Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc
@christosargyrop.bsky.social
Division Chief, Nephrology UNMHSC
(im)personal views & account #zerokale
Firm believer : caveat emptor & stupidity is immoral
Random thoughts about #nephrology #stats #bioinformatics #perl #HPC #nanopore #RNAseq #covid19 #amateurcoding
#ButlerianJihad
(im)personal views & account #zerokale
Firm believer : caveat emptor & stupidity is immoral
Random thoughts about #nephrology #stats #bioinformatics #perl #HPC #nanopore #RNAseq #covid19 #amateurcoding
#ButlerianJihad
One look at the r/DataHoarder and I am surfing Seagate's data store, because setting a 32TB RAID at home and a 120TB one at work is not enough
November 25, 2025 at 9:11 PM
One look at the r/DataHoarder and I am surfing Seagate's data store, because setting a 32TB RAID at home and a 120TB one at work is not enough
I am a Bayesian but for the most part I don't mind p-values because for the common models applied in biomedicine, one can carry out a Bayesian calculation (we call those π - values with @andrewpgrieve.bsky.social ) that are noncontroversial directional measures of effect
arxiv.org/abs/2305.00636
arxiv.org/abs/2305.00636
November 25, 2025 at 6:53 PM
I am a Bayesian but for the most part I don't mind p-values because for the common models applied in biomedicine, one can carry out a Bayesian calculation (we call those π - values with @andrewpgrieve.bsky.social ) that are noncontroversial directional measures of effect
arxiv.org/abs/2305.00636
arxiv.org/abs/2305.00636
I just found out that one can get rid of ai slop summary in Google search by appending -ai at the end of the search string.
November 25, 2025 at 4:38 PM
I just found out that one can get rid of ai slop summary in Google search by appending -ai at the end of the search string.
Reposted by Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc
As a former first generation medical student, loans were vital to allow me to follow my dream of being a doctor. This is a travesty.
Under new Trump administration rules, students won't be able to borrow as much for medical or nursing school or some other health professions. n.pr/49F5HOn
New limits on school loans could narrow physician and nurse pipeline, educators warn
Under new Trump administration rules, students won't be able to borrow as much for medical or nursing school or some other health professions.
n.pr
November 25, 2025 at 2:45 PM
As a former first generation medical student, loans were vital to allow me to follow my dream of being a doctor. This is a travesty.
Seems performance degradation is in the air.
November 25, 2025 at 2:40 PM
Seems performance degradation is in the air.
This point is often missed: a high dimensional embedding makes for a good information retrieval system at scale and this would be a perfectly legit and uncontroversial use of the infrastructure of the LLMs
What models are you using? Gemini is extremely good at advanced statistics (let alone simpler things).
November 25, 2025 at 2:25 PM
This point is often missed: a high dimensional embedding makes for a good information retrieval system at scale and this would be a perfectly legit and uncontroversial use of the infrastructure of the LLMs
Congrats to Christina and Brian
This ecosystem is really the way forward for much of CME and residency education. It has the right structure of not being too reliant on anyone individual, while offering reasonable diverse perspectives.
An announcement
www.nephjc.com/news/2025/11...
#NephJC
@kidneyboy.bsky.social and moi hand over the @nephjc.bsky.social reigns to @nephroseeker.medsky.social & @brianrifkin.bsky.social
www.nephjc.com/news/2025/11...
#NephJC
@kidneyboy.bsky.social and moi hand over the @nephjc.bsky.social reigns to @nephroseeker.medsky.social & @brianrifkin.bsky.social
November 25, 2025 at 2:20 PM
Congrats to Christina and Brian
Reposted by Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc
STAT News: 'I have long Covid. Don’t call my chronic disease a ‘journey’
By Peter Swenson, professor emeritus, Yale University
'Like an estimated 20 million Americans, I have an incurable post-acute infection syndrome that goes by the name of long Covid...'
www.statnews.com/2025/11/25/c...
By Peter Swenson, professor emeritus, Yale University
'Like an estimated 20 million Americans, I have an incurable post-acute infection syndrome that goes by the name of long Covid...'
www.statnews.com/2025/11/25/c...
I have long Covid. Don’t call my chronic disease a ‘journey’
A “journey” is something you choose. No one chooses chronic illness.
www.statnews.com
November 25, 2025 at 2:15 PM
STAT News: 'I have long Covid. Don’t call my chronic disease a ‘journey’
By Peter Swenson, professor emeritus, Yale University
'Like an estimated 20 million Americans, I have an incurable post-acute infection syndrome that goes by the name of long Covid...'
www.statnews.com/2025/11/25/c...
By Peter Swenson, professor emeritus, Yale University
'Like an estimated 20 million Americans, I have an incurable post-acute infection syndrome that goes by the name of long Covid...'
www.statnews.com/2025/11/25/c...
Deliberately rebuilding a 28TB RAID5 (4 X 7.2 TB HDD) to benchmark the process... it will take roughly 27 hours but will be enjoying the colors in the meantime.
(Yes, I know that my cable management sucks, this is why I didn't become a surgeon or a proceduralist)
(Yes, I know that my cable management sucks, this is why I didn't become a surgeon or a proceduralist)
November 25, 2025 at 3:49 AM
Deliberately rebuilding a 28TB RAID5 (4 X 7.2 TB HDD) to benchmark the process... it will take roughly 27 hours but will be enjoying the colors in the meantime.
(Yes, I know that my cable management sucks, this is why I didn't become a surgeon or a proceduralist)
(Yes, I know that my cable management sucks, this is why I didn't become a surgeon or a proceduralist)
Reposted by Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc
November 24, 2025 at 3:08 PM
Reposted by Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc
Also somewhat surprising: risk of infection related badness in lupus = risk of infection related badness in diabetic kidney disease!
Possibly underscoring that (some of us) underestimate the infection related hazards when DM + CKD exist
Any other comments @christosargyrop.bsky.social
#NephSky
Possibly underscoring that (some of us) underestimate the infection related hazards when DM + CKD exist
Any other comments @christosargyrop.bsky.social
#NephSky
November 23, 2025 at 2:50 PM
Also somewhat surprising: risk of infection related badness in lupus = risk of infection related badness in diabetic kidney disease!
Possibly underscoring that (some of us) underestimate the infection related hazards when DM + CKD exist
Any other comments @christosargyrop.bsky.social
#NephSky
Possibly underscoring that (some of us) underestimate the infection related hazards when DM + CKD exist
Any other comments @christosargyrop.bsky.social
#NephSky
Reposted by Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc
The RCTs have been mostly done in those with hypogonadism/low T levels and still resulted in high Hgb/erythrocytosis
It’s pretty plausible that that’s all needed - especially if they already have hypertension and start off with normal T level?
(one of those effects have need phase 4 studies for)
It’s pretty plausible that that’s all needed - especially if they already have hypertension and start off with normal T level?
(one of those effects have need phase 4 studies for)
November 23, 2025 at 12:54 PM
The RCTs have been mostly done in those with hypogonadism/low T levels and still resulted in high Hgb/erythrocytosis
It’s pretty plausible that that’s all needed - especially if they already have hypertension and start off with normal T level?
(one of those effects have need phase 4 studies for)
It’s pretty plausible that that’s all needed - especially if they already have hypertension and start off with normal T level?
(one of those effects have need phase 4 studies for)
Reposted by Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc
It's that time of year
November 22, 2025 at 11:54 AM
It's that time of year
Reposted by Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc
at least the trans $5 exists!
pisses me tf off that NVIDIA appropriated and then hyperscaled the trans cultural practice of “passing the same $5 around, forever”
get your own thing, bubble boys
get your own thing, bubble boys
November 23, 2025 at 12:13 AM
at least the trans $5 exists!
What is legacy (=I can buy it for less than $100 on eBay) GPU with good performance of integer operations ?
November 22, 2025 at 6:44 PM
What is legacy (=I can buy it for less than $100 on eBay) GPU with good performance of integer operations ?
Optimizing fun while in anticipation of receiving bad medical news around a major holiday
#nonnuanced
open.substack.com/pub/christos...
Summing up 3 decades in clinical practice and a #PSA for all men:
sk your doctor if receiving good news before a holiday is right for you.
#nonnuanced
open.substack.com/pub/christos...
Summing up 3 decades in clinical practice and a #PSA for all men:
sk your doctor if receiving good news before a holiday is right for you.
Optimizing fun while receiving bad medical news around a major holiday.
Men, if you are facing a potentially life altering disease and you have the option to find out one week BEFORE or one week AFTER a major holiday, you should near always opt for the AFTER option.
christosargyropoulos.substack.com
November 22, 2025 at 4:45 PM
Optimizing fun while in anticipation of receiving bad medical news around a major holiday
#nonnuanced
open.substack.com/pub/christos...
Summing up 3 decades in clinical practice and a #PSA for all men:
sk your doctor if receiving good news before a holiday is right for you.
#nonnuanced
open.substack.com/pub/christos...
Summing up 3 decades in clinical practice and a #PSA for all men:
sk your doctor if receiving good news before a holiday is right for you.
Simply beautiful
November 21, 2025 at 5:40 PM
Simply beautiful
Reposted by Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc
Your emails aren’t that interesting. Nobody is training their LLM on them.
November 20, 2025 at 11:01 PM
Your emails aren’t that interesting. Nobody is training their LLM on them.
Who could have guessed that high dose better than low dose flu vaccination in reducing cardiovascular events?
Now do covid19 😎
Now do covid19 😎
November 20, 2025 at 3:46 PM
Who could have guessed that high dose better than low dose flu vaccination in reducing cardiovascular events?
Now do covid19 😎
Now do covid19 😎
Reposted by Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc
In the last #KidneyKompass @brendonneuen.bsky.social chats with Sophia Zoungas podcasts.apple.com/ca/podcast/k... on the SURPASS data
G-force FTW @christosargyrop.bsky.social @rnflex.bsky.social
Hey @brianrifkin.bsky.social if sema is captopril what would you call dulaglutide? 😏
G-force FTW @christosargyrop.bsky.social @rnflex.bsky.social
Hey @brianrifkin.bsky.social if sema is captopril what would you call dulaglutide? 😏
Understanding Renal Outcomes in SURPASS-CVOT, With Sophia Zoungas, MBBS, PhD
Podcast Episode · Kidney Compass: Navigating Clinical Trials · 2025-11-13 · 17m
podcasts.apple.com
November 19, 2025 at 2:58 PM
In the last #KidneyKompass @brendonneuen.bsky.social chats with Sophia Zoungas podcasts.apple.com/ca/podcast/k... on the SURPASS data
G-force FTW @christosargyrop.bsky.social @rnflex.bsky.social
Hey @brianrifkin.bsky.social if sema is captopril what would you call dulaglutide? 😏
G-force FTW @christosargyrop.bsky.social @rnflex.bsky.social
Hey @brianrifkin.bsky.social if sema is captopril what would you call dulaglutide? 😏
My week-long attempt to install a functional DISA-STIG hardened RedHat Enterprise Linux had a happy ending!
#AllHailUbuntu
#AllHailUbuntu
November 19, 2025 at 2:31 AM
My week-long attempt to install a functional DISA-STIG hardened RedHat Enterprise Linux had a happy ending!
#AllHailUbuntu
#AllHailUbuntu
The AI copilot in Windows11 is going to be the mother of popcorn.
This is fresh from r/sysadmin
#CanYouFeelTheAGI ?
This is fresh from r/sysadmin
#CanYouFeelTheAGI ?
November 19, 2025 at 2:17 AM
The AI copilot in Windows11 is going to be the mother of popcorn.
This is fresh from r/sysadmin
#CanYouFeelTheAGI ?
This is fresh from r/sysadmin
#CanYouFeelTheAGI ?
About to get humiliated by DISA-STIG hardened Ubuntu
November 18, 2025 at 11:32 PM
About to get humiliated by DISA-STIG hardened Ubuntu
So my perspective on this:
1) I use a throwaway laptop from 2016 as BYOD for work
2) I very rarely log in my personal windows 11 device (and agentic AI is turned off)
3) I use my employer provided win11 at workband lament about the abuse the hardware receives from win11
Personal computing is Linux
1) I use a throwaway laptop from 2016 as BYOD for work
2) I very rarely log in my personal windows 11 device (and agentic AI is turned off)
3) I use my employer provided win11 at workband lament about the abuse the hardware receives from win11
Personal computing is Linux
"Microsoft warns that Windows 11's agentic AI could install malware on your PC: 'Only enable this feature if you understand the security implications.'"
bro what--
what are we doing here, exactly, how can you--anyone be okay with this?
bro what--
what are we doing here, exactly, how can you--anyone be okay with this?
November 18, 2025 at 5:54 PM
So my perspective on this:
1) I use a throwaway laptop from 2016 as BYOD for work
2) I very rarely log in my personal windows 11 device (and agentic AI is turned off)
3) I use my employer provided win11 at workband lament about the abuse the hardware receives from win11
Personal computing is Linux
1) I use a throwaway laptop from 2016 as BYOD for work
2) I very rarely log in my personal windows 11 device (and agentic AI is turned off)
3) I use my employer provided win11 at workband lament about the abuse the hardware receives from win11
Personal computing is Linux