No country will be left behind in the race to chronic diseases and disabling Long C-19
A big call out and thanx to the Swedish
"Infectionists" ππ
At some point they ought to be called to account, perhaps?
Sadly, they are but the canary in everyone's coalmine. No country will be left behind in the race to chronic diseases and disabling Long C-19
Keep dodging the bullet is my motto!
February 5, 2026 at 2:45 PM
Keep dodging the bullet is my motto!
π§ Daily Feed of Brain Damage π§
"The many roads to hell"
ππ»ππ»ππ»
doi.org/10.3390/ijms...
"The many roads to hell"
ππ»ππ»ππ»
doi.org/10.3390/ijms...
doi.org
February 5, 2026 at 2:01 PM
π§ Daily Feed of Brain Damage π§
"The many roads to hell"
ππ»ππ»ππ»
doi.org/10.3390/ijms...
"The many roads to hell"
ππ»ππ»ππ»
doi.org/10.3390/ijms...
Figured you could use a decent giggle, Esther π
February 5, 2026 at 11:05 AM
Figured you could use a decent giggle, Esther π
Neuromuscular disorders and COPD are vastly different in their physiology
Just Sayin' πππ»
Just Sayin' πππ»
February 5, 2026 at 8:14 AM
Neuromuscular disorders and COPD are vastly different in their physiology
Just Sayin' πππ»
Just Sayin' πππ»