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Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc @christosargyrop.bsky.social · 6h

The slopbots didn't fail to code a sys admin utility in Perl tonight. Looking at the stolen code I'd say the original was written with Perl v5.8 but used the PBP book (released in 2005) conventions for documentation. So it was pieced together from stuff written between 2005-2009.

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Reposted by Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc

Morgan @mackenmo.bsky.social · 10h

AlphaKeto here; maybe obvious, but for students reading I would emphasize the importance of purposeful curiosity-driven memorization to facilitate conceptual application. Memorizing facts w/ rigid thinking DOES trap you, while doing so expecting your understanding of them to deepen & change is key.

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Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc @christosargyrop.bsky.social · 12h

We're they kings in no need of last name?

Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc @christosargyrop.bsky.social · 13h

Who are the other 2?

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Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc @christosargyrop.bsky.social · 15h

Screenshot

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Reposted by Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc

Quijote1 @quijote1.bsky.social · 17h

data, prototyping etc. It doesn't matter if you in the end forget and use prof literature instead. These skills are there to stay.

I see it in my students: the ones who tend to put in the effort to memorize are better at *understanding* and sorting new information that they don't have to memorize.

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Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc @christosargyrop.bsky.social · 15h

A couple of technical comments on my approach . It has served me well in medicine, statistics, technology hobbies

mastodon.social/@ChristosArg...

Christos Argyropoulos MD PhD (@[email protected])

@[email protected] paper notes. My mentee @AlphaKeto asked me if I kept my notes from med school and the answer is yes. I use them for cross reference. Same things apply to my programming books whic...

mastodon.social

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Reposted by Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc

Quijote1 @quijote1.bsky.social · 17h

Unpopular opinion: I think memorization fosters transferable skills in *any* job, not just medicine: patience, resilience during inevitable failure, focus for long periods of time, resistance to distractors, task maintenance in working memory, sorting, extracting relevant information, organizing

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Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc @christosargyrop.bsky.social · 20h

I think I may follow the lead of others who have reverted to mid-2010s social media activity when many/most of us would blog elsewhere and then use social media such as Twitter as distribution channels. For those who don't want to bother with their own blogs , #LinkedIn is decent

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Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc @christosargyrop.bsky.social · 20h

data from #EMPAKIDNEY show that one can deliver material benefits among those who don't tolerate the older therapies.
Perhaps I am missing something, but while I see the immense value of programs to deliver #4pillar high value care, I don't see the value to partner with a #VBC.

Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc @christosargyrop.bsky.social · 20h

electronic health record and appointment reminders to track and assist with adherence. Just two of the now generic #4pillars (angiotensin and #flozin) pack more punch than what the #VBC ever promised to deliver. In the angiotensin blocker, intolerant patients ...

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Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc @christosargyrop.bsky.social · 20h

If a physician practice could get somehow get their Medicare patients on #angiotensin blockade #flozin #nsMRA and #glp1 (e.g. secondary insurance or coinsurance) why would they partner with a #VBC and share cost savings from the drugs? Just write a script & use the ...

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Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc @christosargyrop.bsky.social · 20h

underutilized (proven to be wrong by the #UPMC trial that demonstrated that the perceived underutilization was just the ceiling of these therapies). Since most #VBC worked with Medicare Part B (which does not cover drugs), they can not even pay for the #4pillars.

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Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc @christosargyrop.bsky.social · 20h

Can anyone articulate the value of the value based care in chronic kidney disease in the era of the #4pillars? Trad #VBC was based on the premise that generic angiotensin blockade was sufficient (false) and ....

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Reposted by Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc

James 🎃cello 🌉 @jamespirruccello.com · 2d

The implication of this article is that 0.005% of the US's annual CO2 emissions are from inhalers (25 million metric tons cumulatively over 10 years, vs 50 billion/year overall).

Conclusive demonstration that the CO2 release from inhalers is totally inconsequential.

jamanetwork.com/journals/jam...

This cross-sectional study estimates greenhouse gas emissions from all inhalers approved for asthma or chronic obstructive pulmonary disease (COPD) using aggregated dispensing data across the US outpa...

jamanetwork.com

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Reposted by Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc

laurentfranckx.bsky.social @laurentfranckx.bsky.social · 1d

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Reposted by Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc

commamonger 😷 (analogue writing assistant) @commamonger.bsky.social · 22h

Big bada-boom!

Katie Martin @katie0martin.ft.com · 22h

Bank of England flags risk of ‘sudden correction’ in tech stocks inflated by AI - on.ft.com/4o3RheA

Bank of England flags risk of ‘sudden correction’ in tech stocks inflated by AI

Financial Policy Committee warns equity prices are at levels comparable with dotcom bubble

on.ft.com

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Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc @christosargyrop.bsky.social · 1d

Eplerenone for those who don't want to grow boobs.

About to start someone on eple+aprocitentan too

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Reposted by Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc

Harriette Van Spall MD MPH 🇨🇦 @hvanspall.bsky.social · Aug 16

FDA announces approval for #semaglutide 2.4 mg sc weekly for #MASLD based on results of the #ESSENCE #RCT.

Did you know that #CVD is the leading cause of death in patients with #MASLD?

Common mechanisms & now, common treatments for #CKLM diseases
www.novonordisk.com/news-and-med...

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Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc @christosargyrop.bsky.social · 1d

Cool review of hemodynamic monitoring in critical care

www.uscjournal.com/articles/con...

by @hvanspall.bsky.social

It's too bad that the most similar critical article in a journal in my field was published when I was still a fellow.

Contemporary Review of Hemodynamic Monitoring in the Critical Care Setting

Hemodynamic assessment remains the most valuable adjunct to physical examination and laboratory assessment in the diagnosis and management of shock. Through the years, multiple modalities to

www.uscjournal.com

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Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc @christosargyrop.bsky.social · 1d

I was bad @stephensenn.bsky.social : I bad mouthed NNT in a review for a journal that does open reviews.

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Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc @christosargyrop.bsky.social · 1d

The screenshots are so cool (discussed mortality up to the end of 2023)

Interview in late 2025 discusses excess deaths (estimated as 2% by the interviewee and attributed to long covid) and drops in mortality due to glp1ra estimated to be ~6% by 2030.

insurancenewsnet.com/innarticle/s...

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Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc @christosargyrop.bsky.social · 1d

Seems performance worse in ckd

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Reposted by Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc

Journal of Clinical Investigation @jci.org · 1d

The reno-protective effects of SGLT2 inhibitors cannot be fully explained by their glucose-lowering actions.

Quaggin & team now show SGLT2 inhibition increases tissue levels of SAM, resulting in enhanced H3K27 trimethylation & repression of inflammatory genes: www.jci.org/articles/vie...

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Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc @christosargyrop.bsky.social · 1d

He has been for a while (wasn't he one of the 1+1 != 2 ppl @cubiclogic.bsky.social )

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